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Q9Y4E1

- FA21C_HUMAN

UniProt

Q9Y4E1 - FA21C_HUMAN

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Protein
WASH complex subunit FAM21C
Gene
FAM21C, KIAA0592
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit FAM21C
Alternative name(s):
Vaccinia virus penetration factor
Short name:
VPEF
Gene namesi
Name:FAM21C
Synonyms:KIAA0592
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23414. FAM21C.

Subcellular locationi

Early endosome membrane. Cell membrane
Note: Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.2 Publications

GO - Cellular componenti

  1. WASH complex Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. early endosome membrane Source: UniProtKB-SubCell
  4. endosome Source: MGI
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13181318WASH complex subunit FAM21C
PRO_0000186714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei539 – 5391Phosphoserine4 Publications
Modified residuei907 – 9071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y4E1.
PRIDEiQ9Y4E1.

PTM databases

PhosphoSiteiQ9Y4E1.

Expressioni

Gene expression databases

BgeeiQ9Y4E1.
CleanExiHS_FAM21C.
GenevestigatoriQ9Y4E1.

Organism-specific databases

HPAiHPA047844.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct.2 Publications

Protein-protein interaction databases

IntActiQ9Y4E1. 3 interactions.
MINTiMINT-2879251.
STRINGi9606.ENSP00000337541.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4E1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 277176Glu-rich
Add
BLAST
Compositional biasi452 – 46110Poly-Asp
Compositional biasi1072 – 10787Poly-Ala

Sequence similaritiesi

Belongs to the FAM21 family.

Phylogenomic databases

HOGENOMiHOG000112469.
HOVERGENiHBG055529.
InParanoidiQ9Y4E1.
OMAiMMNGSIP.
PhylomeDBiQ9Y4E1.
TreeFamiTF329309.

Family and domain databases

InterProiIPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view]
PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
PfamiPF15255. CAP-ZIP_m. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4E1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF     50
SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY 100
DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ 150
LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG 200
LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNQHTTQMS 250
DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 300
AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED 350
FSPFGSGGGL FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP 400
GKKIPAGAVS VFLGDTDVFG AASVPSLKEP QKPEQPTPRK SPYGPPPTGL 450
FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA DIFGDEEGDL FKEKAVASPE 500
ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD EEDSEDLFSS 550
QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 600
EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ 650
SQEAKAVKKT SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF 700
GSPPTSVPPA TKKKETVSEA PPLLFSDEEE KEAQLGVKSV DKKVESAKES 750
LKFGRTDVAE SEKEGLLTRS AQETVKHSDL FSSSSPWDKG TKPRTKTVLS 800
LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD EELLFSHKLQ 850
KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 900
VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA 950
SQISEVKPVL PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT 1000
LHSANKSRVK MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA 1050
ISPNGHRPQL RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS 1100
RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP 1150
ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 1200
QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL 1250
TVKPKEKSKK KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF 1300
EHKVSNIFDD PLNAFGGQ 1318
Length:1,318
Mass (Da):144,668
Last modified:January 19, 2010 - v3
Checksum:iC3D811B7126425CB
GO
Isoform 2 (identifier: Q9Y4E1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-50: Missing.

Note: Gene prediction confirmed by EST data.

Show »
Length:1,310
Mass (Da):143,649
Checksum:iEC75C67E8A9AD5C8
GO
Isoform 3 (identifier: Q9Y4E1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-97: Missing.

Note: Gene prediction confirmed by EST data.

Show »
Length:1,263
Mass (Da):138,146
Checksum:iEC7677F45D0EA10B
GO
Isoform 4 (identifier: Q9Y4E1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ

Show »
Length:1,320
Mass (Da):144,911
Checksum:i156651EE158BE32F
GO
Isoform 5 (identifier: Q9Y4E1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-335: TLPSGEAKPRKTLKEKKERRTPSDD → N
     623-623: E → EDQ
     713-763: Missing.

Show »
Length:1,245
Mass (Da):136,541
Checksum:iDD8A6029AD1B2CA5
GO
Isoform 6 (identifier: Q9Y4E1-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ
     895-935: Missing.

Show »
Length:1,279
Mass (Da):140,144
Checksum:i1C1ABF0932DF6BC0
GO

Sequence cautioni

The sequence AAH06456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA25518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 9755Missing in isoform 3.
VSP_014854Add
BLAST
Alternative sequencei43 – 508Missing in isoform 2.
VSP_014853
Alternative sequencei311 – 33525TLPSG…TPSDD → N in isoform 5.
VSP_045809Add
BLAST
Alternative sequencei623 – 6231E → EDQ in isoform 4, isoform 5 and isoform 6.
VSP_038662
Alternative sequencei713 – 76351Missing in isoform 5.
VSP_045810Add
BLAST
Alternative sequencei895 – 93541Missing in isoform 6.
VSP_045811Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441Q → R in AAI50612. 1 Publication
Sequence conflicti302 – 3021M → V in AAI50612. 1 Publication
Sequence conflicti342 – 3421A → T in AAI50612. 1 Publication
Sequence conflicti382 – 3821S → P in AAI50612. 1 Publication
Sequence conflicti427 – 4271L → M in AAI50612. 1 Publication
Sequence conflicti474 – 4741R → G in AAI50612. 1 Publication
Sequence conflicti521 – 5211Y → S in BAA25518. 1 Publication
Sequence conflicti521 – 5211Y → S in BAG64168. 1 Publication
Sequence conflicti1038 – 10381V → I in BAA25518. 1 Publication
Sequence conflicti1278 – 12781T → S in BAA25518. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011164 mRNA. Translation: BAA25518.1. Different initiation.
AK303048 mRNA. Translation: BAG64168.1.
AL645998, AL731535 Genomic DNA. Translation: CAI16355.1.
AL645998, AC012044, AL731535 Genomic DNA. Translation: CAI16356.1.
AL731535, AL645998 Genomic DNA. Translation: CAI15257.1.
AL731535, AC012044, AL645998 Genomic DNA. Translation: CAI15258.1.
BC006456 mRNA. Translation: AAH06456.1. Different initiation.
BC150611 mRNA. Translation: AAI50612.1.
AL050279 mRNA. Translation: CAB43380.2.
CCDSiCCDS44374.2. [Q9Y4E1-4]
CCDS53528.1. [Q9Y4E1-6]
CCDS53529.1. [Q9Y4E1-5]
PIRiT00347.
T08735.
RefSeqiNP_001162577.1. NM_001169106.1. [Q9Y4E1-6]
NP_001162578.1. NM_001169107.1. [Q9Y4E1-5]
NP_056077.2. NM_015262.2. [Q9Y4E1-4]
UniGeneiHs.365286.
Hs.449662.

Genome annotation databases

EnsembliENST00000336378; ENSP00000337541; ENSG00000172661. [Q9Y4E1-1]
ENST00000374362; ENSP00000363482; ENSG00000172661. [Q9Y4E1-4]
ENST00000537517; ENSP00000442128; ENSG00000172661. [Q9Y4E1-5]
ENST00000540872; ENSP00000439811; ENSG00000172661. [Q9Y4E1-6]
ENST00000578828; ENSP00000464578; ENSG00000265551. [Q9Y4E1-4]
ENST00000579270; ENSP00000461926; ENSG00000265551. [Q9Y4E1-1]
ENST00000583993; ENSP00000462756; ENSG00000265551. [Q9Y4E1-5]
ENST00000584292; ENSP00000462907; ENSG00000265551. [Q9Y4E1-6]
GeneIDi253725.
KEGGihsa:253725.
UCSCiuc001jcs.2. human. [Q9Y4E1-3]
uc001jcu.3. human. [Q9Y4E1-4]

Polymorphism databases

DMDMi284018172.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011164 mRNA. Translation: BAA25518.1 . Different initiation.
AK303048 mRNA. Translation: BAG64168.1 .
AL645998 , AL731535 Genomic DNA. Translation: CAI16355.1 .
AL645998 , AC012044 , AL731535 Genomic DNA. Translation: CAI16356.1 .
AL731535 , AL645998 Genomic DNA. Translation: CAI15257.1 .
AL731535 , AC012044 , AL645998 Genomic DNA. Translation: CAI15258.1 .
BC006456 mRNA. Translation: AAH06456.1 . Different initiation.
BC150611 mRNA. Translation: AAI50612.1 .
AL050279 mRNA. Translation: CAB43380.2 .
CCDSi CCDS44374.2. [Q9Y4E1-4 ]
CCDS53528.1. [Q9Y4E1-6 ]
CCDS53529.1. [Q9Y4E1-5 ]
PIRi T00347.
T08735.
RefSeqi NP_001162577.1. NM_001169106.1. [Q9Y4E1-6 ]
NP_001162578.1. NM_001169107.1. [Q9Y4E1-5 ]
NP_056077.2. NM_015262.2. [Q9Y4E1-4 ]
UniGenei Hs.365286.
Hs.449662.

3D structure databases

ProteinModelPortali Q9Y4E1.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9Y4E1. 3 interactions.
MINTi MINT-2879251.
STRINGi 9606.ENSP00000337541.

PTM databases

PhosphoSitei Q9Y4E1.

Polymorphism databases

DMDMi 284018172.

Proteomic databases

MaxQBi Q9Y4E1.
PRIDEi Q9Y4E1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336378 ; ENSP00000337541 ; ENSG00000172661 . [Q9Y4E1-1 ]
ENST00000374362 ; ENSP00000363482 ; ENSG00000172661 . [Q9Y4E1-4 ]
ENST00000537517 ; ENSP00000442128 ; ENSG00000172661 . [Q9Y4E1-5 ]
ENST00000540872 ; ENSP00000439811 ; ENSG00000172661 . [Q9Y4E1-6 ]
ENST00000578828 ; ENSP00000464578 ; ENSG00000265551 . [Q9Y4E1-4 ]
ENST00000579270 ; ENSP00000461926 ; ENSG00000265551 . [Q9Y4E1-1 ]
ENST00000583993 ; ENSP00000462756 ; ENSG00000265551 . [Q9Y4E1-5 ]
ENST00000584292 ; ENSP00000462907 ; ENSG00000265551 . [Q9Y4E1-6 ]
GeneIDi 253725.
KEGGi hsa:253725.
UCSCi uc001jcs.2. human. [Q9Y4E1-3 ]
uc001jcu.3. human. [Q9Y4E1-4 ]

Organism-specific databases

CTDi 253725.
GeneCardsi GC10P046222.
H-InvDB HIX0170304.
HGNCi HGNC:23414. FAM21C.
HPAi HPA047844.
MIMi 613631. gene.
neXtProti NX_Q9Y4E1.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000112469.
HOVERGENi HBG055529.
InParanoidi Q9Y4E1.
OMAi MMNGSIP.
PhylomeDBi Q9Y4E1.
TreeFami TF329309.

Miscellaneous databases

GeneWikii FAM21C.
GenomeRNAii 253725.
NextBioi 13656442.
PROi Q9Y4E1.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4E1.
CleanExi HS_FAM21C.
Genevestigatori Q9Y4E1.

Family and domain databases

InterProi IPR027308. FAM21.
IPR029341. FAM21/CAPZIP.
[Graphical view ]
PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
Pfami PF15255. CAP-ZIP_m. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 984-1318.
    Tissue: Lung and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1014-1318.
    Tissue: Kidney.
  6. "A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis."
    Huang C.Y., Lu T.Y., Bair C.H., Chang Y.S., Jwo J.K., Chang W.
    J. Virol. 82:7988-7999(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A FAM21-containing WASH complex regulates retromer-dependent sorting."
    Gomez T.S., Billadeau D.D.
    Dev. Cell 17:699-711(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WASH1.
  9. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."
    Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.
    Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE WASH COMPLEX.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFA21C_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4E1
Secondary accession number(s): B4DZQ6
, B9EK53, F5H0J6, F5H871, Q5SQU4, Q5SQU5, Q7L521, Q9UG79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 19, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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