Q9Y4E5 (ZN451_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 451

Alternative name(s):
Coactivator for steroid receptors

Gene names

Name:	ZNF451
Synonyms:	COASTER, KIAA0576, KIAA1702

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1061 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation. Coactivator for steroid receptors.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers.
Sequence caution	The sequence AAH21712.2 differs from that shown. Reason: Intron retention. The sequence AAH42450.1 differs from that shown. Reason: Contaminating sequence. The sequence AAH58853.1 differs from that shown. Reason: Contaminating sequence. The sequence BAA25502.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB21793.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4E5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4E5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     870-917: Missing.

Isoform 3 (identifier: Q9Y4E5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     63-1061: ENIKRKDHID...EAIRRSLEEM → RMPESKVPSS...DSPERHGYKN

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1061	1061	Zinc finger protein 451		PRO_0000047598
Regions
	Zinc finger	169 – 195	27	C2H2-type 1
	Zinc finger	253 – 277	25	C2H2-type 2
	Zinc finger	315 – 337	23	C2H2-type 3
	Zinc finger	362 – 386	25	C2H2-type 4
	Zinc finger	498 – 521	24	C2H2-type 5
	Zinc finger	531 – 554	24	C2H2-type 6
	Zinc finger	606 – 631	26	C2H2-type 7; atypical
	Zinc finger	636 – 659	24	C2H2-type 8
	Zinc finger	667 – 690	24	C2H2-type 9
	Zinc finger	753 – 776	24	C2H2-type 10
	Zinc finger	789 – 812	24	C2H2-type 11
Natural variations
	Alternative sequence	63 – 1061	999	ENIKR…SLEEM → RMPESKVPSSENHRPEMCSS CNVPLPIGDSSSFSGSCSSS PERIVSQTSSVENPLENQKN DQNNSDTKISETETLKSSQN FQTLPSSPLLVPQESLASSE VKENLRIDSSSASQHGRDAI LYLQTQVAEMSRVIRDLQSR SCFRFHHSRPSENSSVPWDI STSKEENLSTVEEETDYKSP SADDKGQPSDPSQSSFTGLL KRMEQRGVIKRVTLQSEAES CEGKPDCVTSKKRLVPPLHP LLRIATTEVFKDPADCHPSS FMGHRVYPVAKDTSPFQPNP PAEGPIVEALEHSKRGNTTS PLDSTSKEMEVMGCRFYHAA SIAARAASYMAYMTQYQRKL WEDMEDLVHDPEFDRGKARC IISDGMDAGLWQLCTTRDIM DSVVRVMAMAIDYRRQAWLR LTSLTKKTQEKISHLPFDGT SLFGQDVKAVVAEDNNIKEN DYKDHKYYNQHRYFYSHDQK AHYHNRGYSKGDWYKPRNHP YRYRKKGDSPERHGYKN in isoform 3.		VSP_035312
	Alternative sequence	870 – 917	48	Missing in isoform 2.		VSP_008624
Experimental info
	Sequence conflict	169	1	I → T in AAL17975. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 24, 2003. Version 2. Checksum: 8F0446B9FBFF28FA	FASTA	1,061	121,484
	10 20 30 40 50 60 MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 70 80 90 100 110 120 TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF 130 140 150 160 170 180 IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF 190 200 210 220 230 240 DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG 250 260 270 280 290 300 HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA 310 320 330 340 350 360 KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL 370 380 390 400 410 420 RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD 430 440 450 460 470 480 QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF 490 500 510 520 530 540 PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL 550 560 570 580 590 600 TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS 610 620 630 640 650 660 SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD 670 680 690 700 710 720 NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL 730 740 750 760 770 780 TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS 790 800 810 820 830 840 DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT 850 860 870 880 890 900 ERKLKQAINY SKSLDMEKGV ENDLSYQNIE EEIVELPDLD YLRTMTHIVF VDFDNWSNFF 910 920 930 940 950 960 GHLPGHLNQG TFIWGFQGGN TNWKPPLNCK IYNYLNRIGC FFLHPRCSKR KDAADFAICM 970 980 990 1000 1010 1020 HAGRLDEQLP KQIPFTILSG DQGFLELENQ FKKTQRPAHI LNPHHLEGDM MCALLNSISD 1030 1040 1050 1060 TTKECDSDDN MGAKNTSIGE EFISTEDVEL EEAIRRSLEE M
	Isoform 2 [UniParc]. Checksum: 47F3AEA54D754CBB	FASTA	1,013	115,776
	10 20 30 40 50 60 MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 70 80 90 100 110 120 TDENIKRKDH IDYQKDKVAL TLARLARHVE VEKQQKEEKN RAFREKIDFQ HAHGLQELEF 130 140 150 160 170 180 IRGHSDTEAA RLCVDQWLKM PGLKTGTINC GTKSSFRRGG HTWVSGKPIL CPIMHCNKEF 190 200 210 220 230 240 DNGHLLLGHL KRFDHSPCDP TITLHGPFFS SFACVVCYKK FVTQQQYRDH LFDKEATDDG 250 260 270 280 290 300 HNNNLLPQII QCFACPNCFL LFSRKEECSK HMSGKNHFHQ SFKLGDNKGI AHPISFPSFA 310 320 330 340 350 360 KKLLISLCKD VPFQVKCVAC HKTLRSHMEL TAHFRVHCRN AGPVAVAEKS ITQVAEKFIL 370 380 390 400 410 420 RGYCPDCNQV FVDETSTQNH KQNSGHKVRV INSVEESVLL YCHSSEGNKD PSSDLHLLLD 430 440 450 460 470 480 QSKFSSLKRT MSIKESSSLE CIAIPKKKMN LKDKSHEGVA CVQKEKSVVK TWFCECNQRF 490 500 510 520 530 540 PSEDAVEKHV FSANTMGYKC VVCGKVCDDS GVIRLHMSRI HGGAHLNNFL FWCRTCKKEL 550 560 570 580 590 600 TRKDTIMAHV TEFHNGHRYF YEMDEVEGET LPSSSTTLDN LTANKPSSAI TVIDHSPANS 610 620 630 640 650 660 SPRGKWQCRI CEDMFDSQEY VKQHCMSLAS HKFHRYSCAH CRKPFHKIET LYRHCQDEHD 670 680 690 700 710 720 NEIKIKYFCG LCDLIFNVEE AFLSHYEEHH SIDYVFVSEK TETSIKTEDD FPVIETSNQL 730 740 750 760 770 780 TCGCRESYIC KVNRKEDYSR CLQIMLDKGK LWFRCSLCSA TAQNLTDMNT HIHQVHKEKS 790 800 810 820 830 840 DEEEQQYVIK CGTCTKAFHD PESAQQHFHR KHCFLQKPSV AHFGSEKSNL YKFTASASHT 850 860 870 880 890 900 ERKLKQAINY SKSLDMEKGV ENDLSYQNIG GNTNWKPPLN CKIYNYLNRI GCFFLHPRCS 910 920 930 940 950 960 KRKDAADFAI CMHAGRLDEQ LPKQIPFTIL SGDQGFLELE NQFKKTQRPA HILNPHHLEG 970 980 990 1000 1010 DMMCALLNSI SDTTKECDSD DNMGAKNTSI GEEFISTEDV ELEEAIRRSL EEM
	Isoform 3 [UniParc]. Checksum: 4939846709AC5536	FASTA	559	63,021
	10 20 30 40 50 60 MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPLR PVLEYIDLVS SDDEEPSTSY 70 80 90 100 110 120 TDRMPESKVP SSENHRPEMC SSCNVPLPIG DSSSFSGSCS SSPERIVSQT SSVENPLENQ 130 140 150 160 170 180 KNDQNNSDTK ISETETLKSS QNFQTLPSSP LLVPQESLAS SEVKENLRID SSSASQHGRD 190 200 210 220 230 240 AILYLQTQVA EMSRVIRDLQ SRSCFRFHHS RPSENSSVPW DISTSKEENL STVEEETDYK 250 260 270 280 290 300 SPSADDKGQP SDPSQSSFTG LLKRMEQRGV IKRVTLQSEA ESCEGKPDCV TSKKRLVPPL 310 320 330 340 350 360 HPLLRIATTE VFKDPADCHP SSFMGHRVYP VAKDTSPFQP NPPAEGPIVE ALEHSKRGNT 370 380 390 400 410 420 TSPLDSTSKE MEVMGCRFYH AASIAARAAS YMAYMTQYQR KLWEDMEDLV HDPEFDRGKA 430 440 450 460 470 480 RCIISDGMDA GLWQLCTTRD IMDSVVRVMA MAIDYRRQAW LRLTSLTKKT QEKISHLPFD 490 500 510 520 530 540 GTSLFGQDVK AVVAEDNNIK ENDYKDHKYY NQHRYFYSHD QKAHYHNRGY SKGDWYKPRN 550 HPYRYRKKGD SPERHGYKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel coactivator for steroid receptors that alters the intrinsic activity of the estrogen receptor alpha liganded with SERMs." Heldens I.M., Dechering K.J. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-1061 (ISOFORM 3). Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-918 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-1061 (ISOFORM 3). Tissue: Brain and Testis.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY055204 mRNA. Translation: AAL17975.1. AB011148 mRNA. Translation: BAA25502.1. Different initiation. AB051489 mRNA. Translation: BAB21793.1. Different initiation. AL136311, AL450489 Genomic DNA. Translation: CAI20516.1. AL450489, AL136311 Genomic DNA. Translation: CAH71220.1. AL450489 Genomic DNA. Translation: CAH71222.1. BC021712 mRNA. Translation: AAH21712.2. Sequence problems. BC042450 mRNA. Translation: AAH42450.1. Sequence problems. BC058853 mRNA. Translation: AAH58853.1. Sequence problems.
IPI	IPI00000725. IPI00375612. IPI00384690.
PIR	T00341.
RefSeq	NP_001026794.1. NM_001031623.2. NP_001244202.1. NM_001257273.1. NP_056370.2. NM_015555.2.
UniGene	Hs.485628.
3D structure databases
ProteinModelPortal	Q9Y4E5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4E5. 10 interactions.
MINT	MINT-1197511.
STRING	9606.ENSP00000359740.
PTM databases
PhosphoSite	Q9Y4E5.
Polymorphism databases
DMDM	37999825.
Proteomic databases
PaxDb	Q9Y4E5.
PRIDE	Q9Y4E5.
Protocols and materials databases
DNASU	26036.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357489; ENSP00000350083; ENSG00000112200. ENST00000370706; ENSP00000359740; ENSG00000112200. ENST00000370708; ENSP00000359742; ENSG00000112200.
GeneID	26036.
KEGG	hsa:26036.
UCSC	uc003pdk.1. human. uc003pdn.1. human. uc011dxn.2. human.
Organism-specific databases
CTD	26036.
GeneCards	GC06P056951.
HGNC	HGNC:21091. ZNF451.
HPA	HPA015692. HPA028838.
neXtProt	NX_Q9Y4E5.
PharmGKB	PA134967635.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316281.
HOVERGEN	HBG057364.
InParanoid	Q9Y4E5.
OMA	GHRYFYE.
OrthoDB	EOG4H729R.
PhylomeDB	Q9Y4E5.
Gene expression databases
ArrayExpress	Q9Y4E5.
Bgee	Q9Y4E5.
CleanEx	HS_ZNF451.
Genevestigator	Q9Y4E5.
GermOnline	ENSG00000112200. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMART	SM00355. ZnF_C2H2. 12 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 9 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26036.
NextBio	47853.

Entry information

Entry name

ZN451_HUMAN

Accession

Primary (citable) accession number: Q9Y4E5
Secondary accession number(s): Q5VVE9 , Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	October 24, 2003
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.