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Protein

U6 snRNA-associated Sm-like protein LSm4

Gene

LSM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

GO - Molecular functioni

  • PH domain binding Source: CAFA
  • RNA binding Source: UniProtKB
  • U6 snRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm4
Alternative name(s):
Glycine-rich protein
Short name:
GRP
Gene namesi
Name:LSM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130520.10.
HGNCiHGNC:17259. LSM4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi25804.
OpenTargetsiENSG00000130520.
PharmGKBiPA134906569.

Polymorphism and mutation databases

BioMutaiLSM4.
DMDMi10720082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255641 – 139U6 snRNA-associated Sm-like protein LSm4Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9Y4Z0.
MaxQBiQ9Y4Z0.
PaxDbiQ9Y4Z0.
PeptideAtlasiQ9Y4Z0.
PRIDEiQ9Y4Z0.

PTM databases

iPTMnetiQ9Y4Z0.
PhosphoSitePlusiQ9Y4Z0.
SwissPalmiQ9Y4Z0.

Expressioni

Gene expression databases

BgeeiENSG00000130520.
CleanExiHS_LSM4.
ExpressionAtlasiQ9Y4Z0. baseline and differential.
GenevisibleiQ9Y4Z0. HS.

Organism-specific databases

HPAiHPA040932.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.

Binary interactionsi

Show more details

GO - Molecular functioni

  • PH domain binding Source: CAFA

Protein-protein interaction databases

BioGridi117336. 65 interactors.
CORUMiQ9Y4Z0.
DIPiDIP-31209N.
IntActiQ9Y4Z0. 26 interactors.
MINTiMINT-1469332.
STRINGi9606.ENSP00000469468.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0041-139[»]
5O9Zelectron microscopy4.50q1-139[»]
ProteinModelPortaliQ9Y4Z0.
SMRiQ9Y4Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3293. Eukaryota.
ENOG4111TZU. LUCA.
GeneTreeiENSGT00610000086173.
HOGENOMiHOG000182713.
HOVERGENiHBG000486.
InParanoidiQ9Y4Z0.
KOiK12623.
OMAiDRFWKLK.
PhylomeDBiQ9Y4Z0.
TreeFamiTF315027.

Family and domain databases

CDDicd01723. LSm4. 1 hit.
InterProiView protein in InterPro
IPR034101. Lsm4.
IPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
PANTHERiPTHR23338. PTHR23338. 1 hit.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y4Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG
60 70 80 90 100
DKFWRMPECY IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK
110 120 130
GRGMGGAGRG VFGGRGRGGI PGTGRGQPEK KPGRQAGKQ
Length:139
Mass (Da):15,350
Last modified:November 1, 1999 - v1
Checksum:iBCEFB20247335A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238096 mRNA. Translation: CAB45867.1.
AF182290 mRNA. Translation: AAD56228.1.
AF117235 mRNA. Translation: AAF17216.1.
AF251218 mRNA. Translation: AAF90055.1.
BC000387 mRNA. Translation: AAH00387.1.
BC003652 mRNA. Translation: AAH03652.1.
BC022198 mRNA. Translation: AAH22198.1.
BC023665 mRNA. Translation: AAH23665.1.
CCDSiCCDS12374.1.
RefSeqiNP_036453.1. NM_012321.4.
UniGeneiHs.515255.

Genome annotation databases

EnsembliENST00000593829; ENSP00000469468; ENSG00000130520.
GeneIDi25804.
KEGGihsa:25804.
UCSCiuc002niq.4. human.

Similar proteinsi

Entry informationi

Entry nameiLSM4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families