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Protein

Leucine-rich repeat-containing protein 42

Gene

LRRC42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 42
Gene namesi
Name:LRRC42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28792. LRRC42.

Pathology & Biotechi

Organism-specific databases

DisGeNETi115353.
OpenTargetsiENSG00000116212.
PharmGKBiPA142671530.

Polymorphism and mutation databases

BioMutaiLRRC42.
DMDMi74762064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236221 – 428Leucine-rich repeat-containing protein 42Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei406PhosphoserineBy similarity1
Modified residuei407PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y546.
MaxQBiQ9Y546.
PaxDbiQ9Y546.
PeptideAtlasiQ9Y546.
PRIDEiQ9Y546.

PTM databases

iPTMnetiQ9Y546.
PhosphoSitePlusiQ9Y546.

Expressioni

Gene expression databases

BgeeiENSG00000116212.
CleanExiHS_LRRC42.
ExpressionAtlasiQ9Y546. baseline and differential.
GenevisibleiQ9Y546. HS.

Organism-specific databases

HPAiHPA047458.
HPA050537.

Interactioni

Protein-protein interaction databases

BioGridi125429. 12 interactors.
STRINGi9606.ENSP00000318185.

Structurei

3D structure databases

ProteinModelPortaliQ9Y546.
SMRiQ9Y546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 170LRR 1Add BLAST22
Repeati174 – 195LRR 2Add BLAST22
Repeati202 – 222LRR 3Add BLAST21
Repeati234 – 255LRR 4Add BLAST22
Repeati259 – 280LRR 5Add BLAST22

Sequence similaritiesi

Belongs to the LRRC42 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHWD. Eukaryota.
ENOG410YPPD. LUCA.
GeneTreeiENSGT00390000002727.
HOGENOMiHOG000113370.
HOVERGENiHBG071948.
InParanoidiQ9Y546.
OMAiYVRENGQ.
OrthoDBiEOG091G0W1D.
PhylomeDBiQ9Y546.
TreeFamiTF331102.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG
60 70 80 90 100
FSVELCMNRE DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN
110 120 130 140 150
VDHIDSLIGF PEQIAEKLFS AAEARQKFTE PGAGLRALQK FTEAYGSLVL
160 170 180 190 200
CSLCLRNRYL VISEKLEEIK SFRELTCLDL SCCKLGDEHE LLEHLTNEAL
210 220 230 240 250
SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL SCNPEITDAG
260 270 280 290 300
IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN
310 320 330 340 350
CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC
360 370 380 390 400
PLADTHMNSS EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE
410 420
TEQNNSSQPS KQKYVCLAVE DWDLLNSY
Length:428
Mass (Da):48,571
Last modified:November 1, 1999 - v1
Checksum:iEC22D6E407E36B87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362K → R in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti395P → S in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti413 – 428KYVCL…LLNSY → IFLLLWCGRGMLWKYVIISN VYFQYIVIFSNKHFCCP (PubMed:14702039).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075201 mRNA. Translation: BAC11466.1. Different termination.
AK074521 mRNA. Translation: BAC11038.1.
CH471059 Genomic DNA. Translation: EAX06713.1.
CH471059 Genomic DNA. Translation: EAX06714.1.
CH471059 Genomic DNA. Translation: EAX06715.1.
BC013101 mRNA. Translation: AAH13101.1.
CCDSiCCDS585.1.
RefSeqiNP_001243338.1. NM_001256409.1.
NP_443172.1. NM_052940.4.
XP_006710390.1. XM_006710327.3.
XP_006710391.1. XM_006710328.3.
UniGeneiHs.40094.

Genome annotation databases

EnsembliENST00000319223; ENSP00000318185; ENSG00000116212.
ENST00000371370; ENSP00000360421; ENSG00000116212.
GeneIDi115353.
KEGGihsa:115353.
UCSCiuc001cwj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075201 mRNA. Translation: BAC11466.1. Different termination.
AK074521 mRNA. Translation: BAC11038.1.
CH471059 Genomic DNA. Translation: EAX06713.1.
CH471059 Genomic DNA. Translation: EAX06714.1.
CH471059 Genomic DNA. Translation: EAX06715.1.
BC013101 mRNA. Translation: AAH13101.1.
CCDSiCCDS585.1.
RefSeqiNP_001243338.1. NM_001256409.1.
NP_443172.1. NM_052940.4.
XP_006710390.1. XM_006710327.3.
XP_006710391.1. XM_006710328.3.
UniGeneiHs.40094.

3D structure databases

ProteinModelPortaliQ9Y546.
SMRiQ9Y546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125429. 12 interactors.
STRINGi9606.ENSP00000318185.

PTM databases

iPTMnetiQ9Y546.
PhosphoSitePlusiQ9Y546.

Polymorphism and mutation databases

BioMutaiLRRC42.
DMDMi74762064.

Proteomic databases

EPDiQ9Y546.
MaxQBiQ9Y546.
PaxDbiQ9Y546.
PeptideAtlasiQ9Y546.
PRIDEiQ9Y546.

Protocols and materials databases

DNASUi115353.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319223; ENSP00000318185; ENSG00000116212.
ENST00000371370; ENSP00000360421; ENSG00000116212.
GeneIDi115353.
KEGGihsa:115353.
UCSCiuc001cwj.3. human.

Organism-specific databases

CTDi115353.
DisGeNETi115353.
GeneCardsiLRRC42.
HGNCiHGNC:28792. LRRC42.
HPAiHPA047458.
HPA050537.
neXtProtiNX_Q9Y546.
OpenTargetsiENSG00000116212.
PharmGKBiPA142671530.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHWD. Eukaryota.
ENOG410YPPD. LUCA.
GeneTreeiENSGT00390000002727.
HOGENOMiHOG000113370.
HOVERGENiHBG071948.
InParanoidiQ9Y546.
OMAiYVRENGQ.
OrthoDBiEOG091G0W1D.
PhylomeDBiQ9Y546.
TreeFamiTF331102.

Miscellaneous databases

GenomeRNAii115353.
PROiQ9Y546.

Gene expression databases

BgeeiENSG00000116212.
CleanExiHS_LRRC42.
ExpressionAtlasiQ9Y546. baseline and differential.
GenevisibleiQ9Y546. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC42_HUMAN
AccessioniPrimary (citable) accession number: Q9Y546
Secondary accession number(s): D3DQ46, Q8N2Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.