Q9Y4Z0 (LSM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U6 snRNA-associated Sm-like protein LSm4

Alternative name(s):
Glycine-rich protein
Short name=GRP

Gene names

Name:

LSM4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subunit structure	LSm subunits form a heteromer with a doughnut shape.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Traceable author statement Ref.2. Source: ProtInc exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Traceable author statement. Source: Reactome mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	U6 snRNP Traceable author statement Ref.1. Source: ProtInc cytosol Traceable author statement. Source: Reactome spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM7	Q9UK45	5	EBI-372521,EBI-348372
NAA38	O95777	4	EBI-372521,EBI-347779

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	U6 snRNA-associated Sm-like protein LSm4		PRO_0000125564
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9Y4Z0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: BCEFB20247335A1B	FASTA	139	15,350
	10 20 30 40 50 60 MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY 70 80 90 100 110 120 IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI 130 PGTGRGQPEK KPGRQAGKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin." Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B. EMBO J. 18:3451-3462(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[4]	Chan E.K.L. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	Bienvenut W.V., Matallanas D., Cooper W.N., Kolch W. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-20, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Mammary carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ238096 mRNA. Translation: CAB45867.1. AF182290 mRNA. Translation: AAD56228.1. AF117235 mRNA. Translation: AAF17216.1. AF251218 mRNA. Translation: AAF90055.1. BC000387 mRNA. Translation: AAH00387.1. BC003652 mRNA. Translation: AAH03652.1. BC022198 mRNA. Translation: AAH22198.1. BC023665 mRNA. Translation: AAH23665.1.
IPI	IPI00294955.
RefSeq	NP_036453.1. NM_012321.4.
UniGene	Hs.515255.
3D structure databases
ProteinModelPortal	Q9Y4Z0.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31209N.
IntAct	Q9Y4Z0. 14 interactions.
MINT	MINT-1469332.
STRING	9606.ENSP00000252816.
PTM databases
PhosphoSite	Q9Y4Z0.
Polymorphism databases
DMDM	10720082.
Proteomic databases
PaxDb	Q9Y4Z0.
PeptideAtlas	Q9Y4Z0.
PRIDE	Q9Y4Z0.
Protocols and materials databases
DNASU	25804.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000593829; ENSP00000469468; ENSG00000130520.
GeneID	25804.
KEGG	hsa:25804.
UCSC	uc002niq.3. human.
Organism-specific databases
CTD	25804.
GeneCards	GC19M018417.
HGNC	HGNC:17259. LSM4.
HPA	HPA040932.
MIM	607284. gene.
neXtProt	NX_Q9Y4Z0.
PharmGKB	PA134906569.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1958.
HOGENOM	HOG000182713.
HOVERGEN	HBG000486.
InParanoid	Q9Y4Z0.
KO	K12623.
OMA	GMQQQKQ.
OrthoDB	EOG4T784T.
PhylomeDB	Q9Y4Z0.
Enzyme and pathway databases
Reactome	REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	Q9Y4Z0.
CleanEx	HS_LSM4.
Genevestigator	Q9Y4Z0.
GermOnline	ENSG00000130520. Homo sapiens.
Family and domain databases
InterPro	IPR027141. LSm4/Sm_D1/D3. IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. IPR006649. Ribonucl_LSM_euk/arc. [Graphical view]
PANTHER	PTHR23338. PTHR23338. 1 hit.
Pfam	PF01423. LSM. 1 hit. [Graphical view]
SMART	SM00651. Sm. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	LSM4. human.
GenomeRNAi	25804.
NextBio	47015.
SOURCE	Search...

Entry information

Entry name

LSM4_HUMAN

Accession

Primary (citable) accession number: Q9Y4Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.