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Protein

TNF receptor-associated factor 6

Gene

TRAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.11 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 109RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri150 – 202TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri203 – 259TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • ligase activity Source: UniProtKB-KW
  • mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
  • protein kinase B binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • thioesterase binding Source: UniProtKB
  • tumor necrosis factor receptor binding Source: UniProtKB
  • ubiquitin conjugating enzyme binding Source: MGI
  • ubiquitin protein ligase activity Source: Ensembl
  • ubiquitin protein ligase binding Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, Immunity, Osteogenesis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-193692. Regulated proteolysis of p75NTR.
R-HSA-202424. Downstream TCR signaling.
R-HSA-205043. NRIF signals cell death from the nucleus.
R-HSA-209543. p75NTR recruits signalling complexes.
R-HSA-209560. NF-kB is activated and signals survival.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5689896. Ovarian tumor domain proteases.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-933542. TRAF6 mediated NF-kB activation.
R-HSA-937039. IRAK1 recruits IKK complex.
R-HSA-937041. IKK complex recruitment mediated by RIP1.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-HSA-975871. MyD88 cascade initiated on plasma membrane.
SignaLinkiQ9Y4K3.
SIGNORiQ9Y4K3.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 6 (EC:6.3.2.-)
Alternative name(s):
E3 ubiquitin-protein ligase TRAF6
Interleukin-1 signal transducer
RING finger protein 85
Gene namesi
Name:TRAF6
Synonyms:RNF85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12036. TRAF6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcell cortex 1 Publication
  • Nucleus 1 Publication
  • Lipid droplet By similarity

  • Note: Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).By similarity

GO - Cellular componenti

  • CD40 receptor complex Source: BHF-UCL
  • cell cortex Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: BHF-UCL
  • cytosol Source: Reactome
  • endosome membrane Source: Reactome
  • lipid particle Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi57D → K: Loss of interaction with UBE2N. 1 Publication1
Mutagenesisi70C → A: Loss of ligase activity, autoubiquitination and signaling capacity. 2 Publications1
Mutagenesisi72I → D: Loss of interaction with UBE2N. 1 Publication1
Mutagenesisi74L → E or K: Loss of interaction with UBE2N. 1 Publication1
Mutagenesisi88R → A: Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis. Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis; when associated with A-122. 1 Publication1
Mutagenesisi118F → A: Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis. 1 Publication1
Mutagenesisi118F → W: Partially impaired polyubiquitin synthesis. 1 Publication1
Mutagenesisi118F → Y: Partially impaired polyubiquitin synthesis. 1 Publication1
Mutagenesisi122F → A: Loss of TRAF6 homodimerization and partially impaired polyubiquitin synthesis. Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis; when associated with A-88. 1 Publication1
Mutagenesisi124K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. 3 Publications1
Mutagenesisi142K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. 1 Publication1
Mutagenesisi453K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. 1 Publication1

Organism-specific databases

DisGeNETi7189.
MalaCardsiTRAF6.
OpenTargetsiENSG00000175104.
Orphaneti1810. Autosomal dominant hypohidrotic ectodermal dysplasia.
PharmGKBiPA36713.

Chemistry databases

ChEMBLiCHEMBL3588728.

Polymorphism and mutation databases

BioMutaiTRAF6.
DMDMi30580642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564071 – 522TNF receptor-associated factor 6Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.1 Publication
Polyubiquitinated on Lys-124; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage (PubMed:25861989).7 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9Y4K3.
MaxQBiQ9Y4K3.
PaxDbiQ9Y4K3.
PeptideAtlasiQ9Y4K3.
PRIDEiQ9Y4K3.

PTM databases

iPTMnetiQ9Y4K3.
PhosphoSitePlusiQ9Y4K3.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000175104.
CleanExiHS_TRAF6.
GenevisibleiQ9Y4K3. HS.

Organism-specific databases

HPAiCAB004605.
HPA019805.
HPA020599.

Interactioni

Subunit structurei

Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1. Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with TRAF3IP2. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-359276,EBI-359276
Q8V2D13EBI-359276,EBI-8622036From a different organism.
CD40P259422EBI-359276,EBI-525714
EcsitQ9QZH62EBI-359276,EBI-527020From a different organism.
EDARADDQ8WWZ35EBI-359276,EBI-2949647
IL1R1P147782EBI-359276,EBI-525905
IRAK1P516172EBI-359276,EBI-358664
MALT1Q9UDY85EBI-359276,EBI-1047372
MAP3K14Q995582EBI-359276,EBI-358011
MAP3K7O433182EBI-359276,EBI-358684
MEOX2A4D1273EBI-359276,EBI-10172134
NgfrP071742EBI-359276,EBI-1038810From a different organism.
PLEKHF2Q9H8W43EBI-359276,EBI-742388
POLIQ9UNA43EBI-359276,EBI-741774
RUSC1Q9BVN2-22EBI-359276,EBI-6257338
SPHK1Q9NYA12EBI-359276,EBI-985303
SQSTM1Q135012EBI-359276,EBI-307104
TAX1BP1Q86VP18EBI-359276,EBI-529518
TRAF1Q1307713EBI-359276,EBI-359224
TRAF2Q1293310EBI-359276,EBI-355744
TRAF3IP2O437344EBI-359276,EBI-744798
TRAF5O0046314EBI-359276,EBI-523498
UBCP0CG483EBI-359276,EBI-3390054
UBE2D1P516682EBI-359276,EBI-743540
UBE2D2P628374EBI-359276,EBI-347677
UBE2D3P610772EBI-359276,EBI-348268
UBE2NP610884EBI-359276,EBI-1052908
USP2O756043EBI-359276,EBI-743272
VACWR178Q012202EBI-359276,EBI-3863691From a different organism.
VPS52Q8N1B45EBI-359276,EBI-2799833
XIAPP981702EBI-359276,EBI-517127
YES1P079473EBI-359276,EBI-515331
ZNF675Q8TD234EBI-359276,EBI-528190
ZRANB1Q9UGI03EBI-359276,EBI-527853

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
  • protein kinase B binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • thioesterase binding Source: UniProtKB
  • tumor necrosis factor receptor binding Source: UniProtKB
  • ubiquitin conjugating enzyme binding Source: MGI
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113041. 260 interactors.
DIPiDIP-27515N.
IntActiQ9Y4K3. 104 interactors.
MINTiMINT-88585.
STRINGi9606.ENSP00000337853.

Structurei

Secondary structure

1522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 62Combined sources3
Helixi66 – 68Combined sources3
Turni71 – 73Combined sources3
Beta strandi78 – 82Combined sources5
Turni84 – 86Combined sources3
Beta strandi88 – 90Combined sources3
Helixi91 – 101Combined sources11
Turni106 – 108Combined sources3
Helixi114 – 116Combined sources3
Helixi121 – 128Combined sources8
Beta strandi130 – 133Combined sources4
Beta strandi135 – 138Combined sources4
Beta strandi142 – 144Combined sources3
Helixi145 – 147Combined sources3
Helixi149 – 151Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi158 – 161Combined sources4
Turni163 – 165Combined sources3
Beta strandi168 – 170Combined sources3
Helixi171 – 173Combined sources3
Helixi174 – 180Combined sources7
Beta strandi186 – 188Combined sources3
Turni190 – 192Combined sources3
Beta strandi195 – 197Combined sources3
Helixi198 – 200Combined sources3
Helixi201 – 205Combined sources5
Beta strandi351 – 357Combined sources7
Helixi360 – 368Combined sources9
Beta strandi373 – 376Combined sources4
Beta strandi380 – 385Combined sources6
Beta strandi388 – 395Combined sources8
Turni401 – 405Combined sources5
Beta strandi406 – 414Combined sources9
Helixi419 – 421Combined sources3
Beta strandi428 – 434Combined sources7
Helixi440 – 442Combined sources3
Beta strandi446 – 451Combined sources6
Helixi457 – 459Combined sources3
Beta strandi463 – 466Combined sources4
Beta strandi468 – 478Combined sources11
Helixi479 – 483Combined sources5
Turni484 – 486Combined sources3
Beta strandi492 – 500Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB4X-ray2.40A348-504[»]
1LB5X-ray2.40A347-504[»]
1LB6X-ray1.80A347-504[»]
2ECINMR-A50-128[»]
2JMDNMR-A67-124[»]
3HCSX-ray2.20A/B50-211[»]
3HCTX-ray2.10A50-159[»]
3HCUX-ray2.60A/C50-159[»]
4Z8MX-ray2.95A/B346-504[»]
ProteinModelPortaliQ9Y4K3.
SMRiQ9Y4K3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4K3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 499MATHPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 354Interaction with TAX1BP11 PublicationAdd BLAST354
Regioni355 – 522Interaction with TANK1 PublicationAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili288 – 348Sequence analysisAdd BLAST61

Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.
The MATH/TRAF domain binds to receptor cytoplasmic domains.

Sequence similaritiesi

Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 TRAF-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 109RING-typePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri150 – 202TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri203 – 259TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDW. Eukaryota.
ENOG410XTXK. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000006625.
HOVERGENiHBG060248.
InParanoidiQ9Y4K3.
KOiK03175.
OMAiNFQETIH.
OrthoDBiEOG091G0GHD.
PhylomeDBiQ9Y4K3.
TreeFamiTF321154.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027139. TRAF6.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF85. PTHR10131:SF85. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM
60 70 80 90 100
EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD
110 120 130 140 150
AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED
160 170 180 190 200
HQAHCEFALM DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAASMAFED
210 220 230 240 250
KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH
260 270 280 290 300
EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH
310 320 330 340 350
QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN
360 370 380 390 400
GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA
410 420 430 440 450
QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM
460 470 480 490 500
DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS
510 520
TRFDMGSLRR EGFQPRSTDA GV
Length:522
Mass (Da):59,573
Last modified:November 1, 1999 - v1
Checksum:i5AB9C255CCFEE749
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12S → F in AAH31052 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78798 mRNA. Translation: AAB38751.1.
AY228337 Genomic DNA. Translation: AAO38054.1.
AK292978 mRNA. Translation: BAF85667.1.
AC009656 Genomic DNA. No translation available.
AC061999 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68119.1.
CH471064 Genomic DNA. Translation: EAW68120.1.
CH471064 Genomic DNA. Translation: EAW68122.1.
BC031052 mRNA. Translation: AAH31052.1.
CCDSiCCDS7901.1.
PIRiS71821.
RefSeqiNP_004611.1. NM_004620.3.
NP_665802.1. NM_145803.2.
UniGeneiHs.444172.
Hs.591983.

Genome annotation databases

EnsembliENST00000348124; ENSP00000337853; ENSG00000175104.
ENST00000526995; ENSP00000433623; ENSG00000175104.
GeneIDi7189.
KEGGihsa:7189.
UCSCiuc001mwq.3. human.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78798 mRNA. Translation: AAB38751.1.
AY228337 Genomic DNA. Translation: AAO38054.1.
AK292978 mRNA. Translation: BAF85667.1.
AC009656 Genomic DNA. No translation available.
AC061999 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68119.1.
CH471064 Genomic DNA. Translation: EAW68120.1.
CH471064 Genomic DNA. Translation: EAW68122.1.
BC031052 mRNA. Translation: AAH31052.1.
CCDSiCCDS7901.1.
PIRiS71821.
RefSeqiNP_004611.1. NM_004620.3.
NP_665802.1. NM_145803.2.
UniGeneiHs.444172.
Hs.591983.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB4X-ray2.40A348-504[»]
1LB5X-ray2.40A347-504[»]
1LB6X-ray1.80A347-504[»]
2ECINMR-A50-128[»]
2JMDNMR-A67-124[»]
3HCSX-ray2.20A/B50-211[»]
3HCTX-ray2.10A50-159[»]
3HCUX-ray2.60A/C50-159[»]
4Z8MX-ray2.95A/B346-504[»]
ProteinModelPortaliQ9Y4K3.
SMRiQ9Y4K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113041. 260 interactors.
DIPiDIP-27515N.
IntActiQ9Y4K3. 104 interactors.
MINTiMINT-88585.
STRINGi9606.ENSP00000337853.

Chemistry databases

ChEMBLiCHEMBL3588728.

PTM databases

iPTMnetiQ9Y4K3.
PhosphoSitePlusiQ9Y4K3.

Polymorphism and mutation databases

BioMutaiTRAF6.
DMDMi30580642.

Proteomic databases

EPDiQ9Y4K3.
MaxQBiQ9Y4K3.
PaxDbiQ9Y4K3.
PeptideAtlasiQ9Y4K3.
PRIDEiQ9Y4K3.

Protocols and materials databases

DNASUi7189.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348124; ENSP00000337853; ENSG00000175104.
ENST00000526995; ENSP00000433623; ENSG00000175104.
GeneIDi7189.
KEGGihsa:7189.
UCSCiuc001mwq.3. human.

Organism-specific databases

CTDi7189.
DisGeNETi7189.
GeneCardsiTRAF6.
HGNCiHGNC:12036. TRAF6.
HPAiCAB004605.
HPA019805.
HPA020599.
MalaCardsiTRAF6.
MIMi602355. gene.
neXtProtiNX_Q9Y4K3.
OpenTargetsiENSG00000175104.
Orphaneti1810. Autosomal dominant hypohidrotic ectodermal dysplasia.
PharmGKBiPA36713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISDW. Eukaryota.
ENOG410XTXK. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000006625.
HOVERGENiHBG060248.
InParanoidiQ9Y4K3.
KOiK03175.
OMAiNFQETIH.
OrthoDBiEOG091G0GHD.
PhylomeDBiQ9Y4K3.
TreeFamiTF321154.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-193692. Regulated proteolysis of p75NTR.
R-HSA-202424. Downstream TCR signaling.
R-HSA-205043. NRIF signals cell death from the nucleus.
R-HSA-209543. p75NTR recruits signalling complexes.
R-HSA-209560. NF-kB is activated and signals survival.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-5689896. Ovarian tumor domain proteases.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-933542. TRAF6 mediated NF-kB activation.
R-HSA-937039. IRAK1 recruits IKK complex.
R-HSA-937041. IKK complex recruitment mediated by RIP1.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-HSA-975871. MyD88 cascade initiated on plasma membrane.
SignaLinkiQ9Y4K3.
SIGNORiQ9Y4K3.

Miscellaneous databases

ChiTaRSiTRAF6. human.
EvolutionaryTraceiQ9Y4K3.
GeneWikiiTRAF6.
GenomeRNAii7189.
PROiQ9Y4K3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175104.
CleanExiHS_TRAF6.
GenevisibleiQ9Y4K3. HS.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027139. TRAF6.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF85. PTHR10131:SF85. 1 hit.
PfamiPF02176. zf-TRAF. 1 hit.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRAF6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K3
Secondary accession number(s): A6NKI7
, A8KAB3, D3DR16, Q8NEH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 188 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.