Q9Y4L5A8K3Y4Q5T2V9Q7Z2J2RN115_HUMANE3 ubiquitin-protein ligase RNF1152.3.2.27RING finger protein 115RING-type E3 ubiquitin transferase RNF115Rab7-interacting RING finger proteinRabring 7Zinc finger protein 364RNF115ZNF364Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning and characterization of zinc finger protein 364, C3HC4 type (ZNF364), a novel human member of zinc finger protein family.NUCLEOTIDE SEQUENCE [MRNA]NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The DNA sequence and biological annotation of human chromosome 1.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-304A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.FUNCTIONAUTOUBIQUITINATIONTISSUE SPECIFICITYNovel RING E3 ubiquitin ligases in breast cancer.INTERACTION WITH RAB7AAutoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.FUNCTIONPATHWAYCATALYTIC ACTIVITYAUTOUBIQUITINATIONMUTAGENESIS OF LYS-26; LYS-32; CYS-228 AND CYS-231Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.FUNCTIONSUBCELLULAR LOCATIONINTERACTION WITH BST2MUTAGENESIS OF CYS-228 AND CYS-231The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.FUNCTIONINTERACTION WITH EGFR AND FLT3BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner.FUNCTIONSUBCELLULAR LOCATIONDeubiquitinase ubiquitin-specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells.DEUBIQUITINATION BY USP9XFUNCTIONRNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.FUNCTIONINTERACTION WITH STX17RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.FUNCTIONCATALYTIC ACTIVITYMUTAGENESIS OF CYS-228 AND CYS-231RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.FUNCTIONPHOSPHORYLATION AT SER-132 AND SER-133MUTAGENESIS OF SER-132 AND SER-133INTERACTION WITH YWHAESUBCELLULAR LOCATIONE3 ubiquitin-protein ligase that catalyzes the 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of various substrates and thereby plays a role in a number of signaling pathways including autophagy, innate immunity, cell proliferation and cell death (PubMed:20019814, PubMed:30689267). Plays a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4 through their polyubiquitination. Participates together with BST2 in antiviral immunity by facilitating the internalization of HIV-1 virions into intracellular vesicles leading to their lysosomal degradation (PubMed:20019814). Possesses also an antiviral activity independently of BST2 by promoting retroviral GAG proteins ubiquitination, redistribution to endo-lysosomal compartments and, ultimately, lysosomal degradation (PubMed:24852021). Catalyzes distinct types of ubiquitination on MAVS and STING1 at different phases of viral infection to promote innate antiviral response (PubMed:33139700). Mediates the 'Lys-48'-linked ubiquitination of MAVS leading to its proteasomal degradation and ubiquitinates STING1 via 'Lys-63'-linked polyubiquitination, critical for its oligomerization and the subsequent recruitment of TBK1 (PubMed:33139700). Plays a positive role in the autophagosome-lysosome fusion by interacting with STX17 and enhancing its stability without affecting 'Lys-48'- or 'Lys-63'-linked polyubiquitination levels, which in turn promotes autophagosome maturation (PubMed:32980859). Negatively regulates TLR-induced expression of proinflammatory cytokines by catalyzing 'Lys-11'-linked ubiquitination of RAB1A and RAB13 to inhibit post-ER trafficking of TLRs to the Golgi by RAB1A and subsequently from the Golgi apparatus to the cell surface by RAB13 (PubMed:35343654).S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.Protein modification; protein ubiquitination.Interacts with RAB7A. Interacts with EGFR and FLT3. Interacts with BST2 (PubMed:20019814). Interacts with STX17 (PubMed:32980859). Interacts with YWHAE (PubMed:35343654).Q9Y4L5Q15038false5Q9Y4L5Q00987false2Q9Y4L5O15151false3Q9Y4L5P51668false12Q9Y4L5P62837false6Q9Y4L5P61077false11Q9Y4L5Q9Y2X8false12Q9Y4L5Q96LR5false6Q9Y4L5Q969T4false4Q9Y4L5P55072false3CytoplasmNucleusEndoplasmic reticulumGolgi apparatusThe GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes.Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.Phosphorylated by AKT1, allowing association with the 14-3-3 chaperones that facilitates associating with TLRs.RING-type zinc finger-dependent and E2-dependent autoubiquitination.Deubiquitinated by USP9X; antogonizing its autoubiquitination and subsequent proteasomal degradation.AcetylationCytoplasmEndoplasmic reticulumGolgi apparatusMetal-bindingNucleusPhosphoproteinReference proteomeTransferaseUbl conjugationUbl conjugation pathwayZincZinc-fingerGRKRKRSASACACACACAHNMAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGGSRIDNTTTTHFAELWGHLDHTMFFQDFRPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASASNRFSNDSQLHDRWTF
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