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Q9Y4E5 (ZN451_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 451
Alternative name(s):
Coactivator for steroid receptors
Gene names
Name:ZNF451
Synonyms:COASTER, KIAA0576, KIAA1702
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1061 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation. Coactivator for steroid receptors.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Sequence caution

The sequence AAH21712.2 differs from that shown. Reason: Intron retention.

The sequence AAH42450.1 differs from that shown. Reason: Contaminating sequence.

The sequence AAH58853.1 differs from that shown. Reason: Contaminating sequence.

The sequence BAA25502.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB21793.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UBE2IP632793EBI-747230,EBI-80168

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y4E5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y4E5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     870-917: Missing.
Isoform 3 (identifier: Q9Y4E5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     63-1061: ENIKRKDHID...EAIRRSLEEM → RMPESKVPSS...DSPERHGYKN

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10611061Zinc finger protein 451
PRO_0000047598

Regions

Zinc finger169 – 19527C2H2-type 1
Zinc finger253 – 27725C2H2-type 2
Zinc finger315 – 33723C2H2-type 3
Zinc finger362 – 38625C2H2-type 4
Zinc finger498 – 52124C2H2-type 5
Zinc finger531 – 55424C2H2-type 6
Zinc finger606 – 63126C2H2-type 7; atypical
Zinc finger636 – 65924C2H2-type 8
Zinc finger667 – 69024C2H2-type 9
Zinc finger753 – 77624C2H2-type 10
Zinc finger789 – 81224C2H2-type 11

Natural variations

Alternative sequence63 – 1061999ENIKR…SLEEM → RMPESKVPSSENHRPEMCSS CNVPLPIGDSSSFSGSCSSS PERIVSQTSSVENPLENQKN DQNNSDTKISETETLKSSQN FQTLPSSPLLVPQESLASSE VKENLRIDSSSASQHGRDAI LYLQTQVAEMSRVIRDLQSR SCFRFHHSRPSENSSVPWDI STSKEENLSTVEEETDYKSP SADDKGQPSDPSQSSFTGLL KRMEQRGVIKRVTLQSEAES CEGKPDCVTSKKRLVPPLHP LLRIATTEVFKDPADCHPSS FMGHRVYPVAKDTSPFQPNP PAEGPIVEALEHSKRGNTTS PLDSTSKEMEVMGCRFYHAA SIAARAASYMAYMTQYQRKL WEDMEDLVHDPEFDRGKARC IISDGMDAGLWQLCTTRDIM DSVVRVMAMAIDYRRQAWLR LTSLTKKTQEKISHLPFDGT SLFGQDVKAVVAEDNNIKEN DYKDHKYYNQHRYFYSHDQK AHYHNRGYSKGDWYKPRNHP YRYRKKGDSPERHGYKN in isoform 3.
VSP_035312
Alternative sequence870 – 91748Missing in isoform 2.
VSP_008624

Experimental info

Sequence conflict1691I → T in AAL17975. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 24, 2003. Version 2.
Checksum: 8F0446B9FBFF28FA

FASTA1,061121,484
        10         20         30         40         50         60 
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 

        70         80         90        100        110        120 
TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF 

       130        140        150        160        170        180 
IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF 

       190        200        210        220        230        240 
DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG 

       250        260        270        280        290        300 
HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA 

       310        320        330        340        350        360 
KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL 

       370        380        390        400        410        420 
RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD 

       430        440        450        460        470        480 
QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF 

       490        500        510        520        530        540 
PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL 

       550        560        570        580        590        600 
TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS 

       610        620        630        640        650        660 
SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD 

       670        680        690        700        710        720 
NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL 

       730        740        750        760        770        780 
TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS 

       790        800        810        820        830        840 
DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT 

       850        860        870        880        890        900 
ERKLKQAINY SKSLDMEKGV ENDLSYQNIE EEIVELPDLD YLRTMTHIVF VDFDNWSNFF 

       910        920        930        940        950        960 
GHLPGHLNQG TFIWGFQGGN TNWKPPLNCK IYNYLNRIGC FFLHPRCSKR KDAADFAICM 

       970        980        990       1000       1010       1020 
HAGRLDEQLP KQIPFTILSG DQGFLELENQ FKKTQRPAHI LNPHHLEGDM MCALLNSISD 

      1030       1040       1050       1060 
TTKECDSDDN MGAKNTSIGE EFISTEDVEL EEAIRRSLEE M 

« Hide

Isoform 2 [UniParc].

Checksum: 47F3AEA54D754CBB
Show »

FASTA1,013115,776
Isoform 3 [UniParc].

Checksum: 4939846709AC5536
Show »

FASTA55963,021

References

« Hide 'large scale' references
[1]"Isolation of a novel coactivator for steroid receptors that alters the intrinsic activity of the estrogen receptor alpha liganded with SERMs."
Heldens I.M., Dechering K.J.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-1061 (ISOFORM 3).
Tissue: Brain.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-918 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1061 (ISOFORM 3).
Tissue: Brain and Testis.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY055204 mRNA. Translation: AAL17975.1.
AB011148 mRNA. Translation: BAA25502.1. Different initiation.
AB051489 mRNA. Translation: BAB21793.1. Different initiation.
AL136311, AL450489 Genomic DNA. Translation: CAI20516.1.
AL450489, AL136311 Genomic DNA. Translation: CAH71220.1.
AL450489 Genomic DNA. Translation: CAH71222.1.
BC021712 mRNA. Translation: AAH21712.2. Sequence problems.
BC042450 mRNA. Translation: AAH42450.1. Sequence problems.
BC058853 mRNA. Translation: AAH58853.1. Sequence problems.
PIRT00341.
RefSeqNP_001026794.1. NM_001031623.2.
NP_056370.2. NM_015555.2.
UniGeneHs.485628.
Hs.705485.

3D structure databases

ProteinModelPortalQ9Y4E5.
SMRQ9Y4E5. Positions 152-275, 466-570, 600-694, 753-812.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117502. 24 interactions.
IntActQ9Y4E5. 19 interactions.
MINTMINT-1197511.
STRING9606.ENSP00000359740.

PTM databases

PhosphoSiteQ9Y4E5.

Polymorphism databases

DMDM37999825.

Proteomic databases

PaxDbQ9Y4E5.
PRIDEQ9Y4E5.

Protocols and materials databases

DNASU26036.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357489; ENSP00000350083; ENSG00000112200. [Q9Y4E5-2]
ENST00000370706; ENSP00000359740; ENSG00000112200. [Q9Y4E5-1]
ENST00000370708; ENSP00000359742; ENSG00000112200. [Q9Y4E5-4]
GeneID26036.
KEGGhsa:26036.
UCSCuc003pdk.2. human. [Q9Y4E5-1]
uc003pdn.2. human. [Q9Y4E5-2]
uc003pdo.4. human. [Q9Y4E5-4]

Organism-specific databases

CTD26036.
GeneCardsGC06P056951.
HGNCHGNC:21091. ZNF451.
HPAHPA015692.
HPA028838.
neXtProtNX_Q9Y4E5.
PharmGKBPA134967635.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316281.
HOVERGENHBG057364.
InParanoidQ9Y4E5.
OMAGHRYFYE.
OrthoDBEOG7DJSKD.
PhylomeDBQ9Y4E5.
TreeFamTF331947.

Gene expression databases

ArrayExpressQ9Y4E5.
BgeeQ9Y4E5.
CleanExHS_ZNF451.
GenevestigatorQ9Y4E5.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF451.
GenomeRNAi26036.
NextBio47853.
PROQ9Y4E5.

Entry information

Entry nameZN451_HUMAN
AccessionPrimary (citable) accession number: Q9Y4E5
Secondary accession number(s): Q5VVE9 expand/collapse secondary AC list , Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: March 19, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM