Q9Y585 (OR1A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1A2

Alternative name(s):
Olfactory receptor 17-6
Short name=OR17-6
Olfactory receptor OR17-10

Gene names

Name:

OR1A2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Olfactory receptor 1A2		PRO_0000150415
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 218	23	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 270	12	Extracellular Potential
	Transmembrane	271 – 290	20	Helical; Name=7; Potential
	Topological domain	291 – 309	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	244	1	L → F. Corresponds to variant rs56058341 [ dbSNP | Ensembl ].		VAR_062007
	Natural variant	256	1	G → C. Ref.2 Corresponds to variant rs2241091 [ dbSNP | Ensembl ].		VAR_022047
	Natural variant	260	1	R → C. Ref.2 Corresponds to variant rs2469791 [ dbSNP | Ensembl ].		VAR_034162
	Natural variant	293	1	W → C. Ref.2 Corresponds to variant rs12150427 [ dbSNP | Ensembl ].		VAR_034163

Sequences

	Sequence		Length	Mass (Da)
	Q9Y585 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0BB9B26EB8D51B90	FASTA	309	34,396
	10 20 30 40 50 60 MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY 70 80 90 100 110 120 FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ MYFMIALAKA DSYTLAAMAY 130 140 150 160 170 180 DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD 190 200 210 220 230 240 IMPLLKLSCS DVHFNVKMMY LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC 250 260 270 280 290 300 GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ KLFSKRISS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-256; CYS-260 AND CYS-293.
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF155225 Genomic DNA. Translation: AAD39545.1. BC069092 mRNA. Translation: AAH69092.1. BC106733 mRNA. Translation: AAI06734.1. BC106734 mRNA. Translation: AAI06735.1. AF399556 Genomic DNA. Translation: AAK95041.1. BK004242 Genomic DNA. Translation: DAA04640.1.
IPI	IPI00001143.
RefSeq	NP_036484.1. NM_012352.1.
UniGene	Hs.532660.
3D structure databases
ProteinModelPortal	Q9Y585.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371377.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9Y585.
Polymorphism databases
DMDM	9297027.
Proteomic databases
PaxDb	Q9Y585.
PRIDE	Q9Y585.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381951; ENSP00000371377; ENSG00000172150.
GeneID	26189.
KEGG	hsa:26189.
UCSC	uc002fvd.1. human.
Organism-specific databases
CTD	26189.
GeneCards	GC17P003100.
HGNC	HGNC:8180. OR1A2.
neXtProt	NX_Q9Y585.
PharmGKB	PA32052.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150319.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q9Y585.
KO	K04257.
OMA	NFYCDIM.
OrthoDB	EOG4V6ZH5.
PhylomeDB	Q9Y585.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR1A2.
Genevestigator	Q9Y585.
GermOnline	ENSG00000172150. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26189.
NextBio	48318.

Entry information

Entry name

OR1A2_HUMAN

Accession

Primary (citable) accession number: Q9Y585
Secondary accession number(s): Q3KPH3 , Q6IFM0, Q6NTD8, Q96R86

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.