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Q9Y566

- SHAN1_HUMAN

UniProt

Q9Y566 - SHAN1_HUMAN

Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

SHANK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

    GO - Molecular functioni

    1. ankyrin repeat binding Source: BHF-UCL
    2. GKAP/Homer scaffold activity Source: BHF-UCL
    3. identical protein binding Source: BHF-UCL
    4. ionotropic glutamate receptor binding Source: BHF-UCL
    5. protein binding Source: UniProtKB
    6. protein complex binding Source: BHF-UCL
    7. protein C-terminus binding Source: BHF-UCL
    8. scaffold protein binding Source: BHF-UCL
    9. SH3 domain binding Source: BHF-UCL
    10. somatostatin receptor binding Source: BHF-UCL

    GO - Biological processi

    1. adult behavior Source: BHF-UCL
    2. associative learning Source: BHF-UCL
    3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
    4. dendritic spine morphogenesis Source: BHF-UCL
    5. determination of affect Source: BHF-UCL
    6. habituation Source: Ensembl
    7. long-term memory Source: BHF-UCL
    8. negative regulation of actin filament bundle assembly Source: BHF-UCL
    9. neuromuscular process controlling balance Source: BHF-UCL
    10. olfactory behavior Source: Ensembl
    11. positive regulation of dendritic spine development Source: BHF-UCL
    12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    13. protein complex assembly Source: BHF-UCL
    14. protein localization to synapse Source: BHF-UCL
    15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
    16. righting reflex Source: Ensembl
    17. social behavior Source: BHF-UCL
    18. synapse maturation Source: BHF-UCL
    19. vocalization behavior Source: BHF-UCL

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 and multiple ankyrin repeat domains protein 1
    Short name:
    Shank1
    Alternative name(s):
    Somatostatin receptor-interacting protein
    Short name:
    SSTR-interacting protein
    Short name:
    SSTRIP
    Gene namesi
    Name:SHANK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15474. SHANK1.

    Subcellular locationi

    Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
    Note: Colocalizes with alpha-latrotoxin receptor 1.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-SubCell
    3. dendrite Source: UniProtKB
    4. dendritic spine Source: BHF-UCL
    5. excitatory synapse Source: BHF-UCL
    6. intracellular Source: UniProtKB
    7. membrane Source: UniProtKB
    8. neuronal postsynaptic density Source: BHF-UCL
    9. neuron projection Source: BHF-UCL
    10. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
    11. plasma membrane Source: BHF-UCL
    12. postsynaptic membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37965.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21612161SH3 and multiple ankyrin repeat domains protein 1PRO_0000174671Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei186 – 1861PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y566.
    PaxDbiQ9Y566.
    PRIDEiQ9Y566.

    PTM databases

    PhosphoSiteiQ9Y566.

    Expressioni

    Tissue specificityi

    Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

    Gene expression databases

    ArrayExpressiQ9Y566.
    BgeeiQ9Y566.
    CleanExiHS_SHANK1.
    GenevestigatoriQ9Y566.

    Organism-specific databases

    HPAiHPA032129.
    HPA032130.

    Interactioni

    Subunit structurei

    May homomultimerize via its SAM domain By similarity. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 By similarity. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP By similarity. Interacts with BAIAP2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi119171. 14 interactions.
    DIPiDIP-40834N.
    IntActiQ9Y566. 5 interactions.
    MINTiMINT-101428.
    STRINGi9606.ENSP00000293441.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y566.
    SMRiQ9Y566. Positions 152-404, 564-611, 656-759, 2095-2156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati212 – 24534ANK 1Add
    BLAST
    Repeati246 – 27833ANK 2Add
    BLAST
    Repeati279 – 31234ANK 3Add
    BLAST
    Repeati313 – 34533ANK 4Add
    BLAST
    Repeati346 – 37833ANK 5Add
    BLAST
    Repeati379 – 39517ANK 6Add
    BLAST
    Domaini554 – 61360SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini663 – 75795PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini2098 – 216164SAMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1002 – 10076Poly-His
    Compositional biasi1014 – 10196Poly-His
    Compositional biasi1189 – 11957Poly-Gly
    Compositional biasi1709 – 17179Poly-Gly
    Compositional biasi1844 – 185411Poly-ProAdd
    BLAST
    Compositional biasi1896 – 19027Poly-Gly
    Compositional biasi1970 – 197910Poly-Ser

    Sequence similaritiesi

    Belongs to the SHANK family.Curated
    Contains 6 ANK repeats.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000293276.
    HOVERGENiHBG079186.
    KOiK15009.
    OrthoDBiEOG7X6KZ7.
    PhylomeDBiQ9Y566.
    TreeFamiTF324593.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y566-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS     50
    LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK 100
    QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP 150
    YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD 200
    KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA 250
    LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL 300
    LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA 350
    LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR 400
    NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV 450
    FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP 500
    SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL 550
    YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV 600
    GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG 650
    IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ 700
    YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM 750
    VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMEYEQ 800
    QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH 850
    RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY 900
    LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR 950
    GGPFNPGSGG PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP 1000
    PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW 1050
    RGGGPSPTPG APSPSHHGSA GGGGGSSQGP ALRYFQLPPR AASAAMYVPA 1100
    RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP PPAVAAPSEK 1150
    NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP 1200
    APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA 1250
    RRRSTLFLST DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR 1300
    LESAGSGAGY GGYGAGSRAY GGGGGSSAFT SFLPPRPLVH PLTGKALDPA 1350
    SPLGLALAAR ERALKESSEG GGAPQPPPRP PSPRYEAPPP TPHHHSPHAH 1400
    HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA RRSLLHRLPP 1450
    TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP 1500
    RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP 1550
    APSVDVEDGE FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT 1600
    PLPPVPPPAV AAAPPTLDST ASSLTSYDSE VATLTQGASA APGDPHPPGP 1650
    PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS RSSSDHPLET ISSASTLSSL 1700
    SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS STPGPPYPPQ 1750
    LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL 1800
    RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP 1850
    LPGPLAQPQA SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG 1900
    GGDSHHGGAS YVPERTSSLQ RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP 1950
    PLPTGTGVSP TAAAAPGATS PSASSSSTST RHLQGVEFEM RPPLLRRAPS 2000
    PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT GGAGGSADPF 2050
    APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK 2100
    FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN 2150
    IDRALKFFLE R 2161
    Length:2,161
    Mass (Da):224,959
    Last modified:May 5, 2009 - v2
    Checksum:i94BDE56D3D5F319D
    GO
    Isoform 2 (identifier: Q9Y566-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-613: Missing.
         614-654: RSQESKQESR...PSLMDGIGPG → MQLMALEQRF...PPPHFSCLPA

    Show »
    Length:1,548
    Mass (Da):158,792
    Checksum:i450025F37316FBEF
    GO
    Isoform 3 (identifier: Q9Y566-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         646-654: Missing.

    Show »
    Length:2,152
    Mass (Da):224,131
    Checksum:i2BC1557113CF4DDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti927 – 9271S → Y in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti927 – 9271S → Y in AAF35887. (PubMed:10551867)Curated
    Sequence conflicti937 – 9371P → T in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti937 – 9371P → T in AAF35887. (PubMed:10551867)Curated
    Sequence conflicti969 – 9691S → T in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti969 – 9691S → T in AAF35887. (PubMed:10551867)Curated
    Sequence conflicti1085 – 10851F → I in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti1085 – 10851F → I in AAF35887. (PubMed:10551867)Curated
    Sequence conflicti1133 – 11331T → S in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti1133 – 11331T → S in AAF35887. (PubMed:10551867)Curated
    Sequence conflicti1832 – 18321S → C in AAD45121. (PubMed:10551867)Curated
    Sequence conflicti1832 – 18321S → C in AAF35887. (PubMed:10551867)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61A → V.
    Corresponds to variant rs10423744 [ dbSNP | Ensembl ].
    VAR_055318
    Natural varianti569 – 5691A → D in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036541
    Natural varianti1504 – 15041V → A.
    Corresponds to variant rs3745521 [ dbSNP | Ensembl ].
    VAR_022123
    Natural varianti2026 – 20261G → R in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036542

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 613613Missing in isoform 2. 1 PublicationVSP_006069Add
    BLAST
    Alternative sequencei614 – 65441RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2. 1 PublicationVSP_006070Add
    BLAST
    Alternative sequencei646 – 6549Missing in isoform 3. 1 PublicationVSP_006071

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163302 mRNA. Translation: AAD45121.1.
    AF226728 mRNA. Translation: AAF35887.1.
    AC008743 Genomic DNA. No translation available.
    AC010325 Genomic DNA. No translation available.
    CCDSiCCDS12799.1. [Q9Y566-1]
    RefSeqiNP_057232.2. NM_016148.2. [Q9Y566-1]
    XP_006723296.1. XM_006723233.1. [Q9Y566-1]
    XP_006723297.1. XM_006723234.1. [Q9Y566-3]
    UniGeneiHs.274255.
    Hs.715488.

    Genome annotation databases

    EnsembliENST00000293441; ENSP00000293441; ENSG00000161681. [Q9Y566-1]
    ENST00000359082; ENSP00000351984; ENSG00000161681. [Q9Y566-3]
    ENST00000391813; ENSP00000375689; ENSG00000161681. [Q9Y566-2]
    GeneIDi50944.
    KEGGihsa:50944.
    UCSCiuc002psw.1. human. [Q9Y566-2]
    uc002psx.1. human. [Q9Y566-1]

    Polymorphism databases

    DMDMi229462779.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163302 mRNA. Translation: AAD45121.1 .
    AF226728 mRNA. Translation: AAF35887.1 .
    AC008743 Genomic DNA. No translation available.
    AC010325 Genomic DNA. No translation available.
    CCDSi CCDS12799.1. [Q9Y566-1 ]
    RefSeqi NP_057232.2. NM_016148.2. [Q9Y566-1 ]
    XP_006723296.1. XM_006723233.1. [Q9Y566-1 ]
    XP_006723297.1. XM_006723234.1. [Q9Y566-3 ]
    UniGenei Hs.274255.
    Hs.715488.

    3D structure databases

    ProteinModelPortali Q9Y566.
    SMRi Q9Y566. Positions 152-404, 564-611, 656-759, 2095-2156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119171. 14 interactions.
    DIPi DIP-40834N.
    IntActi Q9Y566. 5 interactions.
    MINTi MINT-101428.
    STRINGi 9606.ENSP00000293441.

    PTM databases

    PhosphoSitei Q9Y566.

    Polymorphism databases

    DMDMi 229462779.

    Proteomic databases

    MaxQBi Q9Y566.
    PaxDbi Q9Y566.
    PRIDEi Q9Y566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293441 ; ENSP00000293441 ; ENSG00000161681 . [Q9Y566-1 ]
    ENST00000359082 ; ENSP00000351984 ; ENSG00000161681 . [Q9Y566-3 ]
    ENST00000391813 ; ENSP00000375689 ; ENSG00000161681 . [Q9Y566-2 ]
    GeneIDi 50944.
    KEGGi hsa:50944.
    UCSCi uc002psw.1. human. [Q9Y566-2 ]
    uc002psx.1. human. [Q9Y566-1 ]

    Organism-specific databases

    CTDi 50944.
    GeneCardsi GC19M051165.
    H-InvDB HIX0015364.
    HGNCi HGNC:15474. SHANK1.
    HPAi HPA032129.
    HPA032130.
    MIMi 604999. gene.
    neXtProti NX_Q9Y566.
    PharmGKBi PA37965.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000293276.
    HOVERGENi HBG079186.
    KOi K15009.
    OrthoDBi EOG7X6KZ7.
    PhylomeDBi Q9Y566.
    TreeFami TF324593.

    Miscellaneous databases

    GeneWikii SHANK1.
    GenomeRNAii 50944.
    NextBioi 53409.
    PROi Q9Y566.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y566.
    Bgeei Q9Y566.
    CleanExi HS_SHANK1.
    Genevestigatori Q9Y566.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.25.40.20. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
      Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
      J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INTERACTION WITH SSTR2.
      Tissue: Fetal brain, Hippocampus and Thalamus.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The Shank family of scaffold proteins."
      Sheng M., Kim E.
      J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    4. "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
      Soltau M., Richter D., Kreienkamp H.-J.
      Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAIAP2.
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-569 AND ARG-2026.

    Entry informationi

    Entry nameiSHAN1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y566
    Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3