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Protein

E3 ubiquitin-protein ligase TRIM17

Gene

TRIM17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a ubiquitin E3 ligase.1 Publication

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein autoubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_25078. Interferon gamma signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM17 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 16
Testis RING finger protein
Tripartite motif-containing protein 17
Gene namesi
Name:TRIM17
Synonyms:RBCC, RNF16, TERF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13430. TRIM17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37768.

Polymorphism and mutation databases

BioMutaiTRIM17.
DMDMi38605530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477E3 ubiquitin-protein ligase TRIM17PRO_0000056224Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9Y577.
PaxDbiQ9Y577.
PRIDEiQ9Y577.

PTM databases

PhosphoSiteiQ9Y577.

Expressioni

Tissue specificityi

Almost exclusively in the testis.1 Publication

Gene expression databases

BgeeiQ9Y577.
CleanExiHS_TRIM17.
ExpressionAtlasiQ9Y577. baseline.
GenevisibleiQ9Y577. HS.

Organism-specific databases

HPAiHPA054908.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM44 (via coiled coil).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM39Q9HCM96EBI-743894,EBI-739510

Protein-protein interaction databases

BioGridi119314. 20 interactions.
IntActiQ9Y577. 21 interactions.
MINTiMINT-1433750.
STRINGi9606.ENSP00000295033.

Structurei

3D structure databases

ProteinModelPortaliQ9Y577.
SMRiQ9Y577. Positions 10-65, 96-266, 300-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 475199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 22389Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6651RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 13542B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG317461.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9Y577.
KOiK12007.
OMAiVMLMEPP.
OrthoDBiEOG7V49Z8.
PhylomeDBiQ9Y577.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK
60 70 80 90 100
KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ
110 120 130 140 150
EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM
160 170 180 190 200
EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE
210 220 230 240 250
QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM
260 270 280 290 300
LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD
310 320 330 340 350
ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR
360 370 380 390 400
HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL
410 420 430 440 450
STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG
460 470
PLQPFFCLGA PKSGQMVIST VTMWVKG
Length:477
Mass (Da):54,418
Last modified:November 1, 1999 - v1
Checksum:iECA4010661ADD28A
GO
Isoform 2 (identifier: Q9Y577-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-343: EDVVPDATSA...FVAYPCAVGQ → GKWAPRARTS...DGHWLFTVPS
     344-477: Missing.

Show »
Length:343
Mass (Da):39,153
Checksum:iA57AD2D4185048EF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 34349EDVVP…CAVGQ → GKWAPRARTSDPGSLGDAPL YPLASEATNGGGSTSALPGD GHWLFTVPS in isoform 2. 1 PublicationVSP_040994Add
BLAST
Alternative sequencei344 – 477134Missing in isoform 2. 1 PublicationVSP_040995Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156271 mRNA. Translation: AAD40286.1.
AK301105 mRNA. Translation: BAG62704.1.
AL670729, AL139288 Genomic DNA. Translation: CAH71674.1.
AL139288, AL670729 Genomic DNA. Translation: CAI23334.1.
BC033788 mRNA. Translation: AAH33788.1.
CCDSiCCDS1571.1. [Q9Y577-1]
CCDS44327.1. [Q9Y577-2]
RefSeqiNP_001020111.1. NM_001024940.2. [Q9Y577-1]
NP_001128327.1. NM_001134855.1. [Q9Y577-2]
NP_057186.1. NM_016102.3. [Q9Y577-1]
XP_006711842.1. XM_006711779.1. [Q9Y577-1]
XP_011542511.1. XM_011544209.1. [Q9Y577-1]
XP_011542512.1. XM_011544210.1. [Q9Y577-1]
UniGeneiHs.121748.

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931.
ENST00000366697; ENSP00000355658; ENSG00000162931.
ENST00000366698; ENSP00000355659; ENSG00000162931.
ENST00000456946; ENSP00000403312; ENSG00000162931. [Q9Y577-2]
GeneIDi51127.
KEGGihsa:51127.
UCSCiuc001hsu.3. human. [Q9Y577-1]
uc009xfb.2. human. [Q9Y577-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156271 mRNA. Translation: AAD40286.1.
AK301105 mRNA. Translation: BAG62704.1.
AL670729, AL139288 Genomic DNA. Translation: CAH71674.1.
AL139288, AL670729 Genomic DNA. Translation: CAI23334.1.
BC033788 mRNA. Translation: AAH33788.1.
CCDSiCCDS1571.1. [Q9Y577-1]
CCDS44327.1. [Q9Y577-2]
RefSeqiNP_001020111.1. NM_001024940.2. [Q9Y577-1]
NP_001128327.1. NM_001134855.1. [Q9Y577-2]
NP_057186.1. NM_016102.3. [Q9Y577-1]
XP_006711842.1. XM_006711779.1. [Q9Y577-1]
XP_011542511.1. XM_011544209.1. [Q9Y577-1]
XP_011542512.1. XM_011544210.1. [Q9Y577-1]
UniGeneiHs.121748.

3D structure databases

ProteinModelPortaliQ9Y577.
SMRiQ9Y577. Positions 10-65, 96-266, 300-465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119314. 20 interactions.
IntActiQ9Y577. 21 interactions.
MINTiMINT-1433750.
STRINGi9606.ENSP00000295033.

PTM databases

PhosphoSiteiQ9Y577.

Polymorphism and mutation databases

BioMutaiTRIM17.
DMDMi38605530.

Proteomic databases

MaxQBiQ9Y577.
PaxDbiQ9Y577.
PRIDEiQ9Y577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295033; ENSP00000295033; ENSG00000162931.
ENST00000366697; ENSP00000355658; ENSG00000162931.
ENST00000366698; ENSP00000355659; ENSG00000162931.
ENST00000456946; ENSP00000403312; ENSG00000162931. [Q9Y577-2]
GeneIDi51127.
KEGGihsa:51127.
UCSCiuc001hsu.3. human. [Q9Y577-1]
uc009xfb.2. human. [Q9Y577-2]

Organism-specific databases

CTDi51127.
GeneCardsiGC01M228595.
HGNCiHGNC:13430. TRIM17.
HPAiHPA054908.
MIMi606123. gene.
neXtProtiNX_Q9Y577.
PharmGKBiPA37768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317461.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234134.
HOVERGENiHBG001357.
InParanoidiQ9Y577.
KOiK12007.
OMAiVMLMEPP.
OrthoDBiEOG7V49Z8.
PhylomeDBiQ9Y577.
TreeFamiTF338674.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_25078. Interferon gamma signaling.

Miscellaneous databases

GenomeRNAii51127.
NextBioi53935.
PROiQ9Y577.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y577.
CleanExiHS_TRIM17.
ExpressionAtlasiQ9Y577. baseline.
GenevisibleiQ9Y577. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis."
    Ogawa S., Goto W., Orimo A., Hosoi T., Ouchi Y., Muramatsu M., Inoue S.
    Biochem. Biophys. Res. Commun. 251:515-519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY, AUTOUBIQUITINATION, INTERACTION WITH TRIM44.

Entry informationi

Entry nameiTRI17_HUMAN
AccessioniPrimary (citable) accession number: Q9Y577
Secondary accession number(s): B4DVJ2, Q5VST8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.