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Reviewed, UniProtKB/Swiss-Prot Q9Y4H2 (IRS2_HUMAN)

Last modified September 2, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Insulin receptor substrate 2
      Short name=IRS-2
Gene names
Name: IRS2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May mediate the control of various cellular processes by insulin.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR.

Sequence similarities

Contains 1 IRS-type PTB domain.

Contains 1 PH domain.

Ontologies

Keywords

   Coding sequence diversityPolymorphism
   Molecular functionTransducer
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processglucose metabolic process

Traceable author statement. Source: ProtInc

signal transduction

Traceable author statement. Source: ProtInc

   Cellular componentplasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

signal transducer activity

Traceable author statement. Source: ProtInc

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 13381338Insulin receptor substrate 2

Regions

Domain16 – 144129PH
Domain194 – 298105IRS-type PTB
Motif540 – 5434YXXM motif 1
Motif598 – 6014YXXM motif 2
Motif653 – 6564YXXM motif 3
Motif675 – 6784YXXM motif 4
Motif742 – 7454YXXM motif 5
Motif823 – 8264YXXM motif 6
Motif1072 – 10754YXXM motif 7
Compositional bias19 – 2810Poly-Asn
Compositional bias371 – 38010Poly-Ala
Compositional bias447 – 4526Poly-Ser
Compositional bias460 – 4678Poly-Pro
Compositional bias533 – 5375Poly-Gly
Compositional bias642 – 6454Poly-Ser
Compositional bias694 – 7018Poly-Ala
Compositional bias944 – 9474Poly-Ser
Compositional bias1031 – 10388Poly-Pro
Compositional bias1265 – 127814Poly-Pro

Amino acid modifications

Modified residue751Phosphotyrosine
Modified residue3091Phosphoserine
Modified residue3341Phosphoserine
Modified residue3461Phosphoserine
Modified residue3501Phosphothreonine
Modified residue3881Phosphoserine
Modified residue3911Phosphoserine
Modified residue5201Phosphothreonine
Modified residue5271Phosphothreonine
Modified residue5401Phosphotyrosine; by INSR By similarity
Modified residue5601Phosphoserine
Modified residue5771Phosphoserine
Modified residue5801Phosphothreonine
Modified residue6081Phosphoserine
Modified residue6531Phosphotyrosine; by INSR
Modified residue6751Phosphotyrosine; by INSR
Modified residue7131Phosphothreonine
Modified residue7421Phosphotyrosine
Modified residue7701Phosphoserine
Modified residue7721Phosphoserine
Modified residue8231Phosphotyrosine
Modified residue9151Phosphoserine
Modified residue9191Phosphotyrosine; by INSR By similarity
Modified residue9781Phosphotyrosine; by INSR By similarity
Modified residue11001Phosphoserine
Modified residue11761Phosphoserine
Modified residue12031Phosphoserine
Modified residue12531Phosphotyrosine; by INSR By similarity

Natural variations

Natural variant7891H → Y: dbSNP rs35223808.
Natural variant8791G → S
Natural variant8821G → A
Natural variant9991V → M: dbSNP rs35927012.
Natural variant10571G → D: dbSNP rs1805097.

Experimental info

Sequence conflict281N → NN in AAD21531. Ref.2
Sequence conflict39 – 413KQK → NEE in AAD21531. Ref.2
Sequence conflict591E → K in BAA24500. Ref.1
Sequence conflict811K → N in BAA24500. Ref.1
Sequence conflict1071A → P in BAA24500. Ref.1
Sequence conflict1711L → V in BAA24500. Ref.1
Sequence conflict3711A → R in AAD21531. Ref.2
Sequence conflict379 – 3824GARP → AQRL in AAD21531. Ref.2
Sequence conflict4061S → I in BAA24500. Ref.1
Sequence conflict410 – 41910GGRGSKVALL → RAAGTKWHCF in BAA24500. Ref.1
Sequence conflict4241A → G in BAA24500. Ref.1
Sequence conflict436 – 4383AHS → EHL in BAA24500. Ref.1
Sequence conflict4531G → D in BAA24500. Ref.1
Sequence conflict4561S → W in BAA24500. Ref.1
Sequence conflict4681P → L in BAA24500. Ref.1
Sequence conflict6621L → F in AAD21531. Ref.2
Sequence conflict7041S → F in BAA24500. Ref.1
Sequence conflict7141S → F in BAA24500. Ref.1
Sequence conflict8481S → T in BAA24500. Ref.1
Sequence conflict8721P → R Ref.2
Sequence conflict875 – 8784GRPE → RRS Ref.2
Sequence conflict9561S → L in BAA24500. Ref.1
Sequence conflict12521N → K in BAA24500. Ref.1
Sequence conflict13031G → R in BAA24500. Ref.1
Sequence conflict1314 – 133825LPPAN…TIVKE → PAPCPTTYAQH in BAA24500. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y4H2-1 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 58E569E8BDBAF3D7

FASTA1,338137,334
        10         20         30         40         50         60 
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA 

        70         80         90        100        110        120 
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE 

       130        140        150        160        170        180 
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPAAAPA ASCSASLPGA LGGSAGAAGA 

       190        200        210        220        230        240 
EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL 

       250        260        270        280        290        300 
QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF 

       310        320        330        340        350        360 
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR 

       370        380        390        400        410        420 
VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP 

       430        440        450        460        470        480 
AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR 

       490        500        510        520        530        540 
PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY 

       550        560        570        580        590        600 
GYMTMDRPLS HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL 

       610        620        630        640        650        660 
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA 

       670        680        690        700        710        720 
ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA AVPSAGPAGP APTSAAGRTF 

       730        740        750        760        770        780 
PASGGGYKAS SPAESSPEDS GYMRMWCGSK LSMEHADGKL LPNGDYLNVS PSDAVTTGTP 

       790        800        810        820        830        840 
PDFFSAALHP GGEPLRGVPG CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE 

       850        860        870        880        890        900 
PQATPGPSQA ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS 

       910        920        930        940        950        960 
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS ASSPASSLGS 

       970        980        990       1000       1010       1020 
GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG SLDGLLSPEA SSPYPPLPPR 

      1030       1040       1050       1060       1070       1080 
PSASPSSSLQ PPPPPPAPGE LYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA 

      1090       1100       1110       1120       1130       1140 
ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP 

      1150       1160       1170       1180       1190       1200 
QGGRRRHSSE TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP 

      1210       1220       1230       1240       1250       1260 
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG LNYIAIDVRE 

      1270       1280       1290       1300       1310       1320 
EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG STGGGCGGPG PGALPPANTY 

      1330 
ASIDFLSHHL KEATIVKE 

« Hide

References

« Hide 'large scale' references
[1]"14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain."
Ogihara T., Isobe T., Ichimura T., Taoka M., Funaki M., Sakoda H., Onishi Y., Inukai K., Anai M., Fukushima Y., Kikuchi M., Yazaki Y., Oka Y., Asano T.
J. Biol. Chem. 272:25267-25274(1997) [PubMed: 9312143] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene."
Vassen L., Wegrzyn W., Klein-Hitpass L.
Mol. Endocrinol. 13:485-494(1999) [PubMed: 10077005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Insulin receptor substrate 2 gene sequence."
Heyne B.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulsto