Reviewed,
UniProtKB/Swiss-Prot Q9Y536 (PAL4B_HUMAN)
Last modified
November 4, 2008.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peptidylprolyl cis-trans isomerase A-like 4B Short name=PPIase A-like 4B EC=5.2.1.8 Alternative name(s): Chromosome 1-amplified sequence 2 Short name=COAS-2 Cyclophilin homolog overexpressed in liver cancer | ||||||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 164 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. |
| Catalytic activity | Peptidylproline (omega=180) = peptidylproline (omega=0). |
| Subcellular location | CytoplasmBy similarity. |
| Tissue specificity | Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas. |
| Miscellaneous | It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1. |
| Sequence similarities | Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. Contains 1 PPIase cyclophilin-type domain. |
| Caution | Expression studies do not distinguish between PPIAL4B and PPIAL4 (Ref.3). |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Isomerase Rotamase |
Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
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| AB084917 mRNA. Translation: BAB92073.1. AL022240 Genomic DNA. Translation: CAB46877.1. AL451058 Genomic DNA. Translation: CAH71953.1. BX248398 Genomic DNA. Translation: CAI18814.1. | |
| RefSeq | NP_839944.1. XP_932860.1. XP_933431.1. |
| UniGene | Hs.573713 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E3B based on UniProtKB P52011. |
| SMR | Q9Y536. Positions 1-164. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000198161. Homo sapiens. [Contig view] |
| GeneID | 164022. 653505. 653598. |
| KEGG | hsa:164022. hsa:653505. hsa:653598. |
Organism-specific databases | |
| MIM | 608608. gene. |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q9Y536. |
| HOVERGEN | Q9Y536. |
Family and domain databases | |
| InterPro | IPR002130. PPIase_cyclophilin. [Graphical view] |
| Gene3D | G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit. |
| PANTHER | PTHR11071. PPIase_cyclophilin. 1 hit. |
| Pfam | PF00160. Pro_isomerase. 1 hit. [Graphical view] |
| PRINTS | PR00153. CSAPPISMRASE. |
| PROSITE | PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q9Y536. |
| NextBio | 88425. |
| SOURCE | Search... |
Entry information
| Entry name | PAL4B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y536 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


