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Protein

Insulin-like peptide INSL6

Gene

INSL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in sperm development and fertilization.

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL6
Short name:
Insulin-like peptide 6
Alternative name(s):
Relaxin/insulin-like factor 1
Cleaved into the following 2 chains:
Gene namesi
Name:INSL6
Synonyms:RIF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:6089. INSL6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29896.

Polymorphism and mutation databases

BioMutaiINSL6.
DMDMi20178309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 213193Insulin-like peptide INSL6PRO_0000016172Add
BLAST
Peptidei21 – 5333Insulin-like peptide INSL6 B chainSequence AnalysisPRO_0000016173Add
BLAST
Propeptidei55 – 168114Connecting peptideSequence AnalysisPRO_0000016174Add
BLAST
Peptidei173 – 19826Insulin-like peptide INSL6 A chainSequence AnalysisPRO_0000016175Add
BLAST
Propeptidei201 – 21313Sequence AnalysisPRO_0000016176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 179By similarity
Disulfide bondi45 ↔ 192By similarity
Disulfide bondi178 ↔ 183By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9Y581.
PRIDEiQ9Y581.

PTM databases

PhosphoSiteiQ9Y581.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9Y581.
CleanExiHS_INSL6.
HS_RIF1.
GenevisibleiQ9Y581. HS.

Organism-specific databases

HPAiHPA021364.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371054.

Structurei

3D structure databases

ProteinModelPortaliQ9Y581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47664.
GeneTreeiENSGT00510000049111.
HOGENOMiHOG000113078.
HOVERGENiHBG052136.
InParanoidiQ9Y581.
KOiK05255.
OMAiFWGNHPQ.
OrthoDBiEOG712TXB.
PhylomeDBiQ9Y581.
TreeFamiTF343788.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
[Graphical view]
PANTHERiPTHR12004:SF1. PTHR12004:SF1. 1 hit.
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLLRLSLL WLGLLLVRFS RELSDISSAR KLCGRYLVKE IEKLCGHANW
60 70 80 90 100
SQFRFEEETP FSRLIAQASE KVEAYSPYQF ESPQTASPAR GRGTNPVSTS
110 120 130 140 150
WEEAVNSWEM QSLPEYKDKK GYSPLGKTRE FSSSHNINVY IHENAKFQKK
160 170 180 190 200
RRNKIKTLSN LFWGHHPQRK RRGYSEKCCL TGCTKEELSI ACLPYIDFKR
210
LKEKRSSLVT KIY
Length:213
Mass (Da):24,860
Last modified:April 16, 2002 - v2
Checksum:i12A097659CFAC471
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461K → F in AAD39003 (PubMed:10819760).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801F → L.
Corresponds to variant rs2149554 [ dbSNP | Ensembl ].
VAR_024329

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135824 mRNA. Translation: AAF29604.1.
AF156094 mRNA. Translation: AAD39003.1.
AL161450 Genomic DNA. Translation: CAD13336.1.
BC126473 mRNA. Translation: AAI26474.1.
BC126475 mRNA. Translation: AAI26476.1.
CCDSiCCDS6458.1.
RefSeqiNP_009110.2. NM_007179.2.
UniGeneiHs.632648.

Genome annotation databases

EnsembliENST00000381641; ENSP00000371054; ENSG00000120210.
GeneIDi11172.
KEGGihsa:11172.
UCSCiuc003zix.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135824 mRNA. Translation: AAF29604.1.
AF156094 mRNA. Translation: AAD39003.1.
AL161450 Genomic DNA. Translation: CAD13336.1.
BC126473 mRNA. Translation: AAI26474.1.
BC126475 mRNA. Translation: AAI26476.1.
CCDSiCCDS6458.1.
RefSeqiNP_009110.2. NM_007179.2.
UniGeneiHs.632648.

3D structure databases

ProteinModelPortaliQ9Y581.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371054.

PTM databases

PhosphoSiteiQ9Y581.

Polymorphism and mutation databases

BioMutaiINSL6.
DMDMi20178309.

Proteomic databases

PaxDbiQ9Y581.
PRIDEiQ9Y581.

Protocols and materials databases

DNASUi11172.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381641; ENSP00000371054; ENSG00000120210.
GeneIDi11172.
KEGGihsa:11172.
UCSCiuc003zix.3. human.

Organism-specific databases

CTDi11172.
GeneCardsiGC09M005141.
HGNCiHGNC:6089. INSL6.
HPAiHPA021364.
MIMi606414. gene.
neXtProtiNX_Q9Y581.
PharmGKBiPA29896.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47664.
GeneTreeiENSGT00510000049111.
HOGENOMiHOG000113078.
HOVERGENiHBG052136.
InParanoidiQ9Y581.
KOiK05255.
OMAiFWGNHPQ.
OrthoDBiEOG712TXB.
PhylomeDBiQ9Y581.
TreeFamiTF343788.

Miscellaneous databases

GenomeRNAii11172.
NextBioi42513.
PROiQ9Y581.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y581.
CleanExiHS_INSL6.
HS_RIF1.
GenevisibleiQ9Y581. HS.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
[Graphical view]
PANTHERiPTHR12004:SF1. PTHR12004:SF1. 1 hit.
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
    Hsu S.Y.
    Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat."
    Lok S., Johnston D.S., Conklin D., Lofton-Day C.E., Adams R.L., Jelmberg A.C., Whitmore T.E., Schrader S., Griswold M.D., Jaspers S.R.
    Biol. Reprod. 62:1593-1599(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiINSL6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y581
Secondary accession number(s): A0AVS0, Q9NS16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 16, 2002
Last modified: June 24, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.