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Q9Y4I5

- MTL5_HUMAN

UniProt

Q9Y4I5 - MTL5_HUMAN

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Protein

Tesmin

Gene

MTL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May have a role in spermatogenesis.Curated

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cellular metal ion homeostasis Source: UniProtKB
  3. multicellular organismal development Source: UniProtKB-KW
  4. response to metal ion Source: UniProtKB
  5. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tesmin
Alternative name(s):
Metallothionein-like 5, testis-specific
Testis-specific metallothionein-like protein
Gene namesi
Name:MTL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7446. MTL5.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508TesminPRO_0000096626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9Y4I5.
PRIDEiQ9Y4I5.

PTM databases

PhosphoSiteiQ9Y4I5.

Expressioni

Tissue specificityi

Expressed specifically in testis.

Gene expression databases

BgeeiQ9Y4I5.
CleanExiHS_MTL5.
GenevestigatoriQ9Y4I5.

Organism-specific databases

HPAiHPA018539.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000255087.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini292 – 405114CRCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lin-54 family.Curated
Contains 1 CRC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303998.
GeneTreeiENSGT00390000013974.
HOGENOMiHOG000082453.
HOVERGENiHBG108153.
InParanoidiQ9Y4I5.
OMAiHHLSPTK.
OrthoDBiEOG7DFXBK.
PhylomeDBiQ9Y4I5.
TreeFamiTF313189.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 2 hits.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4I5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEGPLPGGL PSPEDAMVTE LLSPEGPFAS ENIGLKAPVK YEEDEFHVFK
60 70 80 90 100
EAYLGPADPK EPVLHAFNPA LGADCKGQVK AKLAGGDSDG GELLGEYPGI
110 120 130 140 150
PELSALEDVA LLQAPQPPAC NVHFLSSLLP AHRSPAVLPL GAWVLEGASH
160 170 180 190 200
PGVRMIPVEI KEAGGTTTSN NPEEATLQNL LAQESCCKFP SSQELEDASC
210 220 230 240 250
CSLKKDSNPM VICQLKGGTQ MLCIDNSRTR ELKALHLVPQ YQDQNNYLQS
260 270 280 290 300
DVPKPMTALV GRFLPASTKL NLITQQLEGA LPSVVNGSAF PSGSTLPGPP
310 320 330 340 350
KITLAGYCDC FASGDFCNNC NCNNCCNNLH HDIERFKAIK ACLGRNPEAF
360 370 380 390 400
QPKIGKGQLG NVKPQHNKGC NCRRSGCLKN YCECYEAQIM CSSICKCIGC
410 420 430 440 450
KNYEESPERK TLMSMPNYMQ TGGLEGSHYL PPTKFSGLPR FSHDRRPSSC
460 470 480 490 500
ISWEVVEATC ACLLAQGEEA EKEHCSKCLA EQMILEEFGR CLSQILHTEF

KSKGLKME
Length:508
Mass (Da):55,025
Last modified:September 2, 2008 - v2
Checksum:i44DA371A81E012C0
GO
Isoform 2 (identifier: Q9Y4I5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-508: Missing.

Show »
Length:306
Mass (Da):32,305
Checksum:iD9418436E083840A
GO
Isoform 3 (identifier: Q9Y4I5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-251: D → A
     252-508: Missing.

Note: No experimental confirmation available.

Show »
Length:251
Mass (Da):26,737
Checksum:i4D37EB2616DD1106
GO

Sequence cautioni

The sequence AAD24668.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911S → W in AAD24668. (PubMed:10191092)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231C → R.1 Publication
Corresponds to variant rs12365708 [ dbSNP | Ensembl ].
VAR_054067
Natural varianti260 – 2601V → A.
Corresponds to variant rs35773957 [ dbSNP | Ensembl ].
VAR_062236

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 2511D → A in isoform 3. 1 PublicationVSP_035297
Alternative sequencei252 – 508257Missing in isoform 3. 1 PublicationVSP_035298Add
BLAST
Alternative sequencei307 – 508202Missing in isoform 2. 2 PublicationsVSP_035299Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074817 mRNA. Translation: BAC11228.1.
AK292358 mRNA. Translation: BAF85047.1.
CH471076 Genomic DNA. Translation: EAW74719.1.
BC027593 mRNA. Translation: AAH27593.1.
BC064579 mRNA. Translation: AAH64579.1.
U86074 mRNA. Translation: AAD24668.1. Frameshift.
CCDSiCCDS44661.1. [Q9Y4I5-2]
CCDS8184.1. [Q9Y4I5-1]
RefSeqiNP_001034745.1. NM_001039656.1. [Q9Y4I5-2]
NP_004914.2. NM_004923.3. [Q9Y4I5-1]
UniGeneiHs.145932.

Genome annotation databases

EnsembliENST00000255087; ENSP00000255087; ENSG00000132749. [Q9Y4I5-1]
ENST00000443940; ENSP00000403086; ENSG00000132749. [Q9Y4I5-3]
ENST00000544963; ENSP00000440968; ENSG00000132749. [Q9Y4I5-2]
GeneIDi9633.
KEGGihsa:9633.
UCSCiuc001ooc.3. human. [Q9Y4I5-1]
uc009ysi.1. human. [Q9Y4I5-3]

Polymorphism databases

DMDMi205371773.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074817 mRNA. Translation: BAC11228.1 .
AK292358 mRNA. Translation: BAF85047.1 .
CH471076 Genomic DNA. Translation: EAW74719.1 .
BC027593 mRNA. Translation: AAH27593.1 .
BC064579 mRNA. Translation: AAH64579.1 .
U86074 mRNA. Translation: AAD24668.1 . Frameshift.
CCDSi CCDS44661.1. [Q9Y4I5-2 ]
CCDS8184.1. [Q9Y4I5-1 ]
RefSeqi NP_001034745.1. NM_001039656.1. [Q9Y4I5-2 ]
NP_004914.2. NM_004923.3. [Q9Y4I5-1 ]
UniGenei Hs.145932.

3D structure databases

ProteinModelPortali Q9Y4I5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000255087.

PTM databases

PhosphoSitei Q9Y4I5.

Polymorphism databases

DMDMi 205371773.

Proteomic databases

PaxDbi Q9Y4I5.
PRIDEi Q9Y4I5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255087 ; ENSP00000255087 ; ENSG00000132749 . [Q9Y4I5-1 ]
ENST00000443940 ; ENSP00000403086 ; ENSG00000132749 . [Q9Y4I5-3 ]
ENST00000544963 ; ENSP00000440968 ; ENSG00000132749 . [Q9Y4I5-2 ]
GeneIDi 9633.
KEGGi hsa:9633.
UCSCi uc001ooc.3. human. [Q9Y4I5-1 ]
uc009ysi.1. human. [Q9Y4I5-3 ]

Organism-specific databases

CTDi 9633.
GeneCardsi GC11M068474.
H-InvDB HIX0026150.
HGNCi HGNC:7446. MTL5.
HPAi HPA018539.
MIMi 604374. gene.
neXtProti NX_Q9Y4I5.
PharmGKBi PA31249.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303998.
GeneTreei ENSGT00390000013974.
HOGENOMi HOG000082453.
HOVERGENi HBG108153.
InParanoidi Q9Y4I5.
OMAi HHLSPTK.
OrthoDBi EOG7DFXBK.
PhylomeDBi Q9Y4I5.
TreeFami TF313189.

Miscellaneous databases

GenomeRNAii 9633.
NextBioi 36155.
PROi Q9Y4I5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4I5.
CleanExi HS_MTL5.
Genevestigatori Q9Y4I5.

Family and domain databases

InterProi IPR005172. CRC.
IPR028307. Lin-54_fam.
[Graphical view ]
PANTHERi PTHR12446. PTHR12446. 1 hit.
Pfami PF03638. TCR. 2 hits.
[Graphical view ]
PROSITEi PS51634. CRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-223.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  4. "A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation."
    Sugihara T., Wadhwa R., Kaul S.C., Mitsui Y.
    Genomics 57:130-136(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 79-508 (ISOFORM 1).
    Tissue: Testis.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTL5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4I5
Secondary accession number(s): A8K8J3
, Q4G182, Q6P2E2, Q8NCC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3