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Q9Y4K1

- AIM1_HUMAN

UniProt

Q9Y4K1 - AIM1_HUMAN

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Protein

Absent in melanoma 1 protein

Gene
AIM1, CRYBG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

Keywords - Ligandi

Lectin

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Absent in melanoma 1 protein
Alternative name(s):
Beta/gamma crystallin domain-containing protein 1
Gene namesi
Name:AIM1
Synonyms:CRYBG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:356. AIM1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17231723Absent in melanoma 1 proteinPRO_0000057609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine1 Publication
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei525 – 5251Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y4K1.
PaxDbiQ9Y4K1.
PeptideAtlasiQ9Y4K1.
PRIDEiQ9Y4K1.

PTM databases

PhosphoSiteiQ9Y4K1.

Expressioni

Gene expression databases

ArrayExpressiQ9Y4K1.
BgeeiQ9Y4K1.
CleanExiHS_AIM1.
GenevestigatoriQ9Y4K1.

Organism-specific databases

HPAiCAB026378.
HPA030948.

Interactioni

Protein-protein interaction databases

BioGridi106705. 2 interactions.
STRINGi9606.ENSP00000358062.

Structurei

Secondary structure

1
1723
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1023 – 10286
Beta strandi1037 – 10393
Beta strandi1053 – 106917
Turni1070 – 10723
Beta strandi1073 – 10797
Beta strandi1081 – 10888
Helixi1094 – 10963
Beta strandi1098 – 11003
Beta strandi1112 – 11165

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DADNMR-A1416-1495[»]
3CW3X-ray1.88A1022-1117[»]
ProteinModelPortaliQ9Y4K1.
SMRiQ9Y4K1. Positions 1022-1595.

Miscellaneous databases

EvolutionaryTraceiQ9Y4K1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1022 – 106140Beta/gamma crystallin 'Greek key' 1Add
BLAST
Domaini1062 – 111756Beta/gamma crystallin 'Greek key' 2Add
BLAST
Domaini1123 – 116341Beta/gamma crystallin 'Greek key' 3Add
BLAST
Domaini1164 – 120643Beta/gamma crystallin 'Greek key' 4Add
BLAST
Domaini1218 – 127053Beta/gamma crystallin 'Greek key' 5Add
BLAST
Domaini1271 – 131343Beta/gamma crystallin 'Greek key' 6Add
BLAST
Domaini1319 – 136143Beta/gamma crystallin 'Greek key' 7Add
BLAST
Domaini1362 – 140443Beta/gamma crystallin 'Greek key' 8Add
BLAST
Domaini1415 – 145238Beta/gamma crystallin 'Greek key' 9Add
BLAST
Domaini1453 – 149644Beta/gamma crystallin 'Greek key' 10Add
BLAST
Domaini1502 – 154241Beta/gamma crystallin 'Greek key' 11Add
BLAST
Domaini1543 – 158442Beta/gamma crystallin 'Greek key' 12Add
BLAST
Domaini1586 – 1719134Ricin B-type lectinAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44674.
HOGENOMiHOG000033870.
HOVERGENiHBG080825.
InParanoidiQ9Y4K1.
OMAiKARMPNS.
OrthoDBiEOG754HNK.
PhylomeDBiQ9Y4K1.
TreeFamiTF331078.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4K1-1 [UniParc]FASTAAdd to Basket

« Hide

MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS     50
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP 100
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE 150
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG 200
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL 250
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 300
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE 350
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK 400
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT 450
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH 500
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR 550
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 600
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT 650
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF 700
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT 750
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN 800
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP 850
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 900
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE 950
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG 1000
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS 1050
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE 1100
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF 1150
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 1200
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE 1250
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG 1300
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY 1350
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV 1400
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV 1450
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 1500
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY 1550
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF 1600
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS 1650
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN 1700
HIILNTVSKE KFTQVWEAMV LYT 1723
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
Checksum:iF4137765BCE039D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671G → D.
Corresponds to variant rs11968933 [ dbSNP | Ensembl ].
VAR_055687
Natural varianti293 – 2931Q → P.1 Publication
Corresponds to variant rs1159148 [ dbSNP | Ensembl ].
VAR_055688
Natural varianti491 – 4911C → R.
Corresponds to variant rs3747787 [ dbSNP | Ensembl ].
VAR_055689
Natural varianti1096 – 10961L → V.
Corresponds to variant rs1350902 [ dbSNP | Ensembl ].
VAR_055690
Natural varianti1196 – 11961E → A.1 Publication
Corresponds to variant rs783396 [ dbSNP | Ensembl ].
VAR_055691
Natural varianti1395 – 13951C → Y.1 Publication
Corresponds to variant rs2297970 [ dbSNP | Ensembl ].
VAR_055692
Natural varianti1445 – 14451T → S.
Corresponds to variant rs1676015 [ dbSNP | Ensembl ].
VAR_055693

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83116 Genomic DNA. Translation: AAB53792.1.
U83115 mRNA. Translation: AAB53791.1.
AL390074, AL359292 Genomic DNA. Translation: CAH72091.1.
AL359292, AL390074 Genomic DNA. Translation: CAI21046.1.
CCDSiCCDS34506.1.
RefSeqiNP_001615.1. NM_001624.2.
UniGeneiHs.724262.
Hs.744905.

Genome annotation databases

EnsembliENST00000369066; ENSP00000358062; ENSG00000112297.
GeneIDi202.
KEGGihsa:202.
UCSCiuc003prh.3. human.

Polymorphism databases

DMDMi76800646.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83116 Genomic DNA. Translation: AAB53792.1 .
U83115 mRNA. Translation: AAB53791.1 .
AL390074 , AL359292 Genomic DNA. Translation: CAH72091.1 .
AL359292 , AL390074 Genomic DNA. Translation: CAI21046.1 .
CCDSi CCDS34506.1.
RefSeqi NP_001615.1. NM_001624.2.
UniGenei Hs.724262.
Hs.744905.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DAD NMR - A 1416-1495 [» ]
3CW3 X-ray 1.88 A 1022-1117 [» ]
ProteinModelPortali Q9Y4K1.
SMRi Q9Y4K1. Positions 1022-1595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106705. 2 interactions.
STRINGi 9606.ENSP00000358062.

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.

PTM databases

PhosphoSitei Q9Y4K1.

Polymorphism databases

DMDMi 76800646.

Proteomic databases

MaxQBi Q9Y4K1.
PaxDbi Q9Y4K1.
PeptideAtlasi Q9Y4K1.
PRIDEi Q9Y4K1.

Protocols and materials databases

DNASUi 202.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369066 ; ENSP00000358062 ; ENSG00000112297 .
GeneIDi 202.
KEGGi hsa:202.
UCSCi uc003prh.3. human.

Organism-specific databases

CTDi 202.
GeneCardsi GC06P106915.
H-InvDB HIX0006103.
HGNCi HGNC:356. AIM1.
HPAi CAB026378.
HPA030948.
MIMi 601797. gene.
neXtProti NX_Q9Y4K1.
PharmGKBi PA24649.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44674.
HOGENOMi HOG000033870.
HOVERGENi HBG080825.
InParanoidi Q9Y4K1.
OMAi KARMPNS.
OrthoDBi EOG754HNK.
PhylomeDBi Q9Y4K1.
TreeFami TF331078.

Miscellaneous databases

ChiTaRSi AIM1. human.
EvolutionaryTracei Q9Y4K1.
GeneWikii AIM1.
GenomeRNAii 202.
NextBioi 804.
PROi Q9Y4K1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y4K1.
Bgeei Q9Y4K1.
CleanExi HS_AIM1.
Genevestigatori Q9Y4K1.

Family and domain databases

InterProi IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
PRINTSi PR01367. BGCRYSTALLIN.
SMARTi SM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view ]
SUPFAMi SSF49695. SSF49695. 3 hits.
SSF50370. SSF50370. 1 hit.
PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma."
    Ray M.E., Wistow G., Su Y.A., Meltzer P.S., Trent J.M.
    Proc. Natl. Acad. Sci. U.S.A. 94:3229-3234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-86, NUCLEOTIDE SEQUENCE [MRNA] OF 87-1723, VARIANTS PRO-293; ALA-1196 AND TYR-1395.
    Tissue: Liver.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-329 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of the fifth crystallin domain of the non-lens protein, absent in melanoma 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1416-1495.
  8. "Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)."
    Aravind P., Wistow G., Sharma Y., Sankaranarayanan R.
    J. Mol. Biol. 381:509-518(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 1022-1117.

Entry informationi

Entry nameiAIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): O00296, Q5VWJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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