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Q9Y566

- SHAN1_HUMAN

UniProt

Q9Y566 - SHAN1_HUMAN

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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

SHANK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

GO - Molecular functioni

  1. ankyrin repeat binding Source: BHF-UCL
  2. GKAP/Homer scaffold activity Source: BHF-UCL
  3. identical protein binding Source: BHF-UCL
  4. ionotropic glutamate receptor binding Source: BHF-UCL
  5. protein complex binding Source: BHF-UCL
  6. protein C-terminus binding Source: BHF-UCL
  7. scaffold protein binding Source: BHF-UCL
  8. SH3 domain binding Source: BHF-UCL
  9. somatostatin receptor binding Source: BHF-UCL

GO - Biological processi

  1. adult behavior Source: BHF-UCL
  2. associative learning Source: BHF-UCL
  3. cytoskeletal anchoring at plasma membrane Source: UniProtKB
  4. dendritic spine morphogenesis Source: BHF-UCL
  5. determination of affect Source: BHF-UCL
  6. habituation Source: Ensembl
  7. long-term memory Source: BHF-UCL
  8. negative regulation of actin filament bundle assembly Source: BHF-UCL
  9. neuromuscular process controlling balance Source: BHF-UCL
  10. olfactory behavior Source: Ensembl
  11. positive regulation of dendritic spine development Source: BHF-UCL
  12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  13. protein complex assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. righting reflex Source: Ensembl
  17. social behavior Source: BHF-UCL
  18. synapse maturation Source: BHF-UCL
  19. vocalization behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Gene namesi
Name:SHANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15474. SHANK1.

Subcellular locationi

Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
Note: Colocalizes with alpha-latrotoxin receptor 1.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. dendrite Source: UniProtKB
  4. dendritic spine Source: BHF-UCL
  5. excitatory synapse Source: BHF-UCL
  6. intracellular Source: UniProtKB
  7. membrane Source: UniProtKB
  8. neuronal postsynaptic density Source: BHF-UCL
  9. neuron projection Source: BHF-UCL
  10. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
  11. plasma membrane Source: BHF-UCL
  12. postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21612161SH3 and multiple ankyrin repeat domains protein 1PRO_0000174671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y566.
PaxDbiQ9Y566.
PRIDEiQ9Y566.

PTM databases

PhosphoSiteiQ9Y566.

Expressioni

Tissue specificityi

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Gene expression databases

BgeeiQ9Y566.
CleanExiHS_SHANK1.
ExpressionAtlasiQ9Y566. baseline.
GenevestigatoriQ9Y566.

Organism-specific databases

HPAiHPA032129.
HPA032130.

Interactioni

Subunit structurei

May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2.By similarity2 Publications

Protein-protein interaction databases

BioGridi119171. 14 interactions.
DIPiDIP-40834N.
IntActiQ9Y566. 5 interactions.
MINTiMINT-101428.
STRINGi9606.ENSP00000293441.

Structurei

3D structure databases

ProteinModelPortaliQ9Y566.
SMRiQ9Y566. Positions 177-403, 564-611, 656-759, 2095-2156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati212 – 24534ANK 1Add
BLAST
Repeati246 – 27833ANK 2Add
BLAST
Repeati279 – 31234ANK 3Add
BLAST
Repeati313 – 34533ANK 4Add
BLAST
Repeati346 – 37833ANK 5Add
BLAST
Repeati379 – 39517ANK 6Add
BLAST
Domaini554 – 61360SH3PROSITE-ProRule annotationAdd
BLAST
Domaini663 – 75795PDZPROSITE-ProRule annotationAdd
BLAST
Domaini2098 – 216164SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1002 – 10076Poly-His
Compositional biasi1014 – 10196Poly-His
Compositional biasi1189 – 11957Poly-Gly
Compositional biasi1709 – 17179Poly-Gly
Compositional biasi1844 – 185411Poly-ProAdd
BLAST
Compositional biasi1896 – 19027Poly-Gly
Compositional biasi1970 – 197910Poly-Ser

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG079186.
InParanoidiQ9Y566.
KOiK15009.
OrthoDBiEOG7X6KZ7.
PhylomeDBiQ9Y566.
TreeFamiTF324593.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y566) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPRGT RGQGSGAPGS
60 70 80 90 100
LASVRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LFNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ADKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGTGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGAASSG APGPTSGSQG QSQPSAPTTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPREGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQAE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQESKQ ESRSDKAKRL FRHYTVGSYD SFDAPSLMDG
660 670 680 690 700
IGPGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA PQQAKRLPPP TISLRSKSMT SELEEMEYEQ
810 820 830 840 850
QPAPVPSMEK KRTVYQMALN KLDEILAAAQ QTISASESPG PGGLASLGKH
860 870 880 890 900
RPKGFFATES SFDPHHRAQP SYERPSFLPP GPGLMLRQKS IGAAEDDRPY
910 920 930 940 950
LAPPAMKFSR SLSVPGSEDI PPPPTTSPPE PPYSTPPVPS SSGRLTPSPR
960 970 980 990 1000
GGPFNPGSGG PLPASSPASF DGPSPPDTRV GSREKSLYHS GPLPPAHHHP
1010 1020 1030 1040 1050
PHHHHHHAPP PQPHHHHAHP PHPPEMETGG SPDDPPPRLA LGPQPSLRGW
1060 1070 1080 1090 1100
RGGGPSPTPG APSPSHHGSA GGGGGSSQGP ALRYFQLPPR AASAAMYVPA
1110 1120 1130 1140 1150
RSGRGRKGPL VKQTKVEGEP QKGGGLPPAP SPTSPASPQP PPAVAAPSEK
1160 1170 1180 1190 1200
NSIPIPTIII KAPSTSSSGR SSQGSSTEAE PPTQPEPTGG GGGGGSSPSP
1210 1220 1230 1240 1250
APAMSPVPPS PSPVPTPASP SGPATLDFTS QFGAALVGAA RREGGWQNEA
1260 1270 1280 1290 1300
RRRSTLFLST DAGDEDGGDG GLGTGAAPGP RLRHSKSIDE GMFSAEPYLR
1310 1320 1330 1340 1350
LESAGSGAGY GGYGAGSRAY GGGGGSSAFT SFLPPRPLVH PLTGKALDPA
1360 1370 1380 1390 1400
SPLGLALAAR ERALKESSEG GGAPQPPPRP PSPRYEAPPP TPHHHSPHAH
1410 1420 1430 1440 1450
HEPVLRLWGA SPPDPARREL GYRAGLGSQE KSLPASPPAA RRSLLHRLPP
1460 1470 1480 1490 1500
TAPGVGPLLL QLGTEPPAPH PGVSKPWRSA APEEPERLPL HVRFLENCQP
1510 1520 1530 1540 1550
RAPVTSGRGP PSEDGPGVPP PSPRRSVPPS PTSPRASEEN GLPLLVLPPP
1560 1570 1580 1590 1600
APSVDVEDGE FLFVEPLPPP LEFSNSFEKP ESPLTPGPPH PLPDTPAPAT
1610 1620 1630 1640 1650
PLPPVPPPAV AAAPPTLDST ASSLTSYDSE VATLTQGASA APGDPHPPGP
1660 1670 1680 1690 1700
PAPAAPAPAA PQPGPDPPPG TDSGIEEVDS RSSSDHPLET ISSASTLSSL
1710 1720 1730 1740 1750
SAEGGGSAGG GGGAGAGVAS GPELLDTYVA YLDGQAFGGS STPGPPYPPQ
1760 1770 1780 1790 1800
LMTPSKLRGR ALGASGGLRP GPSGGLRDPV TPTSPTVSVT GAGTDGLLAL
1810 1820 1830 1840 1850
RACSGPPTAG VAGGPVAVEP EVPPVPLPTA SSLPRKLLPW EEGPGPPPPP
1860 1870 1880 1890 1900
LPGPLAQPQA SALATVKASI ISELSSKLQQ FGGSSAAGGA LPWARGGSGG
1910 1920 1930 1940 1950
GGDSHHGGAS YVPERTSSLQ RQRLSDDSQS SLLSKPVSSL FQNWPKPPLP
1960 1970 1980 1990 2000
PLPTGTGVSP TAAAAPGATS PSASSSSTST RHLQGVEFEM RPPLLRRAPS
2010 2020 2030 2040 2050
PSLLPASEHK VSPAPRPSSL PILPSGPLYP GLFDIRGSPT GGAGGSADPF
2060 2070 2080 2090 2100
APVFVPPHPG ISGGLGGALS GASRSLSPTR LLSLPPDKPF GAKPLGFWTK
2110 2120 2130 2140 2150
FDVADWLEWL GLAEHRAQFL DHEIDGSHLP ALTKEDYVDL GVTRVGHRMN
2160
IDRALKFFLE R
Length:2,161
Mass (Da):224,959
Last modified:May 5, 2009 - v2
Checksum:i94BDE56D3D5F319D
GO
Isoform 2 (identifier: Q9Y566-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-654: RSQESKQESR...PSLMDGIGPG → MQLMALEQRF...PPPHFSCLPA

Show »
Length:1,548
Mass (Da):158,792
Checksum:i450025F37316FBEF
GO
Isoform 3 (identifier: Q9Y566-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,152
Mass (Da):224,131
Checksum:i2BC1557113CF4DDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti927 – 9271S → Y in AAD45121. (PubMed:10551867)Curated
Sequence conflicti927 – 9271S → Y in AAF35887. (PubMed:10551867)Curated
Sequence conflicti937 – 9371P → T in AAD45121. (PubMed:10551867)Curated
Sequence conflicti937 – 9371P → T in AAF35887. (PubMed:10551867)Curated
Sequence conflicti969 – 9691S → T in AAD45121. (PubMed:10551867)Curated
Sequence conflicti969 – 9691S → T in AAF35887. (PubMed:10551867)Curated
Sequence conflicti1085 – 10851F → I in AAD45121. (PubMed:10551867)Curated
Sequence conflicti1085 – 10851F → I in AAF35887. (PubMed:10551867)Curated
Sequence conflicti1133 – 11331T → S in AAD45121. (PubMed:10551867)Curated
Sequence conflicti1133 – 11331T → S in AAF35887. (PubMed:10551867)Curated
Sequence conflicti1832 – 18321S → C in AAD45121. (PubMed:10551867)Curated
Sequence conflicti1832 – 18321S → C in AAF35887. (PubMed:10551867)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → V.
Corresponds to variant rs10423744 [ dbSNP | Ensembl ].
VAR_055318
Natural varianti569 – 5691A → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036541
Natural varianti1504 – 15041V → A.
Corresponds to variant rs3745521 [ dbSNP | Ensembl ].
VAR_022123
Natural varianti2026 – 20261G → R in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 613613Missing in isoform 2. 1 PublicationVSP_006069Add
BLAST
Alternative sequencei614 – 65441RSQES…GIGPG → MQLMALEQRFGSGLPGGGQP LCLMMSSPLPPPPPHFSCLP A in isoform 2. 1 PublicationVSP_006070Add
BLAST
Alternative sequencei646 – 6549Missing in isoform 3. 1 PublicationVSP_006071

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163302 mRNA. Translation: AAD45121.1.
AF226728 mRNA. Translation: AAF35887.1.
AC008743 Genomic DNA. No translation available.
AC010325 Genomic DNA. No translation available.
CCDSiCCDS12799.1. [Q9Y566-1]
RefSeqiNP_057232.2. NM_016148.2. [Q9Y566-1]
XP_006723296.1. XM_006723233.1. [Q9Y566-1]
XP_006723297.1. XM_006723234.1. [Q9Y566-3]
UniGeneiHs.274255.
Hs.715488.

Genome annotation databases

EnsembliENST00000293441; ENSP00000293441; ENSG00000161681. [Q9Y566-1]
ENST00000359082; ENSP00000351984; ENSG00000161681. [Q9Y566-3]
ENST00000391813; ENSP00000375689; ENSG00000161681. [Q9Y566-2]
GeneIDi50944.
KEGGihsa:50944.
UCSCiuc002psw.1. human. [Q9Y566-2]
uc002psx.1. human. [Q9Y566-1]

Polymorphism databases

DMDMi229462779.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF163302 mRNA. Translation: AAD45121.1 .
AF226728 mRNA. Translation: AAF35887.1 .
AC008743 Genomic DNA. No translation available.
AC010325 Genomic DNA. No translation available.
CCDSi CCDS12799.1. [Q9Y566-1 ]
RefSeqi NP_057232.2. NM_016148.2. [Q9Y566-1 ]
XP_006723296.1. XM_006723233.1. [Q9Y566-1 ]
XP_006723297.1. XM_006723234.1. [Q9Y566-3 ]
UniGenei Hs.274255.
Hs.715488.

3D structure databases

ProteinModelPortali Q9Y566.
SMRi Q9Y566. Positions 177-403, 564-611, 656-759, 2095-2156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119171. 14 interactions.
DIPi DIP-40834N.
IntActi Q9Y566. 5 interactions.
MINTi MINT-101428.
STRINGi 9606.ENSP00000293441.

PTM databases

PhosphoSitei Q9Y566.

Polymorphism databases

DMDMi 229462779.

Proteomic databases

MaxQBi Q9Y566.
PaxDbi Q9Y566.
PRIDEi Q9Y566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293441 ; ENSP00000293441 ; ENSG00000161681 . [Q9Y566-1 ]
ENST00000359082 ; ENSP00000351984 ; ENSG00000161681 . [Q9Y566-3 ]
ENST00000391813 ; ENSP00000375689 ; ENSG00000161681 . [Q9Y566-2 ]
GeneIDi 50944.
KEGGi hsa:50944.
UCSCi uc002psw.1. human. [Q9Y566-2 ]
uc002psx.1. human. [Q9Y566-1 ]

Organism-specific databases

CTDi 50944.
GeneCardsi GC19M051165.
H-InvDB HIX0015364.
HGNCi HGNC:15474. SHANK1.
HPAi HPA032129.
HPA032130.
MIMi 604999. gene.
neXtProti NX_Q9Y566.
PharmGKBi PA37965.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00510000046474.
HOGENOMi HOG000293276.
HOVERGENi HBG079186.
InParanoidi Q9Y566.
KOi K15009.
OrthoDBi EOG7X6KZ7.
PhylomeDBi Q9Y566.
TreeFami TF324593.

Miscellaneous databases

GeneWikii SHANK1.
GenomeRNAii 50944.
NextBioi 53409.
PROi Q9Y566.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y566.
CleanExi HS_SHANK1.
ExpressionAtlasi Q9Y566. baseline.
Genevestigatori Q9Y566.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
    Zitzer H., Hoenck H.-H., Baechner D., Richter D., Kreienkamp H.-J.
    J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INTERACTION WITH SSTR2.
    Tissue: Fetal brain, Hippocampus and Thalamus.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
    Soltau M., Richter D., Kreienkamp H.-J.
    Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAIAP2.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-569 AND ARG-2026.

Entry informationi

Entry nameiSHAN1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y566
Secondary accession number(s): A8MXP5, B7WNY6, Q9NYW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3