Q9Y4E1 (FA21C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WASH complex subunit FAM21C

Alternative name(s):
Vaccinia virus penetration factor
Short name=VPEF

Gene names

Name:	FAM21C
Synonyms:	KIAA0592

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells. Ref.6 Ref.8
Subunit structure	Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct. Ref.8 Ref.9
Subcellular location	Early endosome membrane. Cell membrane. Note: Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane. Ref.6 Ref.8
Miscellaneous	In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.
Sequence similarities	Belongs to the FAM21 family.
Sequence caution	The sequence AAH06456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA25518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Endosome Membrane
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	retrograde transport, endosome to Golgi Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	WASH complex Inferred from direct assay Ref.9. Source: UniProtKB early endosome Inferred from direct assay Ref.8. Source: UniProtKB early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4E1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4E1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-50: Missing.

Note: Gene prediction confirmed by EST data.

Isoform 3 (identifier: Q9Y4E1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     43-97: Missing.

Note: Gene prediction confirmed by EST data.

Isoform 4 (identifier: Q9Y4E1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ

Isoform 5 (identifier: Q9Y4E1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     311-335: TLPSGEAKPRKTLKEKKERRTPSDD → N
     623-623: E → EDQ
     713-763: Missing.

Isoform 6 (identifier: Q9Y4E1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: E → EDQ
     895-935: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1318	1318	WASH complex subunit FAM21C		PRO_0000186714
Regions
	Compositional bias	102 – 277	176	Glu-rich
	Compositional bias	452 – 461	10	Poly-Asp
	Compositional bias	1072 – 1078	7	Poly-Ala
Amino acid modifications
	Modified residue	539	1	Phosphoserine Ref.7 Ref.10 Ref.11 Ref.13
	Modified residue	907	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	43 – 97	55	Missing in isoform 3.		VSP_014854
	Alternative sequence	43 – 50	8	Missing in isoform 2.		VSP_014853
	Alternative sequence	311 – 335	25	TLPSG…TPSDD → N in isoform 5.		VSP_045809
	Alternative sequence	623	1	E → EDQ in isoform 4, isoform 5 and isoform 6.		VSP_038662
	Alternative sequence	713 – 763	51	Missing in isoform 5.		VSP_045810
	Alternative sequence	895 – 935	41	Missing in isoform 6.		VSP_045811
Experimental info
	Sequence conflict	244	1	Q → R in AAI50612. Ref.4
	Sequence conflict	302	1	M → V in AAI50612. Ref.4
	Sequence conflict	342	1	A → T in AAI50612. Ref.4
	Sequence conflict	382	1	S → P in AAI50612. Ref.4
	Sequence conflict	427	1	L → M in AAI50612. Ref.4
	Sequence conflict	474	1	R → G in AAI50612. Ref.4
	Sequence conflict	521	1	Y → S in BAA25518. Ref.1
	Sequence conflict	521	1	Y → S in BAG64168. Ref.2
	Sequence conflict	1038	1	V → I in BAA25518. Ref.1
	Sequence conflict	1278	1	T → S in BAA25518. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 19, 2010. Version 3. Checksum: C3D811B7126425CB	FASTA	1,318	144,668
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 70 80 90 100 110 120 IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 130 140 150 160 170 180 TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 190 200 210 220 230 240 DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 250 260 270 280 290 300 EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 310 320 330 340 350 360 AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 370 380 390 400 410 420 FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 430 440 450 460 470 480 AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 490 500 510 520 530 540 DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 550 560 570 580 590 600 EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 610 620 630 640 650 660 EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ SQEAKAVKKT 670 680 690 700 710 720 SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF GSPPTSVPPA TKKKETVSEA 730 740 750 760 770 780 PPLLFSDEEE KEAQLGVKSV DKKVESAKES LKFGRTDVAE SEKEGLLTRS AQETVKHSDL 790 800 810 820 830 840 FSSSSPWDKG TKPRTKTVLS LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD 850 860 870 880 890 900 EELLFSHKLQ KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 910 920 930 940 950 960 VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA SQISEVKPVL 970 980 990 1000 1010 1020 PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT LHSANKSRVK MRGKRRPQTR 1030 1040 1050 1060 1070 1080 AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL RAASGEDSTE EALAAAAAPW 1090 1100 1110 1120 1130 1140 EGGPVPGVDT SPFAKSLGHS RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV 1150 1160 1170 1180 1190 1200 GGKAKSPMFP ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 1210 1220 1230 1240 1250 1260 QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK 1270 1280 1290 1300 1310 KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD PLNAFGGQ
	Isoform 2 [UniParc]. Checksum: EC75C67E8A9AD5C8	FASTA	1,310	143,649
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGSQQTISRT HEIKKQVDGL 70 80 90 100 110 120 IRETKATDCR LHNVFNDFLM LSNTQFIENR VYDEEVEEPV LKAEAEKTEQ EKTREQKEVD 130 140 150 160 170 180 LIPKVQEAVN YGLQVLDSAF EQLDIKAGNS DSEEDDANGR VELILEPKDL YIDRPLPYLI 190 200 210 220 230 240 GSKLFMEQED VGLGELSSEE GSVGSDRGSI VDTEEEKEEE ESDEDFAHHS DNEQNQHTTQ 250 260 270 280 290 300 MSDEEEDDDG CDLFADSEKE EEDIEDIEEN TRPKRSRPTS FADELAARIK GDAMGRVDEE 310 320 330 340 350 360 PTTLPSGEAK PRKTLKEKKE RRTPSDDEED NLFAPPKLTD EDFSPFGSGG GLFSGGKGLF 370 380 390 400 410 420 DDEDEESDLF TEASQDRQAG ASVKEESSSS KPGKKIPAGA VSVFLGDTDV FGAASVPSLK 430 440 450 460 470 480 EPQKPEQPTP RKSPYGPPPT GLFDDDDGDD DDDFFSAPHS KPSKTRKVQS TADIFGDEEG 490 500 510 520 530 540 DLFKEKAVAS PEATVSQTDE NKARAEKKVT LSYSKNLKPS SETKTQKGLF SDEEDSEDLF 550 560 570 580 590 600 SSQSASNLKG ASLLPGKLPT SVSLFDDEDE EDNLFGGTAA KKQTLSLQAQ REEKAKASEL 610 620 630 640 650 660 SKKKASALLF SSDEEWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK KTSLFEEDKE 670 680 690 700 710 720 DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS EAPPLLFSDE 730 740 750 760 770 780 EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS DLFSSSSPWD 790 800 810 820 830 840 KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGCDP DAHPKSTGVF QDEELLFSHK 850 860 870 880 890 900 LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK KRVVKKDHSV 910 920 930 940 950 960 NSFKNQKHPE SIQGSKEKGI WKPETPQANL AINPAALLPT AASQISEVKP VLPELAFPSS 970 980 990 1000 1010 1020 EHRRSHGLES VPVLPGSGEA GVSFDLPAQA DTLHSANKSR VKMRGKRRPQ TRAARRLAAQ 1030 1040 1050 1060 1070 1080 ESSEAEDMSV PRGPIAQWAD GAISPNGHRP QLRAASGEDS TEEALAAAAA PWEGGPVPGV 1090 1100 1110 1120 1130 1140 DTSPFAKSLG HSRGEADLFD SGDIFSTGTG SQSVERTKPK AKIAENPANP PVGGKAKSPM 1150 1160 1170 1180 1190 1200 FPALGEASSD DDLFQSAKPK PAKKTNPFPL LEDEDDLFTD QKVKKNETKS SSQQDVILTT 1210 1220 1230 1240 1250 1260 QDIFEDDIFA TEAIKPSQKT REKEKTLESN LFDDNIDIFA DLTVKPKEKS KKKVEAKSIF 1270 1280 1290 1300 1310 DDDMDDIFST GIQAKTTKPK SRSAQAAPEP RFEHKVSNIF DDPLNAFGGQ
	Isoform 3 [UniParc]. Checksum: EC7677F45D0EA10B	FASTA	1,263	138,146
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGRVYDEEVE EPVLKAEAEK 70 80 90 100 110 120 TEQEKTREQK EVDLIPKVQE AVNYGLQVLD SAFEQLDIKA GNSDSEEDDA NGRVELILEP 130 140 150 160 170 180 KDLYIDRPLP YLIGSKLFME QEDVGLGELS SEEGSVGSDR GSIVDTEEEK EEEESDEDFA 190 200 210 220 230 240 HHSDNEQNQH TTQMSDEEED DDGCDLFADS EKEEEDIEDI EENTRPKRSR PTSFADELAA 250 260 270 280 290 300 RIKGDAMGRV DEEPTTLPSG EAKPRKTLKE KKERRTPSDD EEDNLFAPPK LTDEDFSPFG 310 320 330 340 350 360 SGGGLFSGGK GLFDDEDEES DLFTEASQDR QAGASVKEES SSSKPGKKIP AGAVSVFLGD 370 380 390 400 410 420 TDVFGAASVP SLKEPQKPEQ PTPRKSPYGP PPTGLFDDDD GDDDDDFFSA PHSKPSKTRK 430 440 450 460 470 480 VQSTADIFGD EEGDLFKEKA VASPEATVSQ TDENKARAEK KVTLSYSKNL KPSSETKTQK 490 500 510 520 530 540 GLFSDEEDSE DLFSSQSASN LKGASLLPGK LPTSVSLFDD EDEEDNLFGG TAAKKQTLSL 550 560 570 580 590 600 QAQREEKAKA SELSKKKASA LLFSSDEEWN IPASQTHLAS DSRSKGEPRD SGTLQSQEAK 610 620 630 640 650 660 AVKKTSLFEE DKEDDLFAIA KDSQKKTQRV SLLFEDDVDS GGSLFGSPPT SVPPATKKKE 670 680 690 700 710 720 TVSEAPPLLF SDEEEKEAQL GVKSVDKKVE SAKESLKFGR TDVAESEKEG LLTRSAQETV 730 740 750 760 770 780 KHSDLFSSSS PWDKGTKPRT KTVLSLFDEE EDKMEDQNII QAPQKEVGKG CDPDAHPKST 790 800 810 820 830 840 GVFQDEELLF SHKLQKDNDP DVDLFAGTKK TKLLEPSVGS LFGDDEDDDL FSSAKSQPLV 850 860 870 880 890 900 QEKKRVVKKD HSVNSFKNQK HPESIQGSKE KGIWKPETPQ ANLAINPAAL LPTAASQISE 910 920 930 940 950 960 VKPVLPELAF PSSEHRRSHG LESVPVLPGS GEAGVSFDLP AQADTLHSAN KSRVKMRGKR 970 980 990 1000 1010 1020 RPQTRAARRL AAQESSEAED MSVPRGPIAQ WADGAISPNG HRPQLRAASG EDSTEEALAA 1030 1040 1050 1060 1070 1080 AAAPWEGGPV PGVDTSPFAK SLGHSRGEAD LFDSGDIFST GTGSQSVERT KPKAKIAENP 1090 1100 1110 1120 1130 1140 ANPPVGGKAK SPMFPALGEA SSDDDLFQSA KPKPAKKTNP FPLLEDEDDL FTDQKVKKNE 1150 1160 1170 1180 1190 1200 TKSSSQQDVI LTTQDIFEDD IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK 1210 1220 1230 1240 1250 1260 EKSKKKVEAK SIFDDDMDDI FSTGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF GGQ
	Isoform 4 [UniParc]. Checksum: 156651EE158BE32F	FASTA	1,320	144,911
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 70 80 90 100 110 120 IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 130 140 150 160 170 180 TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 190 200 210 220 230 240 DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 250 260 270 280 290 300 EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 310 320 330 340 350 360 AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 370 380 390 400 410 420 FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 430 440 450 460 470 480 AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 490 500 510 520 530 540 DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 550 560 570 580 590 600 EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 610 620 630 640 650 660 EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK 670 680 690 700 710 720 KTSLFEEDKE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS 730 740 750 760 770 780 EAPPLLFSDE EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS 790 800 810 820 830 840 DLFSSSSPWD KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGCDP DAHPKSTGVF 850 860 870 880 890 900 QDEELLFSHK LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLVQEK 910 920 930 940 950 960 KRVVKKDHSV NSFKNQKHPE SIQGSKEKGI WKPETPQANL AINPAALLPT AASQISEVKP 970 980 990 1000 1010 1020 VLPELAFPSS EHRRSHGLES VPVLPGSGEA GVSFDLPAQA DTLHSANKSR VKMRGKRRPQ 1030 1040 1050 1060 1070 1080 TRAARRLAAQ ESSEAEDMSV PRGPIAQWAD GAISPNGHRP QLRAASGEDS TEEALAAAAA 1090 1100 1110 1120 1130 1140 PWEGGPVPGV DTSPFAKSLG HSRGEADLFD SGDIFSTGTG SQSVERTKPK AKIAENPANP 1150 1160 1170 1180 1190 1200 PVGGKAKSPM FPALGEASSD DDLFQSAKPK PAKKTNPFPL LEDEDDLFTD QKVKKNETKS 1210 1220 1230 1240 1250 1260 SSQQDVILTT QDIFEDDIFA TEAIKPSQKT REKEKTLESN LFDDNIDIFA DLTVKPKEKS 1270 1280 1290 1300 1310 1320 KKKVEAKSIF DDDMDDIFST GIQAKTTKPK SRSAQAAPEP RFEHKVSNIF DDPLNAFGGQ
	Isoform 5 [UniParc]. Checksum: DD8A6029AD1B2CA5	FASTA	1,245	136,541
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 70 80 90 100 110 120 IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 130 140 150 160 170 180 TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 190 200 210 220 230 240 DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 250 260 270 280 290 300 EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 310 320 330 340 350 360 AMGRVDEEPT NEEDNLFAPP KLTDEDFSPF GSGGGLFSGG KGLFDDEDEE SDLFTEASQD 370 380 390 400 410 420 RQAGASVKEE SSSSKPGKKI PAGAVSVFLG DTDVFGAASV PSLKEPQKPE QPTPRKSPYG 430 440 450 460 470 480 PPPTGLFDDD DGDDDDDFFS APHSKPSKTR KVQSTADIFG DEEGDLFKEK AVASPEATVS 490 500 510 520 530 540 QTDENKARAE KKVTLSYSKN LKPSSETKTQ KGLFSDEEDS EDLFSSQSAS NLKGASLLPG 550 560 570 580 590 600 KLPTSVSLFD DEDEEDNLFG GTAAKKQTLS LQAQREEKAK ASELSKKKAS ALLFSSDEED 610 620 630 640 650 660 QWNIPASQTH LASDSRSKGE PRDSGTLQSQ EAKAVKKTSL FEEDKEDDLF AIAKDSQKKT 670 680 690 700 710 720 QRVSLLFEDD VDSGGSLFGS PPTSVPPATK EGLLTRSAQE TVKHSDLFSS SSPWDKGTKP 730 740 750 760 770 780 RTKTVLSLFD EEEDKMEDQN IIQAPQKEVG KGCDPDAHPK STGVFQDEEL LFSHKLQKDN 790 800 810 820 830 840 DPDVDLFAGT KKTKLLEPSV GSLFGDDEDD DLFSSAKSQP LVQEKKRVVK KDHSVNSFKN 850 860 870 880 890 900 QKHPESIQGS KEKGIWKPET PQANLAINPA ALLPTAASQI SEVKPVLPEL AFPSSEHRRS 910 920 930 940 950 960 HGLESVPVLP GSGEAGVSFD LPAQADTLHS ANKSRVKMRG KRRPQTRAAR RLAAQESSEA 970 980 990 1000 1010 1020 EDMSVPRGPI AQWADGAISP NGHRPQLRAA SGEDSTEEAL AAAAAPWEGG PVPGVDTSPF 1030 1040 1050 1060 1070 1080 AKSLGHSRGE ADLFDSGDIF STGTGSQSVE RTKPKAKIAE NPANPPVGGK AKSPMFPALG 1090 1100 1110 1120 1130 1140 EASSDDDLFQ SAKPKPAKKT NPFPLLEDED DLFTDQKVKK NETKSSSQQD VILTTQDIFE 1150 1160 1170 1180 1190 1200 DDIFATEAIK PSQKTREKEK TLESNLFDDN IDIFADLTVK PKEKSKKKVE AKSIFDDDMD 1210 1220 1230 1240 DIFSTGIQAK TTKPKSRSAQ AAPEPRFEHK VSNIFDDPLN AFGGQ
	Isoform 6 [UniParc]. Checksum: 1C1ABF0932DF6BC0	FASTA	1,279	140,144
	10 20 30 40 50 60 MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 70 80 90 100 110 120 IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 130 140 150 160 170 180 TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 190 200 210 220 230 240 DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 250 260 270 280 290 300 EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 310 320 330 340 350 360 AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 370 380 390 400 410 420 FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 430 440 450 460 470 480 AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 490 500 510 520 530 540 DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 550 560 570 580 590 600 EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 610 620 630 640 650 660 EKAKASELSK KKASALLFSS DEEDQWNIPA SQTHLASDSR SKGEPRDSGT LQSQEAKAVK 670 680 690 700 710 720 KTSLFEEDKE DDLFAIAKDS QKKTQRVSLL FEDDVDSGGS LFGSPPTSVP PATKKKETVS 730 740 750 760 770 780 EAPPLLFSDE EEKEAQLGVK SVDKKVESAK ESLKFGRTDV AESEKEGLLT RSAQETVKHS 790 800 810 820 830 840 DLFSSSSPWD KGTKPRTKTV LSLFDEEEDK MEDQNIIQAP QKEVGKGCDP DAHPKSTGVF 850 860 870 880 890 900 QDEELLFSHK LQKDNDPDVD LFAGTKKTKL LEPSVGSLFG DDEDDDLFSS AKSQPLANLA 910 920 930 940 950 960 INPAALLPTA ASQISEVKPV LPELAFPSSE HRRSHGLESV PVLPGSGEAG VSFDLPAQAD 970 980 990 1000 1010 1020 TLHSANKSRV KMRGKRRPQT RAARRLAAQE SSEAEDMSVP RGPIAQWADG AISPNGHRPQ 1030 1040 1050 1060 1070 1080 LRAASGEDST EEALAAAAAP WEGGPVPGVD TSPFAKSLGH SRGEADLFDS GDIFSTGTGS 1090 1100 1110 1120 1130 1140 QSVERTKPKA KIAENPANPP VGGKAKSPMF PALGEASSDD DLFQSAKPKP AKKTNPFPLL 1150 1160 1170 1180 1190 1200 EDEDDLFTDQ KVKKNETKSS SQQDVILTTQ DIFEDDIFAT EAIKPSQKTR EKEKTLESNL 1210 1220 1230 1240 1250 1260 FDDNIDIFAD LTVKPKEKSK KKVEAKSIFD DDMDDIFSTG IQAKTTKPKS RSAQAAPEPR 1270 FEHKVSNIFD DPLNAFGGQ

References

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[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 984-1318. Tissue: Lung and Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1014-1318. Tissue: Kidney.
[6]	"A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis." Huang C.Y., Lu T.Y., Bair C.H., Chang Y.S., Jwo J.K., Chang W. J. Virol. 82:7988-7999(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, FUNCTION.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A FAM21-containing WASH complex regulates retromer-dependent sorting." Gomez T.S., Billadeau D.D. Dev. Cell 17:699-711(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WASH1.
[9]	"The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex." Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A. Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE WASH COMPLEX.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539 AND SER-907, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB011164 mRNA. Translation: BAA25518.1. Different initiation. AK303048 mRNA. Translation: BAG64168.1. AL645998, AL731535 Genomic DNA. Translation: CAI16355.1. AL645998, AC012044, AL731535 Genomic DNA. Translation: CAI16356.1. AL731535, AL645998 Genomic DNA. Translation: CAI15257.1. AL731535, AC012044, AL645998 Genomic DNA. Translation: CAI15258.1. BC006456 mRNA. Translation: AAH06456.1. Different initiation. BC150611 mRNA. Translation: AAI50612.1. AL050279 mRNA. Translation: CAB43380.2.
IPI	IPI00456853. IPI00514705. IPI00556261. IPI00871172. IPI00954966. IPI00966110.
PIR	T00347. T08735.
RefSeq	NP_001162577.1. NM_001169106.1. NP_001162578.1. NM_001169107.1. NP_056077.2. NM_015262.2.
UniGene	Hs.365286. Hs.449662.
3D structure databases
ProteinModelPortal	Q9Y4E1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4E1. 3 interactions.
MINT	MINT-2879251.
STRING	9606.ENSP00000337541.
PTM databases
PhosphoSite	Q9Y4E1.
Polymorphism databases
DMDM	284018172.
Proteomic databases
PRIDE	Q9Y4E1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336378; ENSP00000337541; ENSG00000172661. ENST00000374362; ENSP00000363482; ENSG00000172661. ENST00000420848; ENSP00000416630; ENSG00000172661. ENST00000537517; ENSP00000442128; ENSG00000172661. ENST00000540872; ENSP00000439811; ENSG00000172661. ENST00000577859; ENSP00000464471; ENSG00000265551. ENST00000578828; ENSP00000464578; ENSG00000265551. ENST00000579270; ENSP00000461926; ENSG00000265551. ENST00000583993; ENSP00000462756; ENSG00000265551. ENST00000584292; ENSP00000462907; ENSG00000265551.
GeneID	253725.
UCSC	uc001jcs.2. human. uc001jcu.3. human.
Organism-specific databases
CTD	253725.
GeneCards	GC10P046222.
H-InvDB	HIX0170304.
HGNC	HGNC:23414. FAM21C.
HPA	HPA047844.
MIM	613631. gene.
neXtProt	NX_Q9Y4E1.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000112469.
HOVERGEN	HBG055529.
InParanoid	Q9Y4E1.
Gene expression databases
ArrayExpress	Q9Y4E1.
Bgee	Q9Y4E1.
CleanEx	HS_FAM21C.
Genevestigator	Q9Y4E1.
GermOnline	ENSG00000172661. Homo sapiens.
Family and domain databases
InterPro	IPR027308. FAM21. [Graphical view]
PANTHER	PTHR21669:SF4. PTHR21669:SF4. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	253725.
NextBio	13656442.
SOURCE	Search...

Entry information

Entry name

FA21C_HUMAN

Accession

Primary (citable) accession number: Q9Y4E1
Secondary accession number(s): B4DZQ6 , B9EK53, F5H0J6, F5H871, Q5SQU4, Q5SQU5, Q7L521, Q9UG79

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	January 19, 2010
Last modified:	May 1, 2013
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.