Reviewed, UniProtKB/Swiss-Prot Q9Y4Y9 (LSM5_HUMAN)

Names and origin

Protein names

Recommended name:
    U6 snRNA-associated Sm-like protein LSm5

Gene names

Name:

LSM5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
Subunit structure	LSm subunits form a heteromer with a donut shape By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EXOSC5	Q9NQT4	1	EBI-373007,EBI-371876
HNRNPD	Q14103-3	1	EBI-373007,EBI-432539
LSM3	P62310	2	EBI-373007,EBI-348239
LSM6	P62312	2	EBI-373007,EBI-373310
LSM7	Q9UK45	2	EBI-373007,EBI-348372
SNRPE	P62304	1	EBI-373007,EBI-348082
SNRPF	P62306	1	EBI-373007,EBI-356900

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 91	90	U6 snRNA-associated Sm-like protein LSm5		PRO_0000125572
Amino acid modifications
	Modified residue	2	1	N-acetylalanine

Sequences

	Sequence		Length	Mass (Da)
	Q9Y4Y9-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 82B5C8830E64C992	FASTA	91	9,937
	10 20 30 40 50 60 MAANATTNPS QLLPLELVDK CIGSRIHIVM KSDKEIVGTL LGFDDFVNMV LEDVTEFEIT 70 80 90 PEGRRITKLD QILLNGNNIT MLVPGGEGPE V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin." Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B. EMBO J. 18:3451-3462(1999) [PubMed: 10369684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238097 mRNA. Translation: CAB45868.1. AF182291 mRNA. Translation: AAD56229.1. BC005938 mRNA. Translation: AAH05938.1.
IPI	IPI00220493.
RefSeq	NP_001124182.1. NP_036454.1.
UniGene	Hs.424908
3D structure databases
HSSP	HSSP built from PDB template 1JBM based on UniProtKB O26745.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4Y9. 7 interactions.
Proteomic databases
PRIDE	Q9Y4Y9.
Genome annotation databases
Ensembl	ENSG00000106355. Homo sapiens. [Contig view]
GeneID	23658.
KEGG	hsa:23658.
UCSC	uc003tct.1. human.
Organism-specific databases
GeneCards	GC07M032491.
H-InvDB	HIX0018822.
HGNC	HGNC:17162. LSM5.
MIM	607285. gene.
PharmGKB	PA134881171.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y4Y9.
HOVERGEN	Q9Y4Y9.
OMA	Q9Y4Y9. CIGSKIW.
Gene expression databases
ArrayExpress	Q9Y4Y9.
Bgee	Q9Y4Y9.
CleanEx	HS_LSM5.
GermOnline	ENSG00000106355. Homo sapiens.
Family and domain databases
InterPro	IPR006649. Euk_arc_LSM_core. IPR001163. LSM_snRNP_core. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
ProDom	PD020287. snRNP. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00651. Sm. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	46501.
SOURCE	Search...

Entry information

Entry name

LSM5_HUMAN

Accession

Primary (citable) accession number: Q9Y4Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	July 7, 2009
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)