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Protein

Krueppel-like factor 12

Gene

KLF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9Y4X4.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:KLF12
Synonyms:AP2REP
ORF Names:HSPC122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6346. KLF12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30132.

Polymorphism and mutation databases

BioMutaiKLF12.
DMDMi91771555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Krueppel-like factor 12PRO_0000047182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Phosphoserine1 Publication
Modified residuei313 – 3131N6-methylated lysine; by EHMT21 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y4X4.
PaxDbiQ9Y4X4.
PRIDEiQ9Y4X4.

PTM databases

PhosphoSiteiQ9Y4X4.

Expressioni

Gene expression databases

BgeeiQ9Y4X4.
CleanExiHS_KLF12.
ExpressionAtlasiQ9Y4X4. baseline and differential.
GenevisibleiQ9Y4X4. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q13363-23EBI-750750,EBI-10171858
THAP1Q9NVV93EBI-750750,EBI-741515

Protein-protein interaction databases

BioGridi116434. 4 interactions.
IntActiQ9Y4X4. 3 interactions.
MINTiMINT-199288.
STRINGi9606.ENSP00000366894.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4X4.
SMRiQ9Y4X4. Positions 306-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiQ9Y4X4.
KOiK09205.
OMAiSLPLMYT.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9Y4X4.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030447. KLF12.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23223:SF136. PTHR23223:SF136. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD
60 70 80 90 100
MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR TSPTAVSSSP
110 120 130 140 150
VSMTASASSP SSTSTSSSSS SRLASSPTVI TSVSSASSSS TVLTPGPLVA
160 170 180 190 200
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV
210 220 230 240 250
RSPGNVNNTI VVPLLEDGRG HGKAQMDPRG LSPRQSKSDS DDDDLPNVTL
260 270 280 290 300
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFPC SISPFSIEST
310 320 330 340 350
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT
360 370 380 390 400
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM

LV
Length:402
Mass (Da):44,240
Last modified:March 7, 2006 - v2
Checksum:i9557E776878BAA8D
GO
Isoform 2 (identifier: Q9Y4X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-402: Missing.

Show »
Length:269
Mass (Da):28,407
Checksum:i6026ED58AB6AA023
GO
Isoform 3 (identifier: Q9Y4X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-309: CSISPFSIESTRRQRRSESP → WRETLQVYLGRLHLEVRSFR
     310-402: Missing.

Show »
Length:309
Mass (Da):33,250
Checksum:i9D3AA6F9D80D2AE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461P → L in CAB46982 (PubMed:10704285).Curated
Sequence conflicti246 – 2461P → L in AAK12082 (PubMed:11433524).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei270 – 402133Missing in isoform 2. 2 PublicationsVSP_006876Add
BLAST
Alternative sequencei290 – 30920CSISP…RSESP → WRETLQVYLGRLHLEVRSFR in isoform 3. 1 PublicationVSP_047486Add
BLAST
Alternative sequencei310 – 40293Missing in isoform 3. 1 PublicationVSP_047487Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243274 mRNA. Translation: CAB46982.1.
AF312872
, AF312866, AF312867, AF312868, AF312869, AF312870, AF312871 Genomic DNA. Translation: AAK12082.1.
HF546212 mRNA. Translation: CCO02798.1.
AF113122 mRNA. Translation: AAF14863.1.
AF161471 mRNA. Translation: AAF29086.1.
AK291397 mRNA. Translation: BAF84086.1.
AL159972
, AL138713, AL139036, AL160032 Genomic DNA. Translation: CAH70670.1.
AL139036
, AL138713, AL159972, AL160032 Genomic DNA. Translation: CAH71998.1.
AL160032
, AL138713, AL139036, AL159972 Genomic DNA. Translation: CAH74171.1.
AL138713
, AL139036, AL159972, AL160032 Genomic DNA. Translation: CAI15634.1.
CH471093 Genomic DNA. Translation: EAW80529.1.
BC019680 mRNA. Translation: AAH19680.1.
CCDSiCCDS9449.1. [Q9Y4X4-1]
RefSeqiNP_009180.3. NM_007249.4. [Q9Y4X4-1]
XP_005266308.1. XM_005266251.2. [Q9Y4X4-1]
XP_005266309.1. XM_005266252.3. [Q9Y4X4-1]
XP_011533211.1. XM_011534909.1. [Q9Y4X4-1]
UniGeneiHs.373857.
Hs.729350.

Genome annotation databases

EnsembliENST00000377669; ENSP00000366897; ENSG00000118922.
GeneIDi11278.
KEGGihsa:11278.
UCSCiuc001vjf.3. human. [Q9Y4X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243274 mRNA. Translation: CAB46982.1.
AF312872
, AF312866, AF312867, AF312868, AF312869, AF312870, AF312871 Genomic DNA. Translation: AAK12082.1.
HF546212 mRNA. Translation: CCO02798.1.
AF113122 mRNA. Translation: AAF14863.1.
AF161471 mRNA. Translation: AAF29086.1.
AK291397 mRNA. Translation: BAF84086.1.
AL159972
, AL138713, AL139036, AL160032 Genomic DNA. Translation: CAH70670.1.
AL139036
, AL138713, AL159972, AL160032 Genomic DNA. Translation: CAH71998.1.
AL160032
, AL138713, AL139036, AL159972 Genomic DNA. Translation: CAH74171.1.
AL138713
, AL139036, AL159972, AL160032 Genomic DNA. Translation: CAI15634.1.
CH471093 Genomic DNA. Translation: EAW80529.1.
BC019680 mRNA. Translation: AAH19680.1.
CCDSiCCDS9449.1. [Q9Y4X4-1]
RefSeqiNP_009180.3. NM_007249.4. [Q9Y4X4-1]
XP_005266308.1. XM_005266251.2. [Q9Y4X4-1]
XP_005266309.1. XM_005266252.3. [Q9Y4X4-1]
XP_011533211.1. XM_011534909.1. [Q9Y4X4-1]
UniGeneiHs.373857.
Hs.729350.

3D structure databases

ProteinModelPortaliQ9Y4X4.
SMRiQ9Y4X4. Positions 306-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116434. 4 interactions.
IntActiQ9Y4X4. 3 interactions.
MINTiMINT-199288.
STRINGi9606.ENSP00000366894.

PTM databases

PhosphoSiteiQ9Y4X4.

Polymorphism and mutation databases

BioMutaiKLF12.
DMDMi91771555.

Proteomic databases

MaxQBiQ9Y4X4.
PaxDbiQ9Y4X4.
PRIDEiQ9Y4X4.

Protocols and materials databases

DNASUi11278.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377669; ENSP00000366897; ENSG00000118922.
GeneIDi11278.
KEGGihsa:11278.
UCSCiuc001vjf.3. human. [Q9Y4X4-1]

Organism-specific databases

CTDi11278.
GeneCardsiGC13M074260.
HGNCiHGNC:6346. KLF12.
MIMi607531. gene.
neXtProtiNX_Q9Y4X4.
PharmGKBiPA30132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiQ9Y4X4.
KOiK09205.
OMAiSLPLMYT.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9Y4X4.
TreeFamiTF350556.

Enzyme and pathway databases

SignaLinkiQ9Y4X4.

Miscellaneous databases

ChiTaRSiKLF12. human.
GeneWikiiKLF12.
GenomeRNAii11278.
NextBioi42933.
PROiQ9Y4X4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y4X4.
CleanExiHS_KLF12.
ExpressionAtlasiQ9Y4X4. baseline and differential.
GenevisibleiQ9Y4X4. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030447. KLF12.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23223:SF136. PTHR23223:SF136. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)."
    Roth C., Schuierer M., Gunther K., Buettner R.
    Genomics 63:384-390(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
  4. "A novel gene expressed in the human hypothalamus."
    Jiang C., Peng Y., Gu J., Gu Y., Fu S., Wu T., Dong H., Jin W., Fu G., Han Z., Chen Z., Wang Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Hypothalamus.
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. Cited for: METHYLATION AT LYS-313.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLF12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X4
Secondary accession number(s): A8K5T2
, L0R3J4, Q5VZM7, Q9UHZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 7, 2006
Last modified: July 22, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.