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Protein

WD repeat-containing protein 7

Gene

WDR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9Y4E6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 7
Alternative name(s):
Rabconnectin-3 beta
TGF-beta resistance-associated protein TRAG
Gene namesi
Name:WDR7
Synonyms:KIAA0541, TRAG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:13490. WDR7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37784.

Polymorphism and mutation databases

BioMutaiWDR7.
DMDMi73920974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14901490WD repeat-containing protein 7PRO_0000051353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei935 – 9351PhosphoserineBy similarity
Modified residuei1456 – 14561PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4E6.
MaxQBiQ9Y4E6.
PaxDbiQ9Y4E6.
PRIDEiQ9Y4E6.

PTM databases

iPTMnetiQ9Y4E6.
PhosphoSiteiQ9Y4E6.

Expressioni

Gene expression databases

BgeeiQ9Y4E6.
CleanExiHS_WDR7.
ExpressionAtlasiQ9Y4E6. baseline and differential.
GenevisibleiQ9Y4E6. HS.

Organism-specific databases

HPAiHPA042074.

Interactioni

Protein-protein interaction databases

BioGridi116922. 6 interactions.
STRINGi9606.ENSP00000254442.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4E6.
SMRiQ9Y4E6. Positions 405-436, 456-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati62 – 10443WD 2Add
BLAST
Repeati156 – 19944WD 3Add
BLAST
Repeati324 – 36643WD 4Add
BLAST
Repeati404 – 44340WD 5Add
BLAST
Repeati462 – 50746WD 6Add
BLAST
Repeati558 – 59740WD 7Add
BLAST
Repeati1351 – 139040WD 8Add
BLAST
Repeati1392 – 143241WD 9Add
BLAST

Sequence similaritiesi

Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410ISJ1. Eukaryota.
ENOG410Y2AE. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ9Y4E6.
OMAiILKVWIV.
OrthoDBiEOG72VH5G.
PhylomeDBiQ9Y4E6.
TreeFamiTF313196.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV
60 70 80 90 100
ELQINPRALL FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR
110 120 130 140 150
CIEFTKLACT HTGIQFYQFS VGNQREGRLL CHGHYPEILV VDATSLEVLY
160 170 180 190 200
SLVSKISPDW ISSMSIIRSH RTQEDTVVAL SVTGILKVWI VTSEISDMQD
210 220 230 240 250
TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV FDAGDYSLLC
260 270 280 290 300
SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
310 320 330 340 350
GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS
360 370 380 390 400
GRLNIWNISD TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI
410 420 430 440 450
PNSNEPLKVT ASVYIPAHGR LVCGREDGSI VIVPATQTAI VQLLQGEHML
460 470 480 490 500
RRGWPPHRTL RGHRNKVTCL LYPHQVSARY DQRYLISGGV DFSVIIWDIF
510 520 530 540 550
SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH SVGLLSLREK
560 570 580 590 600
KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
610 620 630 640 650
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT
660 670 680 690 700
LATNLLASEA SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII
710 720 730 740 750
QLLTEEASRP NTALISPENL QKASGSSDKG GSFLTGKRAA VLFQQVKETI
760 770 780 790 800
KENIKEHLLD DEEEDEEIMR QRREESDPEY RSSKSKPLTL LEYNLTMDTA
810 820 830 840 850
KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR GGHMSLMLPG
860 870 880 890 900
YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
910 920 930 940 950
LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV
960 970 980 990 1000
AAPVVSARSD ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG
1010 1020 1030 1040 1050
LDKFRPPLLE MLARRWQDRC LEVREAAQAL LLAELRRIEQ AGRKEAIDAW
1060 1070 1080 1090 1100
APYLPQYIDH VISPGVTSEA AQTITTAPDA SGPEAKVQEE EHDLVDDDIT
1110 1120 1130 1140 1150
TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE IEPPKLLTRP
1160 1170 1180 1190 1200
RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
1210 1220 1230 1240 1250
AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD
1260 1270 1280 1290 1300
SARSARHALS LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA
1310 1320 1330 1340 1350
RAKGEILRVI EILIEKMPTD VVDLLVEVMD IIMYCLEGSL VKKKGLQECF
1360 1370 1380 1390 1400
PAICRFYMVS YYERNHRIAV GARHGSVALY DIRTGKCQTI HGHKGPITAV
1410 1420 1430 1440 1450
AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ LRCIKTYQVP
1460 1470 1480 1490
PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
Length:1,490
Mass (Da):163,810
Last modified:August 30, 2005 - v2
Checksum:i626E876245696A1F
GO
Isoform 2 (identifier: Q9Y4E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     950-982: Missing.

Show »
Length:1,457
Mass (Da):160,510
Checksum:i4F0D743D9A38F0B9
GO

Sequence cautioni

The sequence BAA25467.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541I → V in AAL03983 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei950 – 98233Missing in isoform 2. 1 PublicationVSP_015274Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099325 mRNA. Translation: AAM33134.1.
AF188125 mRNA. Translation: AAL03983.1.
AB011113 mRNA. Translation: BAA25467.2. Different initiation.
CH471096 Genomic DNA. Translation: EAW63038.1.
BC050352 mRNA. Translation: AAH50352.1.
BC150282 mRNA. Translation: AAI50283.1.
CCDSiCCDS11962.1. [Q9Y4E6-1]
CCDS11963.1. [Q9Y4E6-2]
PIRiT00272.
RefSeqiNP_056100.2. NM_015285.2. [Q9Y4E6-1]
NP_443066.2. NM_052834.2. [Q9Y4E6-2]
XP_006722494.1. XM_006722431.1. [Q9Y4E6-1]
UniGeneiHs.465213.

Genome annotation databases

EnsembliENST00000254442; ENSP00000254442; ENSG00000091157. [Q9Y4E6-1]
ENST00000357574; ENSP00000350187; ENSG00000091157. [Q9Y4E6-2]
GeneIDi23335.
KEGGihsa:23335.
UCSCiuc002lgk.2. human. [Q9Y4E6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099325 mRNA. Translation: AAM33134.1.
AF188125 mRNA. Translation: AAL03983.1.
AB011113 mRNA. Translation: BAA25467.2. Different initiation.
CH471096 Genomic DNA. Translation: EAW63038.1.
BC050352 mRNA. Translation: AAH50352.1.
BC150282 mRNA. Translation: AAI50283.1.
CCDSiCCDS11962.1. [Q9Y4E6-1]
CCDS11963.1. [Q9Y4E6-2]
PIRiT00272.
RefSeqiNP_056100.2. NM_015285.2. [Q9Y4E6-1]
NP_443066.2. NM_052834.2. [Q9Y4E6-2]
XP_006722494.1. XM_006722431.1. [Q9Y4E6-1]
UniGeneiHs.465213.

3D structure databases

ProteinModelPortaliQ9Y4E6.
SMRiQ9Y4E6. Positions 405-436, 456-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116922. 6 interactions.
STRINGi9606.ENSP00000254442.

PTM databases

iPTMnetiQ9Y4E6.
PhosphoSiteiQ9Y4E6.

Polymorphism and mutation databases

BioMutaiWDR7.
DMDMi73920974.

Proteomic databases

EPDiQ9Y4E6.
MaxQBiQ9Y4E6.
PaxDbiQ9Y4E6.
PRIDEiQ9Y4E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254442; ENSP00000254442; ENSG00000091157. [Q9Y4E6-1]
ENST00000357574; ENSP00000350187; ENSG00000091157. [Q9Y4E6-2]
GeneIDi23335.
KEGGihsa:23335.
UCSCiuc002lgk.2. human. [Q9Y4E6-1]

Organism-specific databases

CTDi23335.
GeneCardsiWDR7.
HGNCiHGNC:13490. WDR7.
HPAiHPA042074.
MIMi613473. gene.
neXtProtiNX_Q9Y4E6.
PharmGKBiPA37784.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJ1. Eukaryota.
ENOG410Y2AE. LUCA.
GeneTreeiENSGT00520000055590.
HOGENOMiHOG000001566.
HOVERGENiHBG067501.
InParanoidiQ9Y4E6.
OMAiILKVWIV.
OrthoDBiEOG72VH5G.
PhylomeDBiQ9Y4E6.
TreeFamiTF313196.

Enzyme and pathway databases

SignaLinkiQ9Y4E6.

Miscellaneous databases

ChiTaRSiWDR7. human.
GenomeRNAii23335.
PROiQ9Y4E6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y4E6.
CleanExiHS_WDR7.
ExpressionAtlasiQ9Y4E6. baseline and differential.
GenevisibleiQ9Y4E6. HS.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter."
    Kawabe H., Sakisaka T., Yasumi M., Shingai T., Izumi G., Nagano F., Deguchi-Tawarada M., Takeuchi M., Nakanishi H., Takai Y.
    Genes Cells 8:537-546(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "TRAG: a novel gene associated with TGF-beta resistance."
    Sanders S., Thorgeirsson S.S.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Ishikawa K.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiWDR7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4E6
Secondary accession number(s): A7E2C8
, Q86UX5, Q86VP2, Q96PS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 30, 2005
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.