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Q9Y4K1

- AIM1_HUMAN

UniProt

Q9Y4K1 - AIM1_HUMAN

Protein

Absent in melanoma 1 protein

Gene

AIM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    CAZyiCBM13. Carbohydrate-Binding Module Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Absent in melanoma 1 protein
    Alternative name(s):
    Beta/gamma crystallin domain-containing protein 1
    Gene namesi
    Name:AIM1
    Synonyms:CRYBG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:356. AIM1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24649.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17231723Absent in melanoma 1 proteinPRO_0000057609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751Phosphoserine1 Publication
    Modified residuei329 – 3291Phosphoserine1 Publication
    Modified residuei525 – 5251Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4K1.
    PaxDbiQ9Y4K1.
    PeptideAtlasiQ9Y4K1.
    PRIDEiQ9Y4K1.

    PTM databases

    PhosphoSiteiQ9Y4K1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y4K1.
    BgeeiQ9Y4K1.
    CleanExiHS_AIM1.
    GenevestigatoriQ9Y4K1.

    Organism-specific databases

    HPAiCAB026378.
    HPA030948.

    Interactioni

    Protein-protein interaction databases

    BioGridi106705. 2 interactions.
    STRINGi9606.ENSP00000358062.

    Structurei

    Secondary structure

    1
    1723
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1023 – 10286
    Beta strandi1037 – 10393
    Beta strandi1053 – 106917
    Turni1070 – 10723
    Beta strandi1073 – 10797
    Beta strandi1081 – 10888
    Helixi1094 – 10963
    Beta strandi1098 – 11003
    Beta strandi1112 – 11165

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DADNMR-A1416-1495[»]
    3CW3X-ray1.88A1022-1117[»]
    ProteinModelPortaliQ9Y4K1.
    SMRiQ9Y4K1. Positions 1022-1595.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y4K1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1022 – 106140Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1062 – 111756Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1123 – 116341Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1164 – 120643Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1218 – 127053Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1271 – 131343Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1319 – 136143Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1362 – 140443Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1415 – 145238Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1453 – 149644Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1502 – 154241Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1543 – 158442Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1586 – 1719134Ricin B-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta/gamma-crystallin family.Curated
    Contains 12 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation
    Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG44674.
    HOGENOMiHOG000033870.
    HOVERGENiHBG080825.
    InParanoidiQ9Y4K1.
    OMAiKARMPNS.
    OrthoDBiEOG754HNK.
    PhylomeDBiQ9Y4K1.
    TreeFamiTF331078.

    Family and domain databases

    InterProiIPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF00030. Crystall. 6 hits.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    PRINTSiPR01367. BGCRYSTALLIN.
    SMARTiSM00458. RICIN. 1 hit.
    SM00247. XTALbg. 6 hits.
    [Graphical view]
    SUPFAMiSSF49695. SSF49695. 3 hits.
    SSF50370. SSF50370. 1 hit.
    PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
    PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS     50
    DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP 100
    ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE 150
    SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG 200
    RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL 250
    DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 300
    KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE 350
    EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK 400
    DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT 450
    FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH 500
    KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR 550
    SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 600
    VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT 650
    NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF 700
    TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT 750
    FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN 800
    GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP 850
    SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 900
    LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE 950
    LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG 1000
    MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS 1050
    LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE 1100
    EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF 1150
    GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 1200
    SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE 1250
    EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG 1300
    GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY 1350
    GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV 1400
    QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV 1450
    SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 1500
    EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY 1550
    GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF 1600
    MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS 1650
    LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN 1700
    HIILNTVSKE KFTQVWEAMV LYT 1723
    Length:1,723
    Mass (Da):188,676
    Last modified:September 27, 2005 - v3
    Checksum:iF4137765BCE039D5
    GO
    Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
         27-1207: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:542
    Mass (Da):61,007
    Checksum:i9FA2DAABFE123CCB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671G → D.
    Corresponds to variant rs11968933 [ dbSNP | Ensembl ].
    VAR_055687
    Natural varianti293 – 2931Q → P.1 Publication
    Corresponds to variant rs1159148 [ dbSNP | Ensembl ].
    VAR_055688
    Natural varianti491 – 4911C → R.
    Corresponds to variant rs3747787 [ dbSNP | Ensembl ].
    VAR_055689
    Natural varianti1096 – 10961L → V.
    Corresponds to variant rs1350902 [ dbSNP | Ensembl ].
    VAR_055690
    Natural varianti1196 – 11961E → A.1 Publication
    Corresponds to variant rs783396 [ dbSNP | Ensembl ].
    VAR_055691
    Natural varianti1395 – 13951C → Y.1 Publication
    Corresponds to variant rs2297970 [ dbSNP | Ensembl ].
    VAR_055692
    Natural varianti1445 – 14451T → S.
    Corresponds to variant rs1676015 [ dbSNP | Ensembl ].
    VAR_055693

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationVSP_056580Add
    BLAST
    Alternative sequencei27 – 12071181Missing in isoform 2. 1 PublicationVSP_056581Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83116 Genomic DNA. Translation: AAB53792.1.
    U83115 mRNA. Translation: AAB53791.1.
    AK300443 mRNA. Translation: BAG62166.1.
    AL390074, AL359292 Genomic DNA. Translation: CAH72091.1.
    AL359292, AL390074 Genomic DNA. Translation: CAI21046.1.
    CH471051 Genomic DNA. Translation: EAW48412.1.
    CCDSiCCDS34506.1.
    RefSeqiNP_001615.1. NM_001624.2.
    UniGeneiHs.724262.
    Hs.744905.

    Genome annotation databases

    EnsembliENST00000369066; ENSP00000358062; ENSG00000112297.
    ENST00000535438; ENSP00000439183; ENSG00000112297.
    GeneIDi202.
    KEGGihsa:202.
    UCSCiuc003prh.3. human.

    Polymorphism databases

    DMDMi76800646.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83116 Genomic DNA. Translation: AAB53792.1 .
    U83115 mRNA. Translation: AAB53791.1 .
    AK300443 mRNA. Translation: BAG62166.1 .
    AL390074 , AL359292 Genomic DNA. Translation: CAH72091.1 .
    AL359292 , AL390074 Genomic DNA. Translation: CAI21046.1 .
    CH471051 Genomic DNA. Translation: EAW48412.1 .
    CCDSi CCDS34506.1.
    RefSeqi NP_001615.1. NM_001624.2.
    UniGenei Hs.724262.
    Hs.744905.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DAD NMR - A 1416-1495 [» ]
    3CW3 X-ray 1.88 A 1022-1117 [» ]
    ProteinModelPortali Q9Y4K1.
    SMRi Q9Y4K1. Positions 1022-1595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106705. 2 interactions.
    STRINGi 9606.ENSP00000358062.

    Protein family/group databases

    CAZyi CBM13. Carbohydrate-Binding Module Family 13.

    PTM databases

    PhosphoSitei Q9Y4K1.

    Polymorphism databases

    DMDMi 76800646.

    Proteomic databases

    MaxQBi Q9Y4K1.
    PaxDbi Q9Y4K1.
    PeptideAtlasi Q9Y4K1.
    PRIDEi Q9Y4K1.

    Protocols and materials databases

    DNASUi 202.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369066 ; ENSP00000358062 ; ENSG00000112297 .
    ENST00000535438 ; ENSP00000439183 ; ENSG00000112297 .
    GeneIDi 202.
    KEGGi hsa:202.
    UCSCi uc003prh.3. human.

    Organism-specific databases

    CTDi 202.
    GeneCardsi GC06P106915.
    H-InvDB HIX0006103.
    HGNCi HGNC:356. AIM1.
    HPAi CAB026378.
    HPA030948.
    MIMi 601797. gene.
    neXtProti NX_Q9Y4K1.
    PharmGKBi PA24649.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44674.
    HOGENOMi HOG000033870.
    HOVERGENi HBG080825.
    InParanoidi Q9Y4K1.
    OMAi KARMPNS.
    OrthoDBi EOG754HNK.
    PhylomeDBi Q9Y4K1.
    TreeFami TF331078.

    Miscellaneous databases

    ChiTaRSi AIM1. human.
    EvolutionaryTracei Q9Y4K1.
    GeneWikii AIM1.
    GenomeRNAii 202.
    NextBioi 804.
    PROi Q9Y4K1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y4K1.
    Bgeei Q9Y4K1.
    CleanExi HS_AIM1.
    Genevestigatori Q9Y4K1.

    Family and domain databases

    InterProi IPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF00030. Crystall. 6 hits.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    PRINTSi PR01367. BGCRYSTALLIN.
    SMARTi SM00458. RICIN. 1 hit.
    SM00247. XTALbg. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49695. SSF49695. 3 hits.
    SSF50370. SSF50370. 1 hit.
    PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 12 hits.
    PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma."
      Ray M.E., Wistow G., Su Y.A., Meltzer P.S., Trent J.M.
      Proc. Natl. Acad. Sci. U.S.A. 94:3229-3234(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-86 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 87-1723, VARIANTS PRO-293; ALA-1196 AND TYR-1395.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-329 AND THR-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the fifth crystallin domain of the non-lens protein, absent in melanoma 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1416-1495.
    10. "Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)."
      Aravind P., Wistow G., Sharma Y., Sankaranarayanan R.
      J. Mol. Biol. 381:509-518(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 1022-1117.

    Entry informationi

    Entry nameiAIM1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4K1
    Secondary accession number(s): B4DU04, O00296, Q5VWJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3