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Q9Y4G6

- TLN2_HUMAN

UniProt

Q9Y4G6 - TLN2_HUMAN

Protein

Talin-2

Gene

TLN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 4 (05 May 2009)
      Previous versions | rss
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    Functioni

    As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity By similarity.By similarity

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. structural constituent of cytoskeleton Source: InterPro
    4. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cell-cell junction assembly Source: UniProtKB
    3. cytoskeletal anchoring at plasma membrane Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Talin-2
    Gene namesi
    Name:TLN2
    Synonyms:KIAA0320
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:15447. TLN2.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cell-cell junction Source: UniProtKB
    3. cytoplasm Source: UniProtKB-KW
    4. fascia adherens Source: Ensembl
    5. focal adhesion Source: UniProtKB-SubCell
    6. plasma membrane Source: UniProtKB-SubCell
    7. ruffle Source: InterPro
    8. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37958.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 25422542Talin-2PRO_0000219431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1665 – 16651PhosphotyrosineBy similarity
    Modified residuei1843 – 18431Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4G6.
    PaxDbiQ9Y4G6.
    PRIDEiQ9Y4G6.

    PTM databases

    PhosphoSiteiQ9Y4G6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y4G6.
    BgeeiQ9Y4G6.
    CleanExiHS_TLN2.
    GenevestigatoriQ9Y4G6.

    Organism-specific databases

    HPAiCAB017194.

    Interactioni

    Subunit structurei

    Interacts directly with PIP5K1C.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005193EBI-1220811,EBI-375543
    ITGB2P051075EBI-1220811,EBI-300173

    Protein-protein interaction databases

    BioGridi123717. 8 interactions.
    DIPiDIP-17039N.
    IntActiQ9Y4G6. 6 interactions.
    MINTiMINT-5005773.
    STRINGi9606.ENSP00000303476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4G6.
    SMRiQ9Y4G6. Positions 1-408, 488-914, 916-1046, 1048-1359, 1361-1974, 1976-2292, 2297-2479, 2496-2529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 406319FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini2294 – 2533240I/LWEQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni312 – 40695Interaction with PIP5K1CBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi861 – 1193333Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 I/LWEQ domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG324465.
    HOGENOMiHOG000006734.
    HOVERGENiHBG023870.
    InParanoidiQ9Y4G6.
    KOiK06271.
    OMAiGVMENSK.
    OrthoDBiEOG7TBC1J.
    PhylomeDBiQ9Y4G6.
    TreeFamiTF314677.

    Family and domain databases

    Gene3Di1.20.1410.10. 2 hits.
    1.20.1420.10. 1 hit.
    1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR002558. ILWEQ_dom.
    IPR002404. Insln_rcpt_S1.
    IPR011993. PH_like_dom.
    IPR015711. Talin-2.
    IPR015224. Talin_cent.
    IPR029071. Ubiquitin-rel_dom.
    IPR015009. Vinculin-bd_dom.
    IPR006077. Vinculin/catenin.
    [Graphical view]
    PANTHERiPTHR19981:SF15. PTHR19981:SF15. 1 hit.
    PfamiPF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    PF02174. IRS. 1 hit.
    PF09141. Talin_middle. 1 hit.
    PF08913. VBS. 1 hit.
    [Graphical view]
    ProDomiPD011820. ILWEQ. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00295. B41. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF109880. SSF109880. 1 hit.
    SSF109885. SSF109885. 4 hits.
    SSF47031. SSF47031. 1 hit.
    SSF47220. SSF47220. 5 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y4G6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG     50
    LFLSDEDPRK GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK 100
    TVMVDDSKTV GELLVTICSR IGITNYEEYS LIQETIEEKK EEGTGTLKKD 150
    RTLLRDERKM EKLKAKLHTD DDLNWLDHSR TFREQGVDEN ETLLLRRKFF 200
    YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF GGFQAQIQFG 250
    PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK 300
    YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV 350
    LQEWPLTTVK RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID 400
    IILKKKQSKD RFGLEGDEES TMLEESVSPK KSTILQQQFN RTGKAEHGSV 450
    ALPAVMRSGS SGPETFNVGS MPSPQQQVMV GQMHRGHMPP LTSAQQALMG 500
    TINTSMHAVQ QAQDDLSELD SLPPLGQDMA SRVWVQNKVD ESKHEIHSQV 550
    DAITAGTASV VNLTAGDPAD TDYTAVGCAI TTISSNLTEM SKGVKLLAAL 600
    MDDEVGSGED LLRAARTLAG AVSDLLKAVQ PTSGEPRQTV LTAAGSIGQA 650
    SGDLLRQIGE NETDERFQDV LMSLAKAVAN AAAMLVLKAK NVAQVAEDTV 700
    LQNRVIAAAT QCALSTSQLV ACAKVVSPTI SSPVCQEQLI EAGKLVDRSV 750
    ENCVRACQAA TTDSELLKQV SAAASVVSQA LHDLLQHVRQ FASRGEPIGR 800
    YDQATDTIMC VTESIFSSMG DAGEMVRQAR VLAQATSDLV NAMRSDAEAE 850
    IDMENSKKLL AAAKLLADST ARMVEAAKGA AANPENEDQQ QRLREAAEGL 900
    RVATNAAAQN AIKKKIVNRL EVAAKQAAAA ATQTIAASQN AAVSNKNPAA 950
    QQQLVQSCKA VADHIPQLVQ GVRGSQAQAE DLSAQLALII SSQNFLQPGS 1000
    KMVSSAKAAV PTVSDQAAAM QLSQCAKNLA TSLAELRTAS QKAHEACGPM 1050
    EIDSALNTVQ TLKNELQDAK MAAVESQLKP LPGETLEKCA QDLGSTSKAV 1100
    GSSMAQLLTC AAQGNEHYTG VAARETAQAL KTLAQAARGV AASTTDPAAA 1150
    HAMLDSARDV MEGSAMLIQE AKQALIAPGD AERQQRLAQV AKAVSHSLNN 1200
    CVNCLPGQKD VDVALKSIGE SSKKLLVDSL PPSTKPFQEA QSELNQAAAD 1250
    LNQSAGEVVH ATRGQSGELA AASGKFSDDF DEFLDAGIEM AGQAQTKEDQ 1300
    IQVIGNLKNI SMASSKLLLA AKSLSVDPGA PNAKNLLAAA ARAVTESINQ 1350
    LITLCTQQAP GQKECDNALR ELETVKGMLD NPNEPVSDLS YFDCIESVME 1400
    NSKVLGESMA GISQNAKTGD LPAFGECVGI ASKALCGLTE AAAQAAYLVG 1450
    ISDPNSQAGH QGLVDPIQFA RANQAIQMAC QNLVDPGSSP SQVLSAATIV 1500
    AKHTSALCNA CRIASSKTAN PVAKRHFVQS AKEVANSTAN LVKTIKALDG 1550
    DFSEDNRNKC RIATAPLIEA VENLTAFASN PEFVSIPAQI SSEGSQAQEP 1600
    ILVSAKTMLE SSSYLIRTAR SLAINPKDPP TWSVLAGHSH TVSDSIKSLI 1650
    TSIRDKAPGQ RECDYSIDGI NRCIRDIEQA SLAAVSQSLA TRDDISVEAL 1700
    QEQLTSVVQE IGHLIDPIAT AARGEAAQLG HKVTQLASYF EPLILAAVGV 1750
    ASKILDHQQQ MTVLDQTKTL AESALQMLYA AKEGGGNPKA QHTHDAITEA 1800
    AQLMKEAVDD IMVTLNEAAS EVGLVGGMVD AIAEAMSKLD EGTPPEPKGT 1850
    FVDYQTTVVK YSKAIAVTAQ EMMTKSVTNP EELGGLASQM TSDYGHLAFQ 1900
    GQMAAATAEP EEIGFQIRTR VQDLGHGCIF LVQKAGALQV CPTDSYTKRE 1950
    LIECARAVTE KVSLVLSALQ AGNKGTQACI TAATAVSGII ADLDTTIMFA 2000
    TAGTLNAENS ETFADHRENI LKTAKALVED TKLLVSGAAS TPDKLAQAAQ 2050
    SSAATITQLA EVVKLGAASL GSDDPETQVV LINAIKDVAK ALSDLISATK 2100
    GAASKPVDDP SMYQLKGAAK VMVTNVTSLL KTVKAVEDEA TRGTRALEAT 2150
    IECIKQELTV FQSKDVPEKT SSPEESIRMT KGITMATAKA VAAGNSCRQE 2200
    DVIATANLSR KAVSDMLTAC KQASFHPDVS DEVRTRALRF GTECTLGYLD 2250
    LLEHVLVILQ KPTPEFKQQL AAFSKRVAGA VTELIQAAEA MKGTEWVDPE 2300
    DPTVIAETEL LGAAASIEAA AKKLEQLKPR AKPKQADETL DFEEQILEAA 2350
    KSIAAATSAL VKSASAAQRE LVAQGKVGSI PANAADDGQW SQGLISAARM 2400
    VAAATSSLCE AANASVQGHA SEEKLISSAK QVAASTAQLL VACKVKADQD 2450
    SEAMRRLQAA GNAVKRASDN LVRAAQKAAF GKADDDDVVV KTKFVGGIAQ 2500
    IIAAQEEMLK KERELEEARK KLAQIRQQQY KFLPTELRED EG 2542
    Length:2,542
    Mass (Da):271,613
    Last modified:May 5, 2009 - v4
    Checksum:i802D50915F4FD4B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti285 – 2851E → A in AAM73764. (PubMed:12422219)Curated
    Sequence conflicti1269 – 12691L → F in AAM73764. (PubMed:12422219)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti340 – 3401V → A.
    Corresponds to variant rs11634784 [ dbSNP | Ensembl ].
    VAR_055313
    Natural varianti1148 – 11481A → S.
    Corresponds to variant rs2280279 [ dbSNP | Ensembl ].
    VAR_014432
    Natural varianti1148 – 11481A → T.
    Corresponds to variant rs2280279 [ dbSNP | Ensembl ].
    VAR_059136
    Natural varianti1877 – 18771V → I.
    Corresponds to variant rs7182971 [ dbSNP | Ensembl ].
    VAR_055314
    Natural varianti2144 – 21441T → I.
    Corresponds to variant rs11633796 [ dbSNP | Ensembl ].
    VAR_055315
    Natural varianti2266 – 22661F → L.
    Corresponds to variant rs3816988 [ dbSNP | Ensembl ].
    VAR_014433

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF402000 mRNA. Translation: AAM73764.1.
    AC068233 Genomic DNA. No translation available.
    AC100839 Genomic DNA. No translation available.
    AC103740 Genomic DNA. No translation available.
    AB002318 mRNA. Translation: BAA20778.2.
    CCDSiCCDS32261.1.
    RefSeqiNP_055874.2. NM_015059.2.
    XP_006720781.1. XM_006720718.1.
    UniGeneiHs.569438.
    Hs.610975.

    Genome annotation databases

    EnsembliENST00000306829; ENSP00000303476; ENSG00000171914.
    ENST00000561311; ENSP00000453508; ENSG00000171914.
    GeneIDi83660.
    KEGGihsa:83660.
    UCSCiuc002alb.4. human.

    Polymorphism databases

    DMDMi229463036.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF402000 mRNA. Translation: AAM73764.1 .
    AC068233 Genomic DNA. No translation available.
    AC100839 Genomic DNA. No translation available.
    AC103740 Genomic DNA. No translation available.
    AB002318 mRNA. Translation: BAA20778.2 .
    CCDSi CCDS32261.1.
    RefSeqi NP_055874.2. NM_015059.2.
    XP_006720781.1. XM_006720718.1.
    UniGenei Hs.569438.
    Hs.610975.

    3D structure databases

    ProteinModelPortali Q9Y4G6.
    SMRi Q9Y4G6. Positions 1-408, 488-914, 916-1046, 1048-1359, 1361-1974, 1976-2292, 2297-2479, 2496-2529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123717. 8 interactions.
    DIPi DIP-17039N.
    IntActi Q9Y4G6. 6 interactions.
    MINTi MINT-5005773.
    STRINGi 9606.ENSP00000303476.

    PTM databases

    PhosphoSitei Q9Y4G6.

    Polymorphism databases

    DMDMi 229463036.

    Proteomic databases

    MaxQBi Q9Y4G6.
    PaxDbi Q9Y4G6.
    PRIDEi Q9Y4G6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306829 ; ENSP00000303476 ; ENSG00000171914 .
    ENST00000561311 ; ENSP00000453508 ; ENSG00000171914 .
    GeneIDi 83660.
    KEGGi hsa:83660.
    UCSCi uc002alb.4. human.

    Organism-specific databases

    CTDi 83660.
    GeneCardsi GC15P062682.
    H-InvDB HIX0012315.
    HGNCi HGNC:15447. TLN2.
    HPAi CAB017194.
    MIMi 607349. gene.
    neXtProti NX_Q9Y4G6.
    PharmGKBi PA37958.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324465.
    HOGENOMi HOG000006734.
    HOVERGENi HBG023870.
    InParanoidi Q9Y4G6.
    KOi K06271.
    OMAi GVMENSK.
    OrthoDBi EOG7TBC1J.
    PhylomeDBi Q9Y4G6.
    TreeFami TF314677.

    Miscellaneous databases

    GeneWikii TLN2.
    GenomeRNAii 83660.
    NextBioi 72631.
    PROi Q9Y4G6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y4G6.
    Bgeei Q9Y4G6.
    CleanExi HS_TLN2.
    Genevestigatori Q9Y4G6.

    Family and domain databases

    Gene3Di 1.20.1410.10. 2 hits.
    1.20.1420.10. 1 hit.
    1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR002558. ILWEQ_dom.
    IPR002404. Insln_rcpt_S1.
    IPR011993. PH_like_dom.
    IPR015711. Talin-2.
    IPR015224. Talin_cent.
    IPR029071. Ubiquitin-rel_dom.
    IPR015009. Vinculin-bd_dom.
    IPR006077. Vinculin/catenin.
    [Graphical view ]
    PANTHERi PTHR19981:SF15. PTHR19981:SF15. 1 hit.
    Pfami PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    PF02174. IRS. 1 hit.
    PF09141. Talin_middle. 1 hit.
    PF08913. VBS. 1 hit.
    [Graphical view ]
    ProDomi PD011820. ILWEQ. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00295. B41. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109880. SSF109880. 1 hit.
    SSF109885. SSF109885. 4 hits.
    SSF47031. SSF47031. 1 hit.
    SSF47220. SSF47220. 5 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin."
      Di Paolo G., Pellegrini L., Letinic K., Cestra G., Zoncu R., Voronov S., Chang S., Guo J., Wenk M.R., De Camilli P.
      Nature 420:85-89(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 610-2542.
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTLN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4G6
    Secondary accession number(s): A6NLB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 140 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3