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Q9Y4G6 (TLN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Talin-2
Gene names
Name:TLN2
Synonyms:KIAA0320
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2542 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity By similarity.

Subunit structure

Interacts directly with PIP5K1C.

Subcellular location

Cell junctionfocal adhesion. Cell junctionsynapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcytoskeleton. Note: Focal adhesion plaques and synapses.

Sequence similarities

Contains 1 FERM domain.

Contains 1 I/LWEQ domain.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Cytoplasm
Cytoskeleton
Membrane
Synapse
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Non-traceable author statement PubMed 11907066. Source: UniProtKB

cell-cell junction assembly

Traceable author statement PubMed 15494027. Source: UniProtKB

cytoskeletal anchoring at plasma membrane

Inferred from electronic annotation. Source: InterPro

   Cellular_componentactin cytoskeleton

Non-traceable author statement PubMed 10320934. Source: UniProtKB

cell-cell junction

Inferred by curator PubMed 15494027. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

fascia adherens

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

ruffle

Inferred from electronic annotation. Source: InterPro

synapse

Non-traceable author statement PubMed 11907066. Source: UniProtKB

   Molecular_functionactin binding

Non-traceable author statement PubMed 10320934. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 10320934. Source: UniProtKB

structural constituent of cytoskeleton

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Non-traceable author statement PubMed 10320934. Source: UniProtKB

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25422542Talin-2
PRO_0000219431

Regions

Domain88 – 406319FERM
Domain2294 – 2533240I/LWEQ
Region312 – 40695Interaction with PIP5K1C By similarity
Compositional bias861 – 1193333Ala-rich

Amino acid modifications

Modified residue16651Phosphotyrosine By similarity
Modified residue18431Phosphothreonine Ref.6 Ref.10

Natural variations

Natural variant3401V → A.
Corresponds to variant rs11634784 [ dbSNP | Ensembl ].
VAR_055313
Natural variant11481A → S.
Corresponds to variant rs2280279 [ dbSNP | Ensembl ].
VAR_014432
Natural variant11481A → T.
Corresponds to variant rs2280279 [ dbSNP | Ensembl ].
VAR_059136
Natural variant18771V → I.
Corresponds to variant rs7182971 [ dbSNP | Ensembl ].
VAR_055314
Natural variant21441T → I.
Corresponds to variant rs11633796 [ dbSNP | Ensembl ].
VAR_055315
Natural variant22661F → L.
Corresponds to variant rs3816988 [ dbSNP | Ensembl ].
VAR_014433

Experimental info

Sequence conflict2851E → A in AAM73764. Ref.1
Sequence conflict12691L → F in AAM73764. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y4G6 [UniParc].

Last modified May 5, 2009. Version 4.
Checksum: 802D50915F4FD4B0

FASTA2,542271,613
        10         20         30         40         50         60 
MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG LFLSDEDPRK 

        70         80         90        100        110        120 
GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK TVMVDDSKTV GELLVTICSR 

       130        140        150        160        170        180 
IGITNYEEYS LIQETIEEKK EEGTGTLKKD RTLLRDERKM EKLKAKLHTD DDLNWLDHSR 

       190        200        210        220        230        240 
TFREQGVDEN ETLLLRRKFF YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF 

       250        260        270        280        290        300 
GGFQAQIQFG PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK 

       310        320        330        340        350        360 
YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV LQEWPLTTVK 

       370        380        390        400        410        420 
RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID IILKKKQSKD RFGLEGDEES 

       430        440        450        460        470        480 
TMLEESVSPK KSTILQQQFN RTGKAEHGSV ALPAVMRSGS SGPETFNVGS MPSPQQQVMV 

       490        500        510        520        530        540 
GQMHRGHMPP LTSAQQALMG TINTSMHAVQ QAQDDLSELD SLPPLGQDMA SRVWVQNKVD 

       550        560        570        580        590        600 
ESKHEIHSQV DAITAGTASV VNLTAGDPAD TDYTAVGCAI TTISSNLTEM SKGVKLLAAL 

       610        620        630        640        650        660 
MDDEVGSGED LLRAARTLAG AVSDLLKAVQ PTSGEPRQTV LTAAGSIGQA SGDLLRQIGE 

       670        680        690        700        710        720 
NETDERFQDV LMSLAKAVAN AAAMLVLKAK NVAQVAEDTV LQNRVIAAAT QCALSTSQLV 

       730        740        750        760        770        780 
ACAKVVSPTI SSPVCQEQLI EAGKLVDRSV ENCVRACQAA TTDSELLKQV SAAASVVSQA 

       790        800        810        820        830        840 
LHDLLQHVRQ FASRGEPIGR YDQATDTIMC VTESIFSSMG DAGEMVRQAR VLAQATSDLV 

       850        860        870        880        890        900 
NAMRSDAEAE IDMENSKKLL AAAKLLADST ARMVEAAKGA AANPENEDQQ QRLREAAEGL 

       910        920        930        940        950        960 
RVATNAAAQN AIKKKIVNRL EVAAKQAAAA ATQTIAASQN AAVSNKNPAA QQQLVQSCKA 

       970        980        990       1000       1010       1020 
VADHIPQLVQ GVRGSQAQAE DLSAQLALII SSQNFLQPGS KMVSSAKAAV PTVSDQAAAM 

      1030       1040       1050       1060       1070       1080 
QLSQCAKNLA TSLAELRTAS QKAHEACGPM EIDSALNTVQ TLKNELQDAK MAAVESQLKP 

      1090       1100       1110       1120       1130       1140 
LPGETLEKCA QDLGSTSKAV GSSMAQLLTC AAQGNEHYTG VAARETAQAL KTLAQAARGV 

      1150       1160       1170       1180       1190       1200 
AASTTDPAAA HAMLDSARDV MEGSAMLIQE AKQALIAPGD AERQQRLAQV AKAVSHSLNN 

      1210       1220       1230       1240       1250       1260 
CVNCLPGQKD VDVALKSIGE SSKKLLVDSL PPSTKPFQEA QSELNQAAAD LNQSAGEVVH 

      1270       1280       1290       1300       1310       1320 
ATRGQSGELA AASGKFSDDF DEFLDAGIEM AGQAQTKEDQ IQVIGNLKNI SMASSKLLLA 

      1330       1340       1350       1360       1370       1380 
AKSLSVDPGA PNAKNLLAAA ARAVTESINQ LITLCTQQAP GQKECDNALR ELETVKGMLD 

      1390       1400       1410       1420       1430       1440 
NPNEPVSDLS YFDCIESVME NSKVLGESMA GISQNAKTGD LPAFGECVGI ASKALCGLTE 

      1450       1460       1470       1480       1490       1500 
AAAQAAYLVG ISDPNSQAGH QGLVDPIQFA RANQAIQMAC QNLVDPGSSP SQVLSAATIV 

      1510       1520       1530       1540       1550       1560 
AKHTSALCNA CRIASSKTAN PVAKRHFVQS AKEVANSTAN LVKTIKALDG DFSEDNRNKC 

      1570       1580       1590       1600       1610       1620 
RIATAPLIEA VENLTAFASN PEFVSIPAQI SSEGSQAQEP ILVSAKTMLE SSSYLIRTAR 

      1630       1640       1650       1660       1670       1680 
SLAINPKDPP TWSVLAGHSH TVSDSIKSLI TSIRDKAPGQ RECDYSIDGI NRCIRDIEQA 

      1690       1700       1710       1720       1730       1740 
SLAAVSQSLA TRDDISVEAL QEQLTSVVQE IGHLIDPIAT AARGEAAQLG HKVTQLASYF 

      1750       1760       1770       1780       1790       1800 
EPLILAAVGV ASKILDHQQQ MTVLDQTKTL AESALQMLYA AKEGGGNPKA QHTHDAITEA 

      1810       1820       1830       1840       1850       1860 
AQLMKEAVDD IMVTLNEAAS EVGLVGGMVD AIAEAMSKLD EGTPPEPKGT FVDYQTTVVK 

      1870       1880       1890       1900       1910       1920 
YSKAIAVTAQ EMMTKSVTNP EELGGLASQM TSDYGHLAFQ GQMAAATAEP EEIGFQIRTR 

      1930       1940       1950       1960       1970       1980 
VQDLGHGCIF LVQKAGALQV CPTDSYTKRE LIECARAVTE KVSLVLSALQ AGNKGTQACI 

      1990       2000       2010       2020       2030       2040 
TAATAVSGII ADLDTTIMFA TAGTLNAENS ETFADHRENI LKTAKALVED TKLLVSGAAS 

      2050       2060       2070       2080       2090       2100 
TPDKLAQAAQ SSAATITQLA EVVKLGAASL GSDDPETQVV LINAIKDVAK ALSDLISATK 

      2110       2120       2130       2140       2150       2160 
GAASKPVDDP SMYQLKGAAK VMVTNVTSLL KTVKAVEDEA TRGTRALEAT IECIKQELTV 

      2170       2180       2190       2200       2210       2220 
FQSKDVPEKT SSPEESIRMT KGITMATAKA VAAGNSCRQE DVIATANLSR KAVSDMLTAC 

      2230       2240       2250       2260       2270       2280 
KQASFHPDVS DEVRTRALRF GTECTLGYLD LLEHVLVILQ KPTPEFKQQL AAFSKRVAGA 

      2290       2300       2310       2320       2330       2340 
VTELIQAAEA MKGTEWVDPE DPTVIAETEL LGAAASIEAA AKKLEQLKPR AKPKQADETL 

      2350       2360       2370       2380       2390       2400 
DFEEQILEAA KSIAAATSAL VKSASAAQRE LVAQGKVGSI PANAADDGQW SQGLISAARM 

      2410       2420       2430       2440       2450       2460 
VAAATSSLCE AANASVQGHA SEEKLISSAK QVAASTAQLL VACKVKADQD SEAMRRLQAA 

      2470       2480       2490       2500       2510       2520 
GNAVKRASDN LVRAAQKAAF GKADDDDVVV KTKFVGGIAQ IIAAQEEMLK KERELEEARK 

      2530       2540 
KLAQIRQQQY KFLPTELRED EG 

« Hide

References

« Hide 'large scale' references
[1]"Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin."
Di Paolo G., Pellegrini L., Letinic K., Cestra G., Zoncu R., Voronov S., Chang S., Guo J., Wenk M.R., De Camilli P.
Nature 420:85-89(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Skeletal muscle.
[2]"Analysis of the mammalian talin2 gene TLN2."
Monkley S.J., Pritchard C.A., Critchley D.R.
Biochem. Biophys. Res. Commun. 286:880-885(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 610-2542.
Tissue: Brain.
[5]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[6]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1843, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF402000 mRNA. Translation: AAM73764.1.
AC068233 Genomic DNA. No translation available.
AC100839 Genomic DNA. No translation available.
AC103740 Genomic DNA. No translation available.
AB002318 mRNA. Translation: BAA20778.2.
CCDSCCDS32261.1.
RefSeqNP_055874.2. NM_015059.2.
XP_006720781.1. XM_006720718.1.
UniGeneHs.569438.
Hs.610975.

3D structure databases

ProteinModelPortalQ9Y4G6.
SMRQ9Y4G6. Positions 1-408, 488-914, 916-1046, 1048-1359, 1361-1974, 1976-2292, 2297-2479, 2496-2529.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123717. 8 interactions.
DIPDIP-17039N.
IntActQ9Y4G6. 6 interactions.
MINTMINT-5005773.
STRING9606.ENSP00000303476.

PTM databases

PhosphoSiteQ9Y4G6.

Polymorphism databases

DMDM229463036.

Proteomic databases

MaxQBQ9Y4G6.
PaxDbQ9Y4G6.
PRIDEQ9Y4G6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306829; ENSP00000303476; ENSG00000171914.
ENST00000561311; ENSP00000453508; ENSG00000171914.
GeneID83660.
KEGGhsa:83660.
UCSCuc002alb.4. human.

Organism-specific databases

CTD83660.
GeneCardsGC15P062682.
H-InvDBHIX0012315.
HGNCHGNC:15447. TLN2.
HPACAB017194.
MIM607349. gene.
neXtProtNX_Q9Y4G6.
PharmGKBPA37958.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG324465.
HOGENOMHOG000006734.
HOVERGENHBG023870.
InParanoidQ9Y4G6.
KOK06271.
OMAGVMENSK.
OrthoDBEOG7TBC1J.
PhylomeDBQ9Y4G6.
TreeFamTF314677.

Gene expression databases

ArrayExpressQ9Y4G6.
BgeeQ9Y4G6.
CleanExHS_TLN2.
GenevestigatorQ9Y4G6.

Family and domain databases

Gene3D1.20.1410.10. 2 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR002404. Insln_rcpt_S1.
IPR011993. PH_like_dom.
IPR015711. Talin-2.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERPTHR19981:SF15. PTHR19981:SF15. 1 hit.
PfamPF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 1 hit.
PF02174. IRS. 1 hit.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 1 hit.
[Graphical view]
ProDomPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00295. B41. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 4 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 5 hits.
SSF54236. SSF54236. 1 hit.
PROSITEPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTLN2.
GenomeRNAi83660.
NextBio72631.
PROQ9Y4G6.
SOURCESearch...

Entry information

Entry nameTLN2_HUMAN
AccessionPrimary (citable) accession number: Q9Y4G6
Secondary accession number(s): A6NLB8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM