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Reviewed, UniProtKB/Swiss-Prot Q9Y4W6 (AFG32_HUMAN)

Last modified November 24, 2009. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    AFG3-like protein 2
    EC=3.4.24.-
Alternative name(s):
    Paraplegin-like protein
Gene names
Name: AFG3L2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Putative ATP-dependent protease.

Cofactor

Binds 1 zinc ion per subunit Potential.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous.

Sequence similarities

In the N-terminal section; belongs to the AAA ATPase family.

In the C-terminal section; belongs to the peptidase M41 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 797797AFG3-like protein 2
PRO_0000084673

Regions

Transmembrane143 – 16321 Potential
Transmembrane251 – 27121 Potential
Nucleotide binding348 – 3558ATP Potential

Sites

Active site5751 By similarity
Metal binding5741Zinc; catalytic By similarity
Metal binding5781Zinc; catalytic By similarity

Amino acid modifications

Modified residue3061N6-acetyllysine Ref.4
Modified residue3081N6-acetyllysine By similarity
Modified residue5431N6-acetyllysine Ref.4

Experimental info

Sequence conflict741E → G in CAB48398. Ref.1
Sequence conflict6331V → A in CAB48398. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y4W6-1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: EACBB7C5F2EE5E08

FASTA79788,584
        10         20         30         40         50         60 
MAHRCLRLWG RGGCWPRGLQ QLLVPGGVGP GEQPCLRTLY RFVTTQARAS RNSLLTDIIA 

        70         80         90        100        110        120 
AYQRFCSRPP KGFEKYFPNG KNGKKASEPK EVMGEKKESK PAATTRSSGG GGGGGGKRGG 

       130        140        150        160        170        180 
KKDDSHWWSR FQKGDIPWDD KDFRMFFLWT ALFWGGVMFY LLLKRSGREI TWKDFVNNYL 

       190        200        210        220        230        240 
SKGVVDRLEV VNKRFVRVTF TPGKTPVDGQ YVWFNIGSVD TFERNLETLQ QELGIEGENR 

       250        260        270        280        290        300 
VPVVYIAESD GSFLLSMLPT VLIIAFLLYT IRRGPAGIGR TGRGMGGLFS VGETTAKVLK 

       310        320        330        340        350        360 
DEIDVKFKDV AGCEEAKLEI MEFVNFLKNP KQYQDLGAKI PKGAILTGPP GTGKTLLAKA 

       370        380        390        400        410        420 
TAGEANVPFI TVSGSEFLEM FVGVGPARVR DLFALARKNA PCILFIDEID AVGRKRGRGN 

       430        440        450        460        470        480 
FGGQSEQENT LNQLLVEMDG FNTTTNVVIL AGTNRPDILD PALLRPGRFD RQIFIGPPDI 

       490        500        510        520        530        540 
KGRASIFKVH LRPLKLDSTL EKDKLARKLA SLTPGFSGAD VANVCNEAAL IAARHLSDSI 

       550        560        570        580        590        600 
NQKHFEQAIE RVIGGLEKKT QVLQPEEKKT VAYHEAGHAV AGWYLEHADP LLKVSIIPRG 

       610        620        630        640        650        660 
KGLGYAQYLP KEQYLYTKEQ LLDRMCMTLG GRVSEEIFFG RITTGAQDDL RKVTQSAYAQ 

       670        680        690        700        710        720 
IVQFGMNEKV GQISFDLPRQ GDMVLEKPYS EATARLIDDE VRILINDAYK RTVALLTEKK 

       730        740        750        760        770        780 
ADVEKVALLL LEKEVLDKND MVELLGPRPF AEKSTYEEFV EGTGSLDEDT SLPEGLKDWN 

       790 
KEREKEKEEP PGEKVAN 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of AFG3L2, a novel paraplegin-related gene."
Banfi S., Bassi M.T., Andolfi G., Marchitiello A., Zanotta S., Ballabio A., Casari G., Franco B.
Genomics 59:51-58(1999) [PubMed: 10395799] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-306 AND LYS-543, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

Y18314 mRNA. Translation: CAB48398.1.
BC065016 mRNA. Translation: AAH65016.1.
IPIIPI00001091.
RefSeqNP_006787.1.
UniGeneHs.528996

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y4W6. 2 interactions.
STRINGQ9Y4W6.

Protein family/group databases

MEROPSM41.007.

PTM databases

PhosphoSiteQ9Y4W6.

Proteomic databases

PeptideAtlasQ9Y4W6.
PRIDEQ9Y4W6.

Genome annotation databases

EnsemblENST00000269143; ENSP00000269143; ENSG00000141385; Homo sapiens. [Genome view]
GeneID10939.
KEGGhsa:10939.
UCSCuc002kqz.1. human.

Organism-specific databases

CTD10939.
GeneCardsGC18M012319.
H-InvDBHIX0027367.
HGNCHGNC:315. AFG3L2.
HPAHPA004479.
HPA004480.
MIM604581. gene.
PharmGKBPA24612.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9Y4W6.
OMALNGKKPN
OrthoDBEOG9QNQG0

Gene expression databases

ArrayExpressQ9Y4W6.
BgeeQ9Y4W6.
CleanExHS_AFG3L2.
GenevestigatorQ9Y4W6.
GermOnlineENSG00000141385. Homo sapiens.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. Pept_M41_FtsH.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00171. Adenosine triphosphate.
NextBio41551.
SOURCESearch...

Entry information

Entry nameAFG32_HUMAN
AccessionPrimary (citable) accession number: Q9Y4W6
Secondary accession number(s): Q6P1L0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 20, 2007
Last modified: November 24, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents