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Protein

G-protein-signaling modulator 3

Gene

GPSM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein-signaling modulator 3
Alternative name(s):
Activator of G-protein signaling 4
G18.1b
Protein G18
Gene namesi
Name:GPSM3
Synonyms:AGS4, C6orf9, G18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13945. GPSM3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121A → D: Restores G(i) alpha binding and GDI activity of the GoLoco 2 domain. 1 Publication1

Organism-specific databases

DisGeNETi63940.
OpenTargetsiENSG00000213654.
PharmGKBiPA25940.

Polymorphism and mutation databases

BioMutaiGPSM3.
DMDMi74753502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337171 – 160G-protein-signaling modulator 3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei62PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4H4.
MaxQBiQ9Y4H4.
PaxDbiQ9Y4H4.
PeptideAtlasiQ9Y4H4.
PRIDEiQ9Y4H4.

PTM databases

iPTMnetiQ9Y4H4.
PhosphoSitePlusiQ9Y4H4.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000206314.
CleanExiHS_GPSM3.
ExpressionAtlasiQ9Y4H4. baseline and differential.
GenevisibleiQ9Y4H4. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122005. 9 interactors.
IntActiQ9Y4H4. 39 interactors.
MINTiMINT-1034681.
STRINGi9606.ENSP00000364180.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4H4.
SMRiQ9Y4H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 84GoLoco 1PROSITE-ProRule annotationAdd BLAST23
Domaini104 – 126GoLoco 2PROSITE-ProRule annotationAdd BLAST23
Domaini132 – 155GoLoco 3PROSITE-ProRule annotationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 43Pro-richAdd BLAST28

Domaini

The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IX9U. Eukaryota.
ENOG41113F8. LUCA.
GeneTreeiENSGT00390000002471.
HOGENOMiHOG000232123.
HOVERGENiHBG052882.
InParanoidiQ9Y4H4.
KOiK15838.
OMAiCQRIEAQ.
PhylomeDBiQ9Y4H4.
TreeFamiTF339136.

Family and domain databases

InterProiView protein in InterPro
IPR003109. GoLoco_motif.
PfamiView protein in Pfam
PF02188. GoLoco. 3 hits.
SMARTiView protein in SMART
SM00390. GoLoco. 3 hits.
PROSITEiView protein in PROSITE
PS50877. GOLOCO. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9Y4H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAERPQEEE DGEQGPPQDE EGWPPPNSTT RPWRSAPPSP PPPGTRHTAL
60 70 80 90 100
GPRSASLLSL QTELLLDLVA EAQSRRLEEQ RATFYTPQNP SSLAPAPLRP
110 120 130 140 150
LEDREQLYST ILSHQCQRME AQRSEPPLPP GGQELLELLL RVQGGGRMEE
160
QRSRPPTHTC
Length:160
Mass (Da):17,866
Last modified:November 1, 1999 - v1
Checksum:i42B3D207D2C48428
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14Q → R (PubMed:15096500).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243937 mRNA. Translation: CAB51288.1.
AF155657 mRNA. Translation: AAF67476.1.
AK313922 mRNA. Translation: BAG36643.1.
AL662830 Genomic DNA. No translation available.
AL662884 Genomic DNA. No translation available.
AL845464 Genomic DNA. No translation available.
BX284686 Genomic DNA. No translation available.
BX927239 Genomic DNA. No translation available.
CR933878 Genomic DNA. No translation available.
CR812478 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03620.1.
BC018724 mRNA. Translation: AAH18724.1.
CCDSiCCDS34419.1.
RefSeqiNP_001263430.1. NM_001276501.1.
NP_071390.1. NM_022107.2.
UniGeneiHs.520046.

Genome annotation databases

EnsembliENST00000375040; ENSP00000364180; ENSG00000213654.
ENST00000375043; ENSP00000364183; ENSG00000213654.
ENST00000383265; ENSP00000372752; ENSG00000206314.
ENST00000383269; ENSP00000372756; ENSG00000206314.
ENST00000414839; ENSP00000405026; ENSG00000236697.
ENST00000420041; ENSP00000413975; ENSG00000233490.
ENST00000424520; ENSP00000413430; ENSG00000237052.
ENST00000429209; ENSP00000392487; ENSG00000234243.
ENST00000432871; ENSP00000414939; ENSG00000234508.
ENST00000441705; ENSP00000396786; ENSG00000234243.
ENST00000445326; ENSP00000407538; ENSG00000234508.
ENST00000448684; ENSP00000403132; ENSG00000236697.
ENST00000453667; ENSP00000414024; ENSG00000233490.
ENST00000457070; ENSP00000410087; ENSG00000237052.
GeneIDi63940.
KEGGihsa:63940.
UCSCiuc003oay.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPSM3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4H4
Secondary accession number(s): A2BFJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM