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Q9Y548

- YIPF1_HUMAN

UniProt

Q9Y548 - YIPF1_HUMAN

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Protein
Protein YIPF1
Gene
YIPF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF1
Alternative name(s):
YIP1 family member 1
Gene namesi
Name:YIPF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25231. YIPF1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 119119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Topological domaini141 – 16222Lumenal Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Topological domaini184 – 20017Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 2276Lumenal Reviewed prediction
Transmembranei228 – 24821Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 2568Cytoplasmic Reviewed prediction
Transmembranei257 – 27721Helical; Reviewed prediction
Add
BLAST
Topological domaini278 – 30629Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Protein YIPF1
PRO_0000240868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y548.
PRIDEiQ9Y548.

PTM databases

PhosphoSiteiQ9Y548.

Expressioni

Gene expression databases

ArrayExpressiQ9Y548.
BgeeiQ9Y548.
CleanExiHS_YIPF1.
GenevestigatoriQ9Y548.

Organism-specific databases

HPAiHPA014716.

Interactioni

Protein-protein interaction databases

BioGridi119948. 1 interaction.
IntActiQ9Y548. 1 interaction.
MINTiMINT-3086853.
STRINGi9606.ENSP00000072644.

Structurei

3D structure databases

ProteinModelPortaliQ9Y548.

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG326970.
HOVERGENiHBG056746.
InParanoidiQ9Y548.
OrthoDBiEOG7BW0JR.
PhylomeDBiQ9Y548.
TreeFamiTF313536.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y548-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE    50
EDDELLGNDD SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS 100
LLPIPGKNFV RLYIRSNPDL YGPFWICATL VFAIAISGNL SNFLIHLGEK 150
TYHYVPEFRK VSIAATIIYA YAWLVPLALW GFLMWRNSKV MNIVSYSFLE 200
IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS LLAMTFWPAV 250
REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV 300
AAAKSS 306
Length:306
Mass (Da):34,277
Last modified:November 1, 1999 - v1
Checksum:iFC147CD5F9CAF467
GO
Isoform 2 (identifier: Q9Y548-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:123
Mass (Da):13,753
Checksum:iA82F427DECA3790E
GO

Sequence cautioni

The sequence AAH09674.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 183183Missing in isoform 2.
VSP_019437Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091F → L in AAH09674. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000823 mRNA. Translation: BAA91389.1.
AK315183 mRNA. Translation: BAG37624.1.
AL713668 mRNA. Translation: CAD28474.1.
CH471059 Genomic DNA. Translation: EAX06727.1.
CH471059 Genomic DNA. Translation: EAX06728.1.
CH471059 Genomic DNA. Translation: EAX06729.1.
BC009674 mRNA. Translation: AAH09674.1. Different initiation.
BC064590 mRNA. Translation: AAH64590.1.
CCDSiCCDS584.1. [Q9Y548-1]
RefSeqiNP_061855.1. NM_018982.4. [Q9Y548-1]
UniGeneiHs.11923.

Genome annotation databases

EnsembliENST00000072644; ENSP00000072644; ENSG00000058799. [Q9Y548-1]
ENST00000371399; ENSP00000360452; ENSG00000058799. [Q9Y548-2]
ENST00000464950; ENSP00000432266; ENSG00000058799. [Q9Y548-1]
GeneIDi54432.
KEGGihsa:54432.
UCSCiuc001cvu.3. human. [Q9Y548-1]

Polymorphism databases

DMDMi74735280.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000823 mRNA. Translation: BAA91389.1 .
AK315183 mRNA. Translation: BAG37624.1 .
AL713668 mRNA. Translation: CAD28474.1 .
CH471059 Genomic DNA. Translation: EAX06727.1 .
CH471059 Genomic DNA. Translation: EAX06728.1 .
CH471059 Genomic DNA. Translation: EAX06729.1 .
BC009674 mRNA. Translation: AAH09674.1 . Different initiation.
BC064590 mRNA. Translation: AAH64590.1 .
CCDSi CCDS584.1. [Q9Y548-1 ]
RefSeqi NP_061855.1. NM_018982.4. [Q9Y548-1 ]
UniGenei Hs.11923.

3D structure databases

ProteinModelPortali Q9Y548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119948. 1 interaction.
IntActi Q9Y548. 1 interaction.
MINTi MINT-3086853.
STRINGi 9606.ENSP00000072644.

PTM databases

PhosphoSitei Q9Y548.

Polymorphism databases

DMDMi 74735280.

Proteomic databases

PaxDbi Q9Y548.
PRIDEi Q9Y548.

Protocols and materials databases

DNASUi 54432.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000072644 ; ENSP00000072644 ; ENSG00000058799 . [Q9Y548-1 ]
ENST00000371399 ; ENSP00000360452 ; ENSG00000058799 . [Q9Y548-2 ]
ENST00000464950 ; ENSP00000432266 ; ENSG00000058799 . [Q9Y548-1 ]
GeneIDi 54432.
KEGGi hsa:54432.
UCSCi uc001cvu.3. human. [Q9Y548-1 ]

Organism-specific databases

CTDi 54432.
GeneCardsi GC01M054317.
HGNCi HGNC:25231. YIPF1.
HPAi HPA014716.
neXtProti NX_Q9Y548.
PharmGKBi PA142670555.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326970.
HOVERGENi HBG056746.
InParanoidi Q9Y548.
OrthoDBi EOG7BW0JR.
PhylomeDBi Q9Y548.
TreeFami TF313536.

Miscellaneous databases

ChiTaRSi YIPF1. human.
GeneWikii YIPF1.
GenomeRNAii 54432.
NextBioi 56633.
PROi Q9Y548.

Gene expression databases

ArrayExpressi Q9Y548.
Bgeei Q9Y548.
CleanExi HS_YIPF1.
Genevestigatori Q9Y548.

Family and domain databases

InterProi IPR006977. Yip1.
[Graphical view ]
Pfami PF04893. Yip1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adipose tissue and Synovium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Pancreas.

Entry informationi

Entry nameiYIPF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y548
Secondary accession number(s): B2RCM7, D3DQ40, Q9NWJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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