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Protein

WD repeat domain phosphoinositide-interacting protein 2

Gene

WIPI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.1 Publication
Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Enzyme and pathway databases

SignaLinkiQ9Y4P8.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 2
Short name:
WIPI-2
Alternative name(s):
WIPI49-like protein 2
Gene namesi
Name:WIPI2
ORF Names:CGI-50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:32225. WIPI2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • extrinsic component of membrane Source: GO_Central
  • nucleoplasm Source: HPA
  • pre-autophagosomal structure Source: MGI
  • pre-autophagosomal structure membrane Source: UniProtKB
  • protein complex Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi126 – 1261R → E: Impairs interaction with ATG16L1. 1 Publication
Mutagenesisi143 – 1431R → E: Decreasess interaction with ATG16L1. 1 Publication
Mutagenesisi242 – 2421R → T: Impairs preautophagosomal localization; when associated with T-243. 1 Publication
Mutagenesisi243 – 2431R → T: Impairs preautophagosomal localization; when associated with T-242. 1 Publication

Organism-specific databases

PharmGKBiPA142670576.

Polymorphism and mutation databases

BioMutaiWIPI2.
DMDMi74762063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454WD repeat domain phosphoinositide-interacting protein 2PRO_0000051440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei413 – 4131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y4P8.
PaxDbiQ9Y4P8.
PRIDEiQ9Y4P8.

PTM databases

PhosphoSiteiQ9Y4P8.

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.2 Publications

Inductioni

Expression is repressed by ZKSCAN3.1 Publication

Gene expression databases

BgeeiQ9Y4P8.
CleanExiHS_WIPI2.
ExpressionAtlasiQ9Y4P8. baseline and differential.
GenevisibleiQ9Y4P8. HS.

Organism-specific databases

HPAiHPA019852.
HPA021488.

Interactioni

Subunit structurei

Interacts with TECPR1, ATG16L1 and ATG5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-719396,EBI-714543
RABAC1Q9UI143EBI-719396,EBI-712367

Protein-protein interaction databases

BioGridi117550. 30 interactions.
IntActiQ9Y4P8. 28 interactions.
MINTiMINT-1386092.
STRINGi9606.ENSP00000288828.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4P8.
SMRiQ9Y4P8. Positions 54-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 6046WD 1Sequence AnalysisAdd
BLAST
Repeati67 – 10438WD 2Sequence AnalysisAdd
BLAST
Repeati110 – 14233WD 3Sequence AnalysisAdd
BLAST
Repeati149 – 18941WD 4Sequence AnalysisAdd
BLAST
Repeati193 – 23240WD 5Sequence AnalysisAdd
BLAST
Repeati238 – 27740WD 6Sequence AnalysisAdd
BLAST
Repeati320 – 35940WD 7Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi241 – 2444FRRG motif1 Publication

Domaini

The FRRG motif is required for recruitment to PtdIns3P.1 Publication

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 7 WD repeats.Sequence Analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
GeneTreeiENSGT00730000110845.
HOGENOMiHOG000217544.
HOVERGENiHBG056639.
InParanoidiQ9Y4P8.
KOiK17908.
OMAiLTEMWEP.
OrthoDBiEOG7PS1G4.
PhylomeDBiQ9Y4P8.
TreeFamiTF314879.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4P8-1) [UniParc]FASTAAdd to basket

Also known as: WIPI-2 alpha, WIPI2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK
60 70 80 90 100
SGYKFFSLSS VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK
110 120 130 140 150
VCHFKKGTEI CNYSYSNTIL AVKLNRQRLI VCLEESLYIH NIRDMKVLHT
160 170 180 190 200
IRETPPNPAG LCALSINNDN CYLAYPGSAT IGEVQVFDTI NLRAANMIPA
210 220 230 240 250
HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE FRRGVKRCVS
260 270 280 290 300
ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM
310 320 330 340 350
ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA
360 370 380 390 400
DGYLYMYNLD PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY
410 420 430 440 450
GAAAGKGTYV PSSPTRLAYT DDLGAVGGAC LEDEASALRL DEDSEHPPMI

LRTD
Length:454
Mass (Da):49,408
Last modified:November 1, 1999 - v1
Checksum:iB69CEC399B56F35C
GO
Isoform 2 (identifier: Q9Y4P8-2) [UniParc]FASTAAdd to basket

Also known as: WIPI-2 beta, WIPI2d

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.
     407-417: Missing.

Show »
Length:425
Mass (Da):46,384
Checksum:i5FD85B554CA97F41
GO
Isoform 3 (identifier: Q9Y4P8-3) [UniParc]FASTAAdd to basket

Also known as: WIPI2e

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-71: SVDKLEQIYECT → MFTHVLPFVISA
     407-417: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,077
Checksum:iE4C83CA999C10460
GO
Isoform 4 (identifier: Q9Y4P8-4) [UniParc]FASTAAdd to basket

Also known as: WIPI2b

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.

Show »
Length:436
Mass (Da):47,543
Checksum:i0266FEC9E5338877
GO
Isoform 5 (identifier: Q9Y4P8-5) [UniParc]FASTAAdd to basket

Also known as: WIPI-2 delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MNLASQSGEA...DKLEQIYECT → MLLRLQRIKT...THVLPFVISA
     407-417: Missing.

Show »
Length:438
Mass (Da):48,251
Checksum:iD9F056ACE602F833
GO
Isoform 6 (identifier: Q9Y4P8-6) [UniParc]FASTAAdd to basket

Also known as: WIPI2c

The sequence of this isoform differs from the canonical sequence as follows:
     407-417: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):48,249
Checksum:iA07814F3A3C402A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391I → T in CAG38561 (PubMed:15602573).Curated
Sequence conflicti165 – 1651S → P in AAV80761 (PubMed:15602573).Curated
Sequence conflicti380 – 3801E → K in AAD34045 (PubMed:10810093).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7171MNLAS…IYECT → MLLRLQRIKTLRPPGCPHPM TTCSAGTLSAVPCVSPRQVF VFERRFCLWHSHVEMFTHVL PFVISA in isoform 5. 2 PublicationsVSP_016971Add
BLAST
Alternative sequencei1 – 5959Missing in isoform 3. CuratedVSP_016970Add
BLAST
Alternative sequencei26 – 4318Missing in isoform 2 and isoform 4. 3 PublicationsVSP_016972Add
BLAST
Alternative sequencei60 – 7112SVDKL…IYECT → MFTHVLPFVISA in isoform 3. CuratedVSP_016973Add
BLAST
Alternative sequencei407 – 41711Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 3 PublicationsVSP_016974Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691425 mRNA. Translation: AAV80761.1.
AY691426 mRNA. Translation: AAV80762.1.
AF151808 mRNA. Translation: AAD34045.1.
AL080155 mRNA. Translation: CAB45746.1.
CR533530 mRNA. Translation: CAG38561.1.
AK024279 mRNA. Translation: BAG51284.1.
AC093376 Genomic DNA. Translation: AAQ96865.1.
AC093376 Genomic DNA. Translation: AAQ96866.1.
AC093376 Genomic DNA. Translation: AAQ96867.1.
CH471144 Genomic DNA. Translation: EAW87328.1.
BC004116 mRNA. Translation: AAH04116.1.
BC007596 mRNA. Translation: AAH07596.1.
BC021068 mRNA. No translation available.
BC021200 mRNA. Translation: AAH21200.1.
CCDSiCCDS34593.1. [Q9Y4P8-4]
CCDS47531.1. [Q9Y4P8-6]
CCDS47532.1. [Q9Y4P8-2]
CCDS47533.1. [Q9Y4P8-3]
CCDS5339.1. [Q9Y4P8-1]
PIRiT12539.
RefSeqiNP_001028690.1. NM_001033518.1. [Q9Y4P8-6]
NP_001028691.1. NM_001033519.1. [Q9Y4P8-2]
NP_001028692.1. NM_001033520.1. [Q9Y4P8-3]
NP_001265228.1. NM_001278299.1.
NP_056425.1. NM_015610.3. [Q9Y4P8-1]
NP_057087.2. NM_016003.3. [Q9Y4P8-4]
UniGeneiHs.122363.

Genome annotation databases

EnsembliENST00000288828; ENSP00000288828; ENSG00000157954. [Q9Y4P8-1]
ENST00000382384; ENSP00000371821; ENSG00000157954. [Q9Y4P8-2]
ENST00000401525; ENSP00000384945; ENSG00000157954. [Q9Y4P8-4]
ENST00000404704; ENSP00000385297; ENSG00000157954. [Q9Y4P8-6]
ENST00000484262; ENSP00000429654; ENSG00000157954. [Q9Y4P8-3]
GeneIDi26100.
KEGGihsa:26100.
UCSCiuc003snv.3. human. [Q9Y4P8-1]
uc003snw.3. human. [Q9Y4P8-6]
uc003snx.3. human. [Q9Y4P8-4]
uc003sny.3. human. [Q9Y4P8-2]
uc003soa.3. human. [Q9Y4P8-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691425 mRNA. Translation: AAV80761.1.
AY691426 mRNA. Translation: AAV80762.1.
AF151808 mRNA. Translation: AAD34045.1.
AL080155 mRNA. Translation: CAB45746.1.
CR533530 mRNA. Translation: CAG38561.1.
AK024279 mRNA. Translation: BAG51284.1.
AC093376 Genomic DNA. Translation: AAQ96865.1.
AC093376 Genomic DNA. Translation: AAQ96866.1.
AC093376 Genomic DNA. Translation: AAQ96867.1.
CH471144 Genomic DNA. Translation: EAW87328.1.
BC004116 mRNA. Translation: AAH04116.1.
BC007596 mRNA. Translation: AAH07596.1.
BC021068 mRNA. No translation available.
BC021200 mRNA. Translation: AAH21200.1.
CCDSiCCDS34593.1. [Q9Y4P8-4]
CCDS47531.1. [Q9Y4P8-6]
CCDS47532.1. [Q9Y4P8-2]
CCDS47533.1. [Q9Y4P8-3]
CCDS5339.1. [Q9Y4P8-1]
PIRiT12539.
RefSeqiNP_001028690.1. NM_001033518.1. [Q9Y4P8-6]
NP_001028691.1. NM_001033519.1. [Q9Y4P8-2]
NP_001028692.1. NM_001033520.1. [Q9Y4P8-3]
NP_001265228.1. NM_001278299.1.
NP_056425.1. NM_015610.3. [Q9Y4P8-1]
NP_057087.2. NM_016003.3. [Q9Y4P8-4]
UniGeneiHs.122363.

3D structure databases

ProteinModelPortaliQ9Y4P8.
SMRiQ9Y4P8. Positions 54-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117550. 30 interactions.
IntActiQ9Y4P8. 28 interactions.
MINTiMINT-1386092.
STRINGi9606.ENSP00000288828.

PTM databases

PhosphoSiteiQ9Y4P8.

Polymorphism and mutation databases

BioMutaiWIPI2.
DMDMi74762063.

Proteomic databases

MaxQBiQ9Y4P8.
PaxDbiQ9Y4P8.
PRIDEiQ9Y4P8.

Protocols and materials databases

DNASUi26100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288828; ENSP00000288828; ENSG00000157954. [Q9Y4P8-1]
ENST00000382384; ENSP00000371821; ENSG00000157954. [Q9Y4P8-2]
ENST00000401525; ENSP00000384945; ENSG00000157954. [Q9Y4P8-4]
ENST00000404704; ENSP00000385297; ENSG00000157954. [Q9Y4P8-6]
ENST00000484262; ENSP00000429654; ENSG00000157954. [Q9Y4P8-3]
GeneIDi26100.
KEGGihsa:26100.
UCSCiuc003snv.3. human. [Q9Y4P8-1]
uc003snw.3. human. [Q9Y4P8-6]
uc003snx.3. human. [Q9Y4P8-4]
uc003sny.3. human. [Q9Y4P8-2]
uc003soa.3. human. [Q9Y4P8-3]

Organism-specific databases

CTDi26100.
GeneCardsiGC07P005229.
HGNCiHGNC:32225. WIPI2.
HPAiHPA019852.
HPA021488.
MIMi609225. gene.
neXtProtiNX_Q9Y4P8.
PharmGKBiPA142670576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317564.
GeneTreeiENSGT00730000110845.
HOGENOMiHOG000217544.
HOVERGENiHBG056639.
InParanoidiQ9Y4P8.
KOiK17908.
OMAiLTEMWEP.
OrthoDBiEOG7PS1G4.
PhylomeDBiQ9Y4P8.
TreeFamiTF314879.

Enzyme and pathway databases

SignaLinkiQ9Y4P8.

Miscellaneous databases

ChiTaRSiWIPI2. human.
GeneWikiiWIPI2.
GenomeRNAii26100.
NextBioi48085.
PROiQ9Y4P8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y4P8.
CleanExiHS_WIPI2.
ExpressionAtlasiQ9Y4P8. baseline and differential.
GenevisibleiQ9Y4P8. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
    Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
    Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Lymphoma, Placenta and Skin.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation."
    Polson H.E., de Lartigue J., Rigden D.J., Reedijk M., Urbe S., Clague M.J., Tooze S.A.
    Autophagy 6:506-522(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6), PHOSPHOINOSITIDES-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. Cited for: INTERACTION WITH TECPR1.
  12. "Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."
    Proikas-Cezanne T., Robenek H.
    J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy."
    Orsi A., Razi M., Dooley H.C., Robinson D., Weston A.E., Collinson L.M., Tooze S.A.
    Mol. Biol. Cell 23:1860-1873(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. Cited for: SUBCELLULAR LOCATION.
  15. "ZKSCAN3 is a master transcriptional repressor of autophagy."
    Chauhan S., Goodwin J.G., Chauhan S., Manyam G., Wang J., Kamat A.M., Boyd D.D.
    Mol. Cell 50:16-28(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  16. "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1."
    Dooley H.C., Razi M., Polson H.E., Girardin S.E., Wilson M.I., Tooze S.A.
    Mol. Cell 55:238-252(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG16L1 AND ATG5, DOMAIN, MUTAGENESIS OF ARG-126; ARG-143; ARG-242 AND ARG-243.

Entry informationi

Entry nameiWIPI2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4P8
Secondary accession number(s): B3KNC2
, Q5MNZ8, Q6FI96, Q75L50, Q96IE4, Q9Y364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.