Q9Y573 (IPP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-binding protein IPP

Alternative name(s):
Intracisternal A particle-promoted polypeptide
Short name=IPP
Kelch-like protein 27

Gene names

Name:	IPP
Synonyms:	KLHL27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in organizing the actin cytoskeleton.
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Kelch repeat Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	actin cytoskeleton Traceable author statement. Source: ProtInc cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y573-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y573-2)

The sequence of this isoform differs from the canonical sequence as follows:
     551-584: GTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL → DTHRYEVFRLKWENMCILFNDHKTLTKGIFNL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 584	584	Actin-binding protein IPP		PRO_0000119075
Regions
	Domain	37 – 104	68	BTB
	Repeat	289 – 343	55	Kelch 1
	Repeat	344 – 390	47	Kelch 2
	Repeat	391 – 437	47	Kelch 3
	Repeat	439 – 485	47	Kelch 4
	Repeat	487 – 533	47	Kelch 5
	Repeat	535 – 583	49	Kelch 6
Natural variations
	Alternative sequence	551 – 584	34	GTLDS…GVAVL → DTHRYEVFRLKWENMCILFN DHKTLTKGIFNL in isoform 2.		VSP_040993
	Natural variant	264	1	K → R. Ref.4 Ref.5 Corresponds to variant rs28375469 [ dbSNP | Ensembl ].		VAR_050045

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: C63EF25D74924AB8	FASTA	584	65,261
	10 20 30 40 50 60 MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP 70 80 90 100 110 120 YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT 130 140 150 160 170 180 EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK 190 200 210 220 230 240 DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI 250 260 270 280 290 300 EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ 310 320 330 340 350 360 GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT 370 380 390 400 410 420 ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV 430 440 450 460 470 480 GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV 490 500 510 520 530 540 AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG 550 560 570 580 RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL
	Isoform 2 [UniParc]. Checksum: 25C6E2EF4E26438B	FASTA	582	65,592
	10 20 30 40 50 60 MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP 70 80 90 100 110 120 YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT 130 140 150 160 170 180 EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK 190 200 210 220 230 240 DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI 250 260 270 280 290 300 EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ 310 320 330 340 350 360 GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT 370 380 390 400 410 420 ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV 430 440 450 460 470 480 GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV 490 500 510 520 530 540 AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG 550 560 570 580 RSSSHDFLAP DTHRYEVFRL KWENMCILFN DHKTLTKGIF NL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein." Kim I.F., Mohammadi E., Huang R.C. Gene 228:73-83(1999) [PubMed: 10072760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thyroid.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-264.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-264. Tissue: Uterus.
[6]	"The IPP gene is assigned to human chromosome 1p32-1p22." Chang-Yeh A., Jabs E.W., Li X., Dracopoli N.C., Huang R.C. Genomics 15:239-241(1993) [PubMed: 8432546] [Abstract] Cited for: CHROMOSOMAL LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF156857 mRNA. Translation: AAD39007.1. AK023880 mRNA. Translation: BAG51233.1. AL604028, BX664740, CR589949 Genomic DNA. Translation: CAM12886.1. BX664740, AL604028, CR589949 Genomic DNA. Translation: CAM12889.1. CH471059 Genomic DNA. Translation: EAX06950.1. CH471059 Genomic DNA. Translation: EAX06951.1. BC032544 mRNA. Translation: AAH32544.1.
IPI	IPI00001117. IPI00642759.
RefSeq	NP_001138821.1. NM_001145349.1. NP_005888.1. NM_005897.2.
UniGene	Hs.699548.
3D structure databases
ProteinModelPortal	Q9Y573.
SMR	Q9Y573. Positions 15-246, 287-584.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y573.
Polymorphism databases
DMDM	13431578.
Proteomic databases
PRIDE	Q9Y573.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359942; ENSP00000353024; ENSG00000197429. ENST00000396474; ENSP00000379736; ENSG00000197429. ENST00000396478; ENSP00000379739; ENSG00000197429.
GeneID	3652.
KEGG	hsa:3652.
UCSC	uc001cot.1. human.
Organism-specific databases
CTD	3652.
GeneCards	GC01M046159.
H-InvDB	HIX0199830.
HGNC	HGNC:6108. IPP.
MIM	147485. gene.
neXtProt	NX_Q9Y573.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00570000078759.
HOGENOM	HBG713858.
HOVERGEN	HBG014286.
InParanoid	Q9Y573.
OMA	NLCCEFL.
PhylomeDB	Q9Y573.
Gene expression databases
ArrayExpress	Q9Y573.
Bgee	Q9Y573.
CleanEx	HS_IPP.
Genevestigator	Q9Y573.
GermOnline	ENSG00000197429. Homo sapiens.
Family and domain databases
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015916. Gal_Oxidase_b-propeller. IPR017096. Kelch-like_gigaxonin. IPR006652. Kelch_1. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:2.130.10.80. Gal_Oxidase_b-propeller. 2 hits.
KO	K13956.
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 6 hits. [Graphical view]
PIRSF	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 6 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	14283.
SOURCE	Search...

Entry information

Entry name

IPP_HUMAN

Accession

Primary (citable) accession number: Q9Y573
Secondary accession number(s): A2A6V4, D3DQ11, Q8N5C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.