SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y577

- TRI17_HUMAN

UniProt

Q9Y577 - TRI17_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
E3 ubiquitin-protein ligase TRIM17
Gene
TRIM17, RBCC, RNF16, TERF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a ubiquitin E3 ligase.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6651RING-type
Add
BLAST
Zinc fingeri94 – 13542B box-type
Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein autoubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 16
Testis RING finger protein
Tripartite motif-containing protein 17
Gene namesi
Name:TRIM17
Synonyms:RBCC, RNF16, TERF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13430. TRIM17.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477E3 ubiquitin-protein ligase TRIM17
PRO_0000056224Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9Y577.
PaxDbiQ9Y577.
PRIDEiQ9Y577.

PTM databases

PhosphoSiteiQ9Y577.

Expressioni

Tissue specificityi

Almost exclusively in the testis.1 Publication

Gene expression databases

BgeeiQ9Y577.
CleanExiHS_TRIM17.
GenevestigatoriQ9Y577.

Organism-specific databases

HPAiHPA054908.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM39Q9HCM93EBI-743894,EBI-739510

Protein-protein interaction databases

BioGridi119314. 18 interactions.
IntActiQ9Y577. 12 interactions.
MINTiMINT-1433750.
STRINGi9606.ENSP00000347794.

Structurei

3D structure databases

ProteinModelPortaliQ9Y577.
SMRiQ9Y577. Positions 10-65, 96-134, 300-465.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 475199B30.2/SPRY
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 22389 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.
Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG317461.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9Y577.
KOiK12007.
OMAiCAVGQET.
OrthoDBiEOG7V49Z8.
PhylomeDBiQ9Y577.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y577-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK    50
KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ 100
EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM 150
EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE 200
QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM 250
LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD 300
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR 350
HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL 400
STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG 450
PLQPFFCLGA PKSGQMVIST VTMWVKG 477
Length:477
Mass (Da):54,418
Last modified:November 1, 1999 - v1
Checksum:iECA4010661ADD28A
GO
Isoform 2 (identifier: Q9Y577-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-343: EDVVPDATSA...FVAYPCAVGQ → GKWAPRARTS...DGHWLFTVPS
     344-477: Missing.

Show »
Length:343
Mass (Da):39,153
Checksum:iA57AD2D4185048EF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 34349EDVVP…CAVGQ → GKWAPRARTSDPGSLGDAPL YPLASEATNGGGSTSALPGD GHWLFTVPS in isoform 2.
VSP_040994Add
BLAST
Alternative sequencei344 – 477134Missing in isoform 2.
VSP_040995Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156271 mRNA. Translation: AAD40286.1.
AK301105 mRNA. Translation: BAG62704.1.
AL670729, AL139288 Genomic DNA. Translation: CAH71674.1.
AL139288, AL670729 Genomic DNA. Translation: CAI23334.1.
BC033788 mRNA. Translation: AAH33788.1.
CCDSiCCDS1571.1. [Q9Y577-1]
CCDS44327.1. [Q9Y577-2]
RefSeqiNP_001020111.1. NM_001024940.2. [Q9Y577-1]
NP_001128327.1. NM_001134855.1. [Q9Y577-2]
NP_057186.1. NM_016102.3. [Q9Y577-1]
XP_006711842.1. XM_006711779.1. [Q9Y577-1]
UniGeneiHs.121748.

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931. [Q9Y577-1]
ENST00000366697; ENSP00000355658; ENSG00000162931. [Q9Y577-1]
ENST00000366698; ENSP00000355659; ENSG00000162931. [Q9Y577-1]
ENST00000456946; ENSP00000403312; ENSG00000162931. [Q9Y577-2]
GeneIDi51127.
KEGGihsa:51127.
UCSCiuc001hsu.3. human. [Q9Y577-1]
uc009xfb.2. human. [Q9Y577-2]

Polymorphism databases

DMDMi38605530.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156271 mRNA. Translation: AAD40286.1 .
AK301105 mRNA. Translation: BAG62704.1 .
AL670729 , AL139288 Genomic DNA. Translation: CAH71674.1 .
AL139288 , AL670729 Genomic DNA. Translation: CAI23334.1 .
BC033788 mRNA. Translation: AAH33788.1 .
CCDSi CCDS1571.1. [Q9Y577-1 ]
CCDS44327.1. [Q9Y577-2 ]
RefSeqi NP_001020111.1. NM_001024940.2. [Q9Y577-1 ]
NP_001128327.1. NM_001134855.1. [Q9Y577-2 ]
NP_057186.1. NM_016102.3. [Q9Y577-1 ]
XP_006711842.1. XM_006711779.1. [Q9Y577-1 ]
UniGenei Hs.121748.

3D structure databases

ProteinModelPortali Q9Y577.
SMRi Q9Y577. Positions 10-65, 96-134, 300-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119314. 18 interactions.
IntActi Q9Y577. 12 interactions.
MINTi MINT-1433750.
STRINGi 9606.ENSP00000347794.

PTM databases

PhosphoSitei Q9Y577.

Polymorphism databases

DMDMi 38605530.

Proteomic databases

MaxQBi Q9Y577.
PaxDbi Q9Y577.
PRIDEi Q9Y577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295033 ; ENSP00000295033 ; ENSG00000162931 . [Q9Y577-1 ]
ENST00000366697 ; ENSP00000355658 ; ENSG00000162931 . [Q9Y577-1 ]
ENST00000366698 ; ENSP00000355659 ; ENSG00000162931 . [Q9Y577-1 ]
ENST00000456946 ; ENSP00000403312 ; ENSG00000162931 . [Q9Y577-2 ]
GeneIDi 51127.
KEGGi hsa:51127.
UCSCi uc001hsu.3. human. [Q9Y577-1 ]
uc009xfb.2. human. [Q9Y577-2 ]

Organism-specific databases

CTDi 51127.
GeneCardsi GC01M228595.
HGNCi HGNC:13430. TRIM17.
HPAi HPA054908.
MIMi 606123. gene.
neXtProti NX_Q9Y577.
PharmGKBi PA37768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317461.
HOGENOMi HOG000234134.
HOVERGENi HBG001357.
InParanoidi Q9Y577.
KOi K12007.
OMAi CAVGQET.
OrthoDBi EOG7V49Z8.
PhylomeDBi Q9Y577.
TreeFami TF338674.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GenomeRNAii 51127.
NextBioi 53935.
PROi Q9Y577.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y577.
CleanExi HS_TRIM17.
Genevestigatori Q9Y577.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis."
    Ogawa S., Goto W., Orimo A., Hosoi T., Ouchi Y., Muramatsu M., Inoue S.
    Biochem. Biophys. Res. Commun. 251:515-519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH TRIM44.

Entry informationi

Entry nameiTRI17_HUMAN
AccessioniPrimary (citable) accession number: Q9Y577
Secondary accession number(s): B4DVJ2, Q5VST8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi