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Protein

Olfactory receptor 1A2

Gene

OR1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytokinesis Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1A2
Alternative name(s):
Olfactory receptor 17-6
Short name:
OR17-6
Olfactory receptor OR17-10
Gene namesi
Name:OR1A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172150.4.
HGNCiHGNC:8180. OR1A2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 218Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 270ExtracellularSequence analysisAdd BLAST12
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172150.
PharmGKBiPA32052.

Polymorphism and mutation databases

BioMutaiOR1A2.
DMDMi9297027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504151 – 309Olfactory receptor 1A2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y585.
PRIDEiQ9Y585.

PTM databases

iPTMnetiQ9Y585.
PhosphoSitePlusiQ9Y585.

Expressioni

Gene expression databases

BgeeiENSG00000172150.
CleanExiHS_OR1A2.
ExpressionAtlasiQ9Y585. baseline and differential.
GenevisibleiQ9Y585. HS.

Interactioni

Protein-protein interaction databases

BioGridi117602. 5 interactors.
STRINGi9606.ENSP00000371377.

Structurei

3D structure databases

ProteinModelPortaliQ9Y585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCMB. Eukaryota.
ENOG4110NUF. LUCA.
GeneTreeiENSGT00900000141057.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9Y585.
KOiK04257.
OMAiNFYCDIM.
OrthoDBiEOG091G0FGP.
PhylomeDBiQ9Y585.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC
60 70 80 90 100
ADIRLHNPMY FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ
110 120 130 140 150
MYFMIALAKA DSYTLAAMAY DRAVAISCPL HYTTIMSPRS CILLIAGSWV
160 170 180 190 200
IGNTSALPHT LLTASLSFCG NQEVANFYCD IMPLLKLSCS DVHFNVKMMY
210 220 230 240 250
LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC GSHLTVVFLY
260 270 280 290 300
YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ

KLFSKRISS
Length:309
Mass (Da):34,396
Last modified:November 1, 1999 - v1
Checksum:i0BB9B26EB8D51B90
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062007244L → F. Corresponds to variant dbSNP:rs56058341Ensembl.1
Natural variantiVAR_022047256G → C1 PublicationCorresponds to variant dbSNP:rs2241091Ensembl.1
Natural variantiVAR_034162260R → C1 PublicationCorresponds to variant dbSNP:rs2469791Ensembl.1
Natural variantiVAR_034163293W → C1 PublicationCorresponds to variant dbSNP:rs12150427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155225 Genomic DNA. Translation: AAD39545.1.
BC069092 mRNA. Translation: AAH69092.1.
BC106733 mRNA. Translation: AAI06734.1.
BC106734 mRNA. Translation: AAI06735.1.
AF399556 Genomic DNA. Translation: AAK95041.1.
BK004242 Genomic DNA. Translation: DAA04640.1.
CCDSiCCDS11021.1.
RefSeqiNP_036484.1. NM_012352.2.
UniGeneiHs.532660.

Genome annotation databases

EnsembliENST00000381951; ENSP00000371377; ENSG00000172150.
GeneIDi26189.
KEGGihsa:26189.
UCSCiuc002fvd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1A2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y585
Secondary accession number(s): Q3KPH3
, Q6IFM0, Q6NTD8, Q96R86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families