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Q9Y566

- SHAN1_HUMAN

UniProt

Q9Y566 - SHAN1_HUMAN

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Protein
SH3 and multiple ankyrin repeat domains protein 1
Gene
SHANK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

GO - Molecular functioni

  1. GKAP/Homer scaffold activity Source: BHF-UCL
  2. SH3 domain binding Source: BHF-UCL
  3. ankyrin repeat binding Source: BHF-UCL
  4. identical protein binding Source: BHF-UCL
  5. ionotropic glutamate receptor binding Source: BHF-UCL
  6. protein C-terminus binding Source: BHF-UCL
  7. protein binding Source: UniProtKB
  8. protein complex binding Source: BHF-UCL
  9. scaffold protein binding Source: BHF-UCL
  10. somatostatin receptor binding Source: BHF-UCL

GO - Biological processi

  1. adult behavior Source: BHF-UCL
  2. associative learning Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
  4. dendritic spine morphogenesis Source: BHF-UCL
  5. determination of affect Source: BHF-UCL
  6. habituation Source: Ensembl
  7. long-term memory Source: BHF-UCL
  8. negative regulation of actin filament bundle assembly Source: BHF-UCL
  9. neuromuscular process controlling balance Source: BHF-UCL
  10. olfactory behavior Source: Ensembl
  11. positive regulation of dendritic spine development Source: BHF-UCL
  12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  13. protein complex assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. righting reflex Source: Ensembl
  17. social behavior Source: BHF-UCL
  18. synapse maturation Source: BHF-UCL
  19. vocalization behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Gene namesi
Name:SHANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15474. SHANK1.

Subcellular locationi

Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
Note: Colocalizes with alpha-latrotoxin receptor 1 By similarity.

GO - Cellular componenti

  1. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB-SubCell
  4. dendrite Source: UniProtKB
  5. dendritic spine Source: BHF-UCL
  6. excitatory synapse Source: BHF-UCL
  7. intracellular Source: UniProtKB
  8. membrane Source: UniProtKB
  9. neuron projection Source: BHF-UCL
  10. neuronal postsynaptic density Source: BHF-UCL
  11. plasma membrane Source: BHF-UCL
  12. postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21612161SH3 and multiple ankyrin repeat domains protein 1
PRO_0000174671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y566.
PaxDbiQ9Y566.
PRIDEiQ9Y566.

PTM databases

PhosphoSiteiQ9Y566.

Expressioni

Tissue specificityi

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Gene expression databases

ArrayExpressiQ9Y566.
BgeeiQ9Y566.
CleanExiHS_SHANK1.
GenevestigatoriQ9Y566.

Organism-specific databases

HPAiHPA032129.
HPA032130.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain By similarity. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 By similarity. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP By similarity. Interacts with BAIAP2.2 Publications

Protein-protein interaction databases

BioGridi119171. 14 interactions.
DIPiDIP-40834N.
IntActiQ9Y566. 5 interactions.
MINTiMINT-101428.
STRINGi9606.ENSP00000293441.

Structurei

3D structure databases

ProteinModelPortaliQ9Y566.
SMRiQ9Y566. Positions 152-404, 564-611, 656-759, 2095-2156.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati212 – 24534ANK 1
Add
BLAST
Repeati246 – 27833ANK 2
Add
BLAST
Repeati279 – 31234ANK 3
Add
BLAST
Repeati313 – 34533ANK 4
Add
BLAST
Repeati346 – 37833ANK 5
Add
BLAST
Repeati379 – 39517ANK 6
Add
BLAST
Domaini554 – 61360SH3
Add
BLAST
Domaini663 – 75795PDZ
Add
BLAST
Domaini2098 – 216164SAM
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1002 – 10076Poly-His
Compositional biasi1014 – 10196Poly-His
Compositional biasi1189 – 11957Poly-Gly
Compositional biasi1709 – 17179Poly-Gly
Compositional biasi1844 – 185411Poly-Pro
Add
BLAST
Compositional biasi1896 – 19027Poly-Gly
Compositional biasi1970 – 197910Poly-Ser

Sequence similaritiesi

Belongs to the SHANK family.
Contains 6 ANK repeats.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
KOiK15009.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9Y566.
TreeFamiTF324593.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y566-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS     50
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR 400
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV 450
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP 500
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL 550
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG 650
IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMEYEQ 800
QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH 850
RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY 900
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR 950
GGPFNPGSGG PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP 1000
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW 1050
RGGGPSPTPG APSPSHHGSA GGGGGSSQGP ALRYFQLPPR AASAAMYVPA 1100
RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP PPAVAAPSEK 1150
NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP 1200
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA 1250
RRRSTLFLST DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR 1300
LESAGSGAGY GGYGAGSRAY GGGGGSSAFT SFLPPRPLVH PLTGKALDPA 1350
SPLGLALAAR ERALKESSEG GGAPQPPPRP PSPRYEAPPP TPHHHSPHAH 1400
HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA RRSLLHRLPP 1450
TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP 1500
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP 1550
APSVDVEDGE FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT 1600
PLPPVPPPAV AAAPPTLDST ASSLTSYDSE VATLTQGASA APGDPHPPGP 1650
PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS RSSSDHPLET ISSASTLSSL 1700
SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS STPGPPYPPQ 1750
LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL 1800
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP 1850
LPGPLAQPQA SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG 1900
GGDSHHGGAS YVPERTSSLQ RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP 1950
PLPTGTGVSP TAAAAPGATS PSASSSSTST RHLQGVEFEM RPPLLRRAPS 2000
PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT GGAGGSADPF 2050
APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK 2100
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN 2150
IDRALKFFLE R 2161
Length:2,161
Mass (Da):224,959
Last modified:May 5, 2009 - v2
Checksum:i94BDE56D3D5F319D
GO
Isoform 2 (identifier: Q9Y566-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-654: RSQESKQESR...PSLMDGIGPG → MQLMALEQRF...PPPHFSCLPA

Show »
Length:1,548
Mass (Da):158,792
Checksum:i450025F37316FBEF
GO
Isoform 3 (identifier: Q9Y566-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,152
Mass (Da):224,131
Checksum:i2BC1557113CF4DDF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → V.
Corresponds to variant rs10423744 [ dbSNP | Ensembl ].
VAR_055318
Natural varianti569 – 5691A → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036541
Natural varianti1504 – 15041V → A.
Corresponds to variant rs3745521 [ dbSNP | Ensembl ].
VAR_022123
Natural varianti2026 – 20261G → R in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 613613Missing in isoform 2.
VSP_006069Add
BLAST
Alternative sequencei614 – 65441RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2.
VSP_006070Add
BLAST
Alternative sequencei646 – 6549Missing in isoform 3.
VSP_006071

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti927 – 9271S → Y in AAD45121. 1 Publication
Sequence conflicti927 – 9271S → Y in AAF35887. 1 Publication
Sequence conflicti937 – 9371P → T in AAD45121. 1 Publication
Sequence conflicti937 – 9371P → T in AAF35887. 1 Publication
Sequence conflicti969 – 9691S → T in AAD45121. 1 Publication
Sequence conflicti969 – 9691S → T in AAF35887. 1 Publication
Sequence conflicti1085 – 10851F → I in AAD45121. 1 Publication
Sequence conflicti1085 – 10851F → I in AAF35887. 1 Publication
Sequence conflicti1133 – 11331T → S in AAD45121. 1 Publication
Sequence conflicti1133 – 11331T → S in AAF35887. 1 Publication
Sequence conflicti1832 – 18321S → C in AAD45121. 1 Publication
Sequence conflicti1832 – 18321S → C in AAF35887. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163302 mRNA. Translation: AAD45121.1.
AF226728 mRNA. Translation: AAF35887.1.
AC008743 Genomic DNA. No translation available.
AC010325 Genomic DNA. No translation available.
CCDSiCCDS12799.1. [Q9Y566-1]
RefSeqiNP_057232.2. NM_016148.2. [Q9Y566-1]
XP_006723296.1. XM_006723233.1. [Q9Y566-1]
XP_006723297.1. XM_006723234.1. [Q9Y566-3]
UniGeneiHs.274255.
Hs.715488.

Genome annotation databases

EnsembliENST00000293441; ENSP00000293441; ENSG00000161681. [Q9Y566-1]
ENST00000359082; ENSP00000351984; ENSG00000161681. [Q9Y566-3]
ENST00000391813; ENSP00000375689; ENSG00000161681. [Q9Y566-2]
GeneIDi50944.
KEGGihsa:50944.
UCSCiuc002psw.1. human. [Q9Y566-2]
uc002psx.1. human. [Q9Y566-1]

Polymorphism databases

DMDMi229462779.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163302 mRNA. Translation: AAD45121.1 .
AF226728 mRNA. Translation: AAF35887.1 .
AC008743 Genomic DNA. No translation available.
AC010325 Genomic DNA. No translation available.
CCDSi CCDS12799.1. [Q9Y566-1 ]
RefSeqi NP_057232.2. NM_016148.2. [Q9Y566-1 ]
XP_006723296.1. XM_006723233.1. [Q9Y566-1 ]
XP_006723297.1. XM_006723234.1. [Q9Y566-3 ]
UniGenei Hs.274255.
Hs.715488.

3D structure databases

ProteinModelPortali Q9Y566.
SMRi Q9Y566. Positions 152-404, 564-611, 656-759, 2095-2156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119171. 14 interactions.
DIPi DIP-40834N.
IntActi Q9Y566. 5 interactions.
MINTi MINT-101428.
STRINGi 9606.ENSP00000293441.

PTM databases

PhosphoSitei Q9Y566.

Polymorphism databases

DMDMi 229462779.

Proteomic databases

MaxQBi Q9Y566.
PaxDbi Q9Y566.
PRIDEi Q9Y566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293441 ; ENSP00000293441 ; ENSG00000161681 . [Q9Y566-1 ]
ENST00000359082 ; ENSP00000351984 ; ENSG00000161681 . [Q9Y566-3 ]
ENST00000391813 ; ENSP00000375689 ; ENSG00000161681 . [Q9Y566-2 ]
GeneIDi 50944.
KEGGi hsa:50944.
UCSCi uc002psw.1. human. [Q9Y566-2 ]
uc002psx.1. human. [Q9Y566-1 ]

Organism-specific databases

CTDi 50944.
GeneCardsi GC19M051165.
H-InvDB HIX0015364.
HGNCi HGNC:15474. SHANK1.
HPAi HPA032129.
HPA032130.
MIMi 604999. gene.
neXtProti NX_Q9Y566.
PharmGKBi PA37965.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000293276.
HOVERGENi HBG079186.
KOi K15009.
OrthoDBi EOG7X6KZ7.
PhylomeDBi Q9Y566.
TreeFami TF324593.

Miscellaneous databases

GeneWikii SHANK1.
GenomeRNAii 50944.
NextBioi 53409.
PROi Q9Y566.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y566.
Bgeei Q9Y566.
CleanExi HS_SHANK1.
Genevestigatori Q9Y566.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INTERACTION WITH SSTR2.
    Tissue: Fetal brain, Hippocampus and Thalamus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
    Soltau M., Richter D., Kreienkamp H.-J.
    Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAIAP2.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-569 AND ARG-2026.

Entry informationi

Entry nameiSHAN1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y566
Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi