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Protein

RNA-binding protein 7

Gene

RBM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).1 Publication1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 7
Alternative name(s):
RNA-binding motif protein 7
Gene namesi
Name:RBM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000076053.10.
HGNCiHGNC:9904. RBM7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25L → E: Impaired interaction with ZCCHC8; when associated with E-29. 1 Publication1
Mutagenesisi29L → E: Impaired interaction with ZCCHC8; when associated with E-25. 1 Publication1
Mutagenesisi65Y → A: Reduced interaction with ZCCHC8, and impaired interaction with SF3B2/SAP145; when associated with E-69. 1 Publication1
Mutagenesisi69L → E: Reduced interaction with ZCCHC8, and impaired interaction with SF3B2/SAP145; when associated with A-65. 1 Publication1

Organism-specific databases

DisGeNETi10179.
OpenTargetsiENSG00000076053.
PharmGKBiPA34269.

Polymorphism and mutation databases

DMDMi9978697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000817612 – 266RNA-binding protein 7Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei137PhosphoserineBy similarity1
Modified residuei152Omega-N-methylarginineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y580.
MaxQBiQ9Y580.
PaxDbiQ9Y580.
PeptideAtlasiQ9Y580.
PRIDEiQ9Y580.

PTM databases

iPTMnetiQ9Y580.
PhosphoSitePlusiQ9Y580.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000076053.
CleanExiHS_RBM7.
ExpressionAtlasiQ9Y580. baseline and differential.
GenevisibleiQ9Y580. HS.

Organism-specific databases

HPAiHPA013993.
HPA048003.

Interactioni

Subunit structurei

Component of the nuclear exosome targeting (NEXT) complex composed of SKIV2L2/MTR4, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:27905398, PubMed:27871484). Interacts with ZCCHC8 and SF3B2/SAP145 (PubMed:27905398, PubMed:27871484, PubMed:16263084). Binds to SKIV2L2/MTR4 (PubMed:27871484).3 Publications

Protein-protein interaction databases

BioGridi115478. 66 interactors.
DIPiDIP-48833N.
IntActiQ9Y580. 45 interactors.
MINTiMINT-1453692.
STRINGi9606.ENSP00000439918.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Beta strandi11 – 15Combined sources5
Helixi23 – 31Combined sources9
Beta strandi36 – 40Combined sources5
Beta strandi45 – 47Combined sources3
Beta strandi53 – 59Combined sources7
Helixi62 – 70Combined sources9
Beta strandi75 – 78Combined sources4
Beta strandi81 – 84Combined sources4
Beta strandi89 – 91Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M8HNMR-A4-94[»]
5IQQX-ray2.52A/B/C/D/E1-91[»]
5LXRX-ray2.00A1-86[»]
5LXYX-ray2.85A/B/E/G/I/K/M1-86[»]
ProteinModelPortaliQ9Y580.
SMRiQ9Y580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 35ZCCHC8 bindingCombined sources1 PublicationAdd BLAST11
Regioni59 – 76ZCCHC8 bindingCombined sources1 PublicationAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 196Ser-richPROSITE-ProRule annotationAdd BLAST111

Phylogenomic databases

eggNOGiKOG4454. Eukaryota.
ENOG41123B7. LUCA.
GeneTreeiENSGT00870000136493.
HOGENOMiHOG000059553.
HOVERGENiHBG009324.
InParanoidiQ9Y580.
KOiK13188.
PhylomeDBiQ9Y580.
TreeFamiTF323596.

Family and domain databases

CDDicd12592. RRM_RBM7. 1 hit.
InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR034500. RBM7_RRM.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKPK
60 70 80 90 100
QFAFVNFKHE VSVPYAMNLL NGIKLYGRPI KIQFRSGSSH APQDVSLSYP
110 120 130 140 150
QHHVGNSSPT STSPSRYERT MDNMTSSAQI IQRSFSSPEN FQRQAVMNSA
160 170 180 190 200
LRQMSYGGKF GSSPLDQSGF SPSVQSHSHS FNQSSSSQWR QGTPSSQRKV
210 220 230 240 250
RMNSYPYLAD RHYSREQRYT DHGSDHHYRG KRDDFFYEDR NHDDWSHDYD
260
NRRDSSRDGK WRSSRH
Length:266
Mass (Da):30,504
Last modified:November 1, 1999 - v1
Checksum:i31D344EBFC54B22F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102H → Y in BAA92036 (PubMed:14702039).Curated1
Sequence conflicti114P → PS in BAA92036 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156098 mRNA. Translation: AAD39257.1.
AK002015 mRNA. Translation: BAA92036.1.
AK312619 mRNA. Translation: BAG35505.1.
CH471065 Genomic DNA. Translation: EAW67247.1.
BC034381 mRNA. Translation: AAH34381.1.
CCDSiCCDS8370.1.
RefSeqiNP_001272974.1. NM_001286045.1.
NP_001272975.1. NM_001286046.1.
NP_001272976.1. NM_001286047.1.
NP_001272977.1. NM_001286048.1.
NP_057174.1. NM_016090.3.
UniGeneiHs.7527.

Genome annotation databases

EnsembliENST00000540163; ENSP00000439918; ENSG00000076053.
GeneIDi10179.
KEGGihsa:10179.
UCSCiuc001pov.5. human.

Similar proteinsi

Entry informationi

Entry nameiRBM7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y580
Secondary accession number(s): B2R6K8, Q9NUT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references