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Q9Y4H4

- GPSM3_HUMAN

UniProt

Q9Y4H4 - GPSM3_HUMAN

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Protein

G-protein-signaling modulator 3

Gene

GPSM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.2 Publications

GO - Molecular functioni

  1. GDP-dissociation inhibitor activity Source: InterPro

GO - Biological processi

  1. regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein-signaling modulator 3
Alternative name(s):
Activator of G-protein signaling 4
G18.1b
Protein G18
Gene namesi
Name:GPSM3
Synonyms:AGS4, C6orf9, G18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:13945. GPSM3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi121 – 1211A → D: Restores G(i) alpha binding and GDI activity of the GoLoco 2 domain. 1 Publication

Organism-specific databases

PharmGKBiPA25940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160G-protein-signaling modulator 3PRO_0000233717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei59 – 591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y4H4.
PaxDbiQ9Y4H4.
PRIDEiQ9Y4H4.

PTM databases

PhosphoSiteiQ9Y4H4.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung and liver.1 Publication

Gene expression databases

BgeeiQ9Y4H4.
CleanExiHS_GPSM3.
ExpressionAtlasiQ9Y4H4. baseline and differential.
GenevestigatoriQ9Y4H4.

Interactioni

Protein-protein interaction databases

BioGridi122005. 3 interactions.
IntActiQ9Y4H4. 1 interaction.
MINTiMINT-1034681.
STRINGi9606.ENSP00000364180.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 8423GoLoco 1PROSITE-ProRule annotationAdd
BLAST
Domaini104 – 12623GoLoco 2PROSITE-ProRule annotationAdd
BLAST
Domaini132 – 15524GoLoco 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 4328Pro-richAdd
BLAST

Domaini

The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.1 Publication

Sequence similaritiesi

Contains 3 GoLoco domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG77431.
GeneTreeiENSGT00390000002471.
HOGENOMiHOG000232123.
HOVERGENiHBG052882.
InParanoidiQ9Y4H4.
KOiK15838.
OMAiCQRIEAQ.
PhylomeDBiQ9Y4H4.
TreeFamiTF339136.

Family and domain databases

InterProiIPR024800. G_prot_signal_mod_3.
IPR003109. GoLoco_motif.
[Graphical view]
PANTHERiPTHR10098:SF99. PTHR10098:SF99. 1 hit.
PfamiPF02188. GoLoco. 3 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 3 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAERPQEEE DGEQGPPQDE EGWPPPNSTT RPWRSAPPSP PPPGTRHTAL
60 70 80 90 100
GPRSASLLSL QTELLLDLVA EAQSRRLEEQ RATFYTPQNP SSLAPAPLRP
110 120 130 140 150
LEDREQLYST ILSHQCQRME AQRSEPPLPP GGQELLELLL RVQGGGRMEE
160
QRSRPPTHTC
Length:160
Mass (Da):17,866
Last modified:November 1, 1999 - v1
Checksum:i42B3D207D2C48428
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141Q → R(PubMed:15096500)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243937 mRNA. Translation: CAB51288.1.
AF155657 mRNA. Translation: AAF67476.1.
AK313922 mRNA. Translation: BAG36643.1.
AL662830 Genomic DNA. Translation: CAI17541.1.
AL662884 Genomic DNA. Translation: CAI18360.1.
AL845464 Genomic DNA. Translation: CAI41816.1.
BX284686 Genomic DNA. Translation: CAM26229.1.
BX927239 Genomic DNA. Translation: CAQ06601.1.
CR933878 Genomic DNA. Translation: CAQ09630.1.
CR812478 Genomic DNA. Translation: CAQ10705.1.
CH471081 Genomic DNA. Translation: EAX03620.1.
BC018724 mRNA. Translation: AAH18724.1.
CCDSiCCDS34419.1.
RefSeqiNP_001263430.1. NM_001276501.1.
NP_071390.1. NM_022107.1.
UniGeneiHs.520046.

Genome annotation databases

EnsembliENST00000375040; ENSP00000364180; ENSG00000213654.
ENST00000375043; ENSP00000364183; ENSG00000213654.
ENST00000383265; ENSP00000372752; ENSG00000206314.
ENST00000383269; ENSP00000372756; ENSG00000206314.
ENST00000414839; ENSP00000405026; ENSG00000236697.
ENST00000420041; ENSP00000413975; ENSG00000233490.
ENST00000424520; ENSP00000413430; ENSG00000237052.
ENST00000429209; ENSP00000392487; ENSG00000234243.
ENST00000432871; ENSP00000414939; ENSG00000234508.
ENST00000441705; ENSP00000396786; ENSG00000234243.
ENST00000445326; ENSP00000407538; ENSG00000234508.
ENST00000448684; ENSP00000403132; ENSG00000236697.
ENST00000453667; ENSP00000414024; ENSG00000233490.
ENST00000457070; ENSP00000410087; ENSG00000237052.
GeneIDi63940.
KEGGihsa:63940.
UCSCiuc003oay.4. human.

Polymorphism databases

DMDMi74753502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243937 mRNA. Translation: CAB51288.1 .
AF155657 mRNA. Translation: AAF67476.1 .
AK313922 mRNA. Translation: BAG36643.1 .
AL662830 Genomic DNA. Translation: CAI17541.1 .
AL662884 Genomic DNA. Translation: CAI18360.1 .
AL845464 Genomic DNA. Translation: CAI41816.1 .
BX284686 Genomic DNA. Translation: CAM26229.1 .
BX927239 Genomic DNA. Translation: CAQ06601.1 .
CR933878 Genomic DNA. Translation: CAQ09630.1 .
CR812478 Genomic DNA. Translation: CAQ10705.1 .
CH471081 Genomic DNA. Translation: EAX03620.1 .
BC018724 mRNA. Translation: AAH18724.1 .
CCDSi CCDS34419.1.
RefSeqi NP_001263430.1. NM_001276501.1.
NP_071390.1. NM_022107.1.
UniGenei Hs.520046.

3D structure databases

ProteinModelPortali Q9Y4H4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122005. 3 interactions.
IntActi Q9Y4H4. 1 interaction.
MINTi MINT-1034681.
STRINGi 9606.ENSP00000364180.

PTM databases

PhosphoSitei Q9Y4H4.

Polymorphism databases

DMDMi 74753502.

Proteomic databases

MaxQBi Q9Y4H4.
PaxDbi Q9Y4H4.
PRIDEi Q9Y4H4.

Protocols and materials databases

DNASUi 63940.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375040 ; ENSP00000364180 ; ENSG00000213654 .
ENST00000375043 ; ENSP00000364183 ; ENSG00000213654 .
ENST00000383265 ; ENSP00000372752 ; ENSG00000206314 .
ENST00000383269 ; ENSP00000372756 ; ENSG00000206314 .
ENST00000414839 ; ENSP00000405026 ; ENSG00000236697 .
ENST00000420041 ; ENSP00000413975 ; ENSG00000233490 .
ENST00000424520 ; ENSP00000413430 ; ENSG00000237052 .
ENST00000429209 ; ENSP00000392487 ; ENSG00000234243 .
ENST00000432871 ; ENSP00000414939 ; ENSG00000234508 .
ENST00000441705 ; ENSP00000396786 ; ENSG00000234243 .
ENST00000445326 ; ENSP00000407538 ; ENSG00000234508 .
ENST00000448684 ; ENSP00000403132 ; ENSG00000236697 .
ENST00000453667 ; ENSP00000414024 ; ENSG00000233490 .
ENST00000457070 ; ENSP00000410087 ; ENSG00000237052 .
GeneIDi 63940.
KEGGi hsa:63940.
UCSCi uc003oay.4. human.

Organism-specific databases

CTDi 63940.
GeneCardsi GC06M032165.
GC06Mi32169.
GC06Mj32107.
GC06Ml32197.
GC06Mm32234.
GC06Mn32116.
GC06Mo32165.
HGNCi HGNC:13945. GPSM3.
neXtProti NX_Q9Y4H4.
PharmGKBi PA25940.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77431.
GeneTreei ENSGT00390000002471.
HOGENOMi HOG000232123.
HOVERGENi HBG052882.
InParanoidi Q9Y4H4.
KOi K15838.
OMAi CQRIEAQ.
PhylomeDBi Q9Y4H4.
TreeFami TF339136.

Miscellaneous databases

GenomeRNAii 63940.
NextBioi 65706.
PROi Q9Y4H4.

Gene expression databases

Bgeei Q9Y4H4.
CleanExi HS_GPSM3.
ExpressionAtlasi Q9Y4H4. baseline and differential.
Genevestigatori Q9Y4H4.

Family and domain databases

InterProi IPR024800. G_prot_signal_mod_3.
IPR003109. GoLoco_motif.
[Graphical view ]
PANTHERi PTHR10098:SF99. PTHR10098:SF99. 1 hit.
Pfami PF02188. GoLoco. 3 hits.
[Graphical view ]
SMARTi SM00390. GoLoco. 3 hits.
[Graphical view ]
PROSITEi PS50877. GOLOCO. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha."
    Cao X., Cismowski M.J., Sato M., Blumer J.B., Lanier S.M.
    J. Biol. Chem. 279:27567-27574(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "Characterisation of the novel gene G18, located in the class III region of the human major histocompatibility complex."
    Kendall E., Campbell R.D.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A novel gene expressed in human adrenal gland."
    Li Y., Fu S., Huang C., Jiang C., Ren S., Zhou J., Yu Y., Xu S., Wang Y., Fu G., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.
  8. "Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif."
    Kimple R.J., Willard F.S., Hains M.D., Jones M.B., Nweke G.K., Siderovski D.P.
    Biochem. J. 378:801-808(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ALA-121, DOMAIN.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiGPSM3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4H4
Secondary accession number(s): A2BFJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3