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Q9Y581 (INSL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like peptide INSL6

Short name=Insulin-like peptide 6
Alternative name(s):
Relaxin/insulin-like factor 1
Gene names
Name:INSL6
Synonyms:RIF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in sperm development and fertilization.

Subcellular location

Secreted By similarity.

Tissue specificity

Testis specific.

Sequence similarities

Belongs to the insulin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 213193Insulin-like peptide INSL6
PRO_0000016172
Peptide21 – 5333Insulin-like peptide INSL6 B chain Potential
PRO_0000016173
Propeptide55 – 168114Connecting peptide Potential
PRO_0000016174
Peptide173 – 19826Insulin-like peptide INSL6 A chain Potential
PRO_0000016175
Propeptide201 – 21313 Potential
PRO_0000016176

Amino acid modifications

Disulfide bond33 ↔ 179 By similarity
Disulfide bond45 ↔ 192 By similarity
Disulfide bond178 ↔ 183 By similarity

Natural variations

Natural variant801F → L.
Corresponds to variant rs2149554 [ dbSNP | Ensembl ].
VAR_024329

Experimental info

Sequence conflict1461K → F in AAD39003. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y581 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: 12A097659CFAC471

FASTA21324,860
        10         20         30         40         50         60 
MPRLLRLSLL WLGLLLVRFS RELSDISSAR KLCGRYLVKE IEKLCGHANW SQFRFEEETP 

        70         80         90        100        110        120 
FSRLIAQASE KVEAYSPYQF ESPQTASPAR GRGTNPVSTS WEEAVNSWEM QSLPEYKDKK 

       130        140        150        160        170        180 
GYSPLGKTRE FSSSHNINVY IHENAKFQKK RRNKIKTLSN LFWGHHPQRK RRGYSEKCCL 

       190        200        210 
TGCTKEELSI ACLPYIDFKR LKEKRSSLVT KIY 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney."
Hsu S.Y.
Mol. Endocrinol. 13:2163-2174(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat."
Lok S., Johnston D.S., Conklin D., Lofton-Day C.E., Adams R.L., Jelmberg A.C., Whitmore T.E., Schrader S., Griswold M.D., Jaspers S.R.
Biol. Reprod. 62:1593-1599(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF135824 mRNA. Translation: AAF29604.1.
AF156094 mRNA. Translation: AAD39003.1.
AL161450 Genomic DNA. Translation: CAD13336.1.
BC126473 mRNA. Translation: AAI26474.1.
BC126475 mRNA. Translation: AAI26476.1.
CCDSCCDS6458.1.
RefSeqNP_009110.2. NM_007179.2.
UniGeneHs.632648.

3D structure databases

ProteinModelPortalQ9Y581.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371054.

PTM databases

PhosphoSiteQ9Y581.

Polymorphism databases

DMDM20178309.

Proteomic databases

PaxDbQ9Y581.
PRIDEQ9Y581.

Protocols and materials databases

DNASU11172.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381641; ENSP00000371054; ENSG00000120210.
GeneID11172.
KEGGhsa:11172.
UCSCuc003zix.3. human.

Organism-specific databases

CTD11172.
GeneCardsGC09M005163.
HGNCHGNC:6089. INSL6.
HPAHPA021364.
MIM606414. gene.
neXtProtNX_Q9Y581.
PharmGKBPA29896.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47664.
HOGENOMHOG000113078.
HOVERGENHBG052136.
InParanoidQ9Y581.
KOK05255.
OMASIACLPY.
OrthoDBEOG712TXB.
PhylomeDBQ9Y581.
TreeFamTF343788.

Gene expression databases

BgeeQ9Y581.
CleanExHS_INSL6.
HS_RIF1.
GenevestigatorQ9Y581.

Family and domain databases

Gene3D1.10.100.10. 2 hits.
InterProIPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
[Graphical view]
PANTHERPTHR12004:SF1. PTHR12004:SF1. 1 hit.
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PIRSFPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 2 hits.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi11172.
NextBio42513.
PROQ9Y581.
SOURCESearch...

Entry information

Entry nameINSL6_HUMAN
AccessionPrimary (citable) accession number: Q9Y581
Secondary accession number(s): A0AVS0, Q9NS16
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 16, 2002
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM