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Protein

Mitochondrial import inner membrane translocase subunit Tim22

Gene

TIMM22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).By similarity

GO - Molecular functioni

  • mitochondrion targeting sequence binding Source: GO_Central
  • protein channel activity Source: BHF-UCL

GO - Biological processi

  • protein import into mitochondrial inner membrane Source: BHF-UCL
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177370-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim22
Alternative name(s):
Testis-expressed sequence 4
Gene namesi
Name:TIMM22
Synonyms:TEX4, TIM22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17317. TIMM22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29928.
OpenTargetsiENSG00000177370.
ENSG00000277649.
ENSG00000278501.
PharmGKBiPA38230.

Polymorphism and mutation databases

BioMutaiTIMM22.
DMDMi24638462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102981 – 194Mitochondrial import inner membrane translocase subunit Tim22Add BLAST194

Proteomic databases

EPDiQ9Y584.
MaxQBiQ9Y584.
PaxDbiQ9Y584.
PeptideAtlasiQ9Y584.
PRIDEiQ9Y584.

PTM databases

iPTMnetiQ9Y584.
PhosphoSitePlusiQ9Y584.

Expressioni

Gene expression databases

BgeeiENSG00000177370.
CleanExiHS_TIMM22.
GenevisibleiQ9Y584. HS.

Organism-specific databases

HPAiHPA045138.

Interactioni

Subunit structurei

Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.1 Publication

Protein-protein interaction databases

BioGridi118969. 3 interactors.
IntActiQ9Y584. 4 interactors.
STRINGi9606.ENSP00000320236.

Structurei

3D structure databases

ProteinModelPortaliQ9Y584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000016067.
HOGENOMiHOG000161169.
HOVERGENiHBG054910.
InParanoidiQ9Y584.
KOiK17790.
OMAiTTHSYAK.
OrthoDBiEOG091G0SGH.
PhylomeDBiQ9Y584.
TreeFamiTF105836.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPNAGG SAPETAGSAE APLQYSLLLQ YLVGDKRQPR LLEPGSLGGI
60 70 80 90 100
PSPAKSEEQK MIEKAMESCA FKAALACVGG FVLGGAFGVF TAGIDTNVGF
110 120 130 140 150
DPKDPYRTPT AKEVLKDMGQ RGMSYAKNFA IVGAMFSCTE CLIESYRGTS
160 170 180 190
DWKNSVISGC ITGGAIGFRA GLKAGAIGCG GFAAFSAAID YYLR
Length:194
Mass (Da):20,031
Last modified:November 1, 2002 - v2
Checksum:iA1E6DD9F7F7399D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117 – 118DM → EH in AAD40106 (PubMed:10611480).Curated2
Sequence conflicti140E → W in AAD40106 (PubMed:10611480).Curated1
Sequence conflicti152W → L in AAD40106 (PubMed:10611480).Curated1
Sequence conflicti166 – 167IG → YW in AAD40106 (PubMed:10611480).Curated2
Sequence conflicti177 – 178IG → LL in AAD40106 (PubMed:10611480).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155330 mRNA. Translation: AAD40106.1.
AK000830 mRNA. Translation: BAA91392.1.
BC002324 mRNA. Translation: AAH02324.1.
CCDSiCCDS32521.1.
RefSeqiNP_037469.2. NM_013337.3.
UniGeneiHs.745034.

Genome annotation databases

EnsembliENST00000327158; ENSP00000320236; ENSG00000177370.
ENST00000613269; ENSP00000482204; ENSG00000278501.
ENST00000617832; ENSP00000478463; ENSG00000277649.
GeneIDi29928.
KEGGihsa:29928.
UCSCiuc002fsc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155330 mRNA. Translation: AAD40106.1.
AK000830 mRNA. Translation: BAA91392.1.
BC002324 mRNA. Translation: AAH02324.1.
CCDSiCCDS32521.1.
RefSeqiNP_037469.2. NM_013337.3.
UniGeneiHs.745034.

3D structure databases

ProteinModelPortaliQ9Y584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118969. 3 interactors.
IntActiQ9Y584. 4 interactors.
STRINGi9606.ENSP00000320236.

PTM databases

iPTMnetiQ9Y584.
PhosphoSitePlusiQ9Y584.

Polymorphism and mutation databases

BioMutaiTIMM22.
DMDMi24638462.

Proteomic databases

EPDiQ9Y584.
MaxQBiQ9Y584.
PaxDbiQ9Y584.
PeptideAtlasiQ9Y584.
PRIDEiQ9Y584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327158; ENSP00000320236; ENSG00000177370.
ENST00000613269; ENSP00000482204; ENSG00000278501.
ENST00000617832; ENSP00000478463; ENSG00000277649.
GeneIDi29928.
KEGGihsa:29928.
UCSCiuc002fsc.4. human.

Organism-specific databases

CTDi29928.
DisGeNETi29928.
GeneCardsiTIMM22.
HGNCiHGNC:17317. TIMM22.
HPAiHPA045138.
MIMi607251. gene.
neXtProtiNX_Q9Y584.
OpenTargetsiENSG00000177370.
ENSG00000277649.
ENSG00000278501.
PharmGKBiPA38230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3225. Eukaryota.
COG5596. LUCA.
GeneTreeiENSGT00390000016067.
HOGENOMiHOG000161169.
HOVERGENiHBG054910.
InParanoidiQ9Y584.
KOiK17790.
OMAiTTHSYAK.
OrthoDBiEOG091G0SGH.
PhylomeDBiQ9Y584.
TreeFamiTF105836.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177370-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

GeneWikiiTIMM22.
GenomeRNAii29928.
PROiQ9Y584.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177370.
CleanExiHS_TIMM22.
GenevisibleiQ9Y584. HS.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIM22_HUMAN
AccessioniPrimary (citable) accession number: Q9Y584
Secondary accession number(s): Q9NWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 2002
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.