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Protein

Krueppel-like factor 12

Gene

KLF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118922-MONOMER.
SignaLinkiQ9Y4X4.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:KLF12
Synonyms:AP2REP
ORF Names:HSPC122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6346. KLF12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11278.
OpenTargetsiENSG00000118922.
PharmGKBiPA30132.

Polymorphism and mutation databases

BioMutaiKLF12.
DMDMi91771555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471821 – 402Krueppel-like factor 12Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1
Modified residuei313N6-methylated lysine; by EHMT21 Publication1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Y4X4.
PeptideAtlasiQ9Y4X4.
PRIDEiQ9Y4X4.

PTM databases

iPTMnetiQ9Y4X4.
PhosphoSitePlusiQ9Y4X4.

Expressioni

Gene expression databases

BgeeiENSG00000118922.
CleanExiHS_KLF12.
GenevisibleiQ9Y4X4. HS.

Organism-specific databases

HPAiHPA064146.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q13363-25EBI-750750,EBI-10171858
EHMT2Q96KQ73EBI-750750,EBI-744366
THAP1Q9NVV93EBI-750750,EBI-741515

Protein-protein interaction databases

BioGridi116434. 7 interactors.
IntActiQ9Y4X4. 4 interactors.
MINTiMINT-199288.
STRINGi9606.ENSP00000366894.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4X4.
SMRiQ9Y4X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 341C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri347 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiQ9Y4X4.
KOiK09205.
OMAiRSHVKAQ.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9Y4X4.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD
60 70 80 90 100
MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR TSPTAVSSSP
110 120 130 140 150
VSMTASASSP SSTSTSSSSS SRLASSPTVI TSVSSASSSS TVLTPGPLVA
160 170 180 190 200
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV
210 220 230 240 250
RSPGNVNNTI VVPLLEDGRG HGKAQMDPRG LSPRQSKSDS DDDDLPNVTL
260 270 280 290 300
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFPC SISPFSIEST
310 320 330 340 350
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT
360 370 380 390 400
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM

LV
Length:402
Mass (Da):44,240
Last modified:March 7, 2006 - v2
Checksum:i9557E776878BAA8D
GO
Isoform 2 (identifier: Q9Y4X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-402: Missing.

Show »
Length:269
Mass (Da):28,407
Checksum:i6026ED58AB6AA023
GO
Isoform 3 (identifier: Q9Y4X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-309: CSISPFSIESTRRQRRSESP → WRETLQVYLGRLHLEVRSFR
     310-402: Missing.

Show »
Length:309
Mass (Da):33,250
Checksum:i9D3AA6F9D80D2AE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246P → L in CAB46982 (PubMed:10704285).Curated1
Sequence conflicti246P → L in AAK12082 (PubMed:11433524).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006876270 – 402Missing in isoform 2. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_047486290 – 309CSISP…RSESP → WRETLQVYLGRLHLEVRSFR in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_047487310 – 402Missing in isoform 3. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243274 mRNA. Translation: CAB46982.1.
AF312872
, AF312866, AF312867, AF312868, AF312869, AF312870, AF312871 Genomic DNA. Translation: AAK12082.1.
HF546212 mRNA. Translation: CCO02798.1.
AF113122 mRNA. Translation: AAF14863.1.
AF161471 mRNA. Translation: AAF29086.1.
AK291397 mRNA. Translation: BAF84086.1.
AL159972
, AL138713, AL139036, AL160032 Genomic DNA. Translation: CAH70670.1.
AL139036
, AL138713, AL159972, AL160032 Genomic DNA. Translation: CAH71998.1.
AL160032
, AL138713, AL139036, AL159972 Genomic DNA. Translation: CAH74171.1.
AL138713
, AL139036, AL159972, AL160032 Genomic DNA. Translation: CAI15634.1.
CH471093 Genomic DNA. Translation: EAW80529.1.
BC019680 mRNA. Translation: AAH19680.1.
CCDSiCCDS9449.1. [Q9Y4X4-1]
RefSeqiNP_009180.3. NM_007249.4. [Q9Y4X4-1]
XP_005266308.1. XM_005266251.3. [Q9Y4X4-1]
XP_011533211.1. XM_011534909.2. [Q9Y4X4-1]
UniGeneiHs.373857.
Hs.729350.

Genome annotation databases

EnsembliENST00000377669; ENSP00000366897; ENSG00000118922. [Q9Y4X4-1]
GeneIDi11278.
KEGGihsa:11278.
UCSCiuc058xlm.1. human. [Q9Y4X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243274 mRNA. Translation: CAB46982.1.
AF312872
, AF312866, AF312867, AF312868, AF312869, AF312870, AF312871 Genomic DNA. Translation: AAK12082.1.
HF546212 mRNA. Translation: CCO02798.1.
AF113122 mRNA. Translation: AAF14863.1.
AF161471 mRNA. Translation: AAF29086.1.
AK291397 mRNA. Translation: BAF84086.1.
AL159972
, AL138713, AL139036, AL160032 Genomic DNA. Translation: CAH70670.1.
AL139036
, AL138713, AL159972, AL160032 Genomic DNA. Translation: CAH71998.1.
AL160032
, AL138713, AL139036, AL159972 Genomic DNA. Translation: CAH74171.1.
AL138713
, AL139036, AL159972, AL160032 Genomic DNA. Translation: CAI15634.1.
CH471093 Genomic DNA. Translation: EAW80529.1.
BC019680 mRNA. Translation: AAH19680.1.
CCDSiCCDS9449.1. [Q9Y4X4-1]
RefSeqiNP_009180.3. NM_007249.4. [Q9Y4X4-1]
XP_005266308.1. XM_005266251.3. [Q9Y4X4-1]
XP_011533211.1. XM_011534909.2. [Q9Y4X4-1]
UniGeneiHs.373857.
Hs.729350.

3D structure databases

ProteinModelPortaliQ9Y4X4.
SMRiQ9Y4X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116434. 7 interactors.
IntActiQ9Y4X4. 4 interactors.
MINTiMINT-199288.
STRINGi9606.ENSP00000366894.

PTM databases

iPTMnetiQ9Y4X4.
PhosphoSitePlusiQ9Y4X4.

Polymorphism and mutation databases

BioMutaiKLF12.
DMDMi91771555.

Proteomic databases

PaxDbiQ9Y4X4.
PeptideAtlasiQ9Y4X4.
PRIDEiQ9Y4X4.

Protocols and materials databases

DNASUi11278.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377669; ENSP00000366897; ENSG00000118922. [Q9Y4X4-1]
GeneIDi11278.
KEGGihsa:11278.
UCSCiuc058xlm.1. human. [Q9Y4X4-1]

Organism-specific databases

CTDi11278.
DisGeNETi11278.
GeneCardsiKLF12.
HGNCiHGNC:6346. KLF12.
HPAiHPA064146.
MIMi607531. gene.
neXtProtiNX_Q9Y4X4.
OpenTargetsiENSG00000118922.
PharmGKBiPA30132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiQ9Y4X4.
KOiK09205.
OMAiRSHVKAQ.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ9Y4X4.
TreeFamiTF350556.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118922-MONOMER.
SignaLinkiQ9Y4X4.

Miscellaneous databases

ChiTaRSiKLF12. human.
GeneWikiiKLF12.
GenomeRNAii11278.
PROiQ9Y4X4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118922.
CleanExiHS_KLF12.
GenevisibleiQ9Y4X4. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X4
Secondary accession number(s): A8K5T2
, L0R3J4, Q5VZM7, Q9UHZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.