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Reviewed, UniProtKB/Swiss-Prot Q9Y4X1 (UD2A1_HUMAN)

Last modified July 7, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucuronosyltransferase 2A1
      Short name=UDPGT 2A1
    EC=2.4.1.17
Gene names
Name: UGT2A1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Olfactory epithelium and brain. Ref.1

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Biophysicochemical properties

Kinetic parameters:

KM=75.4 µM for 3-Hydroxybiphenyl

KM=59.5 µM for umbelliferone

KM=51.6 µM for S---b-Citronellol

KM=170.1 µM for borneol

KM=56.2 µM for testosterone

KM=251 µM for UDP-glucuronate

Vmax=2.60 nmol/min/mg enzyme with 3-Hydroxybiphenyl as substrate

Vmax=0.61 nmol/min/mg enzyme with umbelliferone as substrate

Vmax=1.98 nmol/min/mg enzyme with S---b-Citronellol as substrate

Vmax=1.05 nmol/min/mg enzyme with borneol as substrate

Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate

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Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdetection of chemical stimulus Ref.1

Traceable author statement. Source: ProtInc

metabolic process Ref.1

Traceable author statement. Source: ProtInc

sensory perception of smell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 527507UDP-glucuronosyltransferase 2A1
PRO_0000036023

Regions

Topological domain21 – 490470Extracellular Potential
Transmembrane491 – 50717 Potential
Topological domain508 – 52720Cytoplasmic Potential

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential

Natural variations

Natural variant3081G → R: dbSNP rs4148301.
VAR_024686
Natural variant3911V → I: dbSNP rs4148304.
VAR_057326

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Sequences

Sequence LengthMass (Da)Tools
Q9Y4X1-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B99E73AA9A421F17

FASTA52759,872
        10         20         30         40         50         60 
MLNNLLLFSL QISLIGTTLG GNVLIWPMEG SHWLNVKIII DELIKKEHNV TVLVASGALF 

        70         80         90        100        110        120 
ITPTSNPSLT FEIYKVPFGK ERIEGVIKDF VSTWLENRPS PSTIWRFYQE MAKVIKDFHM 

       130        140        150        160        170        180 
VSQEICDGVL KNQQLMAKLK KSKFEVLVSD PVFPCGDIVA LKLGIPFMYS LRFSPASTVE 

       190        200        210        220        230        240 
KHCGKVPYPP SYVPAVLSEL TDQMSFTDRI RNFISYHLQD YMFETLWKSW DSYYSKALGR 

       250        260        270        280        290        300 
PTTLCETMGK AEIWLIRTYW DFEFPRPYLP NFEFVGGLHC KPAKPLPKEM EEFIQSSGKN 

       310        320        330        340        350        360 
GVVVFSLGSM VKNLTEEKAN LIASALAQIP QKVLWRYKGK KPATLGNNTQ LFDWIPQNDL 

       370        380        390        400        410        420 
LGHPKTKAFI THGGTNGIYE AIYHGVPMVG VPMFADQPDN IAHMKAKGAA VEVNLNTMTS 

       430        440        450        460        470        480 
VDLLSALRTV INEPSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD 

       490        500        510        520 
LTWFQYHSLD VIGFLLVCVT TAIFLVIQCC LFSCQKFGKI GKKKKRE

« Hide

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References

[1]"Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase."
Jedlitschky G.A., Cassidy A.J., Sales M., Pratt N., Burchell B.
Biochem. J. 340:837-843(1999) [PubMed: 10359671] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Tissue: Olfactory bulb.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AJ006054 mRNA. Translation: CAB41974.1.
IPIIPI00009556.
RefSeqNP_006789.2.
UniGeneHs.225950

3D structure databases

SMRQ9Y4X1. Positions 283-444.
ModBaseSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEQ9Y4X1.

Genome annotation databases

EnsemblENSG00000173610. Homo sapiens. [Contig view]
GeneID10941.
KEGGhsa:10941.
UCSCuc003hem.2. human.

Organism-specific databases

GeneCardsGC04M070503.
H-InvDBHIX0031395.
HGNCHGNC:12542. UGT2A1.
MIM604716. gene.
PharmGKBPA37184.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y4X1.
HOVERGENQ9Y4X1.

Enzyme and pathway databases

BRENDA2.4.1.17. 247.
ReactomeREACT_13433. Biological oxidations.

Gene expression databases

ArrayExpressQ9Y4X1.
BgeeQ9Y4X1.
CleanExHS_UGT2A1.
GermOnlineENSG00000173610. Homo sapiens.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio41559.
SOURCESearch...

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Entry information

Entry nameUD2A1_HUMAN
AccessionPrimary (citable) accession number: Q9Y4X1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 1, 1999
Last modified: July 7, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents