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Protein

C-C motif chemokine 27

Gene

CCL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

GO - Molecular functioni

  • chemokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • chemotaxis Source: ProtInc
  • immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137099-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 27
Alternative name(s):
CC chemokine ILC
Cutaneous T-cell-attracting chemokine
Short name:
CTACK
ESkine
IL-11 R-alpha-locus chemokine
Skinkine
Small-inducible cytokine A27
Gene namesi
Name:CCL27
Synonyms:ILC, SCYA27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10626. CCL27.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10850.
OpenTargetsiENSG00000213927.
PharmGKBiPA35558.

Polymorphism and mutation databases

BioMutaiCCL27.
DMDMi7674366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000523925 – 112C-C motif chemokine 27Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 621 Publication
Disulfide bondi34 ↔ 771 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y4X3.
PeptideAtlasiQ9Y4X3.
PRIDEiQ9Y4X3.

Expressioni

Tissue specificityi

Testis, thymus, placenta, ovary and skin.

Gene expression databases

BgeeiENSG00000213927.
CleanExiHS_CCL27.
ExpressionAtlasiQ9Y4X3. baseline and differential.
GenevisibleiQ9Y4X3. HS.

Interactioni

Subunit structurei

Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.1 Publication

GO - Molecular functioni

  • chemokine activity Source: ProtInc

Protein-protein interaction databases

DIPiDIP-5872N.
IntActiQ9Y4X3. 1 interactor.
STRINGi9606.ENSP00000259631.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 47Combined sources4
Beta strandi52 – 56Combined sources5
Turni58 – 61Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi66 – 71Combined sources6
Beta strandi74 – 78Combined sources5
Helixi83 – 94Combined sources12
Helixi96 – 98Combined sources3
Turni106 – 110Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUMNMR-A25-112[»]
ProteinModelPortaliQ9Y4X3.
SMRiQ9Y4X3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4X3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4BK. Eukaryota.
ENOG41118KC. LUCA.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000231671.
HOVERGENiHBG050833.
InParanoidiQ9Y4X3.
KOiK16598.
OMAiRRSVCIH.
OrthoDBiEOG091G0OWP.
PhylomeDBiQ9Y4X3.
TreeFamiTF337014.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y4X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV
60 70 80 90 100
IQVELQEADG DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL
110
PKLNFGMLRK MG
Length:112
Mass (Da):12,618
Last modified:November 1, 1999 - v1
Checksum:i7B5940E147ABF820
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02210378I → V.Corresponds to variant rs11575594dbSNPEnsembl.1
Natural variantiVAR_02210496L → F.Corresponds to variant rs11575584dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010445 mRNA. Translation: BAA87046.1.
AF082393 mRNA. Translation: AAD41238.1.
AJ243542 mRNA. Translation: CAB46983.1.
CCDSiCCDS6569.1.
RefSeqiNP_006655.1. NM_006664.3.
UniGeneiHs.648124.

Genome annotation databases

EnsembliENST00000259631; ENSP00000259631; ENSG00000213927.
GeneIDi10850.
KEGGihsa:10850.
UCSCiuc003zvm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL27 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010445 mRNA. Translation: BAA87046.1.
AF082393 mRNA. Translation: AAD41238.1.
AJ243542 mRNA. Translation: CAB46983.1.
CCDSiCCDS6569.1.
RefSeqiNP_006655.1. NM_006664.3.
UniGeneiHs.648124.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUMNMR-A25-112[»]
ProteinModelPortaliQ9Y4X3.
SMRiQ9Y4X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5872N.
IntActiQ9Y4X3. 1 interactor.
STRINGi9606.ENSP00000259631.

Polymorphism and mutation databases

BioMutaiCCL27.
DMDMi7674366.

Proteomic databases

PaxDbiQ9Y4X3.
PeptideAtlasiQ9Y4X3.
PRIDEiQ9Y4X3.

Protocols and materials databases

DNASUi10850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259631; ENSP00000259631; ENSG00000213927.
GeneIDi10850.
KEGGihsa:10850.
UCSCiuc003zvm.1. human.

Organism-specific databases

CTDi10850.
DisGeNETi10850.
GeneCardsiCCL27.
HGNCiHGNC:10626. CCL27.
MIMi604833. gene.
neXtProtiNX_Q9Y4X3.
OpenTargetsiENSG00000213927.
PharmGKBiPA35558.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4BK. Eukaryota.
ENOG41118KC. LUCA.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000231671.
HOVERGENiHBG050833.
InParanoidiQ9Y4X3.
KOiK16598.
OMAiRRSVCIH.
OrthoDBiEOG091G0OWP.
PhylomeDBiQ9Y4X3.
TreeFamiTF337014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137099-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiQ9Y4X3.
GenomeRNAii10850.
PROiQ9Y4X3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213927.
CleanExiHS_CCL27.
ExpressionAtlasiQ9Y4X3. baseline and differential.
GenevisibleiQ9Y4X3. HS.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL27_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.