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Q9Y548

- YIPF1_HUMAN

UniProt

Q9Y548 - YIPF1_HUMAN

Protein

Protein YIPF1

Gene

YIPF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YIPF1
    Alternative name(s):
    YIP1 family member 1
    Gene namesi
    Name:YIPF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25231. YIPF1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Protein YIPF1PRO_0000240868Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y548.
    PRIDEiQ9Y548.

    PTM databases

    PhosphoSiteiQ9Y548.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y548.
    BgeeiQ9Y548.
    CleanExiHS_YIPF1.
    GenevestigatoriQ9Y548.

    Organism-specific databases

    HPAiHPA014716.

    Interactioni

    Protein-protein interaction databases

    BioGridi119948. 1 interaction.
    IntActiQ9Y548. 1 interaction.
    MINTiMINT-3086853.
    STRINGi9606.ENSP00000072644.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y548.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 119119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16222LumenalSequence AnalysisAdd
    BLAST
    Topological domaini184 – 20017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini222 – 2276LumenalSequence Analysis
    Topological domaini249 – 2568CytoplasmicSequence Analysis
    Topological domaini278 – 30629LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YIP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG326970.
    HOVERGENiHBG056746.
    InParanoidiQ9Y548.
    OrthoDBiEOG7BW0JR.
    PhylomeDBiQ9Y548.
    TreeFamiTF313536.

    Family and domain databases

    InterProiIPR006977. Yip1.
    [Graphical view]
    PfamiPF04893. Yip1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y548-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE    50
    EDDELLGNDD SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS 100
    LLPIPGKNFV RLYIRSNPDL YGPFWICATL VFAIAISGNL SNFLIHLGEK 150
    TYHYVPEFRK VSIAATIIYA YAWLVPLALW GFLMWRNSKV MNIVSYSFLE 200
    IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS LLAMTFWPAV 250
    REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV 300
    AAAKSS 306
    Length:306
    Mass (Da):34,277
    Last modified:November 1, 1999 - v1
    Checksum:iFC147CD5F9CAF467
    GO
    Isoform 2 (identifier: Q9Y548-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-183: Missing.

    Show »
    Length:123
    Mass (Da):13,753
    Checksum:iA82F427DECA3790E
    GO

    Sequence cautioni

    The sequence AAH09674.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091F → L in AAH09674. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 183183Missing in isoform 2. 1 PublicationVSP_019437Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000823 mRNA. Translation: BAA91389.1.
    AK315183 mRNA. Translation: BAG37624.1.
    AL713668 mRNA. Translation: CAD28474.1.
    CH471059 Genomic DNA. Translation: EAX06727.1.
    CH471059 Genomic DNA. Translation: EAX06728.1.
    CH471059 Genomic DNA. Translation: EAX06729.1.
    BC009674 mRNA. Translation: AAH09674.1. Different initiation.
    BC064590 mRNA. Translation: AAH64590.1.
    CCDSiCCDS584.1. [Q9Y548-1]
    RefSeqiNP_061855.1. NM_018982.4. [Q9Y548-1]
    UniGeneiHs.11923.

    Genome annotation databases

    EnsembliENST00000072644; ENSP00000072644; ENSG00000058799. [Q9Y548-1]
    ENST00000371399; ENSP00000360452; ENSG00000058799. [Q9Y548-2]
    ENST00000464950; ENSP00000432266; ENSG00000058799. [Q9Y548-1]
    GeneIDi54432.
    KEGGihsa:54432.
    UCSCiuc001cvu.3. human. [Q9Y548-1]

    Polymorphism databases

    DMDMi74735280.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000823 mRNA. Translation: BAA91389.1 .
    AK315183 mRNA. Translation: BAG37624.1 .
    AL713668 mRNA. Translation: CAD28474.1 .
    CH471059 Genomic DNA. Translation: EAX06727.1 .
    CH471059 Genomic DNA. Translation: EAX06728.1 .
    CH471059 Genomic DNA. Translation: EAX06729.1 .
    BC009674 mRNA. Translation: AAH09674.1 . Different initiation.
    BC064590 mRNA. Translation: AAH64590.1 .
    CCDSi CCDS584.1. [Q9Y548-1 ]
    RefSeqi NP_061855.1. NM_018982.4. [Q9Y548-1 ]
    UniGenei Hs.11923.

    3D structure databases

    ProteinModelPortali Q9Y548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119948. 1 interaction.
    IntActi Q9Y548. 1 interaction.
    MINTi MINT-3086853.
    STRINGi 9606.ENSP00000072644.

    PTM databases

    PhosphoSitei Q9Y548.

    Polymorphism databases

    DMDMi 74735280.

    Proteomic databases

    PaxDbi Q9Y548.
    PRIDEi Q9Y548.

    Protocols and materials databases

    DNASUi 54432.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000072644 ; ENSP00000072644 ; ENSG00000058799 . [Q9Y548-1 ]
    ENST00000371399 ; ENSP00000360452 ; ENSG00000058799 . [Q9Y548-2 ]
    ENST00000464950 ; ENSP00000432266 ; ENSG00000058799 . [Q9Y548-1 ]
    GeneIDi 54432.
    KEGGi hsa:54432.
    UCSCi uc001cvu.3. human. [Q9Y548-1 ]

    Organism-specific databases

    CTDi 54432.
    GeneCardsi GC01M054317.
    HGNCi HGNC:25231. YIPF1.
    HPAi HPA014716.
    neXtProti NX_Q9Y548.
    PharmGKBi PA142670555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326970.
    HOVERGENi HBG056746.
    InParanoidi Q9Y548.
    OrthoDBi EOG7BW0JR.
    PhylomeDBi Q9Y548.
    TreeFami TF313536.

    Miscellaneous databases

    ChiTaRSi YIPF1. human.
    GeneWikii YIPF1.
    GenomeRNAii 54432.
    NextBioi 56633.
    PROi Q9Y548.

    Gene expression databases

    ArrayExpressi Q9Y548.
    Bgeei Q9Y548.
    CleanExi HS_YIPF1.
    Genevestigatori Q9Y548.

    Family and domain databases

    InterProi IPR006977. Yip1.
    [Graphical view ]
    Pfami PF04893. Yip1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adipose tissue and Synovium.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Pancreas.

    Entry informationi

    Entry nameiYIPF1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y548
    Secondary accession number(s): B2RCM7, D3DQ40, Q9NWJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3