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Q9Y4Z0 (LSM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U6 snRNA-associated Sm-like protein LSm4
Alternative name(s):
Glycine-rich protein
Short name=GRP
Gene names
Name:LSM4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

Subunit structure

LSm subunits form a heteromer with a doughnut shape.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the snRNP Sm proteins family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139U6 snRNA-associated Sm-like protein LSm4
PRO_0000125564

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9Y4Z0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: BCEFB20247335A1B

FASTA13915,350
        10         20         30         40         50         60 
MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY 

        70         80         90        100        110        120 
IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI 

       130 
PGTGRGQPEK KPGRQAGKQ 

« Hide

References

« Hide 'large scale' references
[1]"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin."
Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B.
EMBO J. 18:3451-3462(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[4]Chan E.K.L.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]Bienvenut W.V., Matallanas D., Cooper W.N., Kolch W.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-20, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Mammary carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ238096 mRNA. Translation: CAB45867.1.
AF182290 mRNA. Translation: AAD56228.1.
AF117235 mRNA. Translation: AAF17216.1.
AF251218 mRNA. Translation: AAF90055.1.
BC000387 mRNA. Translation: AAH00387.1.
BC003652 mRNA. Translation: AAH03652.1.
BC022198 mRNA. Translation: AAH22198.1.
BC023665 mRNA. Translation: AAH23665.1.
CCDSCCDS12374.1.
RefSeqNP_036453.1. NM_012321.4.
UniGeneHs.515255.

3D structure databases

ProteinModelPortalQ9Y4Z0.
SMRQ9Y4Z0. Positions 14-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117336. 46 interactions.
DIPDIP-31209N.
IntActQ9Y4Z0. 16 interactions.
MINTMINT-1469332.
STRING9606.ENSP00000252816.

PTM databases

PhosphoSiteQ9Y4Z0.

Polymorphism databases

DMDM10720082.

Proteomic databases

MaxQBQ9Y4Z0.
PaxDbQ9Y4Z0.
PeptideAtlasQ9Y4Z0.
PRIDEQ9Y4Z0.

Protocols and materials databases

DNASU25804.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000593829; ENSP00000469468; ENSG00000130520.
GeneID25804.
KEGGhsa:25804.
UCSCuc002niq.3. human.

Organism-specific databases

CTD25804.
GeneCardsGC19M018417.
HGNCHGNC:17259. LSM4.
HPAHPA040932.
MIM607284. gene.
neXtProtNX_Q9Y4Z0.
PharmGKBPA134906569.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1958.
HOGENOMHOG000182713.
HOVERGENHBG000486.
InParanoidQ9Y4Z0.
KOK12623.
OMAWMNIHLV.
OrthoDBEOG747PMG.
PhylomeDBQ9Y4Z0.
TreeFamTF315027.

Enzyme and pathway databases

ReactomeREACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9Y4Z0.
BgeeQ9Y4Z0.
CleanExHS_LSM4.
GenevestigatorQ9Y4Z0.

Family and domain databases

InterProIPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PANTHERPTHR23338. PTHR23338. 1 hit.
PfamPF01423. LSM. 1 hit.
[Graphical view]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLSM4. human.
GeneWikiLSM4.
GenomeRNAi25804.
NextBio47015.
PROQ9Y4Z0.
SOURCESearch...

Entry information

Entry nameLSM4_HUMAN
AccessionPrimary (citable) accession number: Q9Y4Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM