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Protein

Ankyrin repeat and SOCS box protein 1

Gene

ASB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 1
Short name:
ASB-1
Gene namesi
Name:ASB1
Synonyms:KIAA1146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16011. ASB1.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25027.

Polymorphism and mutation databases

BioMutaiASB1.
DMDMi20532005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Ankyrin repeat and SOCS box protein 1PRO_0000066923Add
BLAST

Proteomic databases

EPDiQ9Y576.
MaxQBiQ9Y576.
PaxDbiQ9Y576.
PeptideAtlasiQ9Y576.
PRIDEiQ9Y576.

PTM databases

iPTMnetiQ9Y576.
PhosphoSiteiQ9Y576.

Expressioni

Gene expression databases

BgeeiQ9Y576.
CleanExiHS_ASB1.
ExpressionAtlasiQ9Y576. baseline and differential.
GenevisibleiQ9Y576. HS.

Organism-specific databases

HPAiHPA003508.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Protein-protein interaction databases

BioGridi119668. 21 interactions.
IntActiQ9Y576. 3 interactions.
MINTiMINT-1500306.
STRINGi9606.ENSP00000264607.

Structurei

3D structure databases

ProteinModelPortaliQ9Y576.
SMRiQ9Y576. Positions 2-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 6833ANK 1Add
BLAST
Repeati77 – 10630ANK 2Add
BLAST
Repeati110 – 13930ANK 3Add
BLAST
Repeati143 – 17230ANK 4Add
BLAST
Repeati191 – 22030ANK 5Add
BLAST
Repeati235 – 26531ANK 6Add
BLAST
Domaini286 – 33550SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000034084.
HOVERGENiHBG107089.
InParanoidiQ9Y576.
KOiK10323.
OMAiPVNTQEF.
OrthoDBiEOG7TXKGW.
PhylomeDBiQ9Y576.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL
60 70 80 90 100
QTLRSLLQEE SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK
110 120 130 140 150
GAEVDLVDVK GQTALYVAVV NGHLESTQIL LEAGADPNGS RHHRSTPVYH
160 170 180 190 200
ASRVGRADIL KALIRYGADV DVNHHLTPDV QPRFSRRLTS LVVCPLYISA
210 220 230 240 250
AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM DAVLRHGCEA
260 270 280 290 300
AFVSLLVEFG ANLNLVKWES LGPESRGRRK VDPEALQVFK EARSVPRTLL
310 320 330
CLCRVAVRRA LGKHRLHLIP SLPLPDPIKK FLLHE
Length:335
Mass (Da):37,014
Last modified:November 1, 1999 - v1
Checksum:i0843C96AD1AF60D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156777 mRNA. Translation: AAD41894.1.
AC016999 Genomic DNA. Translation: AAX88934.1.
BC014528 mRNA. Translation: AAH14528.1.
AB032972 mRNA. Translation: BAA86460.1.
CCDSiCCDS33416.1.
RefSeqiNP_001035535.1. NM_001040445.1.
UniGeneiHs.516788.

Genome annotation databases

EnsembliENST00000264607; ENSP00000264607; ENSG00000065802.
GeneIDi51665.
KEGGihsa:51665.
UCSCiuc002vyg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156777 mRNA. Translation: AAD41894.1.
AC016999 Genomic DNA. Translation: AAX88934.1.
BC014528 mRNA. Translation: AAH14528.1.
AB032972 mRNA. Translation: BAA86460.1.
CCDSiCCDS33416.1.
RefSeqiNP_001035535.1. NM_001040445.1.
UniGeneiHs.516788.

3D structure databases

ProteinModelPortaliQ9Y576.
SMRiQ9Y576. Positions 2-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119668. 21 interactions.
IntActiQ9Y576. 3 interactions.
MINTiMINT-1500306.
STRINGi9606.ENSP00000264607.

PTM databases

iPTMnetiQ9Y576.
PhosphoSiteiQ9Y576.

Polymorphism and mutation databases

BioMutaiASB1.
DMDMi20532005.

Proteomic databases

EPDiQ9Y576.
MaxQBiQ9Y576.
PaxDbiQ9Y576.
PeptideAtlasiQ9Y576.
PRIDEiQ9Y576.

Protocols and materials databases

DNASUi51665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264607; ENSP00000264607; ENSG00000065802.
GeneIDi51665.
KEGGihsa:51665.
UCSCiuc002vyg.4. human.

Organism-specific databases

CTDi51665.
GeneCardsiASB1.
HGNCiHGNC:16011. ASB1.
HPAiHPA003508.
MIMi605758. gene.
neXtProtiNX_Q9Y576.
PharmGKBiPA25027.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000034084.
HOVERGENiHBG107089.
InParanoidiQ9Y576.
KOiK10323.
OMAiPVNTQEF.
OrthoDBiEOG7TXKGW.
PhylomeDBiQ9Y576.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiASB1. human.
GeneWikiiASB1.
GenomeRNAii51665.
PROiQ9Y576.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y576.
CleanExiHS_ASB1.
ExpressionAtlasiQ9Y576. baseline and differential.
GenevisibleiQ9Y576. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4."
    Kile B.T., Viney E.M., Willson T.A., Brodnicki T.C., Cancilla M.R., Herlihy A.S., Croker B.A., Baca M., Nicola N.A., Hilton D.J., Alexander W.S.
    Gene 258:31-41(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-335.
    Tissue: Brain.
  5. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
    Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
    FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Entry informationi

Entry nameiASB1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y576
Secondary accession number(s): A6NL50, Q4ZG29, Q9ULS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.