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Q9Y561 (LRP12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low-density lipoprotein receptor-related protein 12

Short name=LRP-12
Alternative name(s):
Suppressor of tumorigenicity 7 protein
Gene names
Name:LRP12
Synonyms:ST7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length859 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. Ref.6

Subunit structure

May interact with GNB2L1, ZFYVE9 and NMRK2.

Subcellular location

Membrane; Single-pass type I membrane protein. Membranecoated pit Ref.6.

Tissue specificity

Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines. Ref.1

Sequence similarities

Belongs to the LDLR family.

Contains 2 CUB domains.

Contains 5 LDL-receptor class A domains.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y561-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y561-2)

The sequence of this isoform differs from the canonical sequence as follows:
     27-45: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 859827Low-density lipoprotein receptor-related protein 12
PRO_0000017339

Regions

Topological domain33 – 492460Extracellular Potential
Transmembrane493 – 51321Helical; Potential
Topological domain514 – 859346Cytoplasmic Potential
Domain47 – 159113CUB 1
Domain165 – 20137LDL-receptor class A 1
Domain214 – 25542LDL-receptor class A 2
Domain259 – 372114CUB 2
Domain374 – 41138LDL-receptor class A 3
Domain412 – 44938LDL-receptor class A 4
Domain450 – 48637LDL-receptor class A 5

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 76 By similarity
Disulfide bond103 ↔ 122 By similarity
Disulfide bond166 ↔ 178 By similarity
Disulfide bond173 ↔ 191 By similarity
Disulfide bond185 ↔ 200 By similarity
Disulfide bond215 ↔ 232 By similarity
Disulfide bond222 ↔ 245 By similarity
Disulfide bond239 ↔ 254 By similarity
Disulfide bond259 ↔ 285 By similarity
Disulfide bond375 ↔ 388 By similarity
Disulfide bond382 ↔ 401 By similarity
Disulfide bond395 ↔ 410 By similarity
Disulfide bond413 ↔ 426 By similarity
Disulfide bond420 ↔ 439 By similarity
Disulfide bond433 ↔ 448 By similarity
Disulfide bond451 ↔ 463 By similarity
Disulfide bond458 ↔ 476 By similarity
Disulfide bond470 ↔ 485 By similarity

Natural variations

Alternative sequence27 – 4519Missing in isoform 2.
VSP_040992
Natural variant6941S → G.
Corresponds to variant rs16871494 [ dbSNP | Ensembl ].
VAR_049766

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 41A8FD8121E32A92

FASTA85994,984
        10         20         30         40         50         60 
MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI 

        70         80         90        100        110        120 
ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR 

       130        140        150        160        170        180 
ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP 

       190        200        210        220        230        240 
EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD 

       250        260        270        280        290        300 
GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR 

       310        320        330        340        350        360 
FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN 

       370        380        390        400        410        420 
AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC 

       430        440        450        460        470        480 
SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS 

       490        500        510        520        530        540 
DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL 

       550        560        570        580        590        600 
LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS 

       610        620        630        640        650        660 
NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE 

       670        680        690        700        710        720 
RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS 

       730        740        750        760        770        780 
PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS 

       790        800        810        820        830        840 
DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT 

       850 
CLEVTLKNET SDDEALLLC 

« Hide

Isoform 2 [UniParc].

Checksum: 6C6C3B315296D717
Show »

FASTA84093,123

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines."
Qing J., Wei D., Maher V.M., McCormick J.J.
Oncogene 18:335-342(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retinal pigment epithelium.
[6]"ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways."
Battle M.A., Maher V.M., McCormick J.J.
Biochemistry 42:7270-7282(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, POSSIBLE INTERACTION WITH GNB2L1; ZFYVE9 AND NMRK2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF166350 mRNA. Translation: AAD44360.1.
AK289752 mRNA. Translation: BAF82441.1.
AK299374 mRNA. Translation: BAG61364.1.
AC087370 Genomic DNA. No translation available.
AC090827 Genomic DNA. No translation available.
AP002847 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91897.1.
BC032109 mRNA. Translation: AAH32109.1.
CCDSCCDS47907.1. [Q9Y561-2]
CCDS6303.1. [Q9Y561-1]
RefSeqNP_001129175.1. NM_001135703.2. [Q9Y561-2]
NP_038465.1. NM_013437.4. [Q9Y561-1]
UniGeneHs.600630.
Hs.715867.

3D structure databases

ProteinModelPortalQ9Y561.
SMRQ9Y561. Positions 58-156, 166-370, 413-488.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119000. 1 interaction.
IntActQ9Y561. 6 interactions.
STRING9606.ENSP00000276654.

PTM databases

PhosphoSiteQ9Y561.

Polymorphism databases

DMDM25091287.

Proteomic databases

MaxQBQ9Y561.
PaxDbQ9Y561.
PRIDEQ9Y561.

Protocols and materials databases

DNASU29967.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276654; ENSP00000276654; ENSG00000147650. [Q9Y561-1]
ENST00000424843; ENSP00000399148; ENSG00000147650. [Q9Y561-2]
GeneID29967.
KEGGhsa:29967.
UCSCuc003yma.3. human. [Q9Y561-1]
uc003ymb.3. human. [Q9Y561-2]

Organism-specific databases

CTD29967.
GeneCardsGC08M105501.
HGNCHGNC:31708. LRP12.
HPAHPA017245.
neXtProtNX_Q9Y561.
PharmGKBPA134921850.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242928.
HOGENOMHOG000013017.
HOVERGENHBG103190.
InParanoidQ9Y561.
OMAPTCGQWL.
OrthoDBEOG7PCJG4.
PhylomeDBQ9Y561.
TreeFamTF332149.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

ArrayExpressQ9Y561.
BgeeQ9Y561.
CleanExHS_LRP12.
HS_ST7.
GenevestigatorQ9Y561.

Family and domain databases

Gene3D2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 5 hits.
PROSITEPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29967.
NextBio52701.
PROQ9Y561.

Entry information

Entry nameLRP12_HUMAN
AccessionPrimary (citable) accession number: Q9Y561
Secondary accession number(s): A8K137, B4DRQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM