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Q9Y566 (SHAN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 and multiple ankyrin repeat domains protein 1

Short name=Shank1
Alternative name(s):
Somatostatin receptor-interacting protein
Short name=SSTR-interacting protein
Short name=SSTRIP
Gene names
Name:SHANK1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Subunit structure

May homomultimerize via its SAM domain By similarity. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 By similarity. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP By similarity. Interacts with BAIAP2. Ref.1 Ref.4

Subcellular location

Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity. Note: Colocalizes with alpha-latrotoxin receptor 1 By similarity.

Tissue specificity

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Sequence similarities

Belongs to the SHANK family.

Contains 6 ANK repeats.

Contains 1 PDZ (DHR) domain.

Contains 1 SAM (sterile alpha motif) domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCell junction
Cell membrane
Cytoplasm
Membrane
Postsynaptic cell membrane
Synapse
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Repeat
SH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult behavior

Inferred from mutant phenotype PubMed 22503632. Source: BHF-UCL

associative learning

Inferred from sequence or structural similarity. Source: BHF-UCL

cytoskeletal anchoring at plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

dendritic spine morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

determination of affect

Inferred from mutant phenotype PubMed 22503632. Source: BHF-UCL

habituation

Inferred from electronic annotation. Source: Ensembl

long-term memory

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of actin filament bundle assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

neuromuscular process controlling balance

Inferred from sequence or structural similarity. Source: BHF-UCL

olfactory behavior

Inferred from electronic annotation. Source: Ensembl

positive regulation of dendritic spine development

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of excitatory postsynaptic membrane potential

Inferred from sequence or structural similarity. Source: BHF-UCL

protein complex assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

protein localization to synapse

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

righting reflex

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from mutant phenotype PubMed 22503632. Source: BHF-UCL

synapse maturation

Inferred from sequence or structural similarity. Source: BHF-UCL

vocalization behavior

Inferred from mutant phenotype PubMed 22503632. Source: BHF-UCL

   Cellular_componentN-methyl-D-aspartate selective glutamate receptor complex

Inferred from electronic annotation. Source: Ensembl

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

dendrite

Non-traceable author statement Ref.1. Source: UniProtKB

dendritic spine

Inferred from sequence or structural similarity. Source: BHF-UCL

excitatory synapse

Inferred from sequence or structural similarity. Source: BHF-UCL

intracellular

Non-traceable author statement Ref.1. Source: UniProtKB

membrane

Inferred from direct assay Ref.1. Source: UniProtKB

neuron projection

Inferred from sequence or structural similarity. Source: BHF-UCL

neuronal postsynaptic density

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

postsynaptic membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionGKAP/Homer scaffold activity

Inferred from sequence or structural similarity. Source: BHF-UCL

SH3 domain binding

Inferred from sequence or structural similarity. Source: BHF-UCL

ankyrin repeat binding

Inferred from sequence or structural similarity. Source: BHF-UCL

identical protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

ionotropic glutamate receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

protein C-terminus binding

Inferred from sequence or structural similarity. Source: BHF-UCL

protein binding

Inferred from physical interaction Ref.1PubMed 11583995. Source: UniProtKB

protein complex binding

Inferred from sequence or structural similarity. Source: BHF-UCL

scaffold protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

somatostatin receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y566-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y566-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-654: RSQESKQESR...PSLMDGIGPG → MQLMALEQRF...PPPHFSCLPA
Isoform 3 (identifier: Q9Y566-3)

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21612161SH3 and multiple ankyrin repeat domains protein 1
PRO_0000174671

Regions

Repeat212 – 24534ANK 1
Repeat246 – 27833ANK 2
Repeat279 – 31234ANK 3
Repeat313 – 34533ANK 4
Repeat346 – 37833ANK 5
Repeat379 – 39517ANK 6
Domain554 – 61360SH3
Domain663 – 75795PDZ
Domain2098 – 216164SAM
Compositional bias1002 – 10076Poly-His
Compositional bias1014 – 10196Poly-His
Compositional bias1189 – 11957Poly-Gly
Compositional bias1709 – 17179Poly-Gly
Compositional bias1844 – 185411Poly-Pro
Compositional bias1896 – 19027Poly-Gly
Compositional bias1970 – 197910Poly-Ser

Amino acid modifications

Modified residue1861Phosphotyrosine By similarity

Natural variations

Alternative sequence1 – 613613Missing in isoform 2.
VSP_006069
Alternative sequence614 – 65441RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2.
VSP_006070
Alternative sequence646 – 6549Missing in isoform 3.
VSP_006071
Natural variant61A → V.
Corresponds to variant rs10423744 [ dbSNP | Ensembl ].
VAR_055318
Natural variant5691A → D in a colorectal cancer sample; somatic mutation. Ref.5
VAR_036541
Natural variant15041V → A.
Corresponds to variant rs3745521 [ dbSNP | Ensembl ].
VAR_022123
Natural variant20261G → R in a colorectal cancer sample; somatic mutation. Ref.5
VAR_036542

Experimental info

Sequence conflict9271S → Y in AAD45121. Ref.1
Sequence conflict9271S → Y in AAF35887. Ref.1
Sequence conflict9371P → T in AAD45121. Ref.1
Sequence conflict9371P → T in AAF35887. Ref.1
Sequence conflict9691S → T in AAD45121. Ref.1
Sequence conflict9691S → T in AAF35887. Ref.1
Sequence conflict10851F → I in AAD45121. Ref.1
Sequence conflict10851F → I in AAF35887. Ref.1
Sequence conflict11331T → S in AAD45121. Ref.1
Sequence conflict11331T → S in AAF35887. Ref.1
Sequence conflict18321S → C in AAD45121. Ref.1
Sequence conflict18321S → C in AAF35887. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 94BDE56D3D5F319D

FASTA2,161224,959
        10         20         30         40         50         60 
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS LASVRGLQGR 

        70         80         90        100        110        120 
SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK QQVLCALSES LQDVLNYGLF 

       130        140        150        160        170        180 
QPATSGRDAN FLEEERLLRE YPQSFEKGVP YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL 

       190        200        210        220        230        240 
KKFLEYVQLG TSDKVARLLD KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI 

       250        260        270        280        290        300 
DFRARDGMTA LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 

       310        320        330        340        350        360 
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA LHICALYNKE 

       370        380        390        400        410        420 
TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR NHREQDVVPF QESPKYAARR 

       430        440        450        460        470        480 
RGPPGTGLTV PPALLRANSD TSMALPDWMV FSAPGAASSG APGPTSGSQG QSQPSAPTTK 

       490        500        510        520        530        540 
LSSGTLRSAS SPRGARARSP SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS 

       550        560        570        580        590        600 
LGSRGRRRKL YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 

       610        620        630        640        650        660 
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG IGPGSDYIIK 

       670        680        690        700        710        720 
EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ YLESVDEGGV AWRAGLRMGD 

       730        740        750        760        770        780 
FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP 

       790        800        810        820        830        840 
TISLRSKSMT SELEEMEYEQ QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG 

       850        860        870        880        890        900 
PGGLASLGKH RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY 

       910        920        930        940        950        960 
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR GGPFNPGSGG 

       970        980        990       1000       1010       1020 
PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP PHHHHHHAPP PQPHHHHAHP 

      1030       1040       1050       1060       1070       1080 
PHPPEMETGG SPDDPPPRLA LGPQPSLRGW RGGGPSPTPG APSPSHHGSA GGGGGSSQGP 

      1090       1100       1110       1120       1130       1140 
ALRYFQLPPR AASAAMYVPA RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP 

      1150       1160       1170       1180       1190       1200 
PPAVAAPSEK NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP 

      1210       1220       1230       1240       1250       1260 
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA RRRSTLFLST 

      1270       1280       1290       1300       1310       1320 
DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR LESAGSGAGY GGYGAGSRAY 

      1330       1340       1350       1360       1370       1380 
GGGGGSSAFT SFLPPRPLVH PLTGKALDPA SPLGLALAAR ERALKESSEG GGAPQPPPRP 

      1390       1400       1410       1420       1430       1440 
PSPRYEAPPP TPHHHSPHAH HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA 

      1450       1460       1470       1480       1490       1500 
RRSLLHRLPP TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP 

      1510       1520       1530       1540       1550       1560 
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP APSVDVEDGE 

      1570       1580       1590       1600       1610       1620 
FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT PLPPVPPPAV AAAPPTLDST 

      1630       1640       1650       1660       1670       1680 
ASSLTSYDSE VATLTQGASA APGDPHPPGP PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS 

      1690       1700       1710       1720       1730       1740 
RSSSDHPLET ISSASTLSSL SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS 

      1750       1760       1770       1780       1790       1800 
STPGPPYPPQ LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL 

      1810       1820       1830       1840       1850       1860 
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP LPGPLAQPQA 

      1870       1880       1890       1900       1910       1920 
SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG GGDSHHGGAS YVPERTSSLQ 

      1930       1940       1950       1960       1970       1980 
RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP PLPTGTGVSP TAAAAPGATS PSASSSSTST 

      1990       2000       2010       2020       2030       2040 
RHLQGVEFEM RPPLLRRAPS PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT 

      2050       2060       2070       2080       2090       2100 
GGAGGSADPF APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK 

      2110       2120       2130       2140       2150       2160 
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN IDRALKFFLE 


R 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 450025F37316FBEF
Show »

FASTA1,548158,792
Isoform 3 [UniParc].

Checksum: 2BC1557113CF4DDF
Show »

FASTA2,152224,131

References

« Hide 'large scale' references
[1]"Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INTERACTION WITH SSTR2.
Tissue: Fetal brain, Hippocampus and Thalamus.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The Shank family of scaffold proteins."
Sheng M., Kim E.
J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[4]"The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
Soltau M., Richter D., Kreienkamp H.-J.
Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BAIAP2.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-569 AND ARG-2026.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF163302 mRNA. Translation: AAD45121.1.
AF226728 mRNA. Translation: AAF35887.1.
AC008743 Genomic DNA. No translation available.
AC010325 Genomic DNA. No translation available.
CCDSCCDS12799.1. [Q9Y566-1]
RefSeqNP_057232.2. NM_016148.2. [Q9Y566-1]
XP_006723296.1. XM_006723233.1. [Q9Y566-1]
XP_006723297.1. XM_006723234.1. [Q9Y566-3]
UniGeneHs.274255.
Hs.715488.

3D structure databases

ProteinModelPortalQ9Y566.
SMRQ9Y566. Positions 152-404, 564-611, 656-759, 2095-2156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119171. 14 interactions.
DIPDIP-40834N.
IntActQ9Y566. 5 interactions.
MINTMINT-101428.
STRING9606.ENSP00000293441.

PTM databases

PhosphoSiteQ9Y566.

Polymorphism databases

DMDM229462779.

Proteomic databases

MaxQBQ9Y566.
PaxDbQ9Y566.
PRIDEQ9Y566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293441; ENSP00000293441; ENSG00000161681. [Q9Y566-1]
ENST00000359082; ENSP00000351984; ENSG00000161681. [Q9Y566-3]
ENST00000391813; ENSP00000375689; ENSG00000161681. [Q9Y566-2]
GeneID50944.
KEGGhsa:50944.
UCSCuc002psw.1. human. [Q9Y566-2]
uc002psx.1. human. [Q9Y566-1]

Organism-specific databases

CTD50944.
GeneCardsGC19M051165.
H-InvDBHIX0015364.
HGNCHGNC:15474. SHANK1.
HPAHPA032129.
HPA032130.
MIM604999. gene.
neXtProtNX_Q9Y566.
PharmGKBPA37965.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000293276.
HOVERGENHBG079186.
KOK15009.
OrthoDBEOG7X6KZ7.
PhylomeDBQ9Y566.
TreeFamTF324593.

Gene expression databases

ArrayExpressQ9Y566.
BgeeQ9Y566.
CleanExHS_SHANK1.
GenevestigatorQ9Y566.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSHANK1.
GenomeRNAi50944.
NextBio53409.
PROQ9Y566.
SOURCESearch...

Entry information

Entry nameSHAN1_HUMAN
AccessionPrimary (citable) accession number: Q9Y566
Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM