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Q9Y536

- PAL4A_HUMAN

UniProt

Q9Y536 - PAL4A_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C

Gene

PPIAL4A

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Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C (EC:5.2.1.8)
    Short name:
    PPIase A-like 4A
    Alternative name(s):
    Chromosome 1-amplified sequence 2
    Short name:
    COAS-2
    Cyclophilin homolog overexpressed in liver cancer
    Gene namesi
    Name:PPIAL4A
    Synonyms:COAS2
    AND
    Name:PPIAL4B
    AND
    Name:PPIAL4C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24369. PPIAL4A.
    HGNC:33994. PPIAL4B.
    HGNC:33995. PPIAL4C.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724917.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Peptidyl-prolyl cis-trans isomerase A-like 4A/B/CPRO_0000324640Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y536.
    PaxDbiQ9Y536.
    PRIDEiQ9Y536.

    PTM databases

    PhosphoSiteiQ9Y536.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.1 Publication

    Gene expression databases

    BgeeiQ9Y536.
    GenevestigatoriQ9Y536.

    Interactioni

    Protein-protein interaction databases

    BioGridi127884. 1 interaction.
    STRINGi9606.ENSP00000358224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y536.
    SMRiQ9Y536. Positions 2-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 163157PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000065981.
    HOVERGENiHBG001065.
    InParanoidiQ9Y536.
    KOiK12738.
    OMAiFPSAMVN.
    OrthoDBiEOG79GT7W.
    PhylomeDBiQ9Y536.
    TreeFamiTF316719.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y536-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNSVVFFDI TVDGKPLGRI SIKLFADKIL KTAENFRALS TGEKGFRYKG    50
    SCFHRIIPGF MCQGGDFTRH NGTGDKSIYG EKFDDENLIR KHTGSGILSM 100
    ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS 150
    KTSKKITIAD CGQF 164
    Length:164
    Mass (Da):18,182
    Last modified:November 1, 1999 - v1
    Checksum:i99D50A72B0896C4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084917 mRNA. Translation: BAB92073.1.
    AL022240 Genomic DNA. Translation: CAB46877.1.
    AL451058 Genomic DNA. Translation: CAH71953.1.
    BX248398 Genomic DNA. Translation: CAI18814.1.
    CCDSiCCDS44205.1.
    CCDS44212.1.
    RefSeqiNP_001137355.1. NM_001143883.2.
    UniGeneiHs.573713.
    Hs.631792.

    Genome annotation databases

    EnsembliENST00000369222; ENSP00000358224; ENSG00000275974.
    GeneIDi653505.
    KEGGihsa:164022.
    hsa:653505.
    hsa:653598.
    UCSCiuc001ekw.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084917 mRNA. Translation: BAB92073.1 .
    AL022240 Genomic DNA. Translation: CAB46877.1 .
    AL451058 Genomic DNA. Translation: CAH71953.1 .
    BX248398 Genomic DNA. Translation: CAI18814.1 .
    CCDSi CCDS44205.1.
    CCDS44212.1.
    RefSeqi NP_001137355.1. NM_001143883.2.
    UniGenei Hs.573713.
    Hs.631792.

    3D structure databases

    ProteinModelPortali Q9Y536.
    SMRi Q9Y536. Positions 2-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127884. 1 interaction.
    STRINGi 9606.ENSP00000358224.

    PTM databases

    PhosphoSitei Q9Y536.

    Proteomic databases

    MaxQBi Q9Y536.
    PaxDbi Q9Y536.
    PRIDEi Q9Y536.

    Protocols and materials databases

    DNASUi 164022.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369222 ; ENSP00000358224 ; ENSG00000275974 .
    GeneIDi 653505.
    KEGGi hsa:164022.
    hsa:653505.
    hsa:653598.
    UCSCi uc001ekw.3. human.

    Organism-specific databases

    CTDi 653505.
    GeneCardsi GC01M144360.
    GC01M147954.
    GC01P149552.
    H-InvDB HIX0028837.
    HIX0159741.
    HGNCi HGNC:24369. PPIAL4A.
    HGNC:33994. PPIAL4B.
    HGNC:33995. PPIAL4C.
    MIMi 608608. gene.
    neXtProti NX_Q9Y536.
    PharmGKBi PA164724917.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000065981.
    HOVERGENi HBG001065.
    InParanoidi Q9Y536.
    KOi K12738.
    OMAi FPSAMVN.
    OrthoDBi EOG79GT7W.
    PhylomeDBi Q9Y536.
    TreeFami TF316719.

    Miscellaneous databases

    NextBioi 88425.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y536.
    Genevestigatori Q9Y536.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR024936. Cyclophilin-type_PPIase.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001467. Peptidylpro_ismrse. 1 hit.
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cyclophilin homologue overexpressed in liver cancer."
      Tanaka S.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPAL4A_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y536
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3