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Q9Y585

- OR1A2_HUMAN

UniProt

Q9Y585 - OR1A2_HUMAN

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Protein

Olfactory receptor 1A2

Gene

OR1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro

GO - Biological processi

  1. positive regulation of cytokinesis Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1A2
Alternative name(s):
Olfactory receptor 17-6
Short name:
OR17-6
Olfactory receptor OR17-10
Gene namesi
Name:OR1A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8180. OR1A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27012ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 30919CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 1A2PRO_0000150415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y585.
PRIDEiQ9Y585.

PTM databases

PhosphoSiteiQ9Y585.

Expressioni

Gene expression databases

CleanExiHS_OR1A2.
GenevestigatoriQ9Y585.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371377.

Structurei

3D structure databases

ProteinModelPortaliQ9Y585.
SMRiQ9Y585. Positions 25-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150319.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9Y585.
KOiK04257.
OMAiNFYCDIM.
OrthoDBiEOG7FNC7V.
PhylomeDBiQ9Y585.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y585-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC
60 70 80 90 100
ADIRLHNPMY FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ
110 120 130 140 150
MYFMIALAKA DSYTLAAMAY DRAVAISCPL HYTTIMSPRS CILLIAGSWV
160 170 180 190 200
IGNTSALPHT LLTASLSFCG NQEVANFYCD IMPLLKLSCS DVHFNVKMMY
210 220 230 240 250
LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC GSHLTVVFLY
260 270 280 290 300
YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ

KLFSKRISS
Length:309
Mass (Da):34,396
Last modified:November 1, 1999 - v1
Checksum:i0BB9B26EB8D51B90
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441L → F.
Corresponds to variant rs56058341 [ dbSNP | Ensembl ].
VAR_062007
Natural varianti256 – 2561G → C.1 Publication
Corresponds to variant rs2241091 [ dbSNP | Ensembl ].
VAR_022047
Natural varianti260 – 2601R → C.1 Publication
Corresponds to variant rs2469791 [ dbSNP | Ensembl ].
VAR_034162
Natural varianti293 – 2931W → C.1 Publication
Corresponds to variant rs12150427 [ dbSNP | Ensembl ].
VAR_034163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155225 Genomic DNA. Translation: AAD39545.1.
BC069092 mRNA. Translation: AAH69092.1.
BC106733 mRNA. Translation: AAI06734.1.
BC106734 mRNA. Translation: AAI06735.1.
AF399556 Genomic DNA. Translation: AAK95041.1.
BK004242 Genomic DNA. Translation: DAA04640.1.
CCDSiCCDS11021.1.
RefSeqiNP_036484.1. NM_012352.1.
UniGeneiHs.532660.

Genome annotation databases

EnsembliENST00000381951; ENSP00000371377; ENSG00000172150.
GeneIDi26189.
KEGGihsa:26189.
UCSCiuc002fvd.1. human.

Polymorphism databases

DMDMi9297027.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155225 Genomic DNA. Translation: AAD39545.1 .
BC069092 mRNA. Translation: AAH69092.1 .
BC106733 mRNA. Translation: AAI06734.1 .
BC106734 mRNA. Translation: AAI06735.1 .
AF399556 Genomic DNA. Translation: AAK95041.1 .
BK004242 Genomic DNA. Translation: DAA04640.1 .
CCDSi CCDS11021.1.
RefSeqi NP_036484.1. NM_012352.1.
UniGenei Hs.532660.

3D structure databases

ProteinModelPortali Q9Y585.
SMRi Q9Y585. Positions 25-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371377.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9Y585.

Polymorphism databases

DMDMi 9297027.

Proteomic databases

PaxDbi Q9Y585.
PRIDEi Q9Y585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381951 ; ENSP00000371377 ; ENSG00000172150 .
GeneIDi 26189.
KEGGi hsa:26189.
UCSCi uc002fvd.1. human.

Organism-specific databases

CTDi 26189.
GeneCardsi GC17P003100.
HGNCi HGNC:8180. OR1A2.
neXtProti NX_Q9Y585.
PharmGKBi PA32052.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150319.
GeneTreei ENSGT00760000119207.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q9Y585.
KOi K04257.
OMAi NFYCDIM.
OrthoDBi EOG7FNC7V.
PhylomeDBi Q9Y585.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1A2.
GenomeRNAii 26189.
NextBioi 48318.
PROi Q9Y585.

Gene expression databases

CleanExi HS_OR1A2.
Genevestigatori Q9Y585.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-256; CYS-260 AND CYS-293.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1A2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y585
Secondary accession number(s): Q3KPH3
, Q6IFM0, Q6NTD8, Q96R86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3