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Protein

Meiosis arrest female protein 1

Gene

KIAA0430

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Meiosis, Oogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis arrest female protein 1
Alternative name(s):
Limkain-b1
Gene namesi
Name:KIAA0430
Synonyms:LKAP, MARF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29562. KIAA0430.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148631.

Polymorphism and mutation databases

BioMutaiKIAA0430.
DMDMi387912929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17421742Meiosis arrest female protein 1PRO_0000276846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661PhosphoserineCombined sources
Modified residuei699 – 6991PhosphotyrosineBy similarity
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei1091 – 10911PhosphoserineCombined sources
Modified residuei1093 – 10931PhosphoserineCombined sources
Modified residuei1571 – 15711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4F3.
MaxQBiQ9Y4F3.
PaxDbiQ9Y4F3.
PeptideAtlasiQ9Y4F3.
PRIDEiQ9Y4F3.

PTM databases

iPTMnetiQ9Y4F3.
PhosphoSiteiQ9Y4F3.

Expressioni

Gene expression databases

BgeeiQ9Y4F3.
CleanExiHS_KIAA0430.
ExpressionAtlasiQ9Y4F3. baseline and differential.
GenevisibleiQ9Y4F3. HS.

Organism-specific databases

HPAiHPA017992.

Interactioni

Subunit structurei

Interacts with LIMK2.1 Publication

Protein-protein interaction databases

BioGridi115020. 8 interactions.
IntActiQ9Y4F3. 7 interactions.
STRINGi9606.ENSP00000379654.

Structurei

Secondary structure

1
1742
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi510 – 5189Combined sources
Helixi525 – 53713Combined sources
Turni538 – 5403Combined sources
Beta strandi543 – 5453Combined sources
Beta strandi551 – 5577Combined sources
Helixi558 – 56811Combined sources
Beta strandi573 – 5764Combined sources
Beta strandi579 – 5835Combined sources
Beta strandi791 – 7977Combined sources
Helixi804 – 81815Combined sources
Beta strandi821 – 8266Combined sources
Beta strandi836 – 8427Combined sources
Helixi843 – 85311Combined sources
Beta strandi856 – 8583Combined sources
Beta strandi861 – 8677Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DGXNMR-A789-871[»]
2DIUNMR-A510-592[»]
ProteinModelPortaliQ9Y4F3.
SMRiQ9Y4F3. Positions 510-597, 791-875.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4F3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini353 – 490138NYNAdd
BLAST
Domaini791 – 87080RRMPROSITE-ProRule annotationAdd
BLAST
Domaini875 – 94975HTH OST-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini1003 – 107977HTH OST-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini1099 – 117375HTH OST-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini1175 – 125076HTH OST-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini1259 – 133476HTH OST-type 5PROSITE-ProRule annotationAdd
BLAST
Domaini1335 – 141076HTH OST-type 6PROSITE-ProRule annotationAdd
BLAST
Domaini1411 – 148575HTH OST-type 7PROSITE-ProRule annotationAdd
BLAST
Domaini1486 – 156075HTH OST-type 8PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi117 – 1259Poly-Gly
Compositional biasi1079 – 10824Poly-Pro
Compositional biasi1685 – 16906Poly-Ser

Sequence similaritiesi

Contains 8 HTH OST-type domains.PROSITE-ProRule annotation
Contains 1 NYN domain.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF58. Eukaryota.
ENOG410XQFX. LUCA.
GeneTreeiENSGT00390000002393.
HOVERGENiHBG081919.
InParanoidiQ9Y4F3.
KOiK17573.
OMAiCCGKLHF.
PhylomeDBiQ9Y4F3.
TreeFamiTF329117.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
3.40.50.1010. 1 hit.
InterProiIPR024582. Limkain_b1_cons_dom.
IPR024768. Marf1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR021139. NYN_limkain-b1.
IPR025605. OST-HTH/LOTUS_dom.
IPR029060. PIN_domain-like.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR14379. PTHR14379. 4 hits.
PfamiPF11608. Limkain-b1. 1 hit.
PF01936. NYN. 1 hit.
PF12872. OST-HTH. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS51644. HTH_OST. 8 hits.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4F3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEGNGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE
60 70 80 90 100
YMENKKVAVE LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS
110 120 130 140 150
CCAHCPNEPS TSPMRFGGGG GGSGGTSSLI HPGALLDSQS TRTITCQVGS
160 170 180 190 200
GFAFQSASSL QNASARNNLA GIASDFPSMC LESNLSSCKH LPCCGKLHFQ
210 220 230 240 250
SCHGNVHKLH QFPSLQGCTS AGYFPCSDFT SGAPGHLEEH ISQSELTPHL
260 270 280 290 300
CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP
310 320 330 340 350
APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL
360 370 380 390 400
PPIGVFWDIE NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN
410 420 430 440 450
KEVIQELNNC QVTVAHINAT AKNAADDKLR QSLRRFANTH TAPATVVLVS
460 470 480 490 500
TDVNFALELS DLRHRHGFHI ILVHKNQASE ALLHHANELI RFEEFISDLP
510 520 530 540 550
PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG GKVLSITGCS
560 570 580 590 600
AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD
610 620 630 640 650
KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS ATKNTNVKSL
660 670 680 690 700
QELCRMESKT GHRNSEHQQG HLRLVVPTHG NSSAAVSTPK NSGVAEPVYK
710 720 730 740 750
TSQKKENLSA RSVTSSPVEK KDKEETVFQV SYPSAFSKLV ASRQVSPLLA
760 770 780 790 800
SQSWSSRSMS PNLLNRASPL AFNIANSSSE ADCPDPFANG ADVQVSNIDY
810 820 830 840 850
RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM ENLQDAIGAV
860 870 880 890 900
NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF
910 920 930 940 950
TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS
960 970 980 990 1000
SQSHDGSSTN CSPIIFEELE YHEPVCRQHC SNKDFSEHEF DPDSYKIPFV
1010 1020 1030 1040 1050
ILSLKTFAPQ VHSLLQTHEG TVPLLSFPDC YIAEFGDLEV VQENQGGVPL
1060 1070 1080 1090 1100
EHFITCVPGV NIATAQNGIK VVKWIHNKPP PPNTDPWLLR SKSPVGNPQL
1110 1120 1130 1140 1150
IQFSREVIDL LKSQPSCVIP ISHFIPSYHH HFAKQCRVSD YGYSKLIELL
1160 1170 1180 1190 1200
EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF
1210 1220 1230 1240 1250
SQAYHWCFSK DWDVTEYGVC ELIDIVSEIP DTTICLSQQD NEMVICIPKR
1260 1270 1280 1290 1300
ERTQDEIERT KQFSKDVVDL LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY
1310 1320 1330 1340 1350
YGFTKLLELF EAIPDTLQVL ECGEEKILTL TEVERFKALA AQFVKLLRSQ
1360 1370 1380 1390 1400
KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS SISALTQKLC HVVKVADIES
1410 1420 1430 1440 1450
GRQIQLINRK SLRSLTAQLL VLLMSWEGTT HLSVEELKRH YESTHNTPLN
1460 1470 1480 1490 1500
PCEYGFMTLT ELLKSLPYLV EVFTNDKMEE CVKLTSLYLF AKNVRSLLHT
1510 1520 1530 1540 1550
YHYQQIFLHE FSMAYTKYVG ETLQPKTYGH SSVEELLGAI PQVVWIKGHG
1560 1570 1580 1590 1600
HKRIVVLKND MKSRLSSLSL SPANHENQPS EGERILEVPE SHTASELKLG
1610 1620 1630 1640 1650
ADGSGPSHTE QELLRLTDDS PVDLLCAPVP SCLPSPQLRP DPVILQSADL
1660 1670 1680 1690 1700
IQFEERPQEP SEIMILNQEE KMEIPIPGKS KTLTSDSSSS CISAAVPVPP
1710 1720 1730 1740
CPSSETSESL LSKDPVESPA KKQPKNRVKL AANFSLAPIT KL
Length:1,742
Mass (Da):192,859
Last modified:May 16, 2012 - v6
Checksum:i9A0C0687B93A6A4B
GO
Isoform 2 (identifier: Q9Y4F3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1026-1084: Missing.

Show »
Length:1,683
Mass (Da):186,447
Checksum:iFBB6FE3DF3E14D75
GO
Isoform 3 (identifier: Q9Y4F3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-338: Missing.

Show »
Length:1,739
Mass (Da):192,618
Checksum:iAE0825D8F42C7200
GO
Isoform 4 (identifier: Q9Y4F3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-509: Missing.
     754-754: W → WS

Show »
Length:1,742
Mass (Da):192,818
Checksum:i68D45929E9D4BB88
GO
Isoform 5 (identifier: Q9Y4F3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-291: PARNSIIDAAKVWP → VRIFLFLKLGAAED
     293-1742: Missing.

Note: May be due to an intron retention.
Show »
Length:292
Mass (Da):31,458
Checksum:iA36DF5EF146267CD
GO

Sequence cautioni

The sequence AAC31662.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAH64914.2 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence EAW53920.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti451 – 4511T → A in AC026401 (PubMed:15616553).Curated
Sequence conflicti941 – 9411S → R in BAA24860 (PubMed:9455477).Curated
Sequence conflicti1541 – 15411P → S in AAI44516 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 29114PARNS…AKVWP → VRIFLFLKLGAAED in isoform 5. 1 PublicationVSP_037755Add
BLAST
Alternative sequencei293 – 17421450Missing in isoform 5. 1 PublicationVSP_037756Add
BLAST
Alternative sequencei336 – 3383Missing in isoform 3. 1 PublicationVSP_037757
Alternative sequencei509 – 5091Missing in isoform 4. 1 PublicationVSP_037758
Alternative sequencei754 – 7541W → WS in isoform 4. 1 PublicationVSP_037759
Alternative sequencei1026 – 108459Missing in isoform 2. 1 PublicationVSP_022988Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302667 mRNA. Translation: BAG63901.1.
U95740 Genomic DNA. Translation: AAC31662.1. Sequence problems.
AC026401 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53920.1. Sequence problems.
BC064914 mRNA. Translation: AAH64914.2. Sequence problems.
BC137165 mRNA. Translation: AAI37166.1.
BC137170 mRNA. Translation: AAI37171.1.
BC144514 mRNA. Translation: AAI44515.1.
BC144515 mRNA. Translation: AAI44516.1.
AB007890 mRNA. Translation: BAA24860.3.
AB012134 mRNA. Translation: BAB82433.1.
CCDSiCCDS10562.2. [Q9Y4F3-1]
CCDS53990.1. [Q9Y4F3-5]
CCDS55991.1. [Q9Y4F3-4]
PIRiT00060.
RefSeqiNP_001171927.1. NM_001184998.1. [Q9Y4F3-5]
NP_001171928.1. NM_001184999.1. [Q9Y4F3-4]
NP_055462.2. NM_014647.3. [Q9Y4F3-1]
XP_005255764.1. XM_005255707.1.
XP_006725281.1. XM_006725218.1.
UniGeneiHs.173524.

Genome annotation databases

EnsembliENST00000396368; ENSP00000379654; ENSG00000166783. [Q9Y4F3-1]
ENST00000548025; ENSP00000449376; ENSG00000166783. [Q9Y4F3-4]
ENST00000551742; ENSP00000450309; ENSG00000166783. [Q9Y4F3-5]
ENST00000621511; ENSP00000479383; ENSG00000277140. [Q9Y4F3-1]
ENST00000632465; ENSP00000487685; ENSG00000277140. [Q9Y4F3-4]
ENST00000632628; ENSP00000488025; ENSG00000277140. [Q9Y4F3-5]
GeneIDi9665.
KEGGihsa:9665.
UCSCiuc002ddr.4. human. [Q9Y4F3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302667 mRNA. Translation: BAG63901.1.
U95740 Genomic DNA. Translation: AAC31662.1. Sequence problems.
AC026401 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53920.1. Sequence problems.
BC064914 mRNA. Translation: AAH64914.2. Sequence problems.
BC137165 mRNA. Translation: AAI37166.1.
BC137170 mRNA. Translation: AAI37171.1.
BC144514 mRNA. Translation: AAI44515.1.
BC144515 mRNA. Translation: AAI44516.1.
AB007890 mRNA. Translation: BAA24860.3.
AB012134 mRNA. Translation: BAB82433.1.
CCDSiCCDS10562.2. [Q9Y4F3-1]
CCDS53990.1. [Q9Y4F3-5]
CCDS55991.1. [Q9Y4F3-4]
PIRiT00060.
RefSeqiNP_001171927.1. NM_001184998.1. [Q9Y4F3-5]
NP_001171928.1. NM_001184999.1. [Q9Y4F3-4]
NP_055462.2. NM_014647.3. [Q9Y4F3-1]
XP_005255764.1. XM_005255707.1.
XP_006725281.1. XM_006725218.1.
UniGeneiHs.173524.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DGXNMR-A789-871[»]
2DIUNMR-A510-592[»]
ProteinModelPortaliQ9Y4F3.
SMRiQ9Y4F3. Positions 510-597, 791-875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115020. 8 interactions.
IntActiQ9Y4F3. 7 interactions.
STRINGi9606.ENSP00000379654.

PTM databases

iPTMnetiQ9Y4F3.
PhosphoSiteiQ9Y4F3.

Polymorphism and mutation databases

BioMutaiKIAA0430.
DMDMi387912929.

Proteomic databases

EPDiQ9Y4F3.
MaxQBiQ9Y4F3.
PaxDbiQ9Y4F3.
PeptideAtlasiQ9Y4F3.
PRIDEiQ9Y4F3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396368; ENSP00000379654; ENSG00000166783. [Q9Y4F3-1]
ENST00000548025; ENSP00000449376; ENSG00000166783. [Q9Y4F3-4]
ENST00000551742; ENSP00000450309; ENSG00000166783. [Q9Y4F3-5]
ENST00000621511; ENSP00000479383; ENSG00000277140. [Q9Y4F3-1]
ENST00000632465; ENSP00000487685; ENSG00000277140. [Q9Y4F3-4]
ENST00000632628; ENSP00000488025; ENSG00000277140. [Q9Y4F3-5]
GeneIDi9665.
KEGGihsa:9665.
UCSCiuc002ddr.4. human. [Q9Y4F3-1]

Organism-specific databases

CTDi9665.
GeneCardsiKIAA0430.
HGNCiHGNC:29562. KIAA0430.
HPAiHPA017992.
MIMi614593. gene.
neXtProtiNX_Q9Y4F3.
PharmGKBiPA145148631.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF58. Eukaryota.
ENOG410XQFX. LUCA.
GeneTreeiENSGT00390000002393.
HOVERGENiHBG081919.
InParanoidiQ9Y4F3.
KOiK17573.
OMAiCCGKLHF.
PhylomeDBiQ9Y4F3.
TreeFamiTF329117.

Miscellaneous databases

ChiTaRSiKIAA0430. human.
EvolutionaryTraceiQ9Y4F3.
GeneWikiiKIAA0430.
GenomeRNAii9665.
PROiQ9Y4F3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y4F3.
CleanExiHS_KIAA0430.
ExpressionAtlasiQ9Y4F3. baseline and differential.
GenevisibleiQ9Y4F3. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
3.40.50.1010. 1 hit.
InterProiIPR024582. Limkain_b1_cons_dom.
IPR024768. Marf1.
IPR012677. Nucleotide-bd_a/b_plait.
IPR021139. NYN_limkain-b1.
IPR025605. OST-HTH/LOTUS_dom.
IPR029060. PIN_domain-like.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR14379. PTHR14379. 4 hits.
PfamiPF11608. Limkain-b1. 1 hit.
PF01936. NYN. 1 hit.
PF12872. OST-HTH. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS51644. HTH_OST. 8 hits.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes."
    Dunster K., Lai F.P.L., Sentry J.W.
    Clin. Exp. Immunol. 140:556-563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Brain and Testis.
  7. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-1742 (ISOFORM 1).
    Tissue: Brain.
  8. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  9. "Molecular cloning and characterization of novel large protein, limkain b1, which associates with the LIM-kinase 2."
    Miyamoto K., Nakamura T., Shirakawa K., Matsumoto K.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-615 (ISOFORM 1), INTERACTION WITH LIMK2.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1091, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "LOTUS, a new domain associated with small RNA pathways in the germline."
    Callebaut I., Mornon J.P.
    Bioinformatics 26:1140-1144(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE HTH OST-TYPE DOMAIN.
  13. "OST-HTH: a novel predicted RNA-binding domain."
    Anantharaman V., Zhang D., Aravind L.
    Biol. Direct 5:13-13(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE HTH OST-TYPE DOMAIN.
  14. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-760; SER-1093 AND SER-1571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  15. "Solution structure of the RNA recognition motif in KIAA0430 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 789-875.

Entry informationi

Entry nameiMARF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4F3
Secondary accession number(s): A8MSK2
, B2RNX2, B4DYY9, B7ZMG1, B7ZMG2, F8VV09, Q6P1R6, Q8WYR2, Q9Y4J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2012
Last modified: July 6, 2016
This is version 124 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.