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Protein

Centrosomal protein of 170 kDa protein B

Gene

CEP170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization.By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099814-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa protein B
Alternative name(s):
Centrosomal protein 170B
Short name:
Cep170B
Gene namesi
Name:CEP170B
Synonyms:FAM68C, KIAA0284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20362. CEP170B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000099814.
PharmGKBiPA134863153.

Polymorphism and mutation databases

BioMutaiCEP170B.
DMDMi143342098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828891 – 1589Centrosomal protein of 170 kDa protein BAdd BLAST1589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei480PhosphoserineBy similarity1
Modified residuei492PhosphoserineCombined sources1
Modified residuei536PhosphoserineBy similarity1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei711PhosphoserineBy similarity1
Modified residuei721PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1
Modified residuei972PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1135PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1304PhosphothreonineCombined sources1
Modified residuei1356PhosphoserineBy similarity1
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1545PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4F5.
PaxDbiQ9Y4F5.
PeptideAtlasiQ9Y4F5.
PRIDEiQ9Y4F5.

PTM databases

iPTMnetiQ9Y4F5.
PhosphoSitePlusiQ9Y4F5.

Expressioni

Gene expression databases

BgeeiENSG00000099814.
CleanExiHS_KIAA0284.
ExpressionAtlasiQ9Y4F5. baseline and differential.
GenevisibleiQ9Y4F5. HS.

Organism-specific databases

HPAiHPA000871.
HPA059017.

Interactioni

Protein-protein interaction databases

BioGridi129628. 19 interactors.
IntActiQ9Y4F5. 15 interactors.
STRINGi9606.ENSP00000404151.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4F5.
SMRiQ9Y4F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the CEP170 family.Curated
Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJXX. Eukaryota.
ENOG410XQU2. LUCA.
GeneTreeiENSGT00640000091476.
HOGENOMiHOG000111524.
HOVERGENiHBG108016.
InParanoidiQ9Y4F5.
KOiK16463.
PhylomeDBiQ9Y4F5.
TreeFamiTF328469.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ
60 70 80 90 100
DRDEHWVKDL GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER
110 120 130 140 150
VQHRVPEEAL KHEKYTSQLQ VSVKGLAPKR SEALPEHTPY CEASNPRPEK
160 170 180 190 200
GDRRPGTEAA SYRTPLYGQP SWWGEDDGST LPDAQRQGEP YPERPKGPVQ
210 220 230 240 250
QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP EVPAHEMPTK
260 270 280 290 300
DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK
310 320 330 340 350
EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK
360 370 380 390 400
GHKHEDGTQS DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN
410 420 430 440 450
QQAFVIEFFD EDTPRKKRSQ SFTHSPSGDP KADKRRGPTP ADRDRPSVPA
460 470 480 490 500
PVQAGGRSSG PQRAGSLKRE KTEERLGSPS PASRTPARPF GSVGRRSRLA
510 520 530 540 550
QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP PTPPPAPTDP
560 570 580 590 600
QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL
610 620 630 640 650
SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL
660 670 680 690 700
PVPGSPGGQK WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR
710 720 730 740 750
LPQLPSERAD SPAGPESSRR SGPGPPELDS EQPSRLFGQE ELDPDSLSDA
760 770 780 790 800
SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS RGRRSPRAPG EPTPASFFIG
810 820 830 840 850
DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA NGRMVIQLRP
860 870 880 890 900
GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA
910 920 930 940 950
ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL
960 970 980 990 1000
SGDSDVDTAS TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL
1010 1020 1030 1040 1050
VSAREQSSER QHHPLGPTDM GRGEPVRRSA IRRGHRPRGS LDWPSEERGP
1060 1070 1080 1090 1100
VLAHLPSSDV MASNHETPEA TGAGRLGSRR KPAAPPPSPA AREEQSRSSA
1110 1120 1130 1140 1150
SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA DGERGSLGNP
1160 1170 1180 1190 1200
EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV
1210 1220 1230 1240 1250
ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR
1260 1270 1280 1290 1300
RQQGSDYTST SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG
1310 1320 1330 1340 1350
PRDTDDDEEE PDPYGFIVQT AEIAEIARLS QTLVKDVAIL AQEIHDVAGD
1360 1370 1380 1390 1400
GDTLGSSEPA HSASLSNMPS TPASTISARE ELVQRIPEAS LNFQKVPPGS
1410 1420 1430 1440 1450
LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV SQLSQAIREN
1460 1470 1480 1490 1500
TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR
1510 1520 1530 1540 1550
RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA
1560 1570 1580
SAEALLPALP LRNFPQRASC GPPSLPDPTF LPDAERFLI
Length:1,589
Mass (Da):171,688
Last modified:April 3, 2007 - v4
Checksum:iB232960C12A81244
GO
Isoform 2 (identifier: Q9Y4F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1247-1282: NTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTA → T

Show »
Length:1,554
Mass (Da):167,714
Checksum:i1EBC4872698A20BF
GO
Isoform 3 (identifier: Q9Y4F5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.
Show »
Length:1,519
Mass (Da):163,627
Checksum:i240FDF3FC1A9D934
GO

Sequence cautioni

The sequence AAH47913 differs from that shown. Reason: Frameshift at position 1379.Curated
The sequence BAA22953 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti315A → T in BAA22953 (PubMed:9179496).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242471 – 70Missing in isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0242481247 – 1282NTRRR…HTSTA → T in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006622 mRNA. Translation: BAA22953.3. Different initiation.
AL583810 Genomic DNA. No translation available.
BC047913 mRNA. Translation: AAH47913.1. Frameshift.
BC112928 mRNA. Translation: AAI12929.1.
CCDSiCCDS45175.1. [Q9Y4F5-2]
CCDS45176.2. [Q9Y4F5-3]
PIRiT00037.
RefSeqiNP_001106197.1. NM_001112726.2. [Q9Y4F5-2]
NP_055820.2. NM_015005.2. [Q9Y4F5-3]
XP_005267607.1. XM_005267550.3. [Q9Y4F5-1]
XP_011534967.1. XM_011536665.2. [Q9Y4F5-1]
XP_011534968.1. XM_011536666.2. [Q9Y4F5-1]
UniGeneiHs.533721.

Genome annotation databases

EnsembliENST00000414716; ENSP00000404151; ENSG00000099814. [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814. [Q9Y4F5-3]
GeneIDi283638.
KEGGihsa:283638.
UCSCiuc001yps.4. human. [Q9Y4F5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006622 mRNA. Translation: BAA22953.3. Different initiation.
AL583810 Genomic DNA. No translation available.
BC047913 mRNA. Translation: AAH47913.1. Frameshift.
BC112928 mRNA. Translation: AAI12929.1.
CCDSiCCDS45175.1. [Q9Y4F5-2]
CCDS45176.2. [Q9Y4F5-3]
PIRiT00037.
RefSeqiNP_001106197.1. NM_001112726.2. [Q9Y4F5-2]
NP_055820.2. NM_015005.2. [Q9Y4F5-3]
XP_005267607.1. XM_005267550.3. [Q9Y4F5-1]
XP_011534967.1. XM_011536665.2. [Q9Y4F5-1]
XP_011534968.1. XM_011536666.2. [Q9Y4F5-1]
UniGeneiHs.533721.

3D structure databases

ProteinModelPortaliQ9Y4F5.
SMRiQ9Y4F5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129628. 19 interactors.
IntActiQ9Y4F5. 15 interactors.
STRINGi9606.ENSP00000404151.

PTM databases

iPTMnetiQ9Y4F5.
PhosphoSitePlusiQ9Y4F5.

Polymorphism and mutation databases

BioMutaiCEP170B.
DMDMi143342098.

Proteomic databases

EPDiQ9Y4F5.
PaxDbiQ9Y4F5.
PeptideAtlasiQ9Y4F5.
PRIDEiQ9Y4F5.

Protocols and materials databases

DNASUi283638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414716; ENSP00000404151; ENSG00000099814. [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814. [Q9Y4F5-3]
GeneIDi283638.
KEGGihsa:283638.
UCSCiuc001yps.4. human. [Q9Y4F5-1]

Organism-specific databases

CTDi283638.
GeneCardsiCEP170B.
HGNCiHGNC:20362. CEP170B.
HPAiHPA000871.
HPA059017.
neXtProtiNX_Q9Y4F5.
OpenTargetsiENSG00000099814.
PharmGKBiPA134863153.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXX. Eukaryota.
ENOG410XQU2. LUCA.
GeneTreeiENSGT00640000091476.
HOGENOMiHOG000111524.
HOVERGENiHBG108016.
InParanoidiQ9Y4F5.
KOiK16463.
PhylomeDBiQ9Y4F5.
TreeFamiTF328469.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099814-MONOMER.

Miscellaneous databases

ChiTaRSiCEP170B. human.
GenomeRNAii283638.
PROiQ9Y4F5.

Gene expression databases

BgeeiENSG00000099814.
CleanExiHS_KIAA0284.
ExpressionAtlasiQ9Y4F5. baseline and differential.
GenevisibleiQ9Y4F5. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC170B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4F5
Secondary accession number(s): Q2KHR7, Q86TI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.