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Q9Y4L1

- HYOU1_HUMAN

UniProt

Q9Y4L1 - HYOU1_HUMAN

Protein

Hypoxia up-regulated protein 1

Gene

HYOU1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. endoplasmic reticulum unfolded protein response Source: Reactome
    4. response to ischemia Source: Ensembl
    5. response to stress Source: ProtInc

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_163813. Scavenging by Class F Receptors.
    REACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxia up-regulated protein 1
    Alternative name(s):
    150 kDa oxygen-regulated protein
    Short name:
    ORP-150
    170 kDa glucose-regulated protein
    Short name:
    GRP-170
    Gene namesi
    Name:HYOU1
    Synonyms:GRP170, ORP150
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16931. HYOU1.

    Subcellular locationi

    GO - Cellular componenti

    1. endocytic vesicle lumen Source: Reactome
    2. endoplasmic reticulum Source: ProtInc
    3. endoplasmic reticulum lumen Source: Reactome
    4. extracellular region Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Chaini33 – 999967Hypoxia up-regulated protein 1PRO_0000013538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)1 Publication
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)5 Publications
    Glycosylationi596 – 5961N-linked (GlcNAc...)2 Publications
    Glycosylationi830 – 8301N-linked (GlcNAc...)3 Publications
    Glycosylationi862 – 8621N-linked (GlcNAc...)2 Publications
    Glycosylationi869 – 8691N-linked (GlcNAc...)1 Publication
    Modified residuei883 – 8831N6-acetyllysineBy similarity
    Glycosylationi922 – 9221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi931 – 9311N-linked (GlcNAc...)3 Publications

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y4L1.
    PaxDbiQ9Y4L1.
    PeptideAtlasiQ9Y4L1.
    PRIDEiQ9Y4L1.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00000877.

    PTM databases

    PhosphoSiteiQ9Y4L1.

    Miscellaneous databases

    PMAP-CutDBQ9Y4L1.

    Expressioni

    Tissue specificityi

    Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

    Inductioni

    By hypoxia and also by 2-deoxyglucose or tunicamycin.

    Gene expression databases

    ArrayExpressiQ9Y4L1.
    BgeeiQ9Y4L1.
    CleanExiHS_HYOU1.
    GenevestigatoriQ9Y4L1.

    Organism-specific databases

    HPAiHPA049296.

    Interactioni

    Subunit structurei

    Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Protein-protein interaction databases

    BioGridi115780. 28 interactions.
    IntActiQ9Y4L1. 9 interactions.
    MINTiMINT-4105974.
    STRINGi9606.ENSP00000278752.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4L1.
    SMRiQ9Y4L1. Positions 35-613, 711-817.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi996 – 9994Prevents secretion from ERSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi603 – 6064Poly-Glu
    Compositional biasi636 – 6416Poly-Pro

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000007865.
    HOVERGENiHBG106402.
    InParanoidiQ9Y4L1.
    KOiK09486.
    OMAiDTKENGT.
    PhylomeDBiQ9Y4L1.
    TreeFamiTF105048.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100934. SSF100934. 1 hit.
    PROSITEiPS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4L1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV    50
    KPGVPMEIVL NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF 100
    QHLLGKQADN PHVALYQARF PEHELTFDPQ RQTVHFQISS QLQFSPEEVL 150
    GMVLNYSRSL AEDFAEQPIK DAVITVPVFF NQAERRAVLQ AARMAGLKVL 200
    QLINDNTATA LSYGVFRRKD INTTAQNIMF YDMGSGSTVC TIVTYQMVKT 250
    KEAGMQPQLQ IRGVGFDRTL GGLEMELRLR ERLAGLFNEQ RKGQRAKDVR 300
    ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE 350
    LCADLFERVP GPVQQALQSA EMSLDEIEQV ILVGGATRVP RVQEVLLKAV 400
    GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VVYPILVEFT 450
    REVEEEPGIH SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL 500
    GFLGPEDLRV FGSQNLTTVK LKGVGDSFKK YPDYESKGIK AHFNLDESGV 550
    LSLDRVESVF ETLVEDSAEE ESTLTKLGNT ISSLFGGGTT PDAKENGTDT 600
    VQEEEESPAE GSKDEPGEQV ELKEEAEAPV EDGSQPPPPE PKGDATPEGE 650
    KATEKENGDK SEAQKPSEKA EAGPEGVAPA PEGEKKQKPA RKRRMVEEIG 700
    VELVVLDLPD LPEDKLAQSV QKLQDLTLRD LEKQEREKAA NSLEAFIFET 750
    QDKLYQPEYQ EVSTEEQREE ISGKLSAAST WLEDEGVGAT TVMLKEKLAE 800
    LRKLCQGLFF RVEERKKWPE RLSALDNLLN HSSMFLKGAR LIPEMDQIFT 850
    EVEMTTLEKV INETWAWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR 900
    EVQYLLNKAK FTKPRPRPKD KNGTRAEPPL NASASDQGEK VIPPAGQTED 950
    AEPISEPEKV ETGSEPGDTE PLELGGPGAE PEQKEQSTGQ KRPLKNDEL 999
    Length:999
    Mass (Da):111,335
    Last modified:November 1, 1999 - v1
    Checksum:iFCE0F292466AFAB9
    GO
    Isoform 2 (identifier: Q9Y4L1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         603-646: EEEESPAEGS...PPPEPKGDAT → MLFLCPARLP...RARPAWRLCS
         647-999: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:559
    Mass (Da):62,757
    Checksum:i007EDC619EE8FBD0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751K → E in BAD96476. 1 PublicationCurated
    Sequence conflicti92 – 921N → D in BAD96476. 1 PublicationCurated
    Sequence conflicti255 – 2551M → T in BAD96476. 1 PublicationCurated
    Sequence conflicti442 – 4421V → A in BAD96476. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8787Missing in isoform 2. 1 PublicationVSP_056364Add
    BLAST
    Alternative sequencei603 – 64644EEEES…KGDAT → MLFLCPARLPQSKQAIDRFH TAVTCMEPPWGRRCRARPAW RLCS in isoform 2. 1 PublicationVSP_056365Add
    BLAST
    Alternative sequencei647 – 999353Missing in isoform 2. 1 PublicationVSP_056366Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65785 mRNA. Translation: AAC50947.1.
    AB009979 Genomic DNA. Translation: BAF80348.1.
    DQ350134 mRNA. Translation: ABC75106.1.
    DQ372932 mRNA. Translation: ABD14370.1.
    AK304264 mRNA. Translation: BAH14145.1.
    AK314178 mRNA. Translation: BAG36860.1.
    AK222756 mRNA. Translation: BAD96476.1.
    EF444986 Genomic DNA. Translation: ACA06002.1.
    AP003392 Genomic DNA. No translation available.
    CCDSiCCDS8408.1.
    PIRiJC5278.
    RefSeqiNP_001124463.1. NM_001130991.2.
    NP_006380.1. NM_006389.4.
    UniGeneiHs.277704.

    Genome annotation databases

    EnsembliENST00000404233; ENSP00000384144; ENSG00000149428.
    ENST00000543287; ENSP00000442727; ENSG00000149428.
    GeneIDi10525.
    KEGGihsa:10525.
    UCSCiuc001put.2. human.

    Polymorphism databases

    DMDMi10720185.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65785 mRNA. Translation: AAC50947.1 .
    AB009979 Genomic DNA. Translation: BAF80348.1 .
    DQ350134 mRNA. Translation: ABC75106.1 .
    DQ372932 mRNA. Translation: ABD14370.1 .
    AK304264 mRNA. Translation: BAH14145.1 .
    AK314178 mRNA. Translation: BAG36860.1 .
    AK222756 mRNA. Translation: BAD96476.1 .
    EF444986 Genomic DNA. Translation: ACA06002.1 .
    AP003392 Genomic DNA. No translation available.
    CCDSi CCDS8408.1.
    PIRi JC5278.
    RefSeqi NP_001124463.1. NM_001130991.2.
    NP_006380.1. NM_006389.4.
    UniGenei Hs.277704.

    3D structure databases

    ProteinModelPortali Q9Y4L1.
    SMRi Q9Y4L1. Positions 35-613, 711-817.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115780. 28 interactions.
    IntActi Q9Y4L1. 9 interactions.
    MINTi MINT-4105974.
    STRINGi 9606.ENSP00000278752.

    Chemistry

    ChEMBLi CHEMBL2216741.

    PTM databases

    PhosphoSitei Q9Y4L1.

    Polymorphism databases

    DMDMi 10720185.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00000877.

    Proteomic databases

    MaxQBi Q9Y4L1.
    PaxDbi Q9Y4L1.
    PeptideAtlasi Q9Y4L1.
    PRIDEi Q9Y4L1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000404233 ; ENSP00000384144 ; ENSG00000149428 .
    ENST00000543287 ; ENSP00000442727 ; ENSG00000149428 .
    GeneIDi 10525.
    KEGGi hsa:10525.
    UCSCi uc001put.2. human.

    Organism-specific databases

    CTDi 10525.
    GeneCardsi GC11M118914.
    HGNCi HGNC:16931. HYOU1.
    HPAi HPA049296.
    MIMi 601746. gene.
    neXtProti NX_Q9Y4L1.
    PharmGKBi PA38427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000007865.
    HOVERGENi HBG106402.
    InParanoidi Q9Y4L1.
    KOi K09486.
    OMAi DTKENGT.
    PhylomeDBi Q9Y4L1.
    TreeFami TF105048.

    Enzyme and pathway databases

    Reactomei REACT_163813. Scavenging by Class F Receptors.
    REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi HYOU1. human.
    GeneWikii HYOU1.
    GenomeRNAii 10525.
    NextBioi 39930.
    PMAP-CutDB Q9Y4L1.
    PROi Q9Y4L1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y4L1.
    Bgeei Q9Y4L1.
    CleanExi HS_HYOU1.
    Genevestigatori Q9Y4L1.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100934. SSF100934. 1 hit.
    PROSITEi PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150."
      Ikeda J., Kaneda S., Kuwabara K., Ogawa S., Kobayashi T., Matsumoto M., Yura T., Yanagi H.
      Biochem. Biophys. Res. Commun. 230:94-99(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Astrocytoma.
    2. "Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions."
      Kaneda S., Yura T., Yanagi H.
      J. Biochem. 128:529-538(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone."
      Takeuchi S.
      Protein J. 25:517-528(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Trachea.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    6. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 241-256; 541-555; 577-594 AND 754-768, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    9. "150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death."
      Ozawa K., Kuwabara K., Tamatani M., Takatsuji K., Tsukamoto Y., Kaneda S., Yanagi H., Stern D.M., Eguchi Y., Tsujimoto Y., Ogawa S., Tohyama M.
      J. Biol. Chem. 274:6397-6404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
      Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
      Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF A CHAPERONE COMPLEX.
    11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-155; ASN-515; ASN-596; ASN-830; ASN-862 AND ASN-931.
    12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-515; ASN-830; ASN-869 AND ASN-931.
      Tissue: Plasma.
    13. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U., Moebius J., Walter U., Sickmann A.
      Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-515.
      Tissue: Platelet.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-515; ASN-596; ASN-830; ASN-862 AND ASN-931.
      Tissue: Liver.
    15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-515.
      Tissue: Leukemic T-cell.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHYOU1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4L1
    Secondary accession number(s): A8C1Z0
    , B7Z909, Q2I204, Q53H25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3