Reviewed,
UniProtKB/Swiss-Prot Q9Y4R8 (TELO2_HUMAN)
Last modified
July 7, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Telomere length regulation protein TEL2 homolog Alternative name(s): Protein clk-2 homolog Short name=hCLK2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 837 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in telomere length regulation. May be involved in growth regulation. Ref.8 |
| Subcellular location | |
| Miscellaneous | Cells overexpressing TELO2 are hypersensitive to hydroxyurea (HU) and undergo apoptotic death in response to treatment with HU. |
| Sequence similarities | Belongs to the TEL2 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Chromosomal protein Cytoplasm Membrane Nucleus Telomere |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell membraneInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ATM | Q13315 | 1 | EBI-1043674,EBI-495465 | |
| Frap1 | P42346 | 1 | EBI-1043674,EBI-1571489 | From a different organism. |
| MAGED1 | Q9Y5V3 | 1 | EBI-1043674,EBI-716006 | |
| PSMD6 | Q15008 | 1 | EBI-1043674,EBI-359701 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 837 | 837 | Telomere length regulation protein TEL2 homolog | PRO_0000318515 | |||||
Amino acid modifications | |||||||||
| Modified residue | 688 | 1 | Phosphoserine Ref.9 | ||||||
| Modified residue | 836 | 1 | Phosphoserine Ref.9 Ref.10 | ||||||
Natural variations | |||||||||
| Natural variant | 7 | 1 | E → G: dbSNP rs2667661. | VAR_038752 | |||||
| Natural variant | 146 | 1 | Q → R: dbSNP rs2235624. Ref.2 Ref.3 Ref.6 Ref.7 | VAR_038753 | |||||
| Natural variant | 674 | 1 | Q → R: dbSNP rs2248128. | VAR_038754 | |||||
Experimental info | |||||||||
| Sequence conflict | 7 | 1 | E → R in BAA31658. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [2] | "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A.Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-146. Tissue: Testis. |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-146. Tissue: Testis. |
| [4] | "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-146. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-146. Tissue: Placenta. |
| [8] | "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation." Jiang N., Benard C.Y., Kebir H., Shoubridge E.A., Hekimi S. J. Biol. Chem. 278:21678-21684(2003) [PubMed: 12670948] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| [9] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688 AND SER-836, MASS SPECTROMETRY. |
| [10] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-836, MASS SPECTROMETRY. |
| [11] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AB014583 mRNA. Translation: BAA31658.3. Different initiation. AL080126 mRNA. Translation: CAB45724.1. AL137394 mRNA. Translation: CAB70722.1. AE006467 Genomic DNA. Translation: AAK61284.1. AL031705 Genomic DNA. Translation: CAC37283.1. CH471112 Genomic DNA. Translation: EAW85647.1. BC017188 mRNA. Translation: AAH17188.1. | |
| IPI | IPI00016868. |
| PIR | T12514. |
| RefSeq | NP_057195.2. |
| UniGene | Hs.271044 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y4R8. 11 interactions. |
Proteomic databases | |
| PRIDE | Q9Y4R8. |
Genome annotation databases | |
| Ensembl | ENSG00000100726. Homo sapiens. [Contig view] |
| GeneID | 9894. |
| KEGG | hsa:9894. |
| UCSC | uc002cly.1. human. |
Organism-specific databases | |
| GeneCards | GC16P001484. |
| HGNC | HGNC:29099. TELO2. |
| MIM | 611140. gene. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y4R8. |
| OMA | Q9Y4R8. RIHPEGP. |
Gene expression databases | |
| Bgee | Q9Y4R8. |
| CleanEx | HS_TELO2. |
Family and domain databases | |
| InterPro | IPR019337. Telomere_length_regulation. [Graphical view] |
| Pfam | PF10193. Telomere_reg-2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 37303. |
| SOURCE | Search... |
Entry information
| Entry name | TELO2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y4R8 Secondary accession number(s): O75168, Q7LDV4, Q9BR21 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


