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Protein

Transmembrane protein 184B

Gene

TMEM184B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May activate the MAP kinase signaling pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33715-MONOMER.

Protein family/group databases

TCDBi2.A.82.1.3. the organic solute transporter (ost) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 184B
Alternative name(s):
Putative MAPK-activating protein FM08
Gene namesi
Name:TMEM184B
Synonyms:C22orf5
ORF Names:PSEC0108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1310. TMEM184B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25829.
OpenTargetsiENSG00000198792.
PharmGKBiPA162406140.

Polymorphism and mutation databases

BioMutaiTMEM184B.
DMDMi39932737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115551 – 407Transmembrane protein 184BAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei388PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y519.
PaxDbiQ9Y519.
PeptideAtlasiQ9Y519.
PRIDEiQ9Y519.

PTM databases

iPTMnetiQ9Y519.
PhosphoSitePlusiQ9Y519.
SwissPalmiQ9Y519.

Expressioni

Gene expression databases

BgeeiENSG00000198792.
CleanExiHS_TMEM184B.
ExpressionAtlasiQ9Y519. baseline and differential.
GenevisibleiQ9Y519. HS.

Organism-specific databases

HPAiHPA024076.

Interactioni

Protein-protein interaction databases

BioGridi117357. 18 interactors.
IntActiQ9Y519. 1 interactor.
STRINGi9606.ENSP00000354441.

Structurei

3D structure databases

ProteinModelPortaliQ9Y519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM184 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOVERGENiHBG051270.
InParanoidiQ9Y519.
OMAiKDIMQDA.
OrthoDBiEOG091G07BZ.
PhylomeDBiQ9Y519.
TreeFamiTF314160.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRGDVLAP DPASPTTAAA SPSVSVIPEG SPTAMEQPVF LMTTAAQAIS
60 70 80 90 100
GFFVWTALLI TCHQIYMHLR CYSCPNEQRY IVRILFIVPI YAFDSWLSLL
110 120 130 140 150
FFTNDQYYVY FGTVRDCYEA LVIYNFLSLC YEYLGGESSI MSEIRGKPIE
160 170 180 190 200
SSCMYGTCCL WGKTYSIGFL RFCKQATLQF CVVKPLMAVS TVVLQAFGKY
210 220 230 240 250
RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL SPYSPVLKFF
260 270 280 290 300
MVKSVIFLSF WQGMLLAILE KCGAIPKIHS ARVSVGEGTV AAGYQDFIIC
310 320 330 340 350
VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV
360 370 380 390 400
QDAIHNFSPA YQQYTQQSTL EPGPTWRGGA HGLSRSHSLS GARDNEKTLL

LSSDDEF
Length:407
Mass (Da):45,562
Last modified:December 15, 2003 - v2
Checksum:i29FEAB1219A42934
GO

Sequence cautioni

The sequence BAC11607 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB51403 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218Y → C in BAC11607 (PubMed:16303743).Curated1
Sequence conflicti256I → F in BAC77406 (PubMed:12761501).Curated1
Sequence conflicti366Q → L in BAC11607 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097053 mRNA. Translation: BAC77406.1.
CR456413 mRNA. Translation: CAG30299.1.
BX648345 mRNA. Translation: CAH56159.1.
AL020993, AL021977 Genomic DNA. Translation: CAI21955.1.
AL021977, AL020993 Genomic DNA. Translation: CAI17981.1.
CH471095 Genomic DNA. Translation: EAW60222.1.
BC015489 mRNA. Translation: AAH15489.2.
AL096879 mRNA. Translation: CAB51403.1. Different initiation.
AK075417 mRNA. Translation: BAC11607.1. Different initiation.
AK292652 mRNA. Translation: BAF85341.1.
CCDSiCCDS13969.2.
RefSeqiNP_001182000.1. NM_001195071.1.
NP_001182001.1. NM_001195072.1.
NP_036396.2. NM_012264.4.
UniGeneiHs.182626.

Genome annotation databases

EnsembliENST00000361684; ENSP00000354441; ENSG00000198792.
ENST00000361906; ENSP00000355210; ENSG00000198792.
GeneIDi25829.
KEGGihsa:25829.
UCSCiuc003avf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097053 mRNA. Translation: BAC77406.1.
CR456413 mRNA. Translation: CAG30299.1.
BX648345 mRNA. Translation: CAH56159.1.
AL020993, AL021977 Genomic DNA. Translation: CAI21955.1.
AL021977, AL020993 Genomic DNA. Translation: CAI17981.1.
CH471095 Genomic DNA. Translation: EAW60222.1.
BC015489 mRNA. Translation: AAH15489.2.
AL096879 mRNA. Translation: CAB51403.1. Different initiation.
AK075417 mRNA. Translation: BAC11607.1. Different initiation.
AK292652 mRNA. Translation: BAF85341.1.
CCDSiCCDS13969.2.
RefSeqiNP_001182000.1. NM_001195071.1.
NP_001182001.1. NM_001195072.1.
NP_036396.2. NM_012264.4.
UniGeneiHs.182626.

3D structure databases

ProteinModelPortaliQ9Y519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117357. 18 interactors.
IntActiQ9Y519. 1 interactor.
STRINGi9606.ENSP00000354441.

Protein family/group databases

TCDBi2.A.82.1.3. the organic solute transporter (ost) family.

PTM databases

iPTMnetiQ9Y519.
PhosphoSitePlusiQ9Y519.
SwissPalmiQ9Y519.

Polymorphism and mutation databases

BioMutaiTMEM184B.
DMDMi39932737.

Proteomic databases

MaxQBiQ9Y519.
PaxDbiQ9Y519.
PeptideAtlasiQ9Y519.
PRIDEiQ9Y519.

Protocols and materials databases

DNASUi25829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361684; ENSP00000354441; ENSG00000198792.
ENST00000361906; ENSP00000355210; ENSG00000198792.
GeneIDi25829.
KEGGihsa:25829.
UCSCiuc003avf.2. human.

Organism-specific databases

CTDi25829.
DisGeNETi25829.
GeneCardsiTMEM184B.
HGNCiHGNC:1310. TMEM184B.
HPAiHPA024076.
neXtProtiNX_Q9Y519.
OpenTargetsiENSG00000198792.
PharmGKBiPA162406140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOVERGENiHBG051270.
InParanoidiQ9Y519.
OMAiKDIMQDA.
OrthoDBiEOG091G07BZ.
PhylomeDBiQ9Y519.
TreeFamiTF314160.

Enzyme and pathway databases

BioCyciZFISH:G66-33715-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM184B. human.
GeneWikiiTMEM184B.
GenomeRNAii25829.
PROiQ9Y519.

Gene expression databases

BgeeiENSG00000198792.
CleanExiHS_TMEM184B.
ExpressionAtlasiQ9Y519. baseline and differential.
GenevisibleiQ9Y519. HS.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT184B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y519
Secondary accession number(s): A8K9D7
, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 15, 2003
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.