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Protein

RNA-binding protein 7

Gene

RBM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible involved in germ cell RNA processing and meiosis.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 7
Alternative name(s):
RNA-binding motif protein 7
Gene namesi
Name:RBM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9904. RBM7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34269.

Polymorphism and mutation databases

DMDMi9978697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266RNA-binding protein 7PRO_0000081761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y580.
MaxQBiQ9Y580.
PaxDbiQ9Y580.
PRIDEiQ9Y580.

PTM databases

iPTMnetiQ9Y580.
PhosphoSiteiQ9Y580.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9Y580.
CleanExiHS_RBM7.
ExpressionAtlasiQ9Y580. baseline and differential.
GenevisibleiQ9Y580. HS.

Organism-specific databases

HPAiHPA013993.
HPA048003.

Interactioni

Protein-protein interaction databases

BioGridi115478. 63 interactions.
DIPiDIP-48833N.
IntActiQ9Y580. 40 interactions.
MINTiMINT-1453692.
STRINGi9606.ENSP00000439918.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 168Combined sources
Helixi23 – 308Combined sources
Beta strandi36 – 405Combined sources
Beta strandi52 – 598Combined sources
Helixi66 – 694Combined sources
Beta strandi75 – 784Combined sources
Beta strandi81 – 833Combined sources
Beta strandi89 – 913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M8HNMR-A4-94[»]
ProteinModelPortaliQ9Y580.
SMRiQ9Y580. Positions 4-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8778RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4454. Eukaryota.
ENOG41123B7. LUCA.
GeneTreeiENSGT00840000129882.
HOGENOMiHOG000059553.
HOVERGENiHBG009324.
InParanoidiQ9Y580.
KOiK13188.
OrthoDBiEOG7HB5BD.
PhylomeDBiQ9Y580.
TreeFamiTF323596.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKPK
60 70 80 90 100
QFAFVNFKHE VSVPYAMNLL NGIKLYGRPI KIQFRSGSSH APQDVSLSYP
110 120 130 140 150
QHHVGNSSPT STSPSRYERT MDNMTSSAQI IQRSFSSPEN FQRQAVMNSA
160 170 180 190 200
LRQMSYGGKF GSSPLDQSGF SPSVQSHSHS FNQSSSSQWR QGTPSSQRKV
210 220 230 240 250
RMNSYPYLAD RHYSREQRYT DHGSDHHYRG KRDDFFYEDR NHDDWSHDYD
260
NRRDSSRDGK WRSSRH
Length:266
Mass (Da):30,504
Last modified:November 1, 1999 - v1
Checksum:i31D344EBFC54B22F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021H → Y in BAA92036 (PubMed:14702039).Curated
Sequence conflicti114 – 1141P → PS in BAA92036 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156098 mRNA. Translation: AAD39257.1.
AK002015 mRNA. Translation: BAA92036.1.
AK312619 mRNA. Translation: BAG35505.1.
CH471065 Genomic DNA. Translation: EAW67247.1.
BC034381 mRNA. Translation: AAH34381.1.
CCDSiCCDS8370.1.
RefSeqiNP_001272974.1. NM_001286045.1.
NP_001272975.1. NM_001286046.1.
NP_001272976.1. NM_001286047.1.
NP_001272977.1. NM_001286048.1.
NP_057174.1. NM_016090.3.
UniGeneiHs.7527.

Genome annotation databases

EnsembliENST00000540163; ENSP00000439918; ENSG00000076053.
GeneIDi10179.
KEGGihsa:10179.
UCSCiuc001pov.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156098 mRNA. Translation: AAD39257.1.
AK002015 mRNA. Translation: BAA92036.1.
AK312619 mRNA. Translation: BAG35505.1.
CH471065 Genomic DNA. Translation: EAW67247.1.
BC034381 mRNA. Translation: AAH34381.1.
CCDSiCCDS8370.1.
RefSeqiNP_001272974.1. NM_001286045.1.
NP_001272975.1. NM_001286046.1.
NP_001272976.1. NM_001286047.1.
NP_001272977.1. NM_001286048.1.
NP_057174.1. NM_016090.3.
UniGeneiHs.7527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M8HNMR-A4-94[»]
ProteinModelPortaliQ9Y580.
SMRiQ9Y580. Positions 4-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115478. 63 interactions.
DIPiDIP-48833N.
IntActiQ9Y580. 40 interactions.
MINTiMINT-1453692.
STRINGi9606.ENSP00000439918.

PTM databases

iPTMnetiQ9Y580.
PhosphoSiteiQ9Y580.

Polymorphism and mutation databases

DMDMi9978697.

Proteomic databases

EPDiQ9Y580.
MaxQBiQ9Y580.
PaxDbiQ9Y580.
PRIDEiQ9Y580.

Protocols and materials databases

DNASUi10179.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540163; ENSP00000439918; ENSG00000076053.
GeneIDi10179.
KEGGihsa:10179.
UCSCiuc001pov.5. human.

Organism-specific databases

CTDi10179.
GeneCardsiRBM7.
HGNCiHGNC:9904. RBM7.
HPAiHPA013993.
HPA048003.
MIMi612413. gene.
neXtProtiNX_Q9Y580.
PharmGKBiPA34269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4454. Eukaryota.
ENOG41123B7. LUCA.
GeneTreeiENSGT00840000129882.
HOGENOMiHOG000059553.
HOVERGENiHBG009324.
InParanoidiQ9Y580.
KOiK13188.
OrthoDBiEOG7HB5BD.
PhylomeDBiQ9Y580.
TreeFamiTF323596.

Miscellaneous databases

GeneWikiiRBM7.
GenomeRNAii10179.
NextBioi38534.
PROiQ9Y580.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y580.
CleanExiHS_RBM7.
ExpressionAtlasiQ9Y580. baseline and differential.
GenevisibleiQ9Y580. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors."
    Guo T.B., Boros L.G., Chan K.C., Hikim A.P., Hudson A.P., Swerdloff R.S., Mitchell A.P., Salameh W.A.
    J. Androl. 24:204-214(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRBM7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y580
Secondary accession number(s): B2R6K8, Q9NUT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.