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Q9Y4P8

- WIPI2_HUMAN

UniProt

Q9Y4P8 - WIPI2_HUMAN

Protein

WD repeat domain phosphoinositide-interacting protein 2

Gene

WIPI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P.1 Publication

    GO - Molecular functioni

    1. phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
    2. phosphatidylinositol-3-phosphate binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole assembly Source: UniProtKB

    Keywords - Biological processi

    Autophagy

    Enzyme and pathway databases

    SignaLinkiQ9Y4P8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 2
    Short name:
    WIPI-2
    Alternative name(s):
    WIPI49-like protein 2
    Gene namesi
    Name:WIPI2
    ORF Names:CGI-50
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:32225. WIPI2.

    Subcellular locationi

    Preautophagosomal structure membrane 3 Publications; Peripheral membrane protein 3 Publications; Cytoplasmic side 3 Publications
    Note: Enriched at preautophagosomal structure membranes in response to ptdIns3P.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: UniProtKB
    3. nucleus Source: HPA
    4. pre-autophagosomal structure membrane Source: UniProtKB
    5. protein complex Source: LIFEdb

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454WD repeat domain phosphoinositide-interacting protein 2PRO_0000051440Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei413 – 4131Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4P8.
    PaxDbiQ9Y4P8.
    PRIDEiQ9Y4P8.

    PTM databases

    PhosphoSiteiQ9Y4P8.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.2 Publications

    Gene expression databases

    BgeeiQ9Y4P8.
    CleanExiHS_WIPI2.
    GenevestigatoriQ9Y4P8.

    Organism-specific databases

    HPAiHPA019852.
    HPA021488.

    Interactioni

    Subunit structurei

    Interacts with TECPR1.1 Publication

    Protein-protein interaction databases

    BioGridi117550. 16 interactions.
    IntActiQ9Y4P8. 26 interactions.
    MINTiMINT-1386092.
    STRINGi9606.ENSP00000288828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4P8.
    SMRiQ9Y4P8. Positions 54-277, 326-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati200 – 24041WD 1Add
    BLAST
    Repeati246 – 28540WD 2Add
    BLAST
    Repeati329 – 36739WD 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat SVP1 family.Curated
    Contains 3 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317564.
    HOGENOMiHOG000217544.
    HOVERGENiHBG056639.
    InParanoidiQ9Y4P8.
    KOiK17908.
    OMAiLTEMWEP.
    OrthoDBiEOG7PS1G4.
    PhylomeDBiQ9Y4P8.
    TreeFamiTF314879.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4P8-1) [UniParc]FASTAAdd to Basket

    Also known as: WIPI-2 alpha, WIPI2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK    50
    SGYKFFSLSS VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK 100
    VCHFKKGTEI CNYSYSNTIL AVKLNRQRLI VCLEESLYIH NIRDMKVLHT 150
    IRETPPNPAG LCALSINNDN CYLAYPGSAT IGEVQVFDTI NLRAANMIPA 200
    HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE FRRGVKRCVS 250
    ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM 300
    ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA 350
    DGYLYMYNLD PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY 400
    GAAAGKGTYV PSSPTRLAYT DDLGAVGGAC LEDEASALRL DEDSEHPPMI 450
    LRTD 454
    Length:454
    Mass (Da):49,408
    Last modified:November 1, 1999 - v1
    Checksum:iB69CEC399B56F35C
    GO
    Isoform 2 (identifier: Q9Y4P8-2) [UniParc]FASTAAdd to Basket

    Also known as: WIPI-2 beta, WIPI2d

    The sequence of this isoform differs from the canonical sequence as follows:
         26-43: Missing.
         407-417: Missing.

    Show »
    Length:425
    Mass (Da):46,384
    Checksum:i5FD85B554CA97F41
    GO
    Isoform 3 (identifier: Q9Y4P8-3) [UniParc]FASTAAdd to Basket

    Also known as: WIPI2e

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.
         60-71: SVDKLEQIYECT → MFTHVLPFVISA
         407-417: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:384
    Mass (Da):42,077
    Checksum:iE4C83CA999C10460
    GO
    Isoform 4 (identifier: Q9Y4P8-4) [UniParc]FASTAAdd to Basket

    Also known as: WIPI2b

    The sequence of this isoform differs from the canonical sequence as follows:
         26-43: Missing.

    Show »
    Length:436
    Mass (Da):47,543
    Checksum:i0266FEC9E5338877
    GO
    Isoform 5 (identifier: Q9Y4P8-5) [UniParc]FASTAAdd to Basket

    Also known as: WIPI-2 delta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-71: MNLASQSGEA...DKLEQIYECT → MLLRLQRIKT...THVLPFVISA
         407-417: Missing.

    Show »
    Length:438
    Mass (Da):48,251
    Checksum:iD9F056ACE602F833
    GO
    Isoform 6 (identifier: Q9Y4P8-6) [UniParc]FASTAAdd to Basket

    Also known as: WIPI2c

    The sequence of this isoform differs from the canonical sequence as follows:
         407-417: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:443
    Mass (Da):48,249
    Checksum:iA07814F3A3C402A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391I → T in CAG38561. (PubMed:15602573)Curated
    Sequence conflicti165 – 1651S → P in AAV80761. (PubMed:15602573)Curated
    Sequence conflicti380 – 3801E → K in AAD34045. (PubMed:10810093)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7171MNLAS…IYECT → MLLRLQRIKTLRPPGCPHPM TTCSAGTLSAVPCVSPRQVF VFERRFCLWHSHVEMFTHVL PFVISA in isoform 5. 2 PublicationsVSP_016971Add
    BLAST
    Alternative sequencei1 – 5959Missing in isoform 3. CuratedVSP_016970Add
    BLAST
    Alternative sequencei26 – 4318Missing in isoform 2 and isoform 4. 3 PublicationsVSP_016972Add
    BLAST
    Alternative sequencei60 – 7112SVDKL…IYECT → MFTHVLPFVISA in isoform 3. CuratedVSP_016973Add
    BLAST
    Alternative sequencei407 – 41711Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 3 PublicationsVSP_016974Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691425 mRNA. Translation: AAV80761.1.
    AY691426 mRNA. Translation: AAV80762.1.
    AF151808 mRNA. Translation: AAD34045.1.
    AL080155 mRNA. Translation: CAB45746.1.
    CR533530 mRNA. Translation: CAG38561.1.
    AK024279 mRNA. Translation: BAG51284.1.
    AC093376 Genomic DNA. Translation: AAQ96865.1.
    AC093376 Genomic DNA. Translation: AAQ96866.1.
    AC093376 Genomic DNA. Translation: AAQ96867.1.
    CH471144 Genomic DNA. Translation: EAW87328.1.
    BC004116 mRNA. Translation: AAH04116.1.
    BC007596 mRNA. Translation: AAH07596.1.
    BC021068 mRNA. No translation available.
    BC021200 mRNA. Translation: AAH21200.1.
    CCDSiCCDS34593.1. [Q9Y4P8-4]
    CCDS47531.1. [Q9Y4P8-6]
    CCDS47532.1. [Q9Y4P8-2]
    CCDS47533.1. [Q9Y4P8-3]
    CCDS5339.1. [Q9Y4P8-1]
    PIRiT12539.
    RefSeqiNP_001028690.1. NM_001033518.1. [Q9Y4P8-6]
    NP_001028691.1. NM_001033519.1. [Q9Y4P8-2]
    NP_001028692.1. NM_001033520.1. [Q9Y4P8-3]
    NP_001265228.1. NM_001278299.1.
    NP_056425.1. NM_015610.3. [Q9Y4P8-1]
    NP_057087.2. NM_016003.3. [Q9Y4P8-4]
    UniGeneiHs.122363.

    Genome annotation databases

    EnsembliENST00000288828; ENSP00000288828; ENSG00000157954. [Q9Y4P8-1]
    ENST00000382384; ENSP00000371821; ENSG00000157954. [Q9Y4P8-2]
    ENST00000401525; ENSP00000384945; ENSG00000157954. [Q9Y4P8-4]
    ENST00000404704; ENSP00000385297; ENSG00000157954. [Q9Y4P8-6]
    ENST00000484262; ENSP00000429654; ENSG00000157954. [Q9Y4P8-3]
    GeneIDi26100.
    KEGGihsa:26100.
    UCSCiuc003snv.3. human. [Q9Y4P8-1]
    uc003snw.3. human. [Q9Y4P8-6]
    uc003snx.3. human. [Q9Y4P8-4]
    uc003sny.3. human. [Q9Y4P8-2]
    uc003soa.3. human. [Q9Y4P8-3]

    Polymorphism databases

    DMDMi74762063.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY691425 mRNA. Translation: AAV80761.1 .
    AY691426 mRNA. Translation: AAV80762.1 .
    AF151808 mRNA. Translation: AAD34045.1 .
    AL080155 mRNA. Translation: CAB45746.1 .
    CR533530 mRNA. Translation: CAG38561.1 .
    AK024279 mRNA. Translation: BAG51284.1 .
    AC093376 Genomic DNA. Translation: AAQ96865.1 .
    AC093376 Genomic DNA. Translation: AAQ96866.1 .
    AC093376 Genomic DNA. Translation: AAQ96867.1 .
    CH471144 Genomic DNA. Translation: EAW87328.1 .
    BC004116 mRNA. Translation: AAH04116.1 .
    BC007596 mRNA. Translation: AAH07596.1 .
    BC021068 mRNA. No translation available.
    BC021200 mRNA. Translation: AAH21200.1 .
    CCDSi CCDS34593.1. [Q9Y4P8-4 ]
    CCDS47531.1. [Q9Y4P8-6 ]
    CCDS47532.1. [Q9Y4P8-2 ]
    CCDS47533.1. [Q9Y4P8-3 ]
    CCDS5339.1. [Q9Y4P8-1 ]
    PIRi T12539.
    RefSeqi NP_001028690.1. NM_001033518.1. [Q9Y4P8-6 ]
    NP_001028691.1. NM_001033519.1. [Q9Y4P8-2 ]
    NP_001028692.1. NM_001033520.1. [Q9Y4P8-3 ]
    NP_001265228.1. NM_001278299.1.
    NP_056425.1. NM_015610.3. [Q9Y4P8-1 ]
    NP_057087.2. NM_016003.3. [Q9Y4P8-4 ]
    UniGenei Hs.122363.

    3D structure databases

    ProteinModelPortali Q9Y4P8.
    SMRi Q9Y4P8. Positions 54-277, 326-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117550. 16 interactions.
    IntActi Q9Y4P8. 26 interactions.
    MINTi MINT-1386092.
    STRINGi 9606.ENSP00000288828.

    PTM databases

    PhosphoSitei Q9Y4P8.

    Polymorphism databases

    DMDMi 74762063.

    Proteomic databases

    MaxQBi Q9Y4P8.
    PaxDbi Q9Y4P8.
    PRIDEi Q9Y4P8.

    Protocols and materials databases

    DNASUi 26100.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288828 ; ENSP00000288828 ; ENSG00000157954 . [Q9Y4P8-1 ]
    ENST00000382384 ; ENSP00000371821 ; ENSG00000157954 . [Q9Y4P8-2 ]
    ENST00000401525 ; ENSP00000384945 ; ENSG00000157954 . [Q9Y4P8-4 ]
    ENST00000404704 ; ENSP00000385297 ; ENSG00000157954 . [Q9Y4P8-6 ]
    ENST00000484262 ; ENSP00000429654 ; ENSG00000157954 . [Q9Y4P8-3 ]
    GeneIDi 26100.
    KEGGi hsa:26100.
    UCSCi uc003snv.3. human. [Q9Y4P8-1 ]
    uc003snw.3. human. [Q9Y4P8-6 ]
    uc003snx.3. human. [Q9Y4P8-4 ]
    uc003sny.3. human. [Q9Y4P8-2 ]
    uc003soa.3. human. [Q9Y4P8-3 ]

    Organism-specific databases

    CTDi 26100.
    GeneCardsi GC07P005229.
    HGNCi HGNC:32225. WIPI2.
    HPAi HPA019852.
    HPA021488.
    MIMi 609225. gene.
    neXtProti NX_Q9Y4P8.
    PharmGKBi PA142670576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317564.
    HOGENOMi HOG000217544.
    HOVERGENi HBG056639.
    InParanoidi Q9Y4P8.
    KOi K17908.
    OMAi LTEMWEP.
    OrthoDBi EOG7PS1G4.
    PhylomeDBi Q9Y4P8.
    TreeFami TF314879.

    Enzyme and pathway databases

    SignaLinki Q9Y4P8.

    Miscellaneous databases

    ChiTaRSi WIPI2. human.
    GeneWikii WIPI2.
    GenomeRNAii 26100.
    NextBioi 48085.
    PROi Q9Y4P8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4P8.
    CleanExi HS_WIPI2.
    Genevestigatori Q9Y4P8.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."
      Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A.
      Oncogene 23:9314-9325(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Lymphoma, Placenta and Skin.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation."
      Polson H.E., de Lartigue J., Rigden D.J., Reedijk M., Urbe S., Clague M.J., Tooze S.A.
      Autophagy 6:506-522(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6), PHOSPHOINOSITIDES-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. Cited for: INTERACTION WITH TECPR1.
    12. "Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."
      Proikas-Cezanne T., Robenek H.
      J. Cell. Mol. Med. 15:2007-2010(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. "Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy."
      Orsi A., Razi M., Dooley H.C., Robinson D., Weston A.E., Collinson L.M., Tooze S.A.
      Mol. Biol. Cell 23:1860-1873(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiWIPI2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4P8
    Secondary accession number(s): B3KNC2
    , Q5MNZ8, Q6FI96, Q75L50, Q96IE4, Q9Y364
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3