Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C

Gene

PPIAL4A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C (EC:5.2.1.8)
Short name:
PPIase A-like 4A
Alternative name(s):
Chromosome 1-amplified sequence 2
Short name:
COAS-2
Cyclophilin homolog overexpressed in liver cancer
Gene namesi
Name:PPIAL4A
Synonyms:COAS2
AND
Name:PPIAL4B
AND
Name:PPIAL4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24369. PPIAL4A.
HGNC:33994. PPIAL4B.
HGNC:33995. PPIAL4C.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724917.

Polymorphism and mutation databases

BioMutaiPPIAL4A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Peptidyl-prolyl cis-trans isomerase A-like 4A/B/CPRO_0000324640Add
BLAST

Proteomic databases

MaxQBiQ9Y536.
PaxDbiQ9Y536.
PRIDEiQ9Y536.

PTM databases

PhosphoSiteiQ9Y536.

Expressioni

Tissue specificityi

Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.1 Publication

Gene expression databases

BgeeiQ9Y536.
GenevestigatoriQ9Y536.

Organism-specific databases

HPAiHPA058345.

Interactioni

Protein-protein interaction databases

BioGridi127884. 1 interaction.
STRINGi9606.ENSP00000358224.

Structurei

3D structure databases

ProteinModelPortaliQ9Y536.
SMRiQ9Y536. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 163157PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0652.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ9Y536.
KOiK12738.
OMAiFPSAMVN.
OrthoDBiEOG79GT7W.
PhylomeDBiQ9Y536.
TreeFamiTF316719.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSVVFFDI TVDGKPLGRI SIKLFADKIL KTAENFRALS TGEKGFRYKG
60 70 80 90 100
SCFHRIIPGF MCQGGDFTRH NGTGDKSIYG EKFDDENLIR KHTGSGILSM
110 120 130 140 150
ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE AMEHFGYRNS
160
KTSKKITIAD CGQF
Length:164
Mass (Da):18,182
Last modified:November 1, 1999 - v1
Checksum:i99D50A72B0896C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084917 mRNA. Translation: BAB92073.1.
AL022240 Genomic DNA. Translation: CAB46877.1.
AL451058 Genomic DNA. Translation: CAH71953.1.
BX248398 Genomic DNA. Translation: CAI18814.1.
CCDSiCCDS72898.1.
RefSeqiNP_001137355.1. NM_001143883.2.
UniGeneiHs.534674.
Hs.573713.
Hs.631792.

Genome annotation databases

EnsembliENST00000369222; ENSP00000358224; ENSG00000275974.
GeneIDi653505.
KEGGihsa:653505.
UCSCiuc001ekw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084917 mRNA. Translation: BAB92073.1.
AL022240 Genomic DNA. Translation: CAB46877.1.
AL451058 Genomic DNA. Translation: CAH71953.1.
BX248398 Genomic DNA. Translation: CAI18814.1.
CCDSiCCDS72898.1.
RefSeqiNP_001137355.1. NM_001143883.2.
UniGeneiHs.534674.
Hs.573713.
Hs.631792.

3D structure databases

ProteinModelPortaliQ9Y536.
SMRiQ9Y536. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127884. 1 interaction.
STRINGi9606.ENSP00000358224.

PTM databases

PhosphoSiteiQ9Y536.

Polymorphism and mutation databases

BioMutaiPPIAL4A.

Proteomic databases

MaxQBiQ9Y536.
PaxDbiQ9Y536.
PRIDEiQ9Y536.

Protocols and materials databases

DNASUi164022.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369222; ENSP00000358224; ENSG00000275974.
GeneIDi653505.
KEGGihsa:653505.
UCSCiuc001ekw.3. human.

Organism-specific databases

CTDi653505.
GeneCardsiGC01M144360.
GC01M147954.
GC01P149552.
H-InvDBHIX0028837.
HIX0159741.
HGNCiHGNC:24369. PPIAL4A.
HGNC:33994. PPIAL4B.
HGNC:33995. PPIAL4C.
HPAiHPA058345.
MIMi608608. gene.
neXtProtiNX_Q9Y536.
PharmGKBiPA164724917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0652.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiQ9Y536.
KOiK12738.
OMAiFPSAMVN.
OrthoDBiEOG79GT7W.
PhylomeDBiQ9Y536.
TreeFamiTF316719.

Miscellaneous databases

NextBioi88425.
PROiQ9Y536.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y536.
GenevestigatoriQ9Y536.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cyclophilin homologue overexpressed in liver cancer."
    Tanaka S.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPAL4A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1999
Last modified: May 27, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.