Q9Y548 (YIPF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIPF1

Alternative name(s):
YIP1 family member 1

Gene names

Name:

YIPF1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the YIP1 family.
Sequence caution	The sequence AAH09674.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW transport vesicle Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y548-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y548-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Protein YIPF1		PRO_0000240868
Regions
	Topological domain	1 – 119	119	Cytoplasmic Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Topological domain	141 – 162	22	Lumenal Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Topological domain	184 – 200	17	Cytoplasmic Potential
	Transmembrane	201 – 221	21	Helical; Potential
	Topological domain	222 – 227	6	Lumenal Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Topological domain	249 – 256	8	Cytoplasmic Potential
	Transmembrane	257 – 277	21	Helical; Potential
	Topological domain	278 – 306	29	Lumenal Potential
Amino acid modifications
	Glycosylation	297	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 183	183	Missing in isoform 2.		VSP_019437
Experimental info
	Sequence conflict	109	1	F → L in AAH09674. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: FC147CD5F9CAF467	FASTA	306	34,277
	10 20 30 40 50 60 MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE EDDELLGNDD 70 80 90 100 110 120 SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPIPGKNFV RLYIRSNPDL 130 140 150 160 170 180 YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFRK VSIAATIIYA YAWLVPLALW 190 200 210 220 230 240 GFLMWRNSKV MNIVSYSFLE IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS 250 260 270 280 290 300 LLAMTFWPAV REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV AAAKSS
	Isoform 2 [UniParc]. Checksum: A82F427DECA3790E	FASTA	123	13,753
	10 20 30 40 50 60 MWRNSKVMNI VSYSFLEIVC VYGYSLFIYI PTAILWIIPQ KAVRWILVMI ALGISGSLLA 70 80 90 100 110 120 MTFWPAVRED NRRVALATIV TIVLLHMLLS VGCLAYFFDA PEMDHLPTTT ATPNQTVAAA KSS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adipose tissue and Synovium.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000823 mRNA. Translation: BAA91389.1. AK315183 mRNA. Translation: BAG37624.1. AL713668 mRNA. Translation: CAD28474.1. CH471059 Genomic DNA. Translation: EAX06727.1. CH471059 Genomic DNA. Translation: EAX06728.1. CH471059 Genomic DNA. Translation: EAX06729.1. BC009674 mRNA. Translation: AAH09674.1. Different initiation. BC064590 mRNA. Translation: AAH64590.1.
IPI	IPI00643507. IPI01012314.
RefSeq	NP_061855.1. NM_018982.4.
UniGene	Hs.11923.
3D structure databases
ProteinModelPortal	Q9Y548.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y548.
Polymorphism databases
DMDM	74735280.
Proteomic databases
PRIDE	Q9Y548.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000072644; ENSP00000072644; ENSG00000058799.
GeneID	54432.
KEGG	hsa:54432.
UCSC	uc001cvu.1. human.
Organism-specific databases
CTD	54432.
GeneCards	GC01M054317.
H-InvDB	HIX0000604.
HGNC	HGNC:25231. YIPF1.
HPA	HPA014716.
neXtProt	NX_Q9Y548.
PharmGKB	PA142670555.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06663.
GeneTree	ENSGT00390000010157.
HOVERGEN	HBG056746.
InParanoid	Q9Y548.
OMA	RLYVRSN.
OrthoDB	EOG4DR9CQ.
PhylomeDB	Q9Y548.
Gene expression databases
ArrayExpress	Q9Y548.
Bgee	Q9Y548.
CleanEx	HS_YIPF1.
Genevestigator	Q9Y548.
GermOnline	ENSG00000058799. Homo sapiens.
Family and domain databases
InterPro	IPR006977. Yip1. [Graphical view]
Pfam	PF04893. Yip1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	56633.

Entry information

Entry name

YIPF1_HUMAN

Accession

Primary (citable) accession number: Q9Y548
Secondary accession number(s): B2RCM7, D3DQ40, Q9NWJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.