Reviewed, UniProtKB/Swiss-Prot Q9Y4Z0 (LSM4_HUMAN)

Names and origin

Protein names

Recommended name:
    U6 snRNA-associated Sm-like protein LSm4
Alternative name(s):
    Glycine-rich protein
      Short name=GRP

Gene names

Name:

LSM4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subunit structure	LSm subunits form a heteromer with a donut shape.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	RNA splicing Ref.2 Traceable author statement. Source: ProtInc mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	snRNP U6 Ref.1 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C4orf34	Q96QK8	1	EBI-372521,EBI-373430
LSM1	O15116	1	EBI-372521,EBI-347619
LSM7	Q9UK45	2	EBI-372521,EBI-348372
LSM8	O95777	2	EBI-372521,EBI-347779
NMI	Q13287	1	EBI-372521,EBI-372942
RHOXF2	Q9BQY4	1	EBI-372521,EBI-372094
SNRPE	P62304	1	EBI-372521,EBI-348082
SNRPN	P63162	1	EBI-372521,EBI-712493

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	U6 snRNA-associated Sm-like protein LSm4		PRO_0000125564
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9Y4Z0-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: BCEFB20247335A1B	FASTA	139	15,350
	10 20 30 40 50 60 MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY 70 80 90 100 110 120 IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI 130 PGTGRGQPEK KPGRQAGKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin." Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B. EMBO J. 18:3451-3462(1999) [PubMed: 10369684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[4]	Chan E.K.L. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	Bienvenut W.V., Matallanas D., Cooper W.N., Kolch W. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-20, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Mammary carcinoma.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238096 mRNA. Translation: CAB45867.1. AF182290 mRNA. Translation: AAD56228.1. AF117235 mRNA. Translation: AAF17216.1. AF251218 mRNA. Translation: AAF90055.1. BC000387 mRNA. Translation: AAH00387.1. BC003652 mRNA. Translation: AAH03652.1. BC022198 mRNA. Translation: AAH22198.1. BC023665 mRNA. Translation: AAH23665.1.
IPI	IPI00294955.
RefSeq	NP_036453.1.
UniGene	Hs.515255
3D structure databases
HSSP	HSSP built from PDB template 1N9S based on UniProtKB P54999.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4Z0. 9 interactions.
Proteomic databases
PeptideAtlas	Q9Y4Z0.
PRIDE	Q9Y4Z0.
Genome annotation databases
Ensembl	ENSG00000130520. Homo sapiens. [Contig view]
GeneID	25804.
KEGG	hsa:25804.
Organism-specific databases
GeneCards	GC19M018278.
H-InvDB	HIX0014909.
HGNC	HGNC:17259. LSM4.
MIM	607284. gene.
PharmGKB	PA134906569.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y4Z0.
HOVERGEN	Q9Y4Z0.
OMA	Q9Y4Z0. AVNHPML.
Gene expression databases
ArrayExpress	Q9Y4Z0.
Bgee	Q9Y4Z0.
CleanEx	HS_LSM4.
GermOnline	ENSG00000130520. Homo sapiens.
Family and domain databases
InterPro	IPR006649. Euk_arc_LSM_core. IPR001163. LSM_snRNP_core. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
ProDom	PD020287. snRNP. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00651. Sm. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47015.
SOURCE	Search...

Entry information

Entry name

LSM4_HUMAN

Accession

Primary (citable) accession number: Q9Y4Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)