Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y4X3

- CCL27_HUMAN

UniProt

Q9Y4X3 - CCL27_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-C motif chemokine 27

Gene

CCL27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 27
Alternative name(s):
CC chemokine ILC
Cutaneous T-cell-attracting chemokine
Short name:
CTACK
ESkine
IL-11 R-alpha-locus chemokine
Skinkine
Small-inducible cytokine A27
Gene namesi
Name:CCL27
Synonyms:ILC, SCYA27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10626. CCL27.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 11288C-C motif chemokine 27PRO_0000005239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 621 Publication
Disulfide bondi34 ↔ 771 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y4X3.
PRIDEiQ9Y4X3.

Expressioni

Tissue specificityi

Testis, thymus, placenta, ovary and skin.

Gene expression databases

BgeeiQ9Y4X3.
CleanExiHS_CCL27.
ExpressionAtlasiQ9Y4X3. baseline.
GenevestigatoriQ9Y4X3.

Interactioni

Subunit structurei

Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.1 Publication

Protein-protein interaction databases

DIPiDIP-5872N.
STRINGi9606.ENSP00000259631.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 474
Beta strandi52 – 565
Turni58 – 614
Beta strandi62 – 643
Beta strandi66 – 716
Beta strandi74 – 785
Helixi83 – 9412
Helixi96 – 983
Turni106 – 1105

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KUMNMR-A25-112[»]
ProteinModelPortaliQ9Y4X3.
SMRiQ9Y4X3. Positions 25-112.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4X3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47743.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000231671.
HOVERGENiHBG050833.
InParanoidiQ9Y4X3.
KOiK16598.
OrthoDBiEOG70W3G4.
PhylomeDBiQ9Y4X3.
TreeFamiTF337014.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y4X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV
60 70 80 90 100
IQVELQEADG DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL
110
PKLNFGMLRK MG
Length:112
Mass (Da):12,618
Last modified:November 1, 1999 - v1
Checksum:i7B5940E147ABF820
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781I → V.
Corresponds to variant rs11575594 [ dbSNP | Ensembl ].
VAR_022103
Natural varianti96 – 961L → F.
Corresponds to variant rs11575584 [ dbSNP | Ensembl ].
VAR_022104

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010445 mRNA. Translation: BAA87046.1.
AF082393 mRNA. Translation: AAD41238.1.
AJ243542 mRNA. Translation: CAB46983.1.
CCDSiCCDS6569.1.
RefSeqiNP_006655.1. NM_006664.2.
UniGeneiHs.648124.

Genome annotation databases

EnsembliENST00000259631; ENSP00000259631; ENSG00000213927.
GeneIDi10850.
KEGGihsa:10850.
UCSCiuc003zvm.1. human.

Polymorphism databases

DMDMi7674366.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL27 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010445 mRNA. Translation: BAA87046.1 .
AF082393 mRNA. Translation: AAD41238.1 .
AJ243542 mRNA. Translation: CAB46983.1 .
CCDSi CCDS6569.1.
RefSeqi NP_006655.1. NM_006664.2.
UniGenei Hs.648124.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KUM NMR - A 25-112 [» ]
ProteinModelPortali Q9Y4X3.
SMRi Q9Y4X3. Positions 25-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5872N.
STRINGi 9606.ENSP00000259631.

Polymorphism databases

DMDMi 7674366.

Proteomic databases

PaxDbi Q9Y4X3.
PRIDEi Q9Y4X3.

Protocols and materials databases

DNASUi 10850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259631 ; ENSP00000259631 ; ENSG00000213927 .
GeneIDi 10850.
KEGGi hsa:10850.
UCSCi uc003zvm.1. human.

Organism-specific databases

CTDi 10850.
GeneCardsi GC09M034662.
HGNCi HGNC:10626. CCL27.
MIMi 604833. gene.
neXtProti NX_Q9Y4X3.
PharmGKBi PA35558.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47743.
GeneTreei ENSGT00530000063923.
HOGENOMi HOG000231671.
HOVERGENi HBG050833.
InParanoidi Q9Y4X3.
KOi K16598.
OrthoDBi EOG70W3G4.
PhylomeDBi Q9Y4X3.
TreeFami TF337014.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei Q9Y4X3.
GenomeRNAii 10850.
NextBioi 41193.
PROi Q9Y4X3.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4X3.
CleanExi HS_CCL27.
ExpressionAtlasi Q9Y4X3. baseline.
Genevestigatori Q9Y4X3.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus."
    Ishikawa-Mochizuki I., Kitaura M., Baba M., Nakayama T., Izawa D., Imai T., Yamada H., Hieshima K., Suzuki R., Nomiyama H., Yoshie O.
    FEBS Lett. 460:544-548(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-30.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "CCL27, the human homologue of murine ALP chemokine."
    Zaballos A., Gutierrez J., Marquez G., Hromas R.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  4. "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
    Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
    J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.
  5. "NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27."
    Jansma A.L., Kirkpatrick J.P., Hsu A.R., Handel T.M., Nietlispach D.
    J. Biol. Chem. 285:14424-14437(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 25-112, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiCCL27_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3