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Q9Y585 (OR1A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1A2
Alternative name(s):
Olfactory receptor 17-6
Short name=OR17-6
Olfactory receptor OR17-10
Gene names
Name:OR1A2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Olfactory receptor 1A2
PRO_0000150415

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21823Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27012Extracellular Potential
Transmembrane271 – 29020Helical; Name=7; Potential
Topological domain291 – 30919Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant2441L → F.
Corresponds to variant rs56058341 [ dbSNP | Ensembl ].
VAR_062007
Natural variant2561G → C. Ref.2
Corresponds to variant rs2241091 [ dbSNP | Ensembl ].
VAR_022047
Natural variant2601R → C. Ref.2
Corresponds to variant rs2469791 [ dbSNP | Ensembl ].
VAR_034162
Natural variant2931W → C. Ref.2
Corresponds to variant rs12150427 [ dbSNP | Ensembl ].
VAR_034163

Sequences

Sequence LengthMass (Da)Tools
Q9Y585 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 0BB9B26EB8D51B90

FASTA30934,396
        10         20         30         40         50         60 
MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY 

        70         80         90        100        110        120 
FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ MYFMIALAKA DSYTLAAMAY 

       130        140        150        160        170        180 
DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD 

       190        200        210        220        230        240 
IMPLLKLSCS DVHFNVKMMY LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC 

       250        260        270        280        290        300 
GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ 


KLFSKRISS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-256; CYS-260 AND CYS-293.
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF155225 Genomic DNA. Translation: AAD39545.1.
BC069092 mRNA. Translation: AAH69092.1.
BC106733 mRNA. Translation: AAI06734.1.
BC106734 mRNA. Translation: AAI06735.1.
AF399556 Genomic DNA. Translation: AAK95041.1.
BK004242 Genomic DNA. Translation: DAA04640.1.
CCDSCCDS11021.1.
RefSeqNP_036484.1. NM_012352.1.
UniGeneHs.532660.

3D structure databases

ProteinModelPortalQ9Y585.
SMRQ9Y585. Positions 25-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371377.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Y585.

Polymorphism databases

DMDM9297027.

Proteomic databases

PaxDbQ9Y585.
PRIDEQ9Y585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381951; ENSP00000371377; ENSG00000172150.
GeneID26189.
KEGGhsa:26189.
UCSCuc002fvd.1. human.

Organism-specific databases

CTD26189.
GeneCardsGC17P003100.
HGNCHGNC:8180. OR1A2.
neXtProtNX_Q9Y585.
PharmGKBPA32052.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150319.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ9Y585.
KOK04257.
OMANFYCDIM.
OrthoDBEOG7FNC7V.
PhylomeDBQ9Y585.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1A2.
GenevestigatorQ9Y585.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1A2.
GenomeRNAi26189.
NextBio48318.
PROQ9Y585.

Entry information

Entry nameOR1A2_HUMAN
AccessionPrimary (citable) accession number: Q9Y585
Secondary accession number(s): Q3KPH3 expand/collapse secondary AC list , Q6IFM0, Q6NTD8, Q96R86
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries