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Q9Y581

- INSL6_HUMAN

UniProt

Q9Y581 - INSL6_HUMAN

Protein

Insulin-like peptide INSL6

Gene

INSL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    May have a role in sperm development and fertilization.

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB

    GO - Biological processi

    1. fertilization Source: Ensembl
    2. male gonad development Source: Ensembl
    3. negative regulation of apoptotic process Source: Ensembl
    4. spermatid development Source: Ensembl
    5. sperm motility Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like peptide INSL6
    Short name:
    Insulin-like peptide 6
    Alternative name(s):
    Relaxin/insulin-like factor 1
    Cleaved into the following 2 chains:
    Gene namesi
    Name:INSL6
    Synonyms:RIF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:6089. INSL6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29896.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 213193Insulin-like peptide INSL6PRO_0000016172Add
    BLAST
    Peptidei21 – 5333Insulin-like peptide INSL6 B chainSequence AnalysisPRO_0000016173Add
    BLAST
    Propeptidei55 – 168114Connecting peptideSequence AnalysisPRO_0000016174Add
    BLAST
    Peptidei173 – 19826Insulin-like peptide INSL6 A chainSequence AnalysisPRO_0000016175Add
    BLAST
    Propeptidei201 – 21313Sequence AnalysisPRO_0000016176Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 179By similarity
    Disulfide bondi45 ↔ 192By similarity
    Disulfide bondi178 ↔ 183By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiQ9Y581.
    PRIDEiQ9Y581.

    PTM databases

    PhosphoSiteiQ9Y581.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    BgeeiQ9Y581.
    CleanExiHS_INSL6.
    HS_RIF1.
    GenevestigatoriQ9Y581.

    Organism-specific databases

    HPAiHPA021364.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47664.
    HOGENOMiHOG000113078.
    HOVERGENiHBG052136.
    InParanoidiQ9Y581.
    KOiK05255.
    OMAiSIACLPY.
    OrthoDBiEOG712TXB.
    PhylomeDBiQ9Y581.
    TreeFamiTF343788.

    Family and domain databases

    Gene3Di1.10.100.10. 2 hits.
    InterProiIPR016179. Insulin-like.
    IPR017100. Insulin-like_pep_6.
    IPR022353. Insulin_CS.
    [Graphical view]
    PANTHERiPTHR12004:SF1. PTHR12004:SF1. 1 hit.
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 2 hits.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRLLRLSLL WLGLLLVRFS RELSDISSAR KLCGRYLVKE IEKLCGHANW    50
    SQFRFEEETP FSRLIAQASE KVEAYSPYQF ESPQTASPAR GRGTNPVSTS 100
    WEEAVNSWEM QSLPEYKDKK GYSPLGKTRE FSSSHNINVY IHENAKFQKK 150
    RRNKIKTLSN LFWGHHPQRK RRGYSEKCCL TGCTKEELSI ACLPYIDFKR 200
    LKEKRSSLVT KIY 213
    Length:213
    Mass (Da):24,860
    Last modified:April 16, 2002 - v2
    Checksum:i12A097659CFAC471
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461K → F in AAD39003. (PubMed:10819760)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801F → L.
    Corresponds to variant rs2149554 [ dbSNP | Ensembl ].
    VAR_024329

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135824 mRNA. Translation: AAF29604.1.
    AF156094 mRNA. Translation: AAD39003.1.
    AL161450 Genomic DNA. Translation: CAD13336.1.
    BC126473 mRNA. Translation: AAI26474.1.
    BC126475 mRNA. Translation: AAI26476.1.
    CCDSiCCDS6458.1.
    RefSeqiNP_009110.2. NM_007179.2.
    UniGeneiHs.632648.

    Genome annotation databases

    EnsembliENST00000381641; ENSP00000371054; ENSG00000120210.
    GeneIDi11172.
    KEGGihsa:11172.
    UCSCiuc003zix.3. human.

    Polymorphism databases

    DMDMi20178309.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135824 mRNA. Translation: AAF29604.1 .
    AF156094 mRNA. Translation: AAD39003.1 .
    AL161450 Genomic DNA. Translation: CAD13336.1 .
    BC126473 mRNA. Translation: AAI26474.1 .
    BC126475 mRNA. Translation: AAI26476.1 .
    CCDSi CCDS6458.1.
    RefSeqi NP_009110.2. NM_007179.2.
    UniGenei Hs.632648.

    3D structure databases

    ProteinModelPortali Q9Y581.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371054.

    PTM databases

    PhosphoSitei Q9Y581.

    Polymorphism databases

    DMDMi 20178309.

    Proteomic databases

    PaxDbi Q9Y581.
    PRIDEi Q9Y581.

    Protocols and materials databases

    DNASUi 11172.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381641 ; ENSP00000371054 ; ENSG00000120210 .
    GeneIDi 11172.
    KEGGi hsa:11172.
    UCSCi uc003zix.3. human.

    Organism-specific databases

    CTDi 11172.
    GeneCardsi GC09M005163.
    HGNCi HGNC:6089. INSL6.
    HPAi HPA021364.
    MIMi 606414. gene.
    neXtProti NX_Q9Y581.
    PharmGKBi PA29896.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47664.
    HOGENOMi HOG000113078.
    HOVERGENi HBG052136.
    InParanoidi Q9Y581.
    KOi K05255.
    OMAi SIACLPY.
    OrthoDBi EOG712TXB.
    PhylomeDBi Q9Y581.
    TreeFami TF343788.

    Miscellaneous databases

    GenomeRNAii 11172.
    NextBioi 42513.
    PROi Q9Y581.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y581.
    CleanExi HS_INSL6.
    HS_RIF1.
    Genevestigatori Q9Y581.

    Family and domain databases

    Gene3Di 1.10.100.10. 2 hits.
    InterProi IPR016179. Insulin-like.
    IPR017100. Insulin-like_pep_6.
    IPR022353. Insulin_CS.
    [Graphical view ]
    PANTHERi PTHR12004:SF1. PTHR12004:SF1. 1 hit.
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037062. Insulin-like_peptide_6. 1 hit.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 2 hits.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
      Hsu S.Y.
      Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat."
      Lok S., Johnston D.S., Conklin D., Lofton-Day C.E., Adams R.L., Jelmberg A.C., Whitmore T.E., Schrader S., Griswold M.D., Jaspers S.R.
      Biol. Reprod. 62:1593-1599(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiINSL6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y581
    Secondary accession number(s): A0AVS0, Q9NS16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3