##gff-version 3 Q9Y4E1 UniProtKB Chain 1 1341 . . . ID=PRO_0000186714;Note=WASH complex subunit 2C Q9Y4E1 UniProtKB Region 1 220 . . . Note=Sufficient for interaction with WASHC3%2C WASHC4 and WASHC5%3B required for interaction with WASHC1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19922874,ECO:0000269|PubMed:20498093;Dbxref=PMID:19922874,PMID:20498093 Q9Y4E1 UniProtKB Region 202 405 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 356 600 . . . Note=Sufficient for interaction with CCDC93;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25355947;Dbxref=PMID:25355947 Q9Y4E1 UniProtKB Region 357 1339 . . . Note=Interaction with VPS35;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22513087;Dbxref=PMID:22513087 Q9Y4E1 UniProtKB Region 422 609 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 621 662 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 696 734 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 751 796 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 820 840 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 886 951 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 937 1339 . . . Note=Interaction with phospholipids;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20498093;Dbxref=PMID:20498093 Q9Y4E1 UniProtKB Region 988 1205 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Region 1029 1047 . . . Note=Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20498093;Dbxref=PMID:20498093 Q9Y4E1 UniProtKB Region 1302 1326 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Motif 367 378 . . . Note=LFa 1;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 411 419 . . . Note=LFa 2;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 450 463 . . . Note=LFa 3;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 482 491 . . . Note=LFa 4;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 537 548 . . . Note=LFa 5;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 572 583 . . . Note=LFa 6;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 617 627 . . . Note=LFa 7;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 664 674 . . . Note=LFa 8;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 690 702 . . . Note=LFa 9;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 726 738 . . . Note=LFa 10;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 803 817 . . . Note=LFa 11;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 839 847 . . . Note=LFa 12;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 856 862 . . . Note=LFa 13;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 878 888 . . . Note=LFa 14;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1129 1136 . . . Note=LFa 15;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1171 1185 . . . Note=LFa 16;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1201 1209 . . . Note=LFa 17;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1234 1240 . . . Note=LFa 18;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1262 1270 . . . Note=LFa 19;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1290 1299 . . . Note=LFa 20;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Motif 1330 1338 . . . Note=LFa 21;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Compositional bias 250 275 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 297 344 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 381 395 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 479 494 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 595 609 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 621 638 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 751 772 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 773 793 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 898 933 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Compositional bias 1030 1044 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y4E1 UniProtKB Modified residue 539 539 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:21406692,PMID:23186163 Q9Y4E1 UniProtKB Modified residue 550 550 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9Y4E1 UniProtKB Modified residue 909 909 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 Q9Y4E1 UniProtKB Alternative sequence 43 97 . . . ID=VSP_061811;Note=In isoform 4. Missing Q9Y4E1 UniProtKB Alternative sequence 43 50 . . . ID=VSP_061812;Note=In isoform 3. Missing Q9Y4E1 UniProtKB Alternative sequence 311 335 . . . ID=VSP_061813;Note=In isoform 6. TLPSGEAKPRKTLKEKKERRTPSDD->N Q9Y4E1 UniProtKB Alternative sequence 624 625 . . . ID=VSP_061814;Note=In isoform 3%2C isoform 4 and isoform 5. Missing Q9Y4E1 UniProtKB Alternative sequence 714 764 . . . ID=VSP_061815;Note=In isoform 6. Missing Q9Y4E1 UniProtKB Alternative sequence 897 958 . . . ID=VSP_061816;Note=In isoform 7. Missing Q9Y4E1 UniProtKB Alternative sequence 937 957 . . . ID=VSP_061817;Note=In isoform 2%2C isoform 3%2C isoform 4%2C isoform 5 and isoform 6. Missing Q9Y4E1 UniProtKB Mutagenesis 1031 1031 . . . Note=Disrupts interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3). R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20498093;Dbxref=PMID:20498093 Q9Y4E1 UniProtKB Mutagenesis 1299 1299 . . . Note=Impairs interaction with VPS35. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23331060;Dbxref=PMID:23331060 Q9Y4E1 UniProtKB Mutagenesis 1331 1331 . . . Note=Impairs interaction with VPS35. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23331060;Dbxref=PMID:23331060 Q9Y4E1 UniProtKB Mutagenesis 1333 1333 . . . Note=Disrupts interaction with VPS35. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23331060;Dbxref=PMID:23331060 Q9Y4E1 UniProtKB Sequence conflict 244 244 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 302 302 . . . Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 342 342 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 382 382 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 427 427 . . . Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 474 474 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 521 521 . . . Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 1061 1061 . . . Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y4E1 UniProtKB Sequence conflict 1301 1301 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305