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Q9Y548 (YIPF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YIPF1
Alternative name(s):
YIP1 family member 1
Gene names
Name:YIPF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the YIP1 family.

Sequence caution

The sequence AAH09674.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

transport vesicle

Inferred from direct assay. Source: LIFEdb

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y548-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y548-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Protein YIPF1
PRO_0000240868

Regions

Topological domain1 – 119119Cytoplasmic Potential
Transmembrane120 – 14021Helical; Potential
Topological domain141 – 16222Lumenal Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 20017Cytoplasmic Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 2276Lumenal Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 2568Cytoplasmic Potential
Transmembrane257 – 27721Helical; Potential
Topological domain278 – 30629Lumenal Potential

Amino acid modifications

Glycosylation2971N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 183183Missing in isoform 2.
VSP_019437

Experimental info

Sequence conflict1091F → L in AAH09674. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: FC147CD5F9CAF467

FASTA30634,277
        10         20         30         40         50         60 
MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE EDDELLGNDD 

        70         80         90        100        110        120 
SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPIPGKNFV RLYIRSNPDL 

       130        140        150        160        170        180 
YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFRK VSIAATIIYA YAWLVPLALW 

       190        200        210        220        230        240 
GFLMWRNSKV MNIVSYSFLE IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS 

       250        260        270        280        290        300 
LLAMTFWPAV REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV 


AAAKSS 

« Hide

Isoform 2 [UniParc].

Checksum: A82F427DECA3790E
Show »

FASTA12313,753

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Adipose tissue and Synovium.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung and Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000823 mRNA. Translation: BAA91389.1.
AK315183 mRNA. Translation: BAG37624.1.
AL713668 mRNA. Translation: CAD28474.1.
CH471059 Genomic DNA. Translation: EAX06727.1.
CH471059 Genomic DNA. Translation: EAX06728.1.
CH471059 Genomic DNA. Translation: EAX06729.1.
BC009674 mRNA. Translation: AAH09674.1. Different initiation.
BC064590 mRNA. Translation: AAH64590.1.
RefSeqNP_061855.1. NM_018982.4.
UniGeneHs.11923.

3D structure databases

ProteinModelPortalQ9Y548.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119948. 1 interaction.
IntActQ9Y548. 1 interaction.
MINTMINT-3086853.
STRING9606.ENSP00000072644.

PTM databases

PhosphoSiteQ9Y548.

Polymorphism databases

DMDM74735280.

Proteomic databases

PaxDbQ9Y548.
PRIDEQ9Y548.

Protocols and materials databases

DNASU54432.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000072644; ENSP00000072644; ENSG00000058799. [Q9Y548-1]
ENST00000371399; ENSP00000360452; ENSG00000058799. [Q9Y548-2]
ENST00000464950; ENSP00000432266; ENSG00000058799. [Q9Y548-1]
GeneID54432.
KEGGhsa:54432.
UCSCuc001cvu.3. human. [Q9Y548-1]

Organism-specific databases

CTD54432.
GeneCardsGC01M054317.
HGNCHGNC:25231. YIPF1.
HPAHPA014716.
neXtProtNX_Q9Y548.
PharmGKBPA142670555.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG326970.
HOVERGENHBG056746.
InParanoidQ9Y548.
OrthoDBEOG7BW0JR.
PhylomeDBQ9Y548.
TreeFamTF313536.

Gene expression databases

ArrayExpressQ9Y548.
BgeeQ9Y548.
CleanExHS_YIPF1.
GenevestigatorQ9Y548.

Family and domain databases

InterProIPR006977. Yip1.
[Graphical view]
PfamPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSYIPF1. human.
GeneWikiYIPF1.
GenomeRNAi54432.
NextBio56633.
PROQ9Y548.

Entry information

Entry nameYIPF1_HUMAN
AccessionPrimary (citable) accession number: Q9Y548
Secondary accession number(s): B2RCM7, D3DQ40, Q9NWJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM