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Q9Y4X4

- KLF12_HUMAN

UniProt

Q9Y4X4 - KLF12_HUMAN

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Protein
Krueppel-like factor 12
Gene
KLF12, AP2REP, HSPC122
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1
Add
BLAST
Zinc fingeri347 – 37125C2H2-type 2
Add
BLAST
Zinc fingeri377 – 39923C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9Y4X4.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:KLF12
Synonyms:AP2REP
ORF Names:HSPC122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6346. KLF12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Krueppel-like factor 12
PRO_0000047182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Phosphoserine1 Publication
Modified residuei313 – 3131N6-methylated lysine; by EHMT21 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y4X4.
PaxDbiQ9Y4X4.
PRIDEiQ9Y4X4.

PTM databases

PhosphoSiteiQ9Y4X4.

Expressioni

Gene expression databases

BgeeiQ9Y4X4.
CleanExiHS_KLF12.
GenevestigatoriQ9Y4X4.

Interactioni

Protein-protein interaction databases

BioGridi116434. 3 interactions.
IntActiQ9Y4X4. 1 interaction.
MINTiMINT-199288.
STRINGi9606.ENSP00000366894.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4X4.
SMRiQ9Y4X4. Positions 306-402.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
KOiK09205.
OMAiSLPLMYT.
OrthoDBiEOG747PJ4.
PhylomeDBiQ9Y4X4.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4X4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD    50
MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR TSPTAVSSSP 100
VSMTASASSP SSTSTSSSSS SRLASSPTVI TSVSSASSSS TVLTPGPLVA 150
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV 200
RSPGNVNNTI VVPLLEDGRG HGKAQMDPRG LSPRQSKSDS DDDDLPNVTL 250
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFPC SISPFSIEST 300
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT 350
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM 400
LV 402
Length:402
Mass (Da):44,240
Last modified:March 7, 2006 - v2
Checksum:i9557E776878BAA8D
GO
Isoform 2 (identifier: Q9Y4X4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-402: Missing.

Show »
Length:269
Mass (Da):28,407
Checksum:i6026ED58AB6AA023
GO
Isoform 3 (identifier: Q9Y4X4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-309: CSISPFSIESTRRQRRSESP → WRETLQVYLGRLHLEVRSFR
     310-402: Missing.

Show »
Length:309
Mass (Da):33,250
Checksum:i9D3AA6F9D80D2AE4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei270 – 402133Missing in isoform 2.
VSP_006876Add
BLAST
Alternative sequencei290 – 30920CSISP…RSESP → WRETLQVYLGRLHLEVRSFR in isoform 3.
VSP_047486Add
BLAST
Alternative sequencei310 – 40293Missing in isoform 3.
VSP_047487Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461P → L in CAB46982. 1 Publication
Sequence conflicti246 – 2461P → L in AAK12082. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243274 mRNA. Translation: CAB46982.1.
AF312872
, AF312866, AF312867, AF312868, AF312869, AF312870, AF312871 Genomic DNA. Translation: AAK12082.1.
HF546212 mRNA. Translation: CCO02798.1.
AF113122 mRNA. Translation: AAF14863.1.
AF161471 mRNA. Translation: AAF29086.1.
AK291397 mRNA. Translation: BAF84086.1.
AL159972
, AL138713, AL139036, AL160032 Genomic DNA. Translation: CAH70670.1.
AL139036
, AL138713, AL159972, AL160032 Genomic DNA. Translation: CAH71998.1.
AL160032
, AL138713, AL139036, AL159972 Genomic DNA. Translation: CAH74171.1.
AL138713
, AL139036, AL159972, AL160032 Genomic DNA. Translation: CAI15634.1.
CH471093 Genomic DNA. Translation: EAW80529.1.
BC019680 mRNA. Translation: AAH19680.1.
CCDSiCCDS9449.1. [Q9Y4X4-1]
RefSeqiNP_009180.3. NM_007249.4. [Q9Y4X4-1]
XP_005266308.1. XM_005266251.2. [Q9Y4X4-1]
XP_005266309.1. XM_005266252.2. [Q9Y4X4-1]
XP_006719825.1. XM_006719762.1. [Q9Y4X4-1]
UniGeneiHs.373857.
Hs.729350.

Genome annotation databases

EnsembliENST00000377666; ENSP00000366894; ENSG00000118922. [Q9Y4X4-1]
ENST00000377669; ENSP00000366897; ENSG00000118922. [Q9Y4X4-1]
GeneIDi11278.
KEGGihsa:11278.
UCSCiuc001vjf.3. human. [Q9Y4X4-1]

Polymorphism databases

DMDMi91771555.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243274 mRNA. Translation: CAB46982.1 .
AF312872
, AF312866 , AF312867 , AF312868 , AF312869 , AF312870 , AF312871 Genomic DNA. Translation: AAK12082.1 .
HF546212 mRNA. Translation: CCO02798.1 .
AF113122 mRNA. Translation: AAF14863.1 .
AF161471 mRNA. Translation: AAF29086.1 .
AK291397 mRNA. Translation: BAF84086.1 .
AL159972
, AL138713 , AL139036 , AL160032 Genomic DNA. Translation: CAH70670.1 .
AL139036
, AL138713 , AL159972 , AL160032 Genomic DNA. Translation: CAH71998.1 .
AL160032
, AL138713 , AL139036 , AL159972 Genomic DNA. Translation: CAH74171.1 .
AL138713
, AL139036 , AL159972 , AL160032 Genomic DNA. Translation: CAI15634.1 .
CH471093 Genomic DNA. Translation: EAW80529.1 .
BC019680 mRNA. Translation: AAH19680.1 .
CCDSi CCDS9449.1. [Q9Y4X4-1 ]
RefSeqi NP_009180.3. NM_007249.4. [Q9Y4X4-1 ]
XP_005266308.1. XM_005266251.2. [Q9Y4X4-1 ]
XP_005266309.1. XM_005266252.2. [Q9Y4X4-1 ]
XP_006719825.1. XM_006719762.1. [Q9Y4X4-1 ]
UniGenei Hs.373857.
Hs.729350.

3D structure databases

ProteinModelPortali Q9Y4X4.
SMRi Q9Y4X4. Positions 306-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116434. 3 interactions.
IntActi Q9Y4X4. 1 interaction.
MINTi MINT-199288.
STRINGi 9606.ENSP00000366894.

PTM databases

PhosphoSitei Q9Y4X4.

Polymorphism databases

DMDMi 91771555.

Proteomic databases

MaxQBi Q9Y4X4.
PaxDbi Q9Y4X4.
PRIDEi Q9Y4X4.

Protocols and materials databases

DNASUi 11278.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377666 ; ENSP00000366894 ; ENSG00000118922 . [Q9Y4X4-1 ]
ENST00000377669 ; ENSP00000366897 ; ENSG00000118922 . [Q9Y4X4-1 ]
GeneIDi 11278.
KEGGi hsa:11278.
UCSCi uc001vjf.3. human. [Q9Y4X4-1 ]

Organism-specific databases

CTDi 11278.
GeneCardsi GC13M074260.
HGNCi HGNC:6346. KLF12.
MIMi 607531. gene.
neXtProti NX_Q9Y4X4.
PharmGKBi PA30132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000232138.
HOVERGENi HBG003941.
KOi K09205.
OMAi SLPLMYT.
OrthoDBi EOG747PJ4.
PhylomeDBi Q9Y4X4.
TreeFami TF350556.

Enzyme and pathway databases

SignaLinki Q9Y4X4.

Miscellaneous databases

ChiTaRSi KLF12. human.
GeneWikii KLF12.
GenomeRNAii 11278.
NextBioi 42933.
PROi Q9Y4X4.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4X4.
CleanExi HS_KLF12.
Genevestigatori Q9Y4X4.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)."
    Roth C., Schuierer M., Gunther K., Buettner R.
    Genomics 63:384-390(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
  4. "A novel gene expressed in the human hypothalamus."
    Jiang C., Peng Y., Gu J., Gu Y., Fu S., Wu T., Dong H., Jin W., Fu G., Han Z., Chen Z., Wang Y.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Hypothalamus.
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  10. Cited for: METHYLATION AT LYS-313.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLF12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X4
Secondary accession number(s): A8K5T2
, L0R3J4, Q5VZM7, Q9UHZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi