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Protein

Leucine-rich repeat-containing protein 42

Gene

LRRC42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 42
Gene namesi
Name:LRRC42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116212.14
HGNCiHGNC:28792 LRRC42
neXtProtiNX_Q9Y546

Pathology & Biotechi

Organism-specific databases

DisGeNETi115353
OpenTargetsiENSG00000116212
PharmGKBiPA142671530

Polymorphism and mutation databases

BioMutaiLRRC42
DMDMi74762064

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236221 – 428Leucine-rich repeat-containing protein 42Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei406PhosphoserineBy similarity1
Modified residuei407PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y546
MaxQBiQ9Y546
PaxDbiQ9Y546
PeptideAtlasiQ9Y546
PRIDEiQ9Y546
ProteomicsDBi86287

PTM databases

iPTMnetiQ9Y546
PhosphoSitePlusiQ9Y546

Expressioni

Gene expression databases

BgeeiENSG00000116212
CleanExiHS_LRRC42
ExpressionAtlasiQ9Y546 baseline and differential
GenevisibleiQ9Y546 HS

Organism-specific databases

HPAiHPA047458
HPA050537
HPA064581

Interactioni

Protein-protein interaction databases

BioGridi125429, 12 interactors
STRINGi9606.ENSP00000318185

Structurei

3D structure databases

ProteinModelPortaliQ9Y546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 170LRR 1Add BLAST22
Repeati174 – 195LRR 2Add BLAST22
Repeati202 – 222LRR 3Add BLAST21
Repeati234 – 255LRR 4Add BLAST22
Repeati259 – 280LRR 5Add BLAST22

Sequence similaritiesi

Belongs to the LRRC42 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHWD Eukaryota
ENOG410YPPD LUCA
GeneTreeiENSGT00390000002727
HOGENOMiHOG000113370
HOVERGENiHBG071948
InParanoidiQ9Y546
OMAiYVRENGQ
OrthoDBiEOG091G0W1D
PhylomeDBiQ9Y546
TreeFamiTF331102

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Y546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG
60 70 80 90 100
FSVELCMNRE DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN
110 120 130 140 150
VDHIDSLIGF PEQIAEKLFS AAEARQKFTE PGAGLRALQK FTEAYGSLVL
160 170 180 190 200
CSLCLRNRYL VISEKLEEIK SFRELTCLDL SCCKLGDEHE LLEHLTNEAL
210 220 230 240 250
SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL SCNPEITDAG
260 270 280 290 300
IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN
310 320 330 340 350
CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC
360 370 380 390 400
PLADTHMNSS EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE
410 420
TEQNNSSQPS KQKYVCLAVE DWDLLNSY
Length:428
Mass (Da):48,571
Last modified:November 1, 1999 - v1
Checksum:iEC22D6E407E36B87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362K → R in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti395P → S in BAC11038 (PubMed:14702039).Curated1
Sequence conflicti413 – 428KYVCL…LLNSY → IFLLLWCGRGMLWKYVIISN VYFQYIVIFSNKHFCCP (PubMed:14702039).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075201 mRNA Translation: BAC11466.1 Different termination.
AK074521 mRNA Translation: BAC11038.1
CH471059 Genomic DNA Translation: EAX06713.1
CH471059 Genomic DNA Translation: EAX06714.1
CH471059 Genomic DNA Translation: EAX06715.1
BC013101 mRNA Translation: AAH13101.1
CCDSiCCDS585.1
RefSeqiNP_001243338.1, NM_001256409.1
NP_443172.1, NM_052940.4
XP_006710390.1, XM_006710327.3
XP_006710391.1, XM_006710328.3
UniGeneiHs.40094

Genome annotation databases

EnsembliENST00000319223; ENSP00000318185; ENSG00000116212
ENST00000371370; ENSP00000360421; ENSG00000116212
GeneIDi115353
KEGGihsa:115353
UCSCiuc001cwj.3 human

Similar proteinsi

Entry informationi

Entry nameiLRC42_HUMAN
AccessioniPrimary (citable) accession number: Q9Y546
Secondary accession number(s): D3DQ46, Q8N2Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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