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Q9Y536

- PAL4A_HUMAN

UniProt

Q9Y536 - PAL4A_HUMAN

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Protein
Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C
Gene
PPIAL4A, COAS2
PPIAL4B
PPIAL4C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C (EC:5.2.1.8)
Short name:
PPIase A-like 4A
Alternative name(s):
Chromosome 1-amplified sequence 2
Short name:
COAS-2
Cyclophilin homolog overexpressed in liver cancer
Gene namesi
Name:PPIAL4A
Synonyms:COAS2
AND
Name:PPIAL4B
AND
Name:PPIAL4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1
HGNCiHGNC:24369. PPIAL4A.
HGNC:33994. PPIAL4B.
HGNC:33995. PPIAL4C.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C
PRO_0000324640Add
BLAST

Proteomic databases

MaxQBiQ9Y536.
PaxDbiQ9Y536.
PRIDEiQ9Y536.

PTM databases

PhosphoSiteiQ9Y536.

Expressioni

Tissue specificityi

Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.1 Publication

Gene expression databases

BgeeiQ9Y536.
GenevestigatoriQ9Y536.

Interactioni

Protein-protein interaction databases

BioGridi127884. 1 interaction.
STRINGi9606.ENSP00000358224.

Structurei

3D structure databases

ProteinModelPortaliQ9Y536.
SMRiQ9Y536. Positions 2-164.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 163157PPIase cyclophilin-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ9Y536.
KOiK12738.
OMAiFPSAMVN.
OrthoDBiEOG79GT7W.
PhylomeDBiQ9Y536.
TreeFamiTF316719.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y536-1 [UniParc]FASTAAdd to Basket

« Hide

MVNSVVFFDI TVDGKPLGRI SIKLFADKIL KTAENFRALS TGEKGFRYKG    50
SCFHRIIPGF MCQGGDFTRH NGTGDKSIYG EKFDDENLIR KHTGSGILSM 100
ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS 150
KTSKKITIAD CGQF 164
Length:164
Mass (Da):18,182
Last modified:November 1, 1999 - v1
Checksum:i99D50A72B0896C4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB084917 mRNA. Translation: BAB92073.1.
AL022240 Genomic DNA. Translation: CAB46877.1.
AL451058 Genomic DNA. Translation: CAH71953.1.
BX248398 Genomic DNA. Translation: CAI18814.1.
CCDSiCCDS44205.1.
CCDS44212.1.
RefSeqiNP_001137355.1. NM_001143883.2.
UniGeneiHs.573713.
Hs.631792.

Genome annotation databases

EnsembliENST00000369222; ENSP00000358224; ENSG00000198161.
ENST00000539781; ENSP00000439146; ENSG00000255963.
ENST00000540273; ENSP00000443989; ENSG00000255854.
GeneIDi653505.
KEGGihsa:164022.
hsa:653505.
hsa:653598.
UCSCiuc001ekw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB084917 mRNA. Translation: BAB92073.1 .
AL022240 Genomic DNA. Translation: CAB46877.1 .
AL451058 Genomic DNA. Translation: CAH71953.1 .
BX248398 Genomic DNA. Translation: CAI18814.1 .
CCDSi CCDS44205.1.
CCDS44212.1.
RefSeqi NP_001137355.1. NM_001143883.2.
UniGenei Hs.573713.
Hs.631792.

3D structure databases

ProteinModelPortali Q9Y536.
SMRi Q9Y536. Positions 2-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127884. 1 interaction.
STRINGi 9606.ENSP00000358224.

PTM databases

PhosphoSitei Q9Y536.

Proteomic databases

MaxQBi Q9Y536.
PaxDbi Q9Y536.
PRIDEi Q9Y536.

Protocols and materials databases

DNASUi 164022.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369222 ; ENSP00000358224 ; ENSG00000198161 .
ENST00000539781 ; ENSP00000439146 ; ENSG00000255963 .
ENST00000540273 ; ENSP00000443989 ; ENSG00000255854 .
GeneIDi 653505.
KEGGi hsa:164022.
hsa:653505.
hsa:653598.
UCSCi uc001ekw.3. human.

Organism-specific databases

CTDi 653505.
653598.
GeneCardsi GC01M144360.
GC01M147954.
GC01P149552.
H-InvDB HIX0028837.
HIX0159741.
HGNCi HGNC:24369. PPIAL4A.
HGNC:33994. PPIAL4B.
HGNC:33995. PPIAL4C.
MIMi 608608. gene.
neXtProti NX_Q9Y536.
PharmGKBi PA164724917.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0652.
HOGENOMi HOG000065981.
HOVERGENi HBG001065.
InParanoidi Q9Y536.
KOi K12738.
OMAi FPSAMVN.
OrthoDBi EOG79GT7W.
PhylomeDBi Q9Y536.
TreeFami TF316719.

Miscellaneous databases

NextBioi 88425.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y536.
Genevestigatori Q9Y536.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cyclophilin homologue overexpressed in liver cancer."
    Tanaka S.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPAL4A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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