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Q9Y4X3

- CCL27_HUMAN

UniProt

Q9Y4X3 - CCL27_HUMAN

Protein

C-C motif chemokine 27

Gene

CCL27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. immune response Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 27
    Alternative name(s):
    CC chemokine ILC
    Cutaneous T-cell-attracting chemokine
    Short name:
    CTACK
    ESkine
    IL-11 R-alpha-locus chemokine
    Skinkine
    Small-inducible cytokine A27
    Gene namesi
    Name:CCL27
    Synonyms:ILC, SCYA27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10626. CCL27.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35558.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 11288C-C motif chemokine 27PRO_0000005239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 621 Publication
    Disulfide bondi34 ↔ 771 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9Y4X3.
    PRIDEiQ9Y4X3.

    Expressioni

    Tissue specificityi

    Testis, thymus, placenta, ovary and skin.

    Gene expression databases

    BgeeiQ9Y4X3.
    CleanExiHS_CCL27.
    GenevestigatoriQ9Y4X3.

    Interactioni

    Subunit structurei

    Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.1 Publication

    Protein-protein interaction databases

    DIPiDIP-5872N.
    STRINGi9606.ENSP00000259631.

    Structurei

    Secondary structure

    1
    112
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi44 – 474
    Beta strandi52 – 565
    Turni58 – 614
    Beta strandi62 – 643
    Beta strandi66 – 716
    Beta strandi74 – 785
    Helixi83 – 9412
    Helixi96 – 983
    Turni106 – 1105

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KUMNMR-A25-112[»]
    ProteinModelPortaliQ9Y4X3.
    SMRiQ9Y4X3. Positions 25-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y4X3.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47743.
    HOGENOMiHOG000231671.
    HOVERGENiHBG050833.
    InParanoidiQ9Y4X3.
    KOiK16598.
    OrthoDBiEOG70W3G4.
    PhylomeDBiQ9Y4X3.
    TreeFamiTF337014.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y4X3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV    50
    IQVELQEADG DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL 100
    PKLNFGMLRK MG 112
    Length:112
    Mass (Da):12,618
    Last modified:November 1, 1999 - v1
    Checksum:i7B5940E147ABF820
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781I → V.
    Corresponds to variant rs11575594 [ dbSNP | Ensembl ].
    VAR_022103
    Natural varianti96 – 961L → F.
    Corresponds to variant rs11575584 [ dbSNP | Ensembl ].
    VAR_022104

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010445 mRNA. Translation: BAA87046.1.
    AF082393 mRNA. Translation: AAD41238.1.
    AJ243542 mRNA. Translation: CAB46983.1.
    CCDSiCCDS6569.1.
    RefSeqiNP_006655.1. NM_006664.2.
    UniGeneiHs.648124.

    Genome annotation databases

    EnsembliENST00000259631; ENSP00000259631; ENSG00000213927.
    GeneIDi10850.
    KEGGihsa:10850.
    UCSCiuc003zvm.1. human.

    Polymorphism databases

    DMDMi7674366.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL27 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010445 mRNA. Translation: BAA87046.1 .
    AF082393 mRNA. Translation: AAD41238.1 .
    AJ243542 mRNA. Translation: CAB46983.1 .
    CCDSi CCDS6569.1.
    RefSeqi NP_006655.1. NM_006664.2.
    UniGenei Hs.648124.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KUM NMR - A 25-112 [» ]
    ProteinModelPortali Q9Y4X3.
    SMRi Q9Y4X3. Positions 25-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5872N.
    STRINGi 9606.ENSP00000259631.

    Polymorphism databases

    DMDMi 7674366.

    Proteomic databases

    PaxDbi Q9Y4X3.
    PRIDEi Q9Y4X3.

    Protocols and materials databases

    DNASUi 10850.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259631 ; ENSP00000259631 ; ENSG00000213927 .
    GeneIDi 10850.
    KEGGi hsa:10850.
    UCSCi uc003zvm.1. human.

    Organism-specific databases

    CTDi 10850.
    GeneCardsi GC09M034662.
    HGNCi HGNC:10626. CCL27.
    MIMi 604833. gene.
    neXtProti NX_Q9Y4X3.
    PharmGKBi PA35558.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47743.
    HOGENOMi HOG000231671.
    HOVERGENi HBG050833.
    InParanoidi Q9Y4X3.
    KOi K16598.
    OrthoDBi EOG70W3G4.
    PhylomeDBi Q9Y4X3.
    TreeFami TF337014.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei Q9Y4X3.
    GenomeRNAii 10850.
    NextBioi 41193.
    PROi Q9Y4X3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4X3.
    CleanExi HS_CCL27.
    Genevestigatori Q9Y4X3.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus."
      Ishikawa-Mochizuki I., Kitaura M., Baba M., Nakayama T., Izawa D., Imai T., Yamada H., Hieshima K., Suzuki R., Nomiyama H., Yoshie O.
      FEBS Lett. 460:544-548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-30.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "CCL27, the human homologue of murine ALP chemokine."
      Zaballos A., Gutierrez J., Marquez G., Hromas R.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.
    4. "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
      Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
      J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.
    5. "NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27."
      Jansma A.L., Kirkpatrick J.P., Hsu A.R., Handel T.M., Nietlispach D.
      J. Biol. Chem. 285:14424-14437(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 25-112, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCCL27_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3