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Protein

O-acetyl-ADP-ribose deacetylase 1

Gene

OARD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.

Enzyme regulationi

Subject to competitive inhibition by the product ADP-ribose.1 Publication

Kineticsi

  1. KM=182 µM for O-acetyl-ADP-ribose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei21Substrate; via amide nitrogen1
    Active sitei125Proton acceptor1 Publication1
    Binding sitei152Substrate; via carboxylate1

    GO - Molecular functioni

    • deacetylase activity Source: UniProtKB
    • purine nucleoside binding Source: UniProtKB

    GO - Biological processi

    • purine nucleoside metabolic process Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000124596-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    O-acetyl-ADP-ribose deacetylase 1 (EC:3.5.1.-)
    Gene namesi
    Name:OARD1
    Synonyms:C6orf130
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21257. OARD1.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi32H → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi33C → S: No effect. 1 Publication1
    Mutagenesisi35S → A: Reduced catalytic activity. No effect on affinity towards substrate. 1 Publication1
    Mutagenesisi83T → A: Reduced catalytic activity. No effect on affinity towards substrate. 1
    Mutagenesisi123G → E: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi125D → A: Abolishes enzyme activity. 1 Publication1

    Organism-specific databases

    DisGeNETi221443.
    OpenTargetsiENSG00000124596.
    PharmGKBiPA134879529.

    Polymorphism and mutation databases

    BioMutaiOARD1.
    DMDMi38258957.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedCombined sources
    ChainiPRO_00000895292 – 152O-acetyl-ADP-ribose deacetylase 1Add BLAST151

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei2N-acetylalanineCombined sources1
    Modified residuei4PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiQ9Y530.
    MaxQBiQ9Y530.
    PaxDbiQ9Y530.
    PeptideAtlasiQ9Y530.
    PRIDEiQ9Y530.

    PTM databases

    iPTMnetiQ9Y530.
    PhosphoSitePlusiQ9Y530.

    Expressioni

    Gene expression databases

    BgeeiENSG00000124596.
    CleanExiHS_C6orf130.
    ExpressionAtlasiQ9Y530. baseline and differential.
    GenevisibleiQ9Y530. HS.

    Organism-specific databases

    HPAiHPA029036.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PARP1P098745EBI-8502288,EBI-355676
    PARP10Q53GL73EBI-8502288,EBI-2857573

    Protein-protein interaction databases

    BioGridi128727. 10 interactors.
    IntActiQ9Y530. 3 interactors.
    STRINGi9606.ENSP00000416829.

    Structurei

    Secondary structure

    1152
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi14 – 19Combined sources6
    Helixi21 – 23Combined sources3
    Beta strandi28 – 35Combined sources8
    Beta strandi41 – 43Combined sources3
    Helixi45 – 52Combined sources8
    Helixi55 – 61Combined sources7
    Beta strandi67 – 73Combined sources7
    Beta strandi76 – 86Combined sources11
    Helixi93 – 110Combined sources18
    Beta strandi114 – 117Combined sources4
    Helixi123 – 125Combined sources3
    Helixi129 – 140Combined sources12
    Beta strandi146 – 151Combined sources6

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2EEENMR-A11-152[»]
    2L8RNMR-A3-152[»]
    2LGRNMR-A2-152[»]
    4J5QX-ray1.35A7-152[»]
    4J5RX-ray1.25A/B11-152[»]
    4J5SX-ray1.55A/B/C/D11-152[»]
    ProteinModelPortaliQ9Y530.
    SMRiQ9Y530.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y530.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini2 – 152MacroPROSITE-ProRule annotationAdd BLAST151

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni119 – 125Substrate binding7

    Sequence similaritiesi

    Contains 1 Macro domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiENOG410IFQM. Eukaryota.
    ENOG4111MFZ. LUCA.
    GeneTreeiENSGT00390000006988.
    HOGENOMiHOG000012894.
    HOVERGENiHBG050914.
    InParanoidiQ9Y530.
    OMAiLFACPQT.
    OrthoDBiEOG091G0MUU.
    PhylomeDBiQ9Y530.
    TreeFamiTF324128.

    Family and domain databases

    InterProiIPR002589. Macro_dom.
    [Graphical view]
    PfamiPF01661. Macro. 1 hit.
    [Graphical view]
    SMARTiSM00506. A1pp. 1 hit.
    [Graphical view]
    PROSITEiPS51154. MACRO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y530-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MASSLNEDPE GSRITYVKGD LFACPKTDSL AHCISEDCRM GAGIAVLFKK
    60 70 80 90 100
    KFGGVQELLN QQKKSGEVAV LKRDGRYIYY LITKKRASHK PTYENLQKSL
    110 120 130 140 150
    EAMKSHCLKN GVTDLSMPRI GCGLDRLQWE NVSAMIEEVF EATDIKITVY

    TL
    Length:152
    Mass (Da):17,025
    Last modified:November 7, 2003 - v2
    Checksum:i8CC43CBDABA73E0B
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK290939 mRNA. Translation: BAF83628.1.
    AK313361 mRNA. Translation: BAG36161.1.
    AL031778 Genomic DNA. Translation: CAI20285.1.
    CH471081 Genomic DNA. Translation: EAX04011.1.
    BC011709 mRNA. Translation: AAH11709.1.
    CCDSiCCDS34445.1.
    RefSeqiNP_001316613.1. NM_001329684.1.
    NP_001316614.1. NM_001329685.1.
    NP_001316615.1. NM_001329686.1.
    NP_001316617.1. NM_001329688.1.
    NP_659500.1. NM_145063.3.
    UniGeneiHs.227457.

    Genome annotation databases

    EnsembliENST00000424266; ENSP00000416829; ENSG00000124596.
    ENST00000463088; ENSP00000420193; ENSG00000124596.
    ENST00000468811; ENSP00000420601; ENSG00000124596.
    ENST00000479950; ENSP00000420484; ENSG00000124596.
    GeneIDi221443.
    KEGGihsa:221443.
    UCSCiuc003opm.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK290939 mRNA. Translation: BAF83628.1.
    AK313361 mRNA. Translation: BAG36161.1.
    AL031778 Genomic DNA. Translation: CAI20285.1.
    CH471081 Genomic DNA. Translation: EAX04011.1.
    BC011709 mRNA. Translation: AAH11709.1.
    CCDSiCCDS34445.1.
    RefSeqiNP_001316613.1. NM_001329684.1.
    NP_001316614.1. NM_001329685.1.
    NP_001316615.1. NM_001329686.1.
    NP_001316617.1. NM_001329688.1.
    NP_659500.1. NM_145063.3.
    UniGeneiHs.227457.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2EEENMR-A11-152[»]
    2L8RNMR-A3-152[»]
    2LGRNMR-A2-152[»]
    4J5QX-ray1.35A7-152[»]
    4J5RX-ray1.25A/B11-152[»]
    4J5SX-ray1.55A/B/C/D11-152[»]
    ProteinModelPortaliQ9Y530.
    SMRiQ9Y530.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi128727. 10 interactors.
    IntActiQ9Y530. 3 interactors.
    STRINGi9606.ENSP00000416829.

    PTM databases

    iPTMnetiQ9Y530.
    PhosphoSitePlusiQ9Y530.

    Polymorphism and mutation databases

    BioMutaiOARD1.
    DMDMi38258957.

    Proteomic databases

    EPDiQ9Y530.
    MaxQBiQ9Y530.
    PaxDbiQ9Y530.
    PeptideAtlasiQ9Y530.
    PRIDEiQ9Y530.

    Protocols and materials databases

    DNASUi221443.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000424266; ENSP00000416829; ENSG00000124596.
    ENST00000463088; ENSP00000420193; ENSG00000124596.
    ENST00000468811; ENSP00000420601; ENSG00000124596.
    ENST00000479950; ENSP00000420484; ENSG00000124596.
    GeneIDi221443.
    KEGGihsa:221443.
    UCSCiuc003opm.4. human.

    Organism-specific databases

    CTDi221443.
    DisGeNETi221443.
    GeneCardsiOARD1.
    H-InvDBHIX0005859.
    HGNCiHGNC:21257. OARD1.
    HPAiHPA029036.
    MIMi614393. gene.
    neXtProtiNX_Q9Y530.
    OpenTargetsiENSG00000124596.
    PharmGKBiPA134879529.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiENOG410IFQM. Eukaryota.
    ENOG4111MFZ. LUCA.
    GeneTreeiENSGT00390000006988.
    HOGENOMiHOG000012894.
    HOVERGENiHBG050914.
    InParanoidiQ9Y530.
    OMAiLFACPQT.
    OrthoDBiEOG091G0MUU.
    PhylomeDBiQ9Y530.
    TreeFamiTF324128.

    Enzyme and pathway databases

    BioCyciZFISH:ENSG00000124596-MONOMER.

    Miscellaneous databases

    EvolutionaryTraceiQ9Y530.
    GenomeRNAii221443.
    PROiQ9Y530.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000124596.
    CleanExiHS_C6orf130.
    ExpressionAtlasiQ9Y530. baseline and differential.
    GenevisibleiQ9Y530. HS.

    Family and domain databases

    InterProiIPR002589. Macro_dom.
    [Graphical view]
    PfamiPF01661. Macro. 1 hit.
    [Graphical view]
    SMARTiSM00506. A1pp. 1 hit.
    [Graphical view]
    PROSITEiPS51154. MACRO. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiOARD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y530
    Secondary accession number(s): A6NEK4, A8K4H4, Q96F23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 7, 2003
    Last modified: November 30, 2016
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.