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Q9Y4I5 (MTL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tesmin
Alternative name(s):
Metallothionein-like 5, testis-specific
Testis-specific metallothionein-like protein
Gene names
Name:MTL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in spermatogenesis Probable.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Expressed specifically in testis.

Sequence similarities

Belongs to the lin-54 family.

Contains 1 CRC domain.

Sequence caution

The sequence AAD24668.1 differs from that shown. Reason: Frameshift at several positions.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y4I5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y4I5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     307-508: Missing.
Isoform 3 (identifier: Q9Y4I5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: D → A
     252-508: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Tesmin
PRO_0000096626

Regions

Domain292 – 405114CRC

Amino acid modifications

Modified residue401N6-acetyllysine Ref.5

Natural variations

Alternative sequence2511D → A in isoform 3.
VSP_035297
Alternative sequence252 – 508257Missing in isoform 3.
VSP_035298
Alternative sequence307 – 508202Missing in isoform 2.
VSP_035299
Natural variant2231C → R. Ref.1
Corresponds to variant rs12365708 [ dbSNP | Ensembl ].
VAR_054067
Natural variant2601V → A.
Corresponds to variant rs35773957 [ dbSNP | Ensembl ].
VAR_062236

Experimental info

Sequence conflict1911S → W in AAD24668. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 44DA371A81E012C0

FASTA50855,025
        10         20         30         40         50         60 
MEEGPLPGGL PSPEDAMVTE LLSPEGPFAS ENIGLKAPVK YEEDEFHVFK EAYLGPADPK 

        70         80         90        100        110        120 
EPVLHAFNPA LGADCKGQVK AKLAGGDSDG GELLGEYPGI PELSALEDVA LLQAPQPPAC 

       130        140        150        160        170        180 
NVHFLSSLLP AHRSPAVLPL GAWVLEGASH PGVRMIPVEI KEAGGTTTSN NPEEATLQNL 

       190        200        210        220        230        240 
LAQESCCKFP SSQELEDASC CSLKKDSNPM VICQLKGGTQ MLCIDNSRTR ELKALHLVPQ 

       250        260        270        280        290        300 
YQDQNNYLQS DVPKPMTALV GRFLPASTKL NLITQQLEGA LPSVVNGSAF PSGSTLPGPP 

       310        320        330        340        350        360 
KITLAGYCDC FASGDFCNNC NCNNCCNNLH HDIERFKAIK ACLGRNPEAF QPKIGKGQLG 

       370        380        390        400        410        420 
NVKPQHNKGC NCRRSGCLKN YCECYEAQIM CSSICKCIGC KNYEESPERK TLMSMPNYMQ 

       430        440        450        460        470        480 
TGGLEGSHYL PPTKFSGLPR FSHDRRPSSC ISWEVVEATC ACLLAQGEEA EKEHCSKCLA 

       490        500 
EQMILEEFGR CLSQILHTEF KSKGLKME 

« Hide

Isoform 2 [UniParc].

Checksum: D9418436E083840A
Show »

FASTA30632,305
Isoform 3 [UniParc].

Checksum: 4D37EB2616DD1106
Show »

FASTA25126,737

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-223.
Tissue: Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Testis.
[4]"A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation."
Sugihara T., Wadhwa R., Kaul S.C., Mitsui Y.
Genomics 57:130-136(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 79-508 (ISOFORM 1).
Tissue: Testis.
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074817 mRNA. Translation: BAC11228.1.
AK292358 mRNA. Translation: BAF85047.1.
CH471076 Genomic DNA. Translation: EAW74719.1.
BC027593 mRNA. Translation: AAH27593.1.
BC064579 mRNA. Translation: AAH64579.1.
U86074 mRNA. Translation: AAD24668.1. Frameshift.
CCDSCCDS44661.1. [Q9Y4I5-2]
CCDS8184.1. [Q9Y4I5-1]
RefSeqNP_001034745.1. NM_001039656.1. [Q9Y4I5-2]
NP_004914.2. NM_004923.3. [Q9Y4I5-1]
UniGeneHs.145932.

3D structure databases

ProteinModelPortalQ9Y4I5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000255087.

PTM databases

PhosphoSiteQ9Y4I5.

Polymorphism databases

DMDM205371773.

Proteomic databases

PaxDbQ9Y4I5.
PRIDEQ9Y4I5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255087; ENSP00000255087; ENSG00000132749. [Q9Y4I5-1]
ENST00000443940; ENSP00000403086; ENSG00000132749. [Q9Y4I5-3]
ENST00000544963; ENSP00000440968; ENSG00000132749. [Q9Y4I5-2]
GeneID9633.
KEGGhsa:9633.
UCSCuc001ooc.3. human. [Q9Y4I5-1]
uc009ysi.1. human. [Q9Y4I5-3]

Organism-specific databases

CTD9633.
GeneCardsGC11M068474.
H-InvDBHIX0026150.
HGNCHGNC:7446. MTL5.
HPAHPA018539.
MIM604374. gene.
neXtProtNX_Q9Y4I5.
PharmGKBPA31249.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303998.
HOGENOMHOG000082453.
HOVERGENHBG108153.
InParanoidQ9Y4I5.
OMAHHLSPTK.
OrthoDBEOG7DFXBK.
PhylomeDBQ9Y4I5.
TreeFamTF313189.

Gene expression databases

BgeeQ9Y4I5.
CleanExHS_MTL5.
GenevestigatorQ9Y4I5.

Family and domain databases

InterProIPR005172. CRC.
IPR028307. Lin-54_fam.
[Graphical view]
PANTHERPTHR12446. PTHR12446. 1 hit.
PfamPF03638. TCR. 2 hits.
[Graphical view]
PROSITEPS51634. CRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9633.
NextBio36155.
PROQ9Y4I5.
SOURCESearch...

Entry information

Entry nameMTL5_HUMAN
AccessionPrimary (citable) accession number: Q9Y4I5
Secondary accession number(s): A8K8J3 expand/collapse secondary AC list , Q4G182, Q6P2E2, Q8NCC8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM