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Protein

Sperm flagellar protein 1

Gene

SPEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm flagellar protein 1
Gene namesi
Name:SPEF1
Synonyms:C20orf28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15874. SPEF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404432.

Polymorphism and mutation databases

BioMutaiSPEF1.
DMDMi152031688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Sperm flagellar protein 1PRO_0000079421Add
BLAST

Proteomic databases

PaxDbiQ9Y4P9.
PeptideAtlasiQ9Y4P9.
PRIDEiQ9Y4P9.

PTM databases

PhosphoSiteiQ9Y4P9.

Expressioni

Gene expression databases

BgeeiENSG00000101222.
CleanExiHS_SPEF1.
GenevisibleiQ9Y4P9. HS.

Organism-specific databases

HPAiHPA050786.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-740053,EBI-10171697

Protein-protein interaction databases

BioGridi117391. 3 interactions.
IntActiQ9Y4P9. 3 interactions.
MINTiMINT-1462410.
STRINGi9606.ENSP00000369080.

Structurei

Secondary structure

1
236
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1913Combined sources
Helixi29 – 335Combined sources
Helixi37 – 4610Combined sources
Turni48 – 503Combined sources
Helixi62 – 7514Combined sources
Helixi78 – 803Combined sources
Helixi86 – 938Combined sources
Turni97 – 1004Combined sources
Helixi101 – 11616Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE7NMR-A1-120[»]
ProteinModelPortaliQ9Y4P9.
SMRiQ9Y4P9. Positions 5-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4P9.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYU4. Eukaryota.
ENOG4111WVQ. LUCA.
GeneTreeiENSGT00510000048195.
HOGENOMiHOG000231709.
HOVERGENiHBG051156.
InParanoidiQ9Y4P9.
OMAiDYMDVGL.
OrthoDBiEOG091G0V3B.
PhylomeDBiQ9Y4P9.
TreeFamiTF323506.

Family and domain databases

InterProiIPR001715. CH-domain.
IPR010441. CH_2.
[Graphical view]
PANTHERiPTHR12509. PTHR12509. 1 hit.
PfamiPF06294. CH_2. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4P9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSVDEEAL HQLYLWVDNI PLSRPKRNLS RDFSDGVLVA EVIKFYFPKM
60 70 80 90 100
VEMHNYVPAN SLQQKLSNWG HLNRKVLKRL NFSVPDDVMR KIAQCAPGVV
110 120 130 140 150
ELVLIPLRQR LEERQRRRKQ GAGSLQELAP QDGSGYMDVG VSQKARGEGV
160 170 180 190 200
PDPQGGGQLS WDRPPAPRPP AYNRALQGDP SFVLQIAEKE QELLASQETV
210 220 230
QVLQMKVRRL EHLLQLKNVR IEDLSRRLQQ AERKQR
Note: Gene prediction based on EST data. No experimental confirmation available.
Length:236
Mass (Da):26,987
Last modified:July 10, 2007 - v3
Checksum:i74FE1C07D5DE749E
GO
Isoform 2 (identifier: Q9Y4P9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-162: VSQKARGEGVPDPQGGGQLSWD → KVAFSISPSRLELSFCPSSCHL
     163-236: Missing.

Show »
Length:162
Mass (Da):18,435
Checksum:iA496B8FA659AE66B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 16222VSQKA…QLSWD → KVAFSISPSRLELSFCPSSC HL in isoform 2. 2 PublicationsVSP_017219Add
BLAST
Alternative sequencei163 – 23674Missing in isoform 2. 2 PublicationsVSP_017220Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080154 mRNA. Translation: CAB45745.1.
EF560745 mRNA. Translation: ABQ59055.1.
AL109804 Genomic DNA. Translation: CAI18846.2.
CH471133 Genomic DNA. Translation: EAX10503.1.
CH471133 Genomic DNA. Translation: EAX10504.1.
CH471133 Genomic DNA. Translation: EAX10505.1.
BC022476 mRNA. Translation: AAH22476.1.
CCDSiCCDS13063.2. [Q9Y4P9-1]
PIRiT12538.
RefSeqiNP_056232.2. NM_015417.4. [Q9Y4P9-1]
UniGeneiHs.72620.

Genome annotation databases

EnsembliENST00000379756; ENSP00000369080; ENSG00000101222. [Q9Y4P9-1]
GeneIDi25876.
KEGGihsa:25876.
UCSCiuc002wjj.4. human. [Q9Y4P9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080154 mRNA. Translation: CAB45745.1.
EF560745 mRNA. Translation: ABQ59055.1.
AL109804 Genomic DNA. Translation: CAI18846.2.
CH471133 Genomic DNA. Translation: EAX10503.1.
CH471133 Genomic DNA. Translation: EAX10504.1.
CH471133 Genomic DNA. Translation: EAX10505.1.
BC022476 mRNA. Translation: AAH22476.1.
CCDSiCCDS13063.2. [Q9Y4P9-1]
PIRiT12538.
RefSeqiNP_056232.2. NM_015417.4. [Q9Y4P9-1]
UniGeneiHs.72620.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE7NMR-A1-120[»]
ProteinModelPortaliQ9Y4P9.
SMRiQ9Y4P9. Positions 5-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117391. 3 interactions.
IntActiQ9Y4P9. 3 interactions.
MINTiMINT-1462410.
STRINGi9606.ENSP00000369080.

PTM databases

PhosphoSiteiQ9Y4P9.

Polymorphism and mutation databases

BioMutaiSPEF1.
DMDMi152031688.

Proteomic databases

PaxDbiQ9Y4P9.
PeptideAtlasiQ9Y4P9.
PRIDEiQ9Y4P9.

Protocols and materials databases

DNASUi25876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379756; ENSP00000369080; ENSG00000101222. [Q9Y4P9-1]
GeneIDi25876.
KEGGihsa:25876.
UCSCiuc002wjj.4. human. [Q9Y4P9-1]

Organism-specific databases

CTDi25876.
GeneCardsiSPEF1.
HGNCiHGNC:15874. SPEF1.
HPAiHPA050786.
MIMi610674. gene.
neXtProtiNX_Q9Y4P9.
PharmGKBiPA162404432.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYU4. Eukaryota.
ENOG4111WVQ. LUCA.
GeneTreeiENSGT00510000048195.
HOGENOMiHOG000231709.
HOVERGENiHBG051156.
InParanoidiQ9Y4P9.
OMAiDYMDVGL.
OrthoDBiEOG091G0V3B.
PhylomeDBiQ9Y4P9.
TreeFamiTF323506.

Miscellaneous databases

EvolutionaryTraceiQ9Y4P9.
GeneWikiiSPEF1.
GenomeRNAii25876.
PROiQ9Y4P9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101222.
CleanExiHS_SPEF1.
GenevisibleiQ9Y4P9. HS.

Family and domain databases

InterProiIPR001715. CH-domain.
IPR010441. CH_2.
[Graphical view]
PANTHERiPTHR12509. PTHR12509. 1 hit.
PfamiPF06294. CH_2. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPEF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4P9
Secondary accession number(s): A5YM71, D3DVY0, Q5JX78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.