Q9Y4P8 (WIPI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat domain phosphoinositide-interacting protein 2
Short name=WIPI-2

Alternative name(s):
WIPI49-like protein 2

Gene names

Name:	WIPI2
ORF Names:	CGI-50

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P. Ref.10
Subunit structure	Interacts with TECPR1. Ref.11
Subcellular location	Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note: Enriched at preautophagosomal structure membranes in response to ptdIns3P. Ref.10
Tissue specificity	Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. Ref.1 Ref.10
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 3 WD repeats.

Ontologies

Keywords
Biological process	Autophagy
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagic vacuole assembly Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	autophagic vacuole membrane Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol Inferred from direct assay Ref.10. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA pre-autophagosomal structure membrane Inferred from direct assay Ref.10. Source: UniProtKB protein complex Inferred from direct assay. Source: LIFEdb
Molecular_function	phosphatidylinositol-3,5-bisphosphate binding Inferred from direct assay Ref.10. Source: UniProtKB phosphatidylinositol-3-phosphate binding Inferred from direct assay Ref.10. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4P8-1)

Also known as: WIPI-2 alpha; WIPI2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4P8-2)

Also known as: WIPI-2 beta; WIPI2d;

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.
     407-417: Missing.

Isoform 3 (identifier: Q9Y4P8-3)

Also known as: WIPI2e;

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-71: SVDKLEQIYECT → MFTHVLPFVISA
     407-417: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9Y4P8-4)

Also known as: WIPI2b;

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.

Isoform 5 (identifier: Q9Y4P8-5)

Also known as: WIPI-2 delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MNLASQSGEA...DKLEQIYECT → MLLRLQRIKT...THVLPFVISA
     407-417: Missing.

Isoform 6 (identifier: Q9Y4P8-6)

Also known as: WIPI2c;

The sequence of this isoform differs from the canonical sequence as follows:
     407-417: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	WD repeat domain phosphoinositide-interacting protein 2		PRO_0000051440
Regions
	Repeat	200 – 240	41	WD 1
	Repeat	246 – 285	40	WD 2
	Repeat	329 – 367	39	WD 3
Amino acid modifications
	Modified residue	412	1	Phosphoserine By similarity
	Modified residue	413	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 71	71	MNLAS…IYECT → MLLRLQRIKTLRPPGCPHPM TTCSAGTLSAVPCVSPRQVF VFERRFCLWHSHVEMFTHVL PFVISA in isoform 5.		VSP_016971
	Alternative sequence	1 – 59	59	Missing in isoform 3.		VSP_016970
	Alternative sequence	26 – 43	18	Missing in isoform 2 and isoform 4.		VSP_016972
	Alternative sequence	60 – 71	12	SVDKL…IYECT → MFTHVLPFVISA in isoform 3.		VSP_016973
	Alternative sequence	407 – 417	11	Missing in isoform 2, isoform 3, isoform 5 and isoform 6.		VSP_016974
Experimental info
	Sequence conflict	139	1	I → T in CAG38561. Ref.1
	Sequence conflict	165	1	S → P in AAV80761. Ref.1
	Sequence conflict	380	1	E → K in AAD34045. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (WIPI-2 alpha) (WIPI2a) [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B69CEC399B56F35C	FASTA	454	49,408
	10 20 30 40 50 60 MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK SGYKFFSLSS 70 80 90 100 110 120 VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK VCHFKKGTEI CNYSYSNTIL 130 140 150 160 170 180 AVKLNRQRLI VCLEESLYIH NIRDMKVLHT IRETPPNPAG LCALSINNDN CYLAYPGSAT 190 200 210 220 230 240 IGEVQVFDTI NLRAANMIPA HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE 250 260 270 280 290 300 FRRGVKRCVS ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM 310 320 330 340 350 360 ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA DGYLYMYNLD 370 380 390 400 410 420 PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY GAAAGKGTYV PSSPTRLAYT 430 440 450 DDLGAVGGAC LEDEASALRL DEDSEHPPMI LRTD
	Isoform 2 (WIPI-2 beta) (WIPI2d) [UniParc]. Checksum: 5FD85B554CA97F41	FASTA	425	46,384
	10 20 30 40 50 60 MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 70 80 90 100 110 120 VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 130 140 150 160 170 180 IHNIRDMKVL HTIRETPPNP AGLCALSINN DNCYLAYPGS ATIGEVQVFD TINLRAANMI 190 200 210 220 230 240 PAHDSPLAAL AFDASGTKLA TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM 250 260 270 280 290 300 DGMFLSASSN TETVHIFKLE TVKEKPPEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR 310 320 330 340 350 360 AFATVRLPFC GHKNICSLAT IQKIPRLLVG AADGYLYMYN LDPQEGGECA LMKQHRLDGS 370 380 390 400 410 420 LETTNEILDS ASHDCPLVTQ TYGAAAGKAY TDDLGAVGGA CLEDEASALR LDEDSEHPPM ILRTD
	Isoform 3 (WIPI2e) [UniParc]. Checksum: E4C83CA999C10460	FASTA	384	42,077
	10 20 30 40 50 60 MFTHVLPFVI SADTEDVCIV ERLFSSSLVA IVSLKAPRKL KVCHFKKGTE ICNYSYSNTI 70 80 90 100 110 120 LAVKLNRQRL IVCLEESLYI HNIRDMKVLH TIRETPPNPA GLCALSINND NCYLAYPGSA 130 140 150 160 170 180 TIGEVQVFDT INLRAANMIP AHDSPLAALA FDASGTKLAT ASEKGTVIRV FSIPEGQKLF 190 200 210 220 230 240 EFRRGVKRCV SICSLAFSMD GMFLSASSNT ETVHIFKLET VKEKPPEEPT TWTGYFGKVL 250 260 270 280 290 300 MASTSYLPSQ VTEMFNQGRA FATVRLPFCG HKNICSLATI QKIPRLLVGA ADGYLYMYNL 310 320 330 340 350 360 DPQEGGECAL MKQHRLDGSL ETTNEILDSA SHDCPLVTQT YGAAAGKAYT DDLGAVGGAC 370 380 LEDEASALRL DEDSEHPPMI LRTD
	Isoform 4 (WIPI2b) [UniParc]. Checksum: 0266FEC9E5338877	FASTA	436	47,543
	10 20 30 40 50 60 MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 70 80 90 100 110 120 VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 130 140 150 160 170 180 IHNIRDMKVL HTIRETPPNP AGLCALSINN DNCYLAYPGS ATIGEVQVFD TINLRAANMI 190 200 210 220 230 240 PAHDSPLAAL AFDASGTKLA TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM 250 260 270 280 290 300 DGMFLSASSN TETVHIFKLE TVKEKPPEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR 310 320 330 340 350 360 AFATVRLPFC GHKNICSLAT IQKIPRLLVG AADGYLYMYN LDPQEGGECA LMKQHRLDGS 370 380 390 400 410 420 LETTNEILDS ASHDCPLVTQ TYGAAAGKGT YVPSSPTRLA YTDDLGAVGG ACLEDEASAL 430 RLDEDSEHPP MILRTD
	Isoform 5 (WIPI-2 delta) [UniParc]. Checksum: D9F056ACE602F833	FASTA	438	48,251
	10 20 30 40 50 60 MLLRLQRIKT LRPPGCPHPM TTCSAGTLSA VPCVSPRQVF VFERRFCLWH SHVEMFTHVL 70 80 90 100 110 120 PFVISADTED VCIVERLFSS SLVAIVSLKA PRKLKVCHFK KGTEICNYSY SNTILAVKLN 130 140 150 160 170 180 RQRLIVCLEE SLYIHNIRDM KVLHTIRETP PNPAGLCALS INNDNCYLAY PGSATIGEVQ 190 200 210 220 230 240 VFDTINLRAA NMIPAHDSPL AALAFDASGT KLATASEKGT VIRVFSIPEG QKLFEFRRGV 250 260 270 280 290 300 KRCVSICSLA FSMDGMFLSA SSNTETVHIF KLETVKEKPP EEPTTWTGYF GKVLMASTSY 310 320 330 340 350 360 LPSQVTEMFN QGRAFATVRL PFCGHKNICS LATIQKIPRL LVGAADGYLY MYNLDPQEGG 370 380 390 400 410 420 ECALMKQHRL DGSLETTNEI LDSASHDCPL VTQTYGAAAG KAYTDDLGAV GGACLEDEAS 430 ALRLDEDSEH PPMILRTD
	Isoform 6 (WIPI2c) [UniParc]. Checksum: A07814F3A3C402A1	FASTA	443	48,249
	10 20 30 40 50 60 MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK SGYKFFSLSS 70 80 90 100 110 120 VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK VCHFKKGTEI CNYSYSNTIL 130 140 150 160 170 180 AVKLNRQRLI VCLEESLYIH NIRDMKVLHT IRETPPNPAG LCALSINNDN CYLAYPGSAT 190 200 210 220 230 240 IGEVQVFDTI NLRAANMIPA HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE 250 260 270 280 290 300 FRRGVKRCVS ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM 310 320 330 340 350 360 ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA DGYLYMYNLD 370 380 390 400 410 420 PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY GAAAGKAYTD DLGAVGGACL 430 440 EDEASALRLD EDSEHPPMIL RTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A. Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Lymphoma, Placenta and Skin.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation." Polson H.E., de Lartigue J., Rigden D.J., Reedijk M., Urbe S., Clague M.J., Tooze S.A. Autophagy 6:506-522(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6), PHOSPHOINOSITIDES-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens." Ogawa M., Yoshikawa Y., Kobayashi T., Mimuro H., Fukumatsu M., Kiga K., Piao Z., Ashida H., Yoshida M., Kakuta S., Koyama T., Goto Y., Nagatake T., Nagai S., Kiyono H., Kawalec M., Reichhart J.M., Sasakawa C. Cell Host Microbe 9:376-389(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TECPR1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY691425 mRNA. Translation: AAV80761.1. AY691426 mRNA. Translation: AAV80762.1. AF151808 mRNA. Translation: AAD34045.1. AL080155 mRNA. Translation: CAB45746.1. CR533530 mRNA. Translation: CAG38561.1. AK024279 mRNA. Translation: BAG51284.1. AC093376 Genomic DNA. Translation: AAQ96865.1. AC093376 Genomic DNA. Translation: AAQ96866.1. AC093376 Genomic DNA. Translation: AAQ96867.1. CH471144 Genomic DNA. Translation: EAW87328.1. BC004116 mRNA. Translation: AAH04116.1. BC007596 mRNA. Translation: AAH07596.1. BC021068 mRNA. No translation available. BC021200 mRNA. Translation: AAH21200.1.
IPI	IPI00006533. IPI00024056. IPI00651628. IPI00651631. IPI00651668. IPI00657808.
PIR	T12539.
RefSeq	NP_001028690.1. NM_001033518.1. NP_001028691.1. NM_001033519.1. NP_001028692.1. NM_001033520.1. NP_056425.1. NM_015610.3. NP_057087.2. NM_016003.3.
UniGene	Hs.122363.
3D structure databases
ProteinModelPortal	Q9Y4P8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4P8. 26 interactions.
MINT	MINT-1386092.
STRING	9606.ENSP00000288828.
PTM databases
PhosphoSite	Q9Y4P8.
Polymorphism databases
DMDM	74762063.
Proteomic databases
PaxDb	Q9Y4P8.
PRIDE	Q9Y4P8.
Protocols and materials databases
DNASU	26100.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288828; ENSP00000288828; ENSG00000157954. ENST00000382384; ENSP00000371821; ENSG00000157954. ENST00000401525; ENSP00000384945; ENSG00000157954. ENST00000404704; ENSP00000385297; ENSG00000157954. ENST00000484262; ENSP00000429654; ENSG00000157954.
GeneID	26100.
KEGG	hsa:26100.
UCSC	uc003snv.3. human. uc003snw.3. human. uc003snx.3. human. uc003sny.3. human. uc003soa.3. human.
Organism-specific databases
CTD	26100.
GeneCards	GC07P005229.
HGNC	HGNC:32225. WIPI2.
HPA	HPA019852. HPA021488.
MIM	609225. gene.
neXtProt	NX_Q9Y4P8.
PharmGKB	PA142670576.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317564.
HOGENOM	HOG000217544.
HOVERGEN	HBG056639.
InParanoid	Q9Y4P8.
OMA	METTNEI.
OrthoDB	EOG4S4PG4.
PhylomeDB	Q9Y4P8.
Gene expression databases
ArrayExpress	Q9Y4P8.
Bgee	Q9Y4P8.
CleanEx	HS_WIPI2.
Genevestigator	Q9Y4P8.
GermOnline	ENSG00000157954. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WIPI2. human.
GenomeRNAi	26100.
NextBio	48085.
SOURCE	Search...

Entry information

Entry name

WIPI2_HUMAN

Accession

Primary (citable) accession number: Q9Y4P8
Secondary accession number(s): B3KNC2 , Q5MNZ8, Q6FI96, Q75L50, Q96IE4, Q9Y364

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.