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Protein

Intraflagellar transport protein 25 homolog

Gene

HSPB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Calcium; via carbonyl oxygenBy similarity1
Metal bindingi32CalciumBy similarity1
Metal bindingi37CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Stress response, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 25 homolog
Alternative name(s):
Heat shock protein beta-11
Short name:
Hspb11
Placental protein 25
Short name:
PP25
Gene namesi
Name:HSPB11
Synonyms:C1orf41, IFT25
ORF Names:HSPC034
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000081870.11.
HGNCiHGNC:25019. HSPB11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

DisGeNETi51668.
OpenTargetsiENSG00000081870.
PharmGKBiPA162391751.

Polymorphism and mutation databases

BioMutaiHSPB11.
DMDMi67460979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585311 – 144Intraflagellar transport protein 25 homologAdd BLAST144

Proteomic databases

EPDiQ9Y547.
MaxQBiQ9Y547.
PaxDbiQ9Y547.
PeptideAtlasiQ9Y547.
PRIDEiQ9Y547.

PTM databases

iPTMnetiQ9Y547.
PhosphoSitePlusiQ9Y547.

Expressioni

Tissue specificityi

Detected in placenta.1 Publication

Gene expression databases

BgeeiENSG00000081870.
CleanExiHS_HSPB11.
ExpressionAtlasiQ9Y547. baseline and differential.
GenevisibleiQ9Y547. HS.

Organism-specific databases

HPAiHPA030140.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119671. 18 interactors.
CORUMiQ9Y547.
IntActiQ9Y547. 17 interactors.
MINTiMINT-1456938.
STRINGi9606.ENSP00000194214.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 11Combined sources3
Beta strandi14 – 16Combined sources3
Beta strandi23 – 25Combined sources3
Helixi27 – 31Combined sources5
Beta strandi45 – 77Combined sources33
Beta strandi79 – 82Combined sources4
Beta strandi86 – 92Combined sources7
Beta strandi101 – 105Combined sources5
Beta strandi110 – 125Combined sources16
Beta strandi128 – 139Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TVGX-ray1.60A1-143[»]
1XPWNMR-A1-144[»]
ProteinModelPortaliQ9Y547.
SMRiQ9Y547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y547.

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT25 family.Curated

Phylogenomic databases

eggNOGiENOG410INPG. Eukaryota.
ENOG4111WDR. LUCA.
GeneTreeiENSGT00390000012620.
HOGENOMiHOG000232198.
HOVERGENiHBG060331.
InParanoidiQ9Y547.
KOiK19369.
OMAiHATYLRF.
PhylomeDBiQ9Y547.
TreeFamiTF336031.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR000421. FA58C.
IPR008979. Galactose-bd-like_sf.
IPR033558. IFT25.
PANTHERiPTHR33906. PTHR33906. 1 hit.
PfamiView protein in Pfam
PF00754. F5_F8_type_C. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI
60 70 80 90 100
ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL
110 120 130 140
QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS
Length:144
Mass (Da):16,297
Last modified:November 1, 1999 - v1
Checksum:i43B7DBDD47A528C9
GO

Sequence cautioni

The sequence AAD43011 differs from that shown. Reason: Frameshift at position 77.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416725 mRNA. Translation: AAQ03618.1.
AF417114 mRNA. Translation: AAQ03994.1.
AF100747 mRNA. Translation: AAD43011.1. Frameshift.
AL031427 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06717.1.
CH471059 Genomic DNA. Translation: EAX06719.1.
BC005245 mRNA. Translation: AAH05245.1.
CCDSiCCDS41341.1.
RefSeqiNP_001303864.1. NM_001316935.1.
NP_057210.2. NM_016126.3.
UniGeneiHs.525462.
Hs.624686.

Genome annotation databases

EnsembliENST00000194214; ENSP00000194214; ENSG00000081870.
GeneIDi51668.
KEGGihsa:51668.
UCSCiuc001cwh.4. human.

Similar proteinsi

Entry informationi

Entry nameiIFT25_HUMAN
AccessioniPrimary (citable) accession number: Q9Y547
Secondary accession number(s): A6NG57, D3DQ45, Q9Y684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:19921466).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families