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Q9Y4K1

- AIM1_HUMAN

UniProt

Q9Y4K1 - AIM1_HUMAN

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Protein

Absent in melanoma 1 protein

Gene

AIM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Absent in melanoma 1 protein
Alternative name(s):
Beta/gamma crystallin domain-containing protein 1
Gene namesi
Name:AIM1
Synonyms:CRYBG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:356. AIM1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17231723Absent in melanoma 1 proteinPRO_0000057609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine1 Publication
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei525 – 5251Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y4K1.
PaxDbiQ9Y4K1.
PeptideAtlasiQ9Y4K1.
PRIDEiQ9Y4K1.

PTM databases

PhosphoSiteiQ9Y4K1.

Expressioni

Gene expression databases

BgeeiQ9Y4K1.
CleanExiHS_AIM1.
ExpressionAtlasiQ9Y4K1. baseline and differential.
GenevestigatoriQ9Y4K1.

Organism-specific databases

HPAiCAB026378.
HPA030948.

Interactioni

Protein-protein interaction databases

BioGridi106705. 4 interactions.
STRINGi9606.ENSP00000358062.

Structurei

Secondary structure

1
1723
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1023 – 10286
Beta strandi1037 – 10393
Beta strandi1053 – 106917
Turni1070 – 10723
Beta strandi1073 – 10797
Beta strandi1081 – 10888
Helixi1094 – 10963
Beta strandi1098 – 11003
Beta strandi1112 – 11165

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DADNMR-A1416-1495[»]
3CW3X-ray1.88A1022-1117[»]
ProteinModelPortaliQ9Y4K1.
SMRiQ9Y4K1. Positions 980-1595.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4K1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1022 – 106140Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini1062 – 111756Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini1123 – 116341Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini1164 – 120643Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST
Domaini1218 – 127053Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd
BLAST
Domaini1271 – 131343Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd
BLAST
Domaini1319 – 136143Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd
BLAST
Domaini1362 – 140443Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd
BLAST
Domaini1415 – 145238Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd
BLAST
Domaini1453 – 149644Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd
BLAST
Domaini1502 – 154241Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd
BLAST
Domaini1543 – 158442Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd
BLAST
Domaini1586 – 1719134Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 12 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44674.
GeneTreeiENSGT00670000097933.
HOGENOMiHOG000033870.
HOVERGENiHBG080825.
InParanoidiQ9Y4K1.
OMAiKARMPNS.
OrthoDBiEOG754HNK.
PhylomeDBiQ9Y4K1.
TreeFamiTF331078.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 2 hits.
SSF50370. SSF50370. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS
60 70 80 90 100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP
110 120 130 140 150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE
160 170 180 190 200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG
210 220 230 240 250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL
260 270 280 290 300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS
310 320 330 340 350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE
360 370 380 390 400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK
410 420 430 440 450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT
460 470 480 490 500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH
510 520 530 540 550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR
560 570 580 590 600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE
610 620 630 640 650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT
660 670 680 690 700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF
710 720 730 740 750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT
760 770 780 790 800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN
810 820 830 840 850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP
860 870 880 890 900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS
910 920 930 940 950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE
960 970 980 990 1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG
1010 1020 1030 1040 1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS
1060 1070 1080 1090 1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE
1110 1120 1130 1140 1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF
1160 1170 1180 1190 1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG
1210 1220 1230 1240 1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE
1260 1270 1280 1290 1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG
1310 1320 1330 1340 1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY
1360 1370 1380 1390 1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV
1410 1420 1430 1440 1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV
1460 1470 1480 1490 1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS
1510 1520 1530 1540 1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY
1560 1570 1580 1590 1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF
1610 1620 1630 1640 1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS
1660 1670 1680 1690 1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN
1710 1720
HIILNTVSKE KFTQVWEAMV LYT
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
Checksum:iF4137765BCE039D5
GO
Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
     27-1207: Missing.

Note: No experimental confirmation available.

Show »
Length:542
Mass (Da):61,007
Checksum:i9FA2DAABFE123CCB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671G → D.
Corresponds to variant rs11968933 [ dbSNP | Ensembl ].
VAR_055687
Natural varianti293 – 2931Q → P.1 Publication
Corresponds to variant rs1159148 [ dbSNP | Ensembl ].
VAR_055688
Natural varianti491 – 4911C → R.
Corresponds to variant rs3747787 [ dbSNP | Ensembl ].
VAR_055689
Natural varianti1096 – 10961L → V.
Corresponds to variant rs1350902 [ dbSNP | Ensembl ].
VAR_055690
Natural varianti1196 – 11961E → A.1 Publication
Corresponds to variant rs783396 [ dbSNP | Ensembl ].
VAR_055691
Natural varianti1395 – 13951C → Y.1 Publication
Corresponds to variant rs2297970 [ dbSNP | Ensembl ].
VAR_055692
Natural varianti1445 – 14451T → S.
Corresponds to variant rs1676015 [ dbSNP | Ensembl ].
VAR_055693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationVSP_056580Add
BLAST
Alternative sequencei27 – 12071181Missing in isoform 2. 1 PublicationVSP_056581Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83116 Genomic DNA. Translation: AAB53792.1.
U83115 mRNA. Translation: AAB53791.1.
AK300443 mRNA. Translation: BAG62166.1.
AL390074, AL359292 Genomic DNA. Translation: CAH72091.1.
AL359292, AL390074 Genomic DNA. Translation: CAI21046.1.
CH471051 Genomic DNA. Translation: EAW48412.1.
CCDSiCCDS34506.1. [Q9Y4K1-1]
RefSeqiNP_001615.1. NM_001624.2.
UniGeneiHs.724262.
Hs.744905.

Genome annotation databases

EnsembliENST00000369066; ENSP00000358062; ENSG00000112297. [Q9Y4K1-1]
GeneIDi202.
KEGGihsa:202.
UCSCiuc003prh.3. human. [Q9Y4K1-1]

Polymorphism databases

DMDMi76800646.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U83116 Genomic DNA. Translation: AAB53792.1 .
U83115 mRNA. Translation: AAB53791.1 .
AK300443 mRNA. Translation: BAG62166.1 .
AL390074 , AL359292 Genomic DNA. Translation: CAH72091.1 .
AL359292 , AL390074 Genomic DNA. Translation: CAI21046.1 .
CH471051 Genomic DNA. Translation: EAW48412.1 .
CCDSi CCDS34506.1. [Q9Y4K1-1 ]
RefSeqi NP_001615.1. NM_001624.2.
UniGenei Hs.724262.
Hs.744905.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DAD NMR - A 1416-1495 [» ]
3CW3 X-ray 1.88 A 1022-1117 [» ]
ProteinModelPortali Q9Y4K1.
SMRi Q9Y4K1. Positions 980-1595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106705. 4 interactions.
STRINGi 9606.ENSP00000358062.

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.

PTM databases

PhosphoSitei Q9Y4K1.

Polymorphism databases

DMDMi 76800646.

Proteomic databases

MaxQBi Q9Y4K1.
PaxDbi Q9Y4K1.
PeptideAtlasi Q9Y4K1.
PRIDEi Q9Y4K1.

Protocols and materials databases

DNASUi 202.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369066 ; ENSP00000358062 ; ENSG00000112297 . [Q9Y4K1-1 ]
GeneIDi 202.
KEGGi hsa:202.
UCSCi uc003prh.3. human. [Q9Y4K1-1 ]

Organism-specific databases

CTDi 202.
GeneCardsi GC06P106915.
H-InvDB HIX0006103.
HGNCi HGNC:356. AIM1.
HPAi CAB026378.
HPA030948.
MIMi 601797. gene.
neXtProti NX_Q9Y4K1.
PharmGKBi PA24649.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44674.
GeneTreei ENSGT00670000097933.
HOGENOMi HOG000033870.
HOVERGENi HBG080825.
InParanoidi Q9Y4K1.
OMAi KARMPNS.
OrthoDBi EOG754HNK.
PhylomeDBi Q9Y4K1.
TreeFami TF331078.

Miscellaneous databases

ChiTaRSi AIM1. human.
EvolutionaryTracei Q9Y4K1.
GeneWikii AIM1.
GenomeRNAii 202.
NextBioi 35475061.
PROi Q9Y4K1.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4K1.
CleanExi HS_AIM1.
ExpressionAtlasi Q9Y4K1. baseline and differential.
Genevestigatori Q9Y4K1.

Family and domain databases

InterProi IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00030. Crystall. 6 hits.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
PRINTSi PR01367. BGCRYSTALLIN.
SMARTi SM00458. RICIN. 1 hit.
SM00247. XTALbg. 6 hits.
[Graphical view ]
SUPFAMi SSF49695. SSF49695. 2 hits.
SSF50370. SSF50370. 1 hit.
PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma."
    Ray M.E., Wistow G., Su Y.A., Meltzer P.S., Trent J.M.
    Proc. Natl. Acad. Sci. U.S.A. 94:3229-3234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-86 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 87-1723, VARIANTS PRO-293; ALA-1196 AND TYR-1395.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-329 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the fifth crystallin domain of the non-lens protein, absent in melanoma 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1416-1495.
  10. "Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)."
    Aravind P., Wistow G., Sharma Y., Sankaranarayanan R.
    J. Mol. Biol. 381:509-518(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 1022-1117.

Entry informationi

Entry nameiAIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): B4DU04, O00296, Q5VWJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3