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Q9Y4W2

- LAS1L_HUMAN

UniProt

Q9Y4W2 - LAS1L_HUMAN

Protein

Ribosomal biogenesis protein LAS1L

Gene

LAS1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal biogenesis protein LAS1L
    Alternative name(s):
    Protein LAS1 homolog
    Gene namesi
    Name:LAS1L
    ORF Names:MSTP060
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25726. LAS1L.

    Subcellular locationi

    Nucleusnucleolus 2 Publications. Nucleusnucleoplasm By similarity. Cytoplasm By similarity
    Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions By similarity. Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. membrane Source: UniProtKB
    3. microtubule organizing center Source: HPA
    4. MLL1 complex Source: UniProtKB
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394732.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 734734Ribosomal biogenesis protein LAS1LPRO_0000211559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei523 – 5231Phosphoserine2 Publications
    Modified residuei560 – 5601Phosphoserine2 Publications
    Modified residuei617 – 6171Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4W2.
    PaxDbiQ9Y4W2.
    PRIDEiQ9Y4W2.

    2D gel databases

    SWISS-2DPAGEQ9Y4W2.

    PTM databases

    PhosphoSiteiQ9Y4W2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y4W2.
    BgeeiQ9Y4W2.
    CleanExiHS_LAS1L.
    GenevestigatoriQ9Y4W2.

    Organism-specific databases

    HPAiHPA044431.

    Interactioni

    Subunit structurei

    Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PNKPQ96T601EBI-1051591,EBI-1045072

    Protein-protein interaction databases

    BioGridi123620. 23 interactions.
    IntActiQ9Y4W2. 10 interactions.
    MINTiMINT-4728360.
    STRINGi9606.ENSP00000363944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAS1 family.Curated

    Phylogenomic databases

    eggNOGiNOG323169.
    HOGENOMiHOG000232090.
    HOVERGENiHBG080556.
    InParanoidiQ9Y4W2.
    KOiK16912.
    OMAiPFSQFWQ.
    OrthoDBiEOG7G7KPC.
    PhylomeDBiQ9Y4W2.
    TreeFamiTF314042.

    Family and domain databases

    InterProiIPR007174. Las1.
    [Graphical view]
    PANTHERiPTHR15002. PTHR15002. 1 hit.
    PfamiPF04031. Las1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4W2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE    50
    WDQVTVYLFC DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL 100
    DVTGGLGTDE LRLLYGMALV RFVNLISERK TKFAKVPLKC LAQEVNIPDW 150
    IVDLRHELTH KKMPHINDCR RGCYFVLDWL QKTYWCRQLE NSLRETWELE 200
    EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV KADGDSKGSE 250
    EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP 300
    SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ 350
    TEVQRGEGTD PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE 400
    RMLSELPALG ISGIRPTYIL RWTVELIVAN TKTGRNARRF SAGQWEARRG 450
    WRLFNCSASL DWPRMVESCL GSPCWASPQL LRIIFKAMGQ GLPDEEQEKL 500
    LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK PASSSFGSEA 550
    KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD 600
    EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF 650
    PLGRMPGQTE DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG 700
    VGSGNCSNSS SSNFEGLLWS QGQLHGLKTG LQLF 734
    Length:734
    Mass (Da):83,065
    Last modified:August 30, 2005 - v2
    Checksum:iA35CC38F95C39F7D
    GO
    Isoform 2 (identifier: Q9Y4W2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-365: DGQTEVQRGEGTDPKSHK → E

    Show »
    Length:717
    Mass (Da):81,243
    Checksum:i651B7F0FFB3FD07F
    GO
    Isoform 3 (identifier: Q9Y4W2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-120: Missing.
         348-365: DGQTEVQRGEGTDPKSHK → E

    Note: Gene prediction based on EST data. No experimental confirmation available.

    Show »
    Length:675
    Mass (Da):76,845
    Checksum:iEC904EABA17F0028
    GO
    Isoform 4 (identifier: Q9Y4W2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         283-291: VLEKFRYLP → GGCAGCFSG
         292-734: Missing.

    Show »
    Length:291
    Mass (Da):33,108
    Checksum:i500B863F92E96866
    GO

    Sequence cautioni

    The sequence BAB84913.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701R → C in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036587

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei79 – 12042Missing in isoform 3. CuratedVSP_015178Add
    BLAST
    Alternative sequencei283 – 2919VLEKFRYLP → GGCAGCFSG in isoform 4. 1 PublicationVSP_015179
    Alternative sequencei292 – 734443Missing in isoform 4. 1 PublicationVSP_015180Add
    BLAST
    Alternative sequencei348 – 36518DGQTE…PKSHK → E in isoform 2 and isoform 3. 1 PublicationVSP_015181Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116730 mRNA. Translation: AAO15306.1.
    AK074087 mRNA. Translation: BAB84913.1. Different initiation.
    AK022587 mRNA. Translation: BAB14114.1.
    AL050306 Genomic DNA. Translation: CAB51351.1.
    AL050306 Genomic DNA. Translation: CAI42835.1.
    AL050306 Genomic DNA. Translation: CAI42836.1.
    BC014545 mRNA. Translation: AAH14545.1.
    BC018610 mRNA. Translation: AAH18610.1.
    BC019302 mRNA. Translation: AAH19302.1.
    DQ323624 mRNA. Translation: ABD39127.1.
    CCDSiCCDS14381.1. [Q9Y4W2-1]
    CCDS55433.1. [Q9Y4W2-3]
    CCDS55434.1. [Q9Y4W2-2]
    RefSeqiNP_001164120.1. NM_001170649.1. [Q9Y4W2-2]
    NP_001164121.1. NM_001170650.1. [Q9Y4W2-3]
    NP_112483.1. NM_031206.4. [Q9Y4W2-1]
    UniGeneiHs.522675.

    Genome annotation databases

    EnsembliENST00000374804; ENSP00000363937; ENSG00000001497. [Q9Y4W2-3]
    ENST00000374807; ENSP00000363940; ENSG00000001497. [Q9Y4W2-2]
    ENST00000374811; ENSP00000363944; ENSG00000001497. [Q9Y4W2-1]
    ENST00000484069; ENSP00000473471; ENSG00000001497. [Q9Y4W2-4]
    GeneIDi81887.
    KEGGihsa:81887.
    UCSCiuc004dwa.2. human. [Q9Y4W2-1]
    uc004dwc.2. human. [Q9Y4W2-2]
    uc004dwd.2. human. [Q9Y4W2-3]

    Polymorphism databases

    DMDMi73920837.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116730 mRNA. Translation: AAO15306.1 .
    AK074087 mRNA. Translation: BAB84913.1 . Different initiation.
    AK022587 mRNA. Translation: BAB14114.1 .
    AL050306 Genomic DNA. Translation: CAB51351.1 .
    AL050306 Genomic DNA. Translation: CAI42835.1 .
    AL050306 Genomic DNA. Translation: CAI42836.1 .
    BC014545 mRNA. Translation: AAH14545.1 .
    BC018610 mRNA. Translation: AAH18610.1 .
    BC019302 mRNA. Translation: AAH19302.1 .
    DQ323624 mRNA. Translation: ABD39127.1 .
    CCDSi CCDS14381.1. [Q9Y4W2-1 ]
    CCDS55433.1. [Q9Y4W2-3 ]
    CCDS55434.1. [Q9Y4W2-2 ]
    RefSeqi NP_001164120.1. NM_001170649.1. [Q9Y4W2-2 ]
    NP_001164121.1. NM_001170650.1. [Q9Y4W2-3 ]
    NP_112483.1. NM_031206.4. [Q9Y4W2-1 ]
    UniGenei Hs.522675.

    3D structure databases

    ProteinModelPortali Q9Y4W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123620. 23 interactions.
    IntActi Q9Y4W2. 10 interactions.
    MINTi MINT-4728360.
    STRINGi 9606.ENSP00000363944.

    PTM databases

    PhosphoSitei Q9Y4W2.

    Polymorphism databases

    DMDMi 73920837.

    2D gel databases

    SWISS-2DPAGE Q9Y4W2.

    Proteomic databases

    MaxQBi Q9Y4W2.
    PaxDbi Q9Y4W2.
    PRIDEi Q9Y4W2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374804 ; ENSP00000363937 ; ENSG00000001497 . [Q9Y4W2-3 ]
    ENST00000374807 ; ENSP00000363940 ; ENSG00000001497 . [Q9Y4W2-2 ]
    ENST00000374811 ; ENSP00000363944 ; ENSG00000001497 . [Q9Y4W2-1 ]
    ENST00000484069 ; ENSP00000473471 ; ENSG00000001497 . [Q9Y4W2-4 ]
    GeneIDi 81887.
    KEGGi hsa:81887.
    UCSCi uc004dwa.2. human. [Q9Y4W2-1 ]
    uc004dwc.2. human. [Q9Y4W2-2 ]
    uc004dwd.2. human. [Q9Y4W2-3 ]

    Organism-specific databases

    CTDi 81887.
    GeneCardsi GC0XM064649.
    HGNCi HGNC:25726. LAS1L.
    HPAi HPA044431.
    neXtProti NX_Q9Y4W2.
    PharmGKBi PA128394732.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323169.
    HOGENOMi HOG000232090.
    HOVERGENi HBG080556.
    InParanoidi Q9Y4W2.
    KOi K16912.
    OMAi PFSQFWQ.
    OrthoDBi EOG7G7KPC.
    PhylomeDBi Q9Y4W2.
    TreeFami TF314042.

    Miscellaneous databases

    ChiTaRSi LAS1L. human.
    GeneWikii LAS1L.
    GenomeRNAii 81887.
    NextBioi 72228.
    PROi Q9Y4W2.

    Gene expression databases

    ArrayExpressi Q9Y4W2.
    Bgeei Q9Y4W2.
    CleanExi HS_LAS1L.
    Genevestigatori Q9Y4W2.

    Family and domain databases

    InterProi IPR007174. Las1.
    [Graphical view ]
    PANTHERi PTHR15002. PTHR15002. 1 hit.
    Pfami PF04031. Las1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Aorta.
    2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Spleen.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Bone marrow, Lung and Placenta.
    6. "Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs)."
      Krull M., Petrusma M., Makalowski W., Brosius J., Schmitz J.
      Genome Res. 17:1139-1145(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 345-377.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
      Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
      Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis."
      Castle C.D., Cassimere E.K., Lee J., Denicourt C.
      Mol. Cell. Biol. 30:4404-4414(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560 AND SER-617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560 AND SER-617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
      Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J., Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.
      Mol. Cell. Proteomics 11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE 5FMC COMPLEX.
    18. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-170.

    Entry informationi

    Entry nameiLAS1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4W2
    Secondary accession number(s): A9X410
    , Q5JXQ0, Q8TEN5, Q9H9V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

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