Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y4I5

- MTL5_HUMAN

UniProt

Q9Y4I5 - MTL5_HUMAN

Protein

Tesmin

Gene

MTL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May have a role in spermatogenesis.Curated

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cellular metal ion homeostasis Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. response to metal ion Source: UniProtKB
    5. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tesmin
    Alternative name(s):
    Metallothionein-like 5, testis-specific
    Testis-specific metallothionein-like protein
    Gene namesi
    Name:MTL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7446. MTL5.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31249.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508TesminPRO_0000096626Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9Y4I5.
    PRIDEiQ9Y4I5.

    PTM databases

    PhosphoSiteiQ9Y4I5.

    Expressioni

    Tissue specificityi

    Expressed specifically in testis.

    Gene expression databases

    BgeeiQ9Y4I5.
    CleanExiHS_MTL5.
    GenevestigatoriQ9Y4I5.

    Organism-specific databases

    HPAiHPA018539.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000255087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4I5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini292 – 405114CRCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lin-54 family.Curated
    Contains 1 CRC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303998.
    HOGENOMiHOG000082453.
    HOVERGENiHBG108153.
    InParanoidiQ9Y4I5.
    OMAiHHLSPTK.
    OrthoDBiEOG7DFXBK.
    PhylomeDBiQ9Y4I5.
    TreeFamiTF313189.

    Family and domain databases

    InterProiIPR005172. CRC.
    IPR028307. Lin-54_fam.
    [Graphical view]
    PANTHERiPTHR12446. PTHR12446. 1 hit.
    PfamiPF03638. TCR. 2 hits.
    [Graphical view]
    PROSITEiPS51634. CRC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4I5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEGPLPGGL PSPEDAMVTE LLSPEGPFAS ENIGLKAPVK YEEDEFHVFK    50
    EAYLGPADPK EPVLHAFNPA LGADCKGQVK AKLAGGDSDG GELLGEYPGI 100
    PELSALEDVA LLQAPQPPAC NVHFLSSLLP AHRSPAVLPL GAWVLEGASH 150
    PGVRMIPVEI KEAGGTTTSN NPEEATLQNL LAQESCCKFP SSQELEDASC 200
    CSLKKDSNPM VICQLKGGTQ MLCIDNSRTR ELKALHLVPQ YQDQNNYLQS 250
    DVPKPMTALV GRFLPASTKL NLITQQLEGA LPSVVNGSAF PSGSTLPGPP 300
    KITLAGYCDC FASGDFCNNC NCNNCCNNLH HDIERFKAIK ACLGRNPEAF 350
    QPKIGKGQLG NVKPQHNKGC NCRRSGCLKN YCECYEAQIM CSSICKCIGC 400
    KNYEESPERK TLMSMPNYMQ TGGLEGSHYL PPTKFSGLPR FSHDRRPSSC 450
    ISWEVVEATC ACLLAQGEEA EKEHCSKCLA EQMILEEFGR CLSQILHTEF 500
    KSKGLKME 508
    Length:508
    Mass (Da):55,025
    Last modified:September 2, 2008 - v2
    Checksum:i44DA371A81E012C0
    GO
    Isoform 2 (identifier: Q9Y4I5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         307-508: Missing.

    Show »
    Length:306
    Mass (Da):32,305
    Checksum:iD9418436E083840A
    GO
    Isoform 3 (identifier: Q9Y4I5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-251: D → A
         252-508: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:251
    Mass (Da):26,737
    Checksum:i4D37EB2616DD1106
    GO

    Sequence cautioni

    The sequence AAD24668.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911S → W in AAD24668. (PubMed:10191092)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti223 – 2231C → R.1 Publication
    Corresponds to variant rs12365708 [ dbSNP | Ensembl ].
    VAR_054067
    Natural varianti260 – 2601V → A.
    Corresponds to variant rs35773957 [ dbSNP | Ensembl ].
    VAR_062236

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 2511D → A in isoform 3. 1 PublicationVSP_035297
    Alternative sequencei252 – 508257Missing in isoform 3. 1 PublicationVSP_035298Add
    BLAST
    Alternative sequencei307 – 508202Missing in isoform 2. 2 PublicationsVSP_035299Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074817 mRNA. Translation: BAC11228.1.
    AK292358 mRNA. Translation: BAF85047.1.
    CH471076 Genomic DNA. Translation: EAW74719.1.
    BC027593 mRNA. Translation: AAH27593.1.
    BC064579 mRNA. Translation: AAH64579.1.
    U86074 mRNA. Translation: AAD24668.1. Frameshift.
    CCDSiCCDS44661.1. [Q9Y4I5-2]
    CCDS8184.1. [Q9Y4I5-1]
    RefSeqiNP_001034745.1. NM_001039656.1. [Q9Y4I5-2]
    NP_004914.2. NM_004923.3. [Q9Y4I5-1]
    UniGeneiHs.145932.

    Genome annotation databases

    EnsembliENST00000255087; ENSP00000255087; ENSG00000132749. [Q9Y4I5-1]
    ENST00000443940; ENSP00000403086; ENSG00000132749. [Q9Y4I5-3]
    ENST00000544963; ENSP00000440968; ENSG00000132749. [Q9Y4I5-2]
    GeneIDi9633.
    KEGGihsa:9633.
    UCSCiuc001ooc.3. human. [Q9Y4I5-1]
    uc009ysi.1. human. [Q9Y4I5-3]

    Polymorphism databases

    DMDMi205371773.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074817 mRNA. Translation: BAC11228.1 .
    AK292358 mRNA. Translation: BAF85047.1 .
    CH471076 Genomic DNA. Translation: EAW74719.1 .
    BC027593 mRNA. Translation: AAH27593.1 .
    BC064579 mRNA. Translation: AAH64579.1 .
    U86074 mRNA. Translation: AAD24668.1 . Frameshift.
    CCDSi CCDS44661.1. [Q9Y4I5-2 ]
    CCDS8184.1. [Q9Y4I5-1 ]
    RefSeqi NP_001034745.1. NM_001039656.1. [Q9Y4I5-2 ]
    NP_004914.2. NM_004923.3. [Q9Y4I5-1 ]
    UniGenei Hs.145932.

    3D structure databases

    ProteinModelPortali Q9Y4I5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000255087.

    PTM databases

    PhosphoSitei Q9Y4I5.

    Polymorphism databases

    DMDMi 205371773.

    Proteomic databases

    PaxDbi Q9Y4I5.
    PRIDEi Q9Y4I5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255087 ; ENSP00000255087 ; ENSG00000132749 . [Q9Y4I5-1 ]
    ENST00000443940 ; ENSP00000403086 ; ENSG00000132749 . [Q9Y4I5-3 ]
    ENST00000544963 ; ENSP00000440968 ; ENSG00000132749 . [Q9Y4I5-2 ]
    GeneIDi 9633.
    KEGGi hsa:9633.
    UCSCi uc001ooc.3. human. [Q9Y4I5-1 ]
    uc009ysi.1. human. [Q9Y4I5-3 ]

    Organism-specific databases

    CTDi 9633.
    GeneCardsi GC11M068474.
    H-InvDB HIX0026150.
    HGNCi HGNC:7446. MTL5.
    HPAi HPA018539.
    MIMi 604374. gene.
    neXtProti NX_Q9Y4I5.
    PharmGKBi PA31249.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303998.
    HOGENOMi HOG000082453.
    HOVERGENi HBG108153.
    InParanoidi Q9Y4I5.
    OMAi HHLSPTK.
    OrthoDBi EOG7DFXBK.
    PhylomeDBi Q9Y4I5.
    TreeFami TF313189.

    Miscellaneous databases

    GenomeRNAii 9633.
    NextBioi 36155.
    PROi Q9Y4I5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4I5.
    CleanExi HS_MTL5.
    Genevestigatori Q9Y4I5.

    Family and domain databases

    InterProi IPR005172. CRC.
    IPR028307. Lin-54_fam.
    [Graphical view ]
    PANTHERi PTHR12446. PTHR12446. 1 hit.
    Pfami PF03638. TCR. 2 hits.
    [Graphical view ]
    PROSITEi PS51634. CRC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-223.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    4. "A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation."
      Sugihara T., Wadhwa R., Kaul S.C., Mitsui Y.
      Genomics 57:130-136(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 79-508 (ISOFORM 1).
      Tissue: Testis.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMTL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4I5
    Secondary accession number(s): A8K8J3
    , Q4G182, Q6P2E2, Q8NCC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3