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Protein

Mitogen-activated protein kinase kinase kinase kinase 5

Gene

MAP4K5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1 Publication1
Active sitei140Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • MAP kinase kinase kinase kinase activity Source: GO_Central
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • activation of JUN kinase activity Source: ProtInc
  • intracellular signal transduction Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y4K4
SIGNORiQ9Y4K4

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinase 5 (EC:2.7.11.1)
Alternative name(s):
Kinase homologous to SPS1/STE20
Short name:
KHS
MAPK/ERK kinase kinase kinase 5
Short name:
MEK kinase kinase 5
Short name:
MEKKK 5
Gene namesi
Name:MAP4K5
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000012983.11
HGNCiHGNC:6867 MAP4K5
MIMi604923 gene
neXtProtiNX_Q9Y4K4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49K → R: Loss of kinase activity and ability to activate JNK family. 1 Publication1

Organism-specific databases

DisGeNETi11183
OpenTargetsiENSG00000012983
PharmGKBiPA30613

Chemistry databases

ChEMBLiCHEMBL4852
GuidetoPHARMACOLOGYi2089

Polymorphism and mutation databases

BioMutaiMAP4K5
DMDMi30316147

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862821 – 846Mitogen-activated protein kinase kinase kinase kinase 5Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei335PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4K4
PaxDbiQ9Y4K4
PeptideAtlasiQ9Y4K4
PRIDEiQ9Y4K4

PTM databases

iPTMnetiQ9Y4K4
PhosphoSitePlusiQ9Y4K4

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.1 Publication

Gene expression databases

CleanExiHS_MAP4K5

Organism-specific databases

HPAiHPA036696

Interactioni

Subunit structurei

Interacts with both SH3 domains of the adapter proteins CRK and CRKL.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116353, 17 interactors
IntActiQ9Y4K4, 10 interactors
MINTiQ9Y4K4
STRINGi9606.ENSP00000013125

Chemistry databases

BindingDBiQ9Y4K4

Structurei

3D structure databases

ProteinModelPortaliQ9Y4K4
SMRiQ9Y4K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini506 – 819CNHPROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0576 Eukaryota
ENOG410XP9G LUCA
GeneTreeiENSGT00900000140794
HOGENOMiHOG000230824
HOVERGENiHBG036702
InParanoidiQ9Y4K4
KOiK08833
OMAiKWSSTFH
PhylomeDBiQ9Y4K4
TreeFamiTF105121

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR021160 MAPKKKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF038172 MAPKKKK, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPLRPAAD ILRRNPQQDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI
60 70 80 90 100
IKLEPGDDFS LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG
110 120 130 140 150
SLQDIYHVTG PLSELQIAYV CRETLQGLAY LHTKGKMHRD IKGANILLTD
160 170 180 190 200
HGDVKLADFG VAAKITATIA KRKSFIGTPY WMAPEVAAVE KNGGYNQLCD
210 220 230 240 250
IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL KDKTKWSSTF
260 270 280 290 300
HNFVKIALTK NPKKRPTAER LLTHTFVAQP GLSRALAVEL LDKVNNPDNH
310 320 330 340 350
AHYTEADDDD FEPHAIIRHT IRSTNRNARA ERTASEINFD KLQFEPPLRK
360 370 380 390 400
ETEARDEMGL SSDPNFMLQW NPFVDGANTG KSTSKRAIPP PLPPKPRISS
410 420 430 440 450
YPEDNFPDEE KASTIKHCPD SESRAPQILR RQSSPSCGPV AETSSIGNGD
460 470 480 490 500
GISKLMSENT EGSAQAPQLP RKKDKRDFPK PAINGLPPTP KVLMGACFSK
510 520 530 540 550
VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE LHEATMEQLF
560 570 580 590 600
PRKCTWLYVI NNTLMSLSVG KTFQLYSHNL IALFEHAKKP GLAAHIQTHR
610 620 630 640 650
FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ
660 670 680 690 700
WYEPMQKFML IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGTESNQ
710 720 730 740 750
VVQFETINLN SASSWFTEIG AGSQQLDSIH VTQLERDTVL VCLDKFVKIV
760 770 780 790 800
NLQGKLKSSK KLASELSFDF RIESVVCLQD SVLAFWKHGM QGKSFKSDEV
810 820 830 840
TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA GHENSY
Length:846
Mass (Da):95,024
Last modified:January 31, 2018 - v2
Checksum:i4E74B9BD9BA62272
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti569V → E in AAB48435 (PubMed:9038372).1
Sequence conflicti569V → E in AAH36013 (PubMed:15489334).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05710241H → Y. Corresponds to variant dbSNP:rs34726242Ensembl.1
Natural variantiVAR_040747334A → T1 PublicationCorresponds to variant dbSNP:rs12881869Ensembl.1
Natural variantiVAR_040748407P → L1 PublicationCorresponds to variant dbSNP:rs34818002Ensembl.1
Natural variantiVAR_040749446I → V1 PublicationCorresponds to variant dbSNP:rs55815015Ensembl.1
Natural variantiVAR_040750473K → N1 PublicationCorresponds to variant dbSNP:rs35768475Ensembl.1
Natural variantiVAR_040751552R → Q1 PublicationCorresponds to variant dbSNP:rs55997280Ensembl.1
Natural variantiVAR_040752633T → M1 PublicationCorresponds to variant dbSNP:rs17780143Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77129 mRNA Translation: AAB48435.1
BC036013 mRNA Translation: AAH36013.1
AL118556 Genomic DNA No translation available.
RefSeqiNP_006566.2, NM_006575.4
NP_942089.1, NM_198794.2
XP_006720076.1, XM_006720013.3
UniGeneiHs.130491

Genome annotation databases

EnsembliENST00000013125; ENSP00000013125; ENSG00000012983
GeneIDi11183
KEGGihsa:11183

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiM4K5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K4
Secondary accession number(s): A0A0A0MQR1, Q8IYF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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