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Q9Y585

- OR1A2_HUMAN

UniProt

Q9Y585 - OR1A2_HUMAN

Protein

Olfactory receptor 1A2

Gene

OR1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of cytokinesis Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1A2
    Alternative name(s):
    Olfactory receptor 17-6
    Short name:
    OR17-6
    Olfactory receptor OR17-10
    Gene namesi
    Name:OR1A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8180. OR1A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32052.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Olfactory receptor 1A2PRO_0000150415Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y585.
    PRIDEiQ9Y585.

    PTM databases

    PhosphoSiteiQ9Y585.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1A2.
    GenevestigatoriQ9Y585.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y585.
    SMRiQ9Y585. Positions 25-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 30919CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150319.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ9Y585.
    KOiK04257.
    OMAiNFYCDIM.
    OrthoDBiEOG7FNC7V.
    PhylomeDBiQ9Y585.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC    50
    ADIRLHNPMY FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ 100
    MYFMIALAKA DSYTLAAMAY DRAVAISCPL HYTTIMSPRS CILLIAGSWV 150
    IGNTSALPHT LLTASLSFCG NQEVANFYCD IMPLLKLSCS DVHFNVKMMY 200
    LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC GSHLTVVFLY 250
    YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ 300
    KLFSKRISS 309
    Length:309
    Mass (Da):34,396
    Last modified:November 1, 1999 - v1
    Checksum:i0BB9B26EB8D51B90
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti244 – 2441L → F.
    Corresponds to variant rs56058341 [ dbSNP | Ensembl ].
    VAR_062007
    Natural varianti256 – 2561G → C.1 Publication
    Corresponds to variant rs2241091 [ dbSNP | Ensembl ].
    VAR_022047
    Natural varianti260 – 2601R → C.1 Publication
    Corresponds to variant rs2469791 [ dbSNP | Ensembl ].
    VAR_034162
    Natural varianti293 – 2931W → C.1 Publication
    Corresponds to variant rs12150427 [ dbSNP | Ensembl ].
    VAR_034163

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155225 Genomic DNA. Translation: AAD39545.1.
    BC069092 mRNA. Translation: AAH69092.1.
    BC106733 mRNA. Translation: AAI06734.1.
    BC106734 mRNA. Translation: AAI06735.1.
    AF399556 Genomic DNA. Translation: AAK95041.1.
    BK004242 Genomic DNA. Translation: DAA04640.1.
    CCDSiCCDS11021.1.
    RefSeqiNP_036484.1. NM_012352.1.
    UniGeneiHs.532660.

    Genome annotation databases

    EnsembliENST00000381951; ENSP00000371377; ENSG00000172150.
    GeneIDi26189.
    KEGGihsa:26189.
    UCSCiuc002fvd.1. human.

    Polymorphism databases

    DMDMi9297027.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155225 Genomic DNA. Translation: AAD39545.1 .
    BC069092 mRNA. Translation: AAH69092.1 .
    BC106733 mRNA. Translation: AAI06734.1 .
    BC106734 mRNA. Translation: AAI06735.1 .
    AF399556 Genomic DNA. Translation: AAK95041.1 .
    BK004242 Genomic DNA. Translation: DAA04640.1 .
    CCDSi CCDS11021.1.
    RefSeqi NP_036484.1. NM_012352.1.
    UniGenei Hs.532660.

    3D structure databases

    ProteinModelPortali Q9Y585.
    SMRi Q9Y585. Positions 25-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371377.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Y585.

    Polymorphism databases

    DMDMi 9297027.

    Proteomic databases

    PaxDbi Q9Y585.
    PRIDEi Q9Y585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381951 ; ENSP00000371377 ; ENSG00000172150 .
    GeneIDi 26189.
    KEGGi hsa:26189.
    UCSCi uc002fvd.1. human.

    Organism-specific databases

    CTDi 26189.
    GeneCardsi GC17P003100.
    HGNCi HGNC:8180. OR1A2.
    neXtProti NX_Q9Y585.
    PharmGKBi PA32052.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150319.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q9Y585.
    KOi K04257.
    OMAi NFYCDIM.
    OrthoDBi EOG7FNC7V.
    PhylomeDBi Q9Y585.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1A2.
    GenomeRNAii 26189.
    NextBioi 48318.
    PROi Q9Y585.

    Gene expression databases

    CleanExi HS_OR1A2.
    Genevestigatori Q9Y585.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
      Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
      Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-256; CYS-260 AND CYS-293.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1A2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y585
    Secondary accession number(s): Q3KPH3
    , Q6IFM0, Q6NTD8, Q96R86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3