Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y4E1 (FA21C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WASH complex subunit FAM21C
Alternative name(s):
Vaccinia virus penetration factor
Short name=VPEF
Gene names
Name:FAM21C
Synonyms:KIAA0592
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. Ref.6 Ref.8

Subunit structure

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct. Ref.8 Ref.9

Subcellular location

Early endosome membrane. Cell membrane. Note: Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane. Ref.6 Ref.8

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Sequence similarities

Belongs to the FAM21 family.

Sequence caution

The sequence AAH06456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA25518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Endosome
Membrane
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processretrograde transport, endosome to Golgi

Inferred from mutant phenotype Ref.8. Source: UniProtKB

   Cellular_componentWASH complex

Inferred from direct assay Ref.9. Source: UniProtKB

early endosome

Inferred from direct assay Ref.8. Source: UniProtKB

early endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

endosome

Inferred from direct assay PubMed 20923837. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y4E1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y4E1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-50: Missing.
Note: Gene prediction confirmed by EST data.
Isoform 3 (identifier: Q9Y4E1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     43-97: Missing.
Note: Gene prediction confirmed by EST data.
Isoform 4 (identifier: Q9Y4E1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ
Isoform 5 (identifier: Q9Y4E1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     311-335: TLPSGEAKPRKTLKEKKERRTPSDD → N
     623-623: E → EDQ
     713-763: Missing.
Isoform 6 (identifier: Q9Y4E1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ
     895-935: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13181318WASH complex subunit FAM21C
PRO_0000186714

Regions

Compositional bias102 – 277176Glu-rich
Compositional bias452 – 46110Poly-Asp
Compositional bias1072 – 10787Poly-Ala

Amino acid modifications

Modified residue5391Phosphoserine Ref.7 Ref.10 Ref.11 Ref.13
Modified residue9071Phosphoserine Ref.13

Natural variations

Alternative sequence43 – 9755Missing in isoform 3.
VSP_014854
Alternative sequence43 – 508Missing in isoform 2.
VSP_014853
Alternative sequence311 – 33525TLPSG…TPSDD → N in isoform 5.
VSP_045809
Alternative sequence6231E → EDQ in isoform 4, isoform 5 and isoform 6.
VSP_038662
Alternative sequence713 – 76351Missing in isoform 5.
VSP_045810
Alternative sequence895 – 93541Missing in isoform 6.
VSP_045811

Experimental info

Sequence conflict2441Q → R in AAI50612. Ref.4
Sequence conflict3021M → V in AAI50612. Ref.4
Sequence conflict3421A → T in AAI50612. Ref.4
Sequence conflict3821S → P in AAI50612. Ref.4
Sequence conflict4271L → M in AAI50612. Ref.4
Sequence conflict4741R → G in AAI50612. Ref.4
Sequence conflict5211Y → S in BAA25518. Ref.1
Sequence conflict5211Y → S in BAG64168. Ref.2
Sequence conflict10381V → I in BAA25518. Ref.1
Sequence conflict12781T → S in BAA25518. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 19, 2010. Version 3.
Checksum: C3D811B7126425CB

FASTA1,318144,668
        10         20         30         40         50         60 
MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 

        70         80         90        100        110        120 
IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 

       130        140        150        160        170        180 
TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 

       190        200        210        220        230        240 
DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 

       250        260        270        280        290        300 
EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 

       310        320        330        340        350        360 
AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 

       370        380        390        400        410        420 
FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 

       430        440        450        460        470        480 
AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 

       490        500        510        520        530        540 
DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 

       550        560        570        580        590        600 
EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 

       610        620        630        640        650        660 
EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ SQEAKAVKKT 

       670        680        690        700        710        720 
SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF GSPPTSVPPA TKKKETVSEA 

       730        740        750        760        770        780 
PPLLFSDEEE KEAQLGVKSV DKKVESAKES LKFGRTDVAE SEKEGLLTRS AQETVKHSDL 

       790        800        810        820        830        840 
FSSSSPWDKG TKPRTKTVLS LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD 

       850        860        870        880        890        900 
EELLFSHKLQ KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 

       910        920        930        940        950        960 
VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA SQISEVKPVL 

       970        980        990       1000       1010       1020 
PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT LHSANKSRVK MRGKRRPQTR 

      1030       1040       1050       1060       1070       1080 
AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL RAASGEDSTE EALAAAAAPW 

      1090       1100       1110       1120       1130       1140 
EGGPVPGVDT SPFAKSLGHS RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV 

      1150       1160       1170       1180       1190       1200 
GGKAKSPMFP ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 

      1210       1220       1230       1240       1250       1260 
QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK 

      1270       1280       1290       1300       1310 
KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD PLNAFGGQ 

« Hide

Isoform 2 [UniParc].

Checksum: EC75C67E8A9AD5C8
Show »

FASTA1,310143,649
Isoform 3 [UniParc].

Checksum: EC7677F45D0EA10B
Show »

FASTA1,263138,146
Isoform 4 [UniParc].

Checksum: 156651EE158BE32F
Show »

FASTA1,320144,911
Isoform 5 [UniParc].

Checksum: DD8A6029AD1B2CA5
Show »

FASTA1,245136,541
Isoform 6 [UniParc].

Checksum: 1C1ABF0932DF6BC0
Show »

FASTA1,279140,144

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Testis.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 984-1318.
Tissue: Lung and Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1014-1318.
Tissue: Kidney.
[6]"A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis."
Huang C.Y., Lu T.Y., Bair C.H., Chang Y.S., Jwo J.K., Chang W.
J. Virol. 82:7988-7999(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A FAM21-containing WASH complex regulates retromer-dependent sorting."
Gomez T.S., Billadeau D.D.
Dev. Cell 17:699-711(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WASH1.
[9]"The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."
Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.
Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE WASH COMPLEX.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011164 mRNA. Translation: BAA25518.1. Different initiation.
AK303048 mRNA. Translation: BAG64168.1.
AL645998, AL731535 Genomic DNA. Translation: CAI16355.1.
AL645998, AC012044, AL731535 Genomic DNA. Translation: CAI16356.1.
AL731535, AL645998 Genomic DNA. Translation: CAI15257.1.
AL731535, AC012044, AL645998 Genomic DNA. Translation: CAI15258.1.
BC006456 mRNA. Translation: AAH06456.1. Different initiation.
BC150611 mRNA. Translation: AAI50612.1.
AL050279 mRNA. Translation: CAB43380.2.
PIRT00347.
T08735.
RefSeqNP_001162577.1. NM_001169106.1.
NP_001162578.1. NM_001169107.1.
NP_056077.2. NM_015262.2.
UniGeneHs.365286.
Hs.449662.

3D structure databases

ProteinModelPortalQ9Y4E1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Y4E1. 3 interactions.
MINTMINT-2879251.
STRING9606.ENSP00000337541.

PTM databases

PhosphoSiteQ9Y4E1.

Polymorphism databases

DMDM284018172.

Proteomic databases

PRIDEQ9Y4E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336378; ENSP00000337541; ENSG00000172661. [Q9Y4E1-1]
ENST00000374362; ENSP00000363482; ENSG00000172661. [Q9Y4E1-4]
ENST00000537517; ENSP00000442128; ENSG00000172661. [Q9Y4E1-5]
ENST00000540872; ENSP00000439811; ENSG00000172661. [Q9Y4E1-6]
ENST00000578828; ENSP00000464578; ENSG00000265551. [Q9Y4E1-4]
ENST00000579270; ENSP00000461926; ENSG00000265551. [Q9Y4E1-1]
ENST00000583993; ENSP00000462756; ENSG00000265551. [Q9Y4E1-5]
ENST00000584292; ENSP00000462907; ENSG00000265551. [Q9Y4E1-6]
GeneID253725.
KEGGhsa:253725.
UCSCuc001jcs.2. human. [Q9Y4E1-3]
uc001jcu.3. human. [Q9Y4E1-4]

Organism-specific databases

CTD253725.
GeneCardsGC10P046222.
H-InvDBHIX0170304.
HGNCHGNC:23414. FAM21C.
HPAHPA047844.
MIM613631. gene.
neXtProtNX_Q9Y4E1.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000112469.
HOVERGENHBG055529.
InParanoidQ9Y4E1.
OMAMMNGSIP.
PhylomeDBQ9Y4E1.
TreeFamTF329309.

Gene expression databases

BgeeQ9Y4E1.
CleanExHS_FAM21C.
GenevestigatorQ9Y4E1.

Family and domain databases

InterProIPR027308. FAM21.
[Graphical view]
PANTHERPTHR21669:SF4. PTHR21669:SF4. 1 hit.
ProtoNetSearch...

Other

GeneWikiFAM21C.
GenomeRNAi253725.
NextBio13656442.
PROQ9Y4E1.
SOURCESearch...

Entry information

Entry nameFA21C_HUMAN
AccessionPrimary (citable) accession number: Q9Y4E1
Secondary accession number(s): B4DZQ6 expand/collapse secondary AC list , B9EK53, F5H0J6, F5H871, Q5SQU4, Q5SQU5, Q7L521, Q9UG79
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 19, 2010
Last modified: April 16, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM