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Q9Y4H4

- GPSM3_HUMAN

UniProt

Q9Y4H4 - GPSM3_HUMAN

Protein

G-protein-signaling modulator 3

Gene

GPSM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.2 Publications

    GO - Molecular functioni

    1. GDP-dissociation inhibitor activity Source: InterPro

    GO - Biological processi

    1. regulation of G-protein coupled receptor protein signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein-signaling modulator 3
    Alternative name(s):
    Activator of G-protein signaling 4
    G18.1b
    Protein G18
    Gene namesi
    Name:GPSM3
    Synonyms:AGS4, C6orf9, G18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13945. GPSM3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi121 – 1211A → D: Restores G(i) alpha binding and GDI activity of the GoLoco 2 domain. 1 Publication

    Organism-specific databases

    PharmGKBiPA25940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 160160G-protein-signaling modulator 3PRO_0000233717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei56 – 561PhosphoserineBy similarity
    Modified residuei59 – 591PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4H4.
    PaxDbiQ9Y4H4.
    PRIDEiQ9Y4H4.

    PTM databases

    PhosphoSiteiQ9Y4H4.

    Expressioni

    Tissue specificityi

    Expressed in heart, placenta, lung and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y4H4.
    BgeeiQ9Y4H4.
    CleanExiHS_GPSM3.
    GenevestigatoriQ9Y4H4.

    Interactioni

    Protein-protein interaction databases

    BioGridi122005. 3 interactions.
    IntActiQ9Y4H4. 1 interaction.
    MINTiMINT-1034681.
    STRINGi9606.ENSP00000364180.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 8423GoLoco 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini104 – 12623GoLoco 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini132 – 15524GoLoco 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 4328Pro-richAdd
    BLAST

    Domaini

    The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain.1 Publication

    Sequence similaritiesi

    Contains 3 GoLoco domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG77431.
    HOGENOMiHOG000232123.
    HOVERGENiHBG052882.
    InParanoidiQ9Y4H4.
    KOiK15838.
    OMAiCQRIEAQ.
    PhylomeDBiQ9Y4H4.
    TreeFamiTF339136.

    Family and domain databases

    InterProiIPR024800. G_prot_signal_mod_3.
    IPR003109. GoLoco_motif.
    [Graphical view]
    PANTHERiPTHR10098:SF99. PTHR10098:SF99. 1 hit.
    PfamiPF02188. GoLoco. 3 hits.
    [Graphical view]
    SMARTiSM00390. GoLoco. 3 hits.
    [Graphical view]
    PROSITEiPS50877. GOLOCO. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y4H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAERPQEEE DGEQGPPQDE EGWPPPNSTT RPWRSAPPSP PPPGTRHTAL    50
    GPRSASLLSL QTELLLDLVA EAQSRRLEEQ RATFYTPQNP SSLAPAPLRP 100
    LEDREQLYST ILSHQCQRME AQRSEPPLPP GGQELLELLL RVQGGGRMEE 150
    QRSRPPTHTC 160
    Length:160
    Mass (Da):17,866
    Last modified:November 1, 1999 - v1
    Checksum:i42B3D207D2C48428
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141Q → R(PubMed:15096500)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243937 mRNA. Translation: CAB51288.1.
    AF155657 mRNA. Translation: AAF67476.1.
    AK313922 mRNA. Translation: BAG36643.1.
    AL662830 Genomic DNA. Translation: CAI17541.1.
    AL662884 Genomic DNA. Translation: CAI18360.1.
    AL845464 Genomic DNA. Translation: CAI41816.1.
    BX284686 Genomic DNA. Translation: CAM26229.1.
    BX927239 Genomic DNA. Translation: CAQ06601.1.
    CR933878 Genomic DNA. Translation: CAQ09630.1.
    CR812478 Genomic DNA. Translation: CAQ10705.1.
    CH471081 Genomic DNA. Translation: EAX03620.1.
    BC018724 mRNA. Translation: AAH18724.1.
    CCDSiCCDS34419.1.
    RefSeqiNP_001263430.1. NM_001276501.1.
    NP_071390.1. NM_022107.1.
    UniGeneiHs.520046.

    Genome annotation databases

    EnsembliENST00000375040; ENSP00000364180; ENSG00000213654.
    ENST00000375043; ENSP00000364183; ENSG00000213654.
    ENST00000383265; ENSP00000372752; ENSG00000206314.
    ENST00000383269; ENSP00000372756; ENSG00000206314.
    ENST00000414839; ENSP00000405026; ENSG00000236697.
    ENST00000420041; ENSP00000413975; ENSG00000233490.
    ENST00000424520; ENSP00000413430; ENSG00000237052.
    ENST00000429209; ENSP00000392487; ENSG00000234243.
    ENST00000432871; ENSP00000414939; ENSG00000234508.
    ENST00000441705; ENSP00000396786; ENSG00000234243.
    ENST00000445326; ENSP00000407538; ENSG00000234508.
    ENST00000448684; ENSP00000403132; ENSG00000236697.
    ENST00000453667; ENSP00000414024; ENSG00000233490.
    ENST00000457070; ENSP00000410087; ENSG00000237052.
    GeneIDi63940.
    KEGGihsa:63940.
    UCSCiuc003oay.4. human.

    Polymorphism databases

    DMDMi74753502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243937 mRNA. Translation: CAB51288.1 .
    AF155657 mRNA. Translation: AAF67476.1 .
    AK313922 mRNA. Translation: BAG36643.1 .
    AL662830 Genomic DNA. Translation: CAI17541.1 .
    AL662884 Genomic DNA. Translation: CAI18360.1 .
    AL845464 Genomic DNA. Translation: CAI41816.1 .
    BX284686 Genomic DNA. Translation: CAM26229.1 .
    BX927239 Genomic DNA. Translation: CAQ06601.1 .
    CR933878 Genomic DNA. Translation: CAQ09630.1 .
    CR812478 Genomic DNA. Translation: CAQ10705.1 .
    CH471081 Genomic DNA. Translation: EAX03620.1 .
    BC018724 mRNA. Translation: AAH18724.1 .
    CCDSi CCDS34419.1.
    RefSeqi NP_001263430.1. NM_001276501.1.
    NP_071390.1. NM_022107.1.
    UniGenei Hs.520046.

    3D structure databases

    ProteinModelPortali Q9Y4H4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122005. 3 interactions.
    IntActi Q9Y4H4. 1 interaction.
    MINTi MINT-1034681.
    STRINGi 9606.ENSP00000364180.

    PTM databases

    PhosphoSitei Q9Y4H4.

    Polymorphism databases

    DMDMi 74753502.

    Proteomic databases

    MaxQBi Q9Y4H4.
    PaxDbi Q9Y4H4.
    PRIDEi Q9Y4H4.

    Protocols and materials databases

    DNASUi 63940.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375040 ; ENSP00000364180 ; ENSG00000213654 .
    ENST00000375043 ; ENSP00000364183 ; ENSG00000213654 .
    ENST00000383265 ; ENSP00000372752 ; ENSG00000206314 .
    ENST00000383269 ; ENSP00000372756 ; ENSG00000206314 .
    ENST00000414839 ; ENSP00000405026 ; ENSG00000236697 .
    ENST00000420041 ; ENSP00000413975 ; ENSG00000233490 .
    ENST00000424520 ; ENSP00000413430 ; ENSG00000237052 .
    ENST00000429209 ; ENSP00000392487 ; ENSG00000234243 .
    ENST00000432871 ; ENSP00000414939 ; ENSG00000234508 .
    ENST00000441705 ; ENSP00000396786 ; ENSG00000234243 .
    ENST00000445326 ; ENSP00000407538 ; ENSG00000234508 .
    ENST00000448684 ; ENSP00000403132 ; ENSG00000236697 .
    ENST00000453667 ; ENSP00000414024 ; ENSG00000233490 .
    ENST00000457070 ; ENSP00000410087 ; ENSG00000237052 .
    GeneIDi 63940.
    KEGGi hsa:63940.
    UCSCi uc003oay.4. human.

    Organism-specific databases

    CTDi 63940.
    GeneCardsi GC06M032229.
    GC06Mi32169.
    GC06Mj32107.
    GC06Ml32197.
    GC06Mm32234.
    GC06Mn32116.
    GC06Mo32165.
    HGNCi HGNC:13945. GPSM3.
    neXtProti NX_Q9Y4H4.
    PharmGKBi PA25940.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77431.
    HOGENOMi HOG000232123.
    HOVERGENi HBG052882.
    InParanoidi Q9Y4H4.
    KOi K15838.
    OMAi CQRIEAQ.
    PhylomeDBi Q9Y4H4.
    TreeFami TF339136.

    Miscellaneous databases

    GenomeRNAii 63940.
    NextBioi 65706.
    PROi Q9Y4H4.

    Gene expression databases

    ArrayExpressi Q9Y4H4.
    Bgeei Q9Y4H4.
    CleanExi HS_GPSM3.
    Genevestigatori Q9Y4H4.

    Family and domain databases

    InterProi IPR024800. G_prot_signal_mod_3.
    IPR003109. GoLoco_motif.
    [Graphical view ]
    PANTHERi PTHR10098:SF99. PTHR10098:SF99. 1 hit.
    Pfami PF02188. GoLoco. 3 hits.
    [Graphical view ]
    SMARTi SM00390. GoLoco. 3 hits.
    [Graphical view ]
    PROSITEi PS50877. GOLOCO. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha."
      Cao X., Cismowski M.J., Sato M., Blumer J.B., Lanier S.M.
      J. Biol. Chem. 279:27567-27574(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Lung.
    2. "Characterisation of the novel gene G18, located in the class III region of the human major histocompatibility complex."
      Kendall E., Campbell R.D.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "A novel gene expressed in human adrenal gland."
      Li Y., Fu S., Huang C., Jiang C., Ren S., Zhou J., Yu Y., Xu S., Wang Y., Fu G., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell.
    8. "Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif."
      Kimple R.J., Willard F.S., Hains M.D., Jones M.B., Nweke G.K., Siderovski D.P.
      Biochem. J. 378:801-808(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ALA-121, DOMAIN.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiGPSM3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4H4
    Secondary accession number(s): A2BFJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3