Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y4X3 (CCL27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 27
Alternative name(s):
CC chemokine ILC
Cutaneous T-cell-attracting chemokine
Short name=CTACK
ESkine
IL-11 R-alpha-locus chemokine
Skinkine
Small-inducible cytokine A27
Gene names
Name:CCL27
Synonyms:ILC, SCYA27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit structure

Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Ref.5

Subcellular location

Secreted.

Tissue specificity

Testis, thymus, placenta, ovary and skin.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Traceable author statement Ref.2. Source: GOC

cell-cell signaling

Traceable author statement Ref.2. Source: ProtInc

chemotaxis

Traceable author statement Ref.2. Source: ProtInc

immune response

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemokine activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.1
Chain25 – 11288C-C motif chemokine 27
PRO_0000005239

Amino acid modifications

Disulfide bond33 ↔ 62 Ref.5
Disulfide bond34 ↔ 77 Ref.5

Natural variations

Natural variant781I → V.
Corresponds to variant rs11575594 [ dbSNP | Ensembl ].
VAR_022103
Natural variant961L → F.
Corresponds to variant rs11575584 [ dbSNP | Ensembl ].
VAR_022104

Secondary structure

.................. 112
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y4X3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7B5940E147ABF820

FASTA11212,618
        10         20         30         40         50         60 
MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV IQVELQEADG 

        70         80         90        100        110 
DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL PKLNFGMLRK MG 

« Hide

References

[1]"Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus."
Ishikawa-Mochizuki I., Kitaura M., Baba M., Nakayama T., Izawa D., Imai T., Yamada H., Hieshima K., Suzuki R., Nomiyama H., Yoshie O.
FEBS Lett. 460:544-548(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-30.
Tissue: Thymus.
[2]"CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells."
Morales J., Homey B., Vicari A.P., Hudak S., Oldham E., Hedrick J., Orozco R., Copeland N.G., Jenkins N.A., McEvoy L.M., Zlotnik A.
Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"CCL27, the human homologue of murine ALP chemokine."
Zaballos A., Gutierrez J., Marquez G., Hromas R.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.
[4]"The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR INTERACTION.
[5]"NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27."
Jansma A.L., Kirkpatrick J.P., Hsu A.R., Handel T.M., Nietlispach D.
J. Biol. Chem. 285:14424-14437(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 25-112, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL27 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010445 mRNA. Translation: BAA87046.1.
AF082393 mRNA. Translation: AAD41238.1.
AJ243542 mRNA. Translation: CAB46983.1.
RefSeqNP_006655.1. NM_006664.2.
UniGeneHs.648124.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KUMNMR-A25-112[»]
ProteinModelPortalQ9Y4X3.
SMRQ9Y4X3. Positions 25-112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5872N.
STRING9606.ENSP00000259631.

Polymorphism databases

DMDM7674366.

Proteomic databases

PaxDbQ9Y4X3.
PRIDEQ9Y4X3.

Protocols and materials databases

DNASU10850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259631; ENSP00000259631; ENSG00000213927.
GeneID10850.
KEGGhsa:10850.
UCSCuc003zvm.1. human.

Organism-specific databases

CTD10850.
GeneCardsGC09M034662.
HGNCHGNC:10626. CCL27.
MIM604833. gene.
neXtProtNX_Q9Y4X3.
PharmGKBPA35558.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47743.
HOGENOMHOG000231671.
HOVERGENHBG050833.
InParanoidQ9Y4X3.
KOK16598.
OMARRSVCIH.
OrthoDBEOG70W3G4.
PhylomeDBQ9Y4X3.
TreeFamTF337014.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9Y4X3.
CleanExHS_CCL27.
GenevestigatorQ9Y4X3.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y4X3.
GenomeRNAi10850.
NextBio41193.
PROQ9Y4X3.
SOURCESearch...

Entry information

Entry nameCCL27_HUMAN
AccessionPrimary (citable) accession number: Q9Y4X3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM