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Protein

Low-density lipoprotein receptor-related protein 12

Gene

LRP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.1 Publication

GO - Molecular functioni

  • low-density lipoprotein receptor activity Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • regulation of growth Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004866-MONOMER.
ReactomeiR-HSA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 12
Short name:
LRP-12
Alternative name(s):
Suppressor of tumorigenicity 7 protein
Gene namesi
Name:LRP12
Synonyms:ST7
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:31708. LRP12.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Membranecoated pit 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 492ExtracellularSequence analysisAdd BLAST460
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 859CytoplasmicSequence analysisAdd BLAST346

GO - Cellular componenti

  • clathrin-coated pit Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29967.
OpenTargetsiENSG00000147650.
PharmGKBiPA134921850.

Polymorphism and mutation databases

BioMutaiLRP12.
DMDMi25091287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001733933 – 859Low-density lipoprotein receptor-related protein 12Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76By similarity
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 122By similarity
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Disulfide bondi215 ↔ 232By similarity
Disulfide bondi222 ↔ 245By similarity
Disulfide bondi239 ↔ 254By similarity
Disulfide bondi259 ↔ 285By similarity
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi375 ↔ 388By similarity
Disulfide bondi382 ↔ 401By similarity
Disulfide bondi395 ↔ 410By similarity
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi420 ↔ 439By similarity
Disulfide bondi433 ↔ 448By similarity
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi451 ↔ 463By similarity
Disulfide bondi458 ↔ 476By similarity
Disulfide bondi470 ↔ 485By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y561.
PeptideAtlasiQ9Y561.
PRIDEiQ9Y561.

PTM databases

iPTMnetiQ9Y561.
PhosphoSitePlusiQ9Y561.
SwissPalmiQ9Y561.

Expressioni

Tissue specificityi

Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.1 Publication

Gene expression databases

BgeeiENSG00000147650.
CleanExiHS_LRP12.
HS_ST7.
ExpressionAtlasiQ9Y561. baseline and differential.
GenevisibleiQ9Y561. HS.

Organism-specific databases

HPAiHPA017245.

Interactioni

Subunit structurei

May interact with RACK1, ZFYVE9 and NMRK2.

Binary interactionsi

WithEntry#Exp.IntActNotes
NMRK2Q9NPI52EBI-296693,EBI-514059
RACK1P632442EBI-296693,EBI-296739
ZFYVE9O954052EBI-296693,EBI-296817

Protein-protein interaction databases

BioGridi119000. 17 interactors.
IntActiQ9Y561. 7 interactors.
STRINGi9606.ENSP00000276654.

Structurei

3D structure databases

ProteinModelPortaliQ9Y561.
SMRiQ9Y561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 159CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini214 – 255LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST42
Domaini259 – 372CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini374 – 411LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini412 – 449LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini450 – 486LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 5 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT2. Eukaryota.
ENOG410YUIT. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG103190.
InParanoidiQ9Y561.
KOiK20050.
OMAiISFQDFD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiQ9Y561.
TreeFamiTF332149.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 4 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 5 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y561-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET
60 70 80 90 100
PEQIRAPSGI ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS
110 120 130 140 150
RRCNLDWLTI ETYKNIESYR ACGSTIPPPY ISSQDHIWIR FHSDDNISRK
160 170 180 190 200
GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP EAWKCNNMDE CGDSSDEEIC
210 220 230 240 250
AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD GNIDCLDLGD
260 270 280 290 300
EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
310 320 330 340 350
FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI
360 370 380 390 400
RVHFCADKVN AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH
410 420 430 440 450
CPNGRDETNC TMCQKEEFPC SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF
460 470 480 490 500
CQPGNFHCKN NRCVFESWVC DSQDDCGDGS DEENCPVIVP TRVITAAVIG
510 520 530 540 550
SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL LRREAPPSYG
560 570 580 590 600
QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS
610 620 630 640 650
NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV
660 670 680 690 700
ESDDTDTENE RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST
710 720 730 740 750
RGGHADNGRD VTSVEPPSVS PARHQLTSAL SRMTQGLRWV RFTLGRSSSL
760 770 780 790 800
SQNQSPLRQL DNGVSGREDD DDVEMLIPIS DGSSDFDVND CSRPLLDLAS
810 820 830 840 850
DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT CLEVTLKNET

SDDEALLLC
Length:859
Mass (Da):94,984
Last modified:November 1, 1999 - v1
Checksum:i41A8FD8121E32A92
GO
Isoform 2 (identifier: Q9Y561-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-45: Missing.

Show »
Length:840
Mass (Da):93,123
Checksum:i6C6C3B315296D717
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049766694S → G.Corresponds to variant rs16871494dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04099227 – 45Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166350 mRNA. Translation: AAD44360.1.
AK289752 mRNA. Translation: BAF82441.1.
AK299374 mRNA. Translation: BAG61364.1.
AC087370 Genomic DNA. No translation available.
AC090827 Genomic DNA. No translation available.
AP002847 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91897.1.
BC032109 mRNA. Translation: AAH32109.1.
CCDSiCCDS47907.1. [Q9Y561-2]
CCDS6303.1. [Q9Y561-1]
RefSeqiNP_001129175.1. NM_001135703.2. [Q9Y561-2]
NP_038465.1. NM_013437.4. [Q9Y561-1]
UniGeneiHs.600630.
Hs.715867.

Genome annotation databases

EnsembliENST00000276654; ENSP00000276654; ENSG00000147650. [Q9Y561-1]
ENST00000424843; ENSP00000399148; ENSG00000147650. [Q9Y561-2]
GeneIDi29967.
KEGGihsa:29967.
UCSCiuc003yma.4. human. [Q9Y561-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166350 mRNA. Translation: AAD44360.1.
AK289752 mRNA. Translation: BAF82441.1.
AK299374 mRNA. Translation: BAG61364.1.
AC087370 Genomic DNA. No translation available.
AC090827 Genomic DNA. No translation available.
AP002847 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91897.1.
BC032109 mRNA. Translation: AAH32109.1.
CCDSiCCDS47907.1. [Q9Y561-2]
CCDS6303.1. [Q9Y561-1]
RefSeqiNP_001129175.1. NM_001135703.2. [Q9Y561-2]
NP_038465.1. NM_013437.4. [Q9Y561-1]
UniGeneiHs.600630.
Hs.715867.

3D structure databases

ProteinModelPortaliQ9Y561.
SMRiQ9Y561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119000. 17 interactors.
IntActiQ9Y561. 7 interactors.
STRINGi9606.ENSP00000276654.

PTM databases

iPTMnetiQ9Y561.
PhosphoSitePlusiQ9Y561.
SwissPalmiQ9Y561.

Polymorphism and mutation databases

BioMutaiLRP12.
DMDMi25091287.

Proteomic databases

PaxDbiQ9Y561.
PeptideAtlasiQ9Y561.
PRIDEiQ9Y561.

Protocols and materials databases

DNASUi29967.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276654; ENSP00000276654; ENSG00000147650. [Q9Y561-1]
ENST00000424843; ENSP00000399148; ENSG00000147650. [Q9Y561-2]
GeneIDi29967.
KEGGihsa:29967.
UCSCiuc003yma.4. human. [Q9Y561-1]

Organism-specific databases

CTDi29967.
DisGeNETi29967.
GeneCardsiLRP12.
HGNCiHGNC:31708. LRP12.
HPAiHPA017245.
neXtProtiNX_Q9Y561.
OpenTargetsiENSG00000147650.
PharmGKBiPA134921850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPT2. Eukaryota.
ENOG410YUIT. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG103190.
InParanoidiQ9Y561.
KOiK20050.
OMAiISFQDFD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiQ9Y561.
TreeFamiTF332149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004866-MONOMER.
ReactomeiR-HSA-975634. Retinoid metabolism and transport.

Miscellaneous databases

GenomeRNAii29967.
PROiQ9Y561.

Gene expression databases

BgeeiENSG00000147650.
CleanExiHS_LRP12.
HS_ST7.
ExpressionAtlasiQ9Y561. baseline and differential.
GenevisibleiQ9Y561. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 4 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 5 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRP12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y561
Secondary accession number(s): A8K137, B4DRQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.