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Protein

Peptidyl-prolyl cis-trans isomerase A-like 4A

Gene

PPIAL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciZFISH:HS04107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A-like 4ACurated (EC:5.2.1.8)
Short name:
PPIase A-like 4A
Alternative name(s):
Chromosome one-amplified sequence 21 Publication
Short name:
COAS-21 Publication
Cyclophilin homolog overexpressed in liver cancer1 Publication
Gene namesi
Name:PPIAL4AImported
Synonyms:COAS2Imported, PPIAL4BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24369. PPIAL4A.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000263353.
PharmGKBiPA164724917.

Polymorphism and mutation databases

BioMutaiPPIAL4A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246401 – 164Peptidyl-prolyl cis-trans isomerase A-like 4AAdd BLAST164

Proteomic databases

EPDiQ9Y536.
MaxQBiQ9Y536.
PaxDbiQ9Y536.
PeptideAtlasiQ9Y536.
PRIDEiQ9Y536.

PTM databases

iPTMnetiQ9Y536.
PhosphoSitePlusiQ9Y536.
SwissPalmiQ9Y536.

Expressioni

Tissue specificityi

Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000198161.

Organism-specific databases

HPAiHPA058345.

Interactioni

Protein-protein interaction databases

BioGridi575836. 1 interactor.
IntActiQ9Y536. 1 interactor.
STRINGi9606.ENSP00000443989.

Structurei

3D structure databases

ProteinModelPortaliQ9Y536.
SMRiQ9Y536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 163PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ9Y536.
KOiK12738.
OMAiFPSAMVN.
OrthoDBiEOG091G0BGL.
PhylomeDBiQ9Y536.
TreeFamiTF316719.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSVVFFDI TVDGKPLGRI SIKLFADKIL KTAENFRALS TGEKGFRYKG
60 70 80 90 100
SCFHRIIPGF MCQGGDFTRH NGTGDKSIYG EKFDDENLIR KHTGSGILSM
110 120 130 140 150
ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS
160
KTSKKITIAD CGQF
Length:164
Mass (Da):18,182
Last modified:November 1, 1999 - v1
Checksum:i99D50A72B0896C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084917 mRNA. Translation: BAB92073.1.
AC253572 Genomic DNA. No translation available.
AL022240 Genomic DNA. Translation: CAB46877.1.
AL451058 Genomic DNA. Translation: CAH71953.1.
BX248398 Genomic DNA. Translation: CAI18814.1.
CCDSiCCDS76197.1.
RefSeqiNP_001137355.1. NM_001143883.2.
UniGeneiHs.534674.
Hs.573713.
Hs.631792.

Genome annotation databases

EnsembliENST00000577856; ENSP00000485206; ENSG00000263353.
GeneIDi653505.
KEGGihsa:653505.
UCSCiuc031upa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084917 mRNA. Translation: BAB92073.1.
AC253572 Genomic DNA. No translation available.
AL022240 Genomic DNA. Translation: CAB46877.1.
AL451058 Genomic DNA. Translation: CAH71953.1.
BX248398 Genomic DNA. Translation: CAI18814.1.
CCDSiCCDS76197.1.
RefSeqiNP_001137355.1. NM_001143883.2.
UniGeneiHs.534674.
Hs.573713.
Hs.631792.

3D structure databases

ProteinModelPortaliQ9Y536.
SMRiQ9Y536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575836. 1 interactor.
IntActiQ9Y536. 1 interactor.
STRINGi9606.ENSP00000443989.

PTM databases

iPTMnetiQ9Y536.
PhosphoSitePlusiQ9Y536.
SwissPalmiQ9Y536.

Polymorphism and mutation databases

BioMutaiPPIAL4A.

Proteomic databases

EPDiQ9Y536.
MaxQBiQ9Y536.
PaxDbiQ9Y536.
PeptideAtlasiQ9Y536.
PRIDEiQ9Y536.

Protocols and materials databases

DNASUi164022.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000577856; ENSP00000485206; ENSG00000263353.
GeneIDi653505.
KEGGihsa:653505.
UCSCiuc031upa.2. human.

Organism-specific databases

CTDi653505.
GeneCardsiPPIAL4A.
PPIAL4C.
H-InvDBHIX0028837.
HIX0159741.
HGNCiHGNC:24369. PPIAL4A.
HPAiHPA058345.
MIMi608608. gene.
neXtProtiNX_Q9Y536.
OpenTargetsiENSG00000263353.
PharmGKBiPA164724917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ9Y536.
KOiK12738.
OMAiFPSAMVN.
OrthoDBiEOG091G0BGL.
PhylomeDBiQ9Y536.
TreeFamiTF316719.

Enzyme and pathway databases

BioCyciZFISH:HS04107-MONOMER.

Miscellaneous databases

GenomeRNAii653505.
PROiQ9Y536.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198161.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAL4A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.