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Protein

Protein YIPF1

Gene

YIPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Protein family/group databases

TCDBi9.B.135.2.3. the membrane trafficking yip (yip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF1
Alternative name(s):
YIP1 family member 1
Gene namesi
Name:YIPF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000058799.13.
HGNCiHGNC:25231. YIPF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 119CytoplasmicSequence analysisAdd BLAST119
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 162LumenalSequence analysisAdd BLAST22
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 200CytoplasmicSequence analysisAdd BLAST17
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 227LumenalSequence analysis6
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 256CytoplasmicSequence analysis8
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 306LumenalSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000058799.
PharmGKBiPA142670555.

Polymorphism and mutation databases

BioMutaiYIPF1.
DMDMi74735280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408681 – 306Protein YIPF1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y548.
PaxDbiQ9Y548.
PeptideAtlasiQ9Y548.
PRIDEiQ9Y548.

PTM databases

iPTMnetiQ9Y548.
PhosphoSitePlusiQ9Y548.

Expressioni

Gene expression databases

BgeeiENSG00000058799.
CleanExiHS_YIPF1.
GenevisibleiQ9Y548. HS.

Organism-specific databases

HPAiHPA014716.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YIPF6Q96EC89EBI-7850136,EBI-751210

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119948. 5 interactors.
IntActiQ9Y548. 7 interactors.
MINTiMINT-3086853.
STRINGi9606.ENSP00000072644.

Structurei

3D structure databases

ProteinModelPortaliQ9Y548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBM. Eukaryota.
ENOG410XSEJ. LUCA.
GeneTreeiENSGT00390000010157.
HOVERGENiHBG056746.
InParanoidiQ9Y548.
OMAiFYAQFFD.
OrthoDBiEOG091G0JY5.
PhylomeDBiQ9Y548.
TreeFamiTF313536.

Family and domain databases

InterProiView protein in InterPro
IPR006977. Yip1.
PfamiView protein in Pfam
PF04893. Yip1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y548-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE
60 70 80 90 100
EDDELLGNDD SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS
110 120 130 140 150
LLPIPGKNFV RLYIRSNPDL YGPFWICATL VFAIAISGNL SNFLIHLGEK
160 170 180 190 200
TYHYVPEFRK VSIAATIIYA YAWLVPLALW GFLMWRNSKV MNIVSYSFLE
210 220 230 240 250
IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS LLAMTFWPAV
260 270 280 290 300
REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV

AAAKSS
Length:306
Mass (Da):34,277
Last modified:November 1, 1999 - v1
Checksum:iFC147CD5F9CAF467
GO
Isoform 2 (identifier: Q9Y548-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:123
Mass (Da):13,753
Checksum:iA82F427DECA3790E
GO

Sequence cautioni

The sequence AAH09674 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109F → L in AAH09674 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194371 – 183Missing in isoform 2. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000823 mRNA. Translation: BAA91389.1.
AK315183 mRNA. Translation: BAG37624.1.
AL713668 mRNA. Translation: CAD28474.1.
CH471059 Genomic DNA. Translation: EAX06727.1.
CH471059 Genomic DNA. Translation: EAX06728.1.
CH471059 Genomic DNA. Translation: EAX06729.1.
BC009674 mRNA. Translation: AAH09674.1. Different initiation.
BC064590 mRNA. Translation: AAH64590.1.
CCDSiCCDS584.1. [Q9Y548-1]
RefSeqiNP_061855.1. NM_018982.4. [Q9Y548-1]
XP_016856988.1. XM_017001499.1. [Q9Y548-1]
UniGeneiHs.11923.

Genome annotation databases

EnsembliENST00000072644; ENSP00000072644; ENSG00000058799. [Q9Y548-1]
ENST00000371399; ENSP00000360452; ENSG00000058799. [Q9Y548-2]
ENST00000464950; ENSP00000432266; ENSG00000058799. [Q9Y548-1]
GeneIDi54432.
KEGGihsa:54432.
UCSCiuc001cvu.4. human. [Q9Y548-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiYIPF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y548
Secondary accession number(s): B2RCM7, D3DQ40, Q9NWJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families