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Q9Y577

- TRI17_HUMAN

UniProt

Q9Y577 - TRI17_HUMAN

Protein

E3 ubiquitin-protein ligase TRIM17

Gene

TRIM17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May function as a ubiquitin E3 ligase.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. ubiquitin-protein transferase activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein autoubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM17 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 16
    Testis RING finger protein
    Tripartite motif-containing protein 17
    Gene namesi
    Name:TRIM17
    Synonyms:RBCC, RNF16, TERF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13430. TRIM17.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477E3 ubiquitin-protein ligase TRIM17PRO_0000056224Add
    BLAST

    Post-translational modificationi

    Auto-ubiquitinated.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9Y577.
    PaxDbiQ9Y577.
    PRIDEiQ9Y577.

    PTM databases

    PhosphoSiteiQ9Y577.

    Expressioni

    Tissue specificityi

    Almost exclusively in the testis.1 Publication

    Gene expression databases

    BgeeiQ9Y577.
    CleanExiHS_TRIM17.
    GenevestigatoriQ9Y577.

    Organism-specific databases

    HPAiHPA054908.

    Interactioni

    Subunit structurei

    Interacts (via coiled coil) with TRIM44 (via coiled coil).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRIM39Q9HCM93EBI-743894,EBI-739510

    Protein-protein interaction databases

    BioGridi119314. 18 interactions.
    IntActiQ9Y577. 21 interactions.
    MINTiMINT-1433750.
    STRINGi9606.ENSP00000347794.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y577.
    SMRiQ9Y577. Positions 10-65, 96-134, 300-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini277 – 475199B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili135 – 22389Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG317461.
    HOGENOMiHOG000234134.
    HOVERGENiHBG001357.
    InParanoidiQ9Y577.
    KOiK12007.
    OMAiCAVGQET.
    OrthoDBiEOG7V49Z8.
    PhylomeDBiQ9Y577.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y577-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK    50
    KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ 100
    EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM 150
    EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE 200
    QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM 250
    LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD 300
    ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR 350
    HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL 400
    STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG 450
    PLQPFFCLGA PKSGQMVIST VTMWVKG 477
    Length:477
    Mass (Da):54,418
    Last modified:November 1, 1999 - v1
    Checksum:iECA4010661ADD28A
    GO
    Isoform 2 (identifier: Q9Y577-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         295-343: EDVVPDATSA...FVAYPCAVGQ → GKWAPRARTS...DGHWLFTVPS
         344-477: Missing.

    Show »
    Length:343
    Mass (Da):39,153
    Checksum:iA57AD2D4185048EF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei295 – 34349EDVVP…CAVGQ → GKWAPRARTSDPGSLGDAPL YPLASEATNGGGSTSALPGD GHWLFTVPS in isoform 2. 1 PublicationVSP_040994Add
    BLAST
    Alternative sequencei344 – 477134Missing in isoform 2. 1 PublicationVSP_040995Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156271 mRNA. Translation: AAD40286.1.
    AK301105 mRNA. Translation: BAG62704.1.
    AL670729, AL139288 Genomic DNA. Translation: CAH71674.1.
    AL139288, AL670729 Genomic DNA. Translation: CAI23334.1.
    BC033788 mRNA. Translation: AAH33788.1.
    CCDSiCCDS1571.1. [Q9Y577-1]
    CCDS44327.1. [Q9Y577-2]
    RefSeqiNP_001020111.1. NM_001024940.2. [Q9Y577-1]
    NP_001128327.1. NM_001134855.1. [Q9Y577-2]
    NP_057186.1. NM_016102.3. [Q9Y577-1]
    XP_006711842.1. XM_006711779.1. [Q9Y577-1]
    UniGeneiHs.121748.

    Genome annotation databases

    EnsembliENST00000295033; ENSP00000295033; ENSG00000162931. [Q9Y577-1]
    ENST00000366697; ENSP00000355658; ENSG00000162931. [Q9Y577-1]
    ENST00000366698; ENSP00000355659; ENSG00000162931. [Q9Y577-1]
    ENST00000456946; ENSP00000403312; ENSG00000162931. [Q9Y577-2]
    GeneIDi51127.
    KEGGihsa:51127.
    UCSCiuc001hsu.3. human. [Q9Y577-1]
    uc009xfb.2. human. [Q9Y577-2]

    Polymorphism databases

    DMDMi38605530.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156271 mRNA. Translation: AAD40286.1 .
    AK301105 mRNA. Translation: BAG62704.1 .
    AL670729 , AL139288 Genomic DNA. Translation: CAH71674.1 .
    AL139288 , AL670729 Genomic DNA. Translation: CAI23334.1 .
    BC033788 mRNA. Translation: AAH33788.1 .
    CCDSi CCDS1571.1. [Q9Y577-1 ]
    CCDS44327.1. [Q9Y577-2 ]
    RefSeqi NP_001020111.1. NM_001024940.2. [Q9Y577-1 ]
    NP_001128327.1. NM_001134855.1. [Q9Y577-2 ]
    NP_057186.1. NM_016102.3. [Q9Y577-1 ]
    XP_006711842.1. XM_006711779.1. [Q9Y577-1 ]
    UniGenei Hs.121748.

    3D structure databases

    ProteinModelPortali Q9Y577.
    SMRi Q9Y577. Positions 10-65, 96-134, 300-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119314. 18 interactions.
    IntActi Q9Y577. 21 interactions.
    MINTi MINT-1433750.
    STRINGi 9606.ENSP00000347794.

    PTM databases

    PhosphoSitei Q9Y577.

    Polymorphism databases

    DMDMi 38605530.

    Proteomic databases

    MaxQBi Q9Y577.
    PaxDbi Q9Y577.
    PRIDEi Q9Y577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295033 ; ENSP00000295033 ; ENSG00000162931 . [Q9Y577-1 ]
    ENST00000366697 ; ENSP00000355658 ; ENSG00000162931 . [Q9Y577-1 ]
    ENST00000366698 ; ENSP00000355659 ; ENSG00000162931 . [Q9Y577-1 ]
    ENST00000456946 ; ENSP00000403312 ; ENSG00000162931 . [Q9Y577-2 ]
    GeneIDi 51127.
    KEGGi hsa:51127.
    UCSCi uc001hsu.3. human. [Q9Y577-1 ]
    uc009xfb.2. human. [Q9Y577-2 ]

    Organism-specific databases

    CTDi 51127.
    GeneCardsi GC01M228595.
    HGNCi HGNC:13430. TRIM17.
    HPAi HPA054908.
    MIMi 606123. gene.
    neXtProti NX_Q9Y577.
    PharmGKBi PA37768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317461.
    HOGENOMi HOG000234134.
    HOVERGENi HBG001357.
    InParanoidi Q9Y577.
    KOi K12007.
    OMAi CAVGQET.
    OrthoDBi EOG7V49Z8.
    PhylomeDBi Q9Y577.
    TreeFami TF338674.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GenomeRNAii 51127.
    NextBioi 53935.
    PROi Q9Y577.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y577.
    CleanExi HS_TRIM17.
    Genevestigatori Q9Y577.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis."
      Ogawa S., Goto W., Orimo A., Hosoi T., Ouchi Y., Muramatsu M., Inoue S.
      Biochem. Biophys. Res. Commun. 251:515-519(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. Cited for: FUNCTION, TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH TRIM44.

    Entry informationi

    Entry nameiTRI17_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y577
    Secondary accession number(s): B4DVJ2, Q5VST8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3