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Protein

Intraflagellar transport protein 25 homolog

Gene

HSPB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Calcium; via carbonyl oxygenBy similarity
Metal bindingi32 – 321CalciumBy similarity
Metal bindingi37 – 371CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Stress response, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 25 homolog
Alternative name(s):
Heat shock protein beta-11
Short name:
Hspb11
Placental protein 25
Short name:
PP25
Gene namesi
Name:HSPB11
Synonyms:C1orf41, IFT25
ORF Names:HSPC034
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25019. HSPB11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391751.

Polymorphism and mutation databases

BioMutaiHSPB11.
DMDMi67460979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Intraflagellar transport protein 25 homologPRO_0000058531Add
BLAST

Proteomic databases

EPDiQ9Y547.
MaxQBiQ9Y547.
PaxDbiQ9Y547.
PeptideAtlasiQ9Y547.
PRIDEiQ9Y547.

PTM databases

iPTMnetiQ9Y547.
PhosphoSiteiQ9Y547.

Expressioni

Tissue specificityi

Detected in placenta.1 Publication

Gene expression databases

BgeeiENSG00000081870.
CleanExiHS_HSPB11.
ExpressionAtlasiQ9Y547. baseline and differential.
GenevisibleiQ9Y547. HS.

Organism-specific databases

HPAiHPA030140.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
IFT27Q9BW836EBI-747101,EBI-747093
SEC23IPQ9Y6Y83EBI-747101,EBI-1767971

Protein-protein interaction databases

BioGridi119671. 4 interactions.
IntActiQ9Y547. 3 interactions.
MINTiMINT-1456938.
STRINGi9606.ENSP00000194214.

Structurei

Secondary structure

1
144
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 113Combined sources
Beta strandi14 – 163Combined sources
Beta strandi23 – 253Combined sources
Helixi27 – 315Combined sources
Beta strandi45 – 7733Combined sources
Beta strandi79 – 824Combined sources
Beta strandi86 – 927Combined sources
Beta strandi101 – 1055Combined sources
Beta strandi110 – 12516Combined sources
Beta strandi128 – 13912Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TVGX-ray1.60A1-143[»]
1XPWNMR-A1-144[»]
ProteinModelPortaliQ9Y547.
SMRiQ9Y547. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y547.

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT25 family.Curated

Phylogenomic databases

eggNOGiENOG410INPG. Eukaryota.
ENOG4111WDR. LUCA.
GeneTreeiENSGT00390000012620.
HOGENOMiHOG000232198.
HOVERGENiHBG060331.
InParanoidiQ9Y547.
KOiK19369.
OMAiFIIKSAF.
PhylomeDBiQ9Y547.
TreeFamiTF336031.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR033558. IFT25.
[Graphical view]
PANTHERiPTHR33906. PTHR33906. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI
60 70 80 90 100
ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL
110 120 130 140
QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS
Length:144
Mass (Da):16,297
Last modified:November 1, 1999 - v1
Checksum:i43B7DBDD47A528C9
GO

Sequence cautioni

The sequence AAD43011 differs from that shown. Reason: Frameshift at position 77. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416725 mRNA. Translation: AAQ03618.1.
AF417114 mRNA. Translation: AAQ03994.1.
AF100747 mRNA. Translation: AAD43011.1. Frameshift.
AL031427 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06717.1.
CH471059 Genomic DNA. Translation: EAX06719.1.
BC005245 mRNA. Translation: AAH05245.1.
CCDSiCCDS41341.1.
RefSeqiNP_001303864.1. NM_001316935.1.
NP_057210.2. NM_016126.3.
UniGeneiHs.525462.
Hs.624686.

Genome annotation databases

EnsembliENST00000194214; ENSP00000194214; ENSG00000081870.
GeneIDi51668.
KEGGihsa:51668.
UCSCiuc001cwh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416725 mRNA. Translation: AAQ03618.1.
AF417114 mRNA. Translation: AAQ03994.1.
AF100747 mRNA. Translation: AAD43011.1. Frameshift.
AL031427 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06717.1.
CH471059 Genomic DNA. Translation: EAX06719.1.
BC005245 mRNA. Translation: AAH05245.1.
CCDSiCCDS41341.1.
RefSeqiNP_001303864.1. NM_001316935.1.
NP_057210.2. NM_016126.3.
UniGeneiHs.525462.
Hs.624686.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TVGX-ray1.60A1-143[»]
1XPWNMR-A1-144[»]
ProteinModelPortaliQ9Y547.
SMRiQ9Y547. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119671. 4 interactions.
IntActiQ9Y547. 3 interactions.
MINTiMINT-1456938.
STRINGi9606.ENSP00000194214.

PTM databases

iPTMnetiQ9Y547.
PhosphoSiteiQ9Y547.

Polymorphism and mutation databases

BioMutaiHSPB11.
DMDMi67460979.

Proteomic databases

EPDiQ9Y547.
MaxQBiQ9Y547.
PaxDbiQ9Y547.
PeptideAtlasiQ9Y547.
PRIDEiQ9Y547.

Protocols and materials databases

DNASUi51668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194214; ENSP00000194214; ENSG00000081870.
GeneIDi51668.
KEGGihsa:51668.
UCSCiuc001cwh.4. human.

Organism-specific databases

CTDi51668.
GeneCardsiHSPB11.
H-InvDBHIX0029364.
HGNCiHGNC:25019. HSPB11.
HPAiHPA030140.
neXtProtiNX_Q9Y547.
PharmGKBiPA162391751.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INPG. Eukaryota.
ENOG4111WDR. LUCA.
GeneTreeiENSGT00390000012620.
HOGENOMiHOG000232198.
HOVERGENiHBG060331.
InParanoidiQ9Y547.
KOiK19369.
OMAiFIIKSAF.
PhylomeDBiQ9Y547.
TreeFamiTF336031.

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

EvolutionaryTraceiQ9Y547.
GenomeRNAii51668.
PROiQ9Y547.

Gene expression databases

BgeeiENSG00000081870.
CleanExiHS_HSPB11.
ExpressionAtlasiQ9Y547. baseline and differential.
GenevisibleiQ9Y547. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR033558. IFT25.
[Graphical view]
PANTHERiPTHR33906. PTHR33906. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFT25_HUMAN
AccessioniPrimary (citable) accession number: Q9Y547
Secondary accession number(s): A6NG57, D3DQ45, Q9Y684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:19921466).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.