Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y4E1

- FA21C_HUMAN

UniProt

Q9Y4E1 - FA21C_HUMAN

Protein

WASH complex subunit FAM21C

Gene

FAM21C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (19 Jan 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WASH complex subunit FAM21C
    Alternative name(s):
    Vaccinia virus penetration factor
    Short name:
    VPEF
    Gene namesi
    Name:FAM21C
    Synonyms:KIAA0592
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23414. FAM21C.

    Subcellular locationi

    Early endosome membrane. Cell membrane
    Note: Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell
    3. endosome Source: MGI
    4. plasma membrane Source: UniProtKB-SubCell
    5. WASH complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13181318WASH complex subunit FAM21CPRO_0000186714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei539 – 5391Phosphoserine4 Publications
    Modified residuei907 – 9071Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y4E1.
    PRIDEiQ9Y4E1.

    PTM databases

    PhosphoSiteiQ9Y4E1.

    Expressioni

    Gene expression databases

    BgeeiQ9Y4E1.
    CleanExiHS_FAM21C.
    GenevestigatoriQ9Y4E1.

    Organism-specific databases

    HPAiHPA047844.

    Interactioni

    Subunit structurei

    Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct.2 Publications

    Protein-protein interaction databases

    IntActiQ9Y4E1. 3 interactions.
    MINTiMINT-2879251.
    STRINGi9606.ENSP00000337541.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi102 – 277176Glu-richAdd
    BLAST
    Compositional biasi452 – 46110Poly-Asp
    Compositional biasi1072 – 10787Poly-Ala

    Sequence similaritiesi

    Belongs to the FAM21 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000112469.
    HOVERGENiHBG055529.
    InParanoidiQ9Y4E1.
    OMAiMMNGSIP.
    PhylomeDBiQ9Y4E1.
    TreeFamiTF329309.

    Family and domain databases

    InterProiIPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view]
    PANTHERiPTHR21669:SF4. PTHR21669:SF4. 1 hit.
    PfamiPF15255. CAP-ZIP_m. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4E1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF     50
    SQQTISRTHE IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY 100
    DEEVEEPVLK AEAEKTEQEK TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ 150
    LDIKAGNSDS EEDDANGRVE LILEPKDLYI DRPLPYLIGS KLFMEQEDVG 200
    LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN EQNQHTTQMS 250
    DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 300
    AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED 350
    FSPFGSGGGL FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP 400
    GKKIPAGAVS VFLGDTDVFG AASVPSLKEP QKPEQPTPRK SPYGPPPTGL 450
    FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA DIFGDEEGDL FKEKAVASPE 500
    ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD EEDSEDLFSS 550
    QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 600
    EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ 650
    SQEAKAVKKT SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF 700
    GSPPTSVPPA TKKKETVSEA PPLLFSDEEE KEAQLGVKSV DKKVESAKES 750
    LKFGRTDVAE SEKEGLLTRS AQETVKHSDL FSSSSPWDKG TKPRTKTVLS 800
    LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD EELLFSHKLQ 850
    KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 900
    VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA 950
    SQISEVKPVL PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT 1000
    LHSANKSRVK MRGKRRPQTR AARRLAAQES SEAEDMSVPR GPIAQWADGA 1050
    ISPNGHRPQL RAASGEDSTE EALAAAAAPW EGGPVPGVDT SPFAKSLGHS 1100
    RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV GGKAKSPMFP 1150
    ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 1200
    QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL 1250
    TVKPKEKSKK KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF 1300
    EHKVSNIFDD PLNAFGGQ 1318
    Length:1,318
    Mass (Da):144,668
    Last modified:January 19, 2010 - v3
    Checksum:iC3D811B7126425CB
    GO
    Isoform 2 (identifier: Q9Y4E1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-50: Missing.

    Note: Gene prediction confirmed by EST data.

    Show »
    Length:1,310
    Mass (Da):143,649
    Checksum:iEC75C67E8A9AD5C8
    GO
    Isoform 3 (identifier: Q9Y4E1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-97: Missing.

    Note: Gene prediction confirmed by EST data.

    Show »
    Length:1,263
    Mass (Da):138,146
    Checksum:iEC7677F45D0EA10B
    GO
    Isoform 4 (identifier: Q9Y4E1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         623-623: E → EDQ

    Show »
    Length:1,320
    Mass (Da):144,911
    Checksum:i156651EE158BE32F
    GO
    Isoform 5 (identifier: Q9Y4E1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         311-335: TLPSGEAKPRKTLKEKKERRTPSDD → N
         623-623: E → EDQ
         713-763: Missing.

    Show »
    Length:1,245
    Mass (Da):136,541
    Checksum:iDD8A6029AD1B2CA5
    GO
    Isoform 6 (identifier: Q9Y4E1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         623-623: E → EDQ
         895-935: Missing.

    Show »
    Length:1,279
    Mass (Da):140,144
    Checksum:i1C1ABF0932DF6BC0
    GO

    Sequence cautioni

    The sequence AAH06456.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA25518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441Q → R in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti302 – 3021M → V in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti342 – 3421A → T in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti382 – 3821S → P in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti427 – 4271L → M in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti474 – 4741R → G in AAI50612. (PubMed:15489334)Curated
    Sequence conflicti521 – 5211Y → S in BAA25518. (PubMed:9628581)Curated
    Sequence conflicti521 – 5211Y → S in BAG64168. (PubMed:14702039)Curated
    Sequence conflicti1038 – 10381V → I in BAA25518. (PubMed:9628581)Curated
    Sequence conflicti1278 – 12781T → S in BAA25518. (PubMed:9628581)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei43 – 9755Missing in isoform 3. CuratedVSP_014854Add
    BLAST
    Alternative sequencei43 – 508Missing in isoform 2. CuratedVSP_014853
    Alternative sequencei311 – 33525TLPSG…TPSDD → N in isoform 5. 1 PublicationVSP_045809Add
    BLAST
    Alternative sequencei623 – 6231E → EDQ in isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_038662
    Alternative sequencei713 – 76351Missing in isoform 5. 1 PublicationVSP_045810Add
    BLAST
    Alternative sequencei895 – 93541Missing in isoform 6. 1 PublicationVSP_045811Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011164 mRNA. Translation: BAA25518.1. Different initiation.
    AK303048 mRNA. Translation: BAG64168.1.
    AL645998, AL731535 Genomic DNA. Translation: CAI16355.1.
    AL645998, AC012044, AL731535 Genomic DNA. Translation: CAI16356.1.
    AL731535, AL645998 Genomic DNA. Translation: CAI15257.1.
    AL731535, AC012044, AL645998 Genomic DNA. Translation: CAI15258.1.
    BC006456 mRNA. Translation: AAH06456.1. Different initiation.
    BC150611 mRNA. Translation: AAI50612.1.
    AL050279 mRNA. Translation: CAB43380.2.
    CCDSiCCDS44374.2. [Q9Y4E1-4]
    CCDS53528.1. [Q9Y4E1-6]
    CCDS53529.1. [Q9Y4E1-5]
    PIRiT00347.
    T08735.
    RefSeqiNP_001162577.1. NM_001169106.1. [Q9Y4E1-6]
    NP_001162578.1. NM_001169107.1. [Q9Y4E1-5]
    NP_056077.2. NM_015262.2. [Q9Y4E1-4]
    UniGeneiHs.365286.
    Hs.449662.

    Genome annotation databases

    EnsembliENST00000336378; ENSP00000337541; ENSG00000172661. [Q9Y4E1-1]
    ENST00000374362; ENSP00000363482; ENSG00000172661. [Q9Y4E1-4]
    ENST00000537517; ENSP00000442128; ENSG00000172661. [Q9Y4E1-5]
    ENST00000540872; ENSP00000439811; ENSG00000172661. [Q9Y4E1-6]
    GeneIDi253725.
    KEGGihsa:253725.
    UCSCiuc001jcs.2. human. [Q9Y4E1-3]
    uc001jcu.3. human. [Q9Y4E1-4]

    Polymorphism databases

    DMDMi284018172.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011164 mRNA. Translation: BAA25518.1 . Different initiation.
    AK303048 mRNA. Translation: BAG64168.1 .
    AL645998 , AL731535 Genomic DNA. Translation: CAI16355.1 .
    AL645998 , AC012044 , AL731535 Genomic DNA. Translation: CAI16356.1 .
    AL731535 , AL645998 Genomic DNA. Translation: CAI15257.1 .
    AL731535 , AC012044 , AL645998 Genomic DNA. Translation: CAI15258.1 .
    BC006456 mRNA. Translation: AAH06456.1 . Different initiation.
    BC150611 mRNA. Translation: AAI50612.1 .
    AL050279 mRNA. Translation: CAB43380.2 .
    CCDSi CCDS44374.2. [Q9Y4E1-4 ]
    CCDS53528.1. [Q9Y4E1-6 ]
    CCDS53529.1. [Q9Y4E1-5 ]
    PIRi T00347.
    T08735.
    RefSeqi NP_001162577.1. NM_001169106.1. [Q9Y4E1-6 ]
    NP_001162578.1. NM_001169107.1. [Q9Y4E1-5 ]
    NP_056077.2. NM_015262.2. [Q9Y4E1-4 ]
    UniGenei Hs.365286.
    Hs.449662.

    3D structure databases

    ProteinModelPortali Q9Y4E1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Y4E1. 3 interactions.
    MINTi MINT-2879251.
    STRINGi 9606.ENSP00000337541.

    PTM databases

    PhosphoSitei Q9Y4E1.

    Polymorphism databases

    DMDMi 284018172.

    Proteomic databases

    MaxQBi Q9Y4E1.
    PRIDEi Q9Y4E1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336378 ; ENSP00000337541 ; ENSG00000172661 . [Q9Y4E1-1 ]
    ENST00000374362 ; ENSP00000363482 ; ENSG00000172661 . [Q9Y4E1-4 ]
    ENST00000537517 ; ENSP00000442128 ; ENSG00000172661 . [Q9Y4E1-5 ]
    ENST00000540872 ; ENSP00000439811 ; ENSG00000172661 . [Q9Y4E1-6 ]
    GeneIDi 253725.
    KEGGi hsa:253725.
    UCSCi uc001jcs.2. human. [Q9Y4E1-3 ]
    uc001jcu.3. human. [Q9Y4E1-4 ]

    Organism-specific databases

    CTDi 253725.
    GeneCardsi GC10P046222.
    H-InvDB HIX0170304.
    HGNCi HGNC:23414. FAM21C.
    HPAi HPA047844.
    MIMi 613631. gene.
    neXtProti NX_Q9Y4E1.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000112469.
    HOVERGENi HBG055529.
    InParanoidi Q9Y4E1.
    OMAi MMNGSIP.
    PhylomeDBi Q9Y4E1.
    TreeFami TF329309.

    Miscellaneous databases

    GeneWikii FAM21C.
    GenomeRNAii 253725.
    NextBioi 13656442.
    PROi Q9Y4E1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4E1.
    CleanExi HS_FAM21C.
    Genevestigatori Q9Y4E1.

    Family and domain databases

    InterProi IPR027308. FAM21.
    IPR029341. FAM21/CAPZIP.
    [Graphical view ]
    PANTHERi PTHR21669:SF4. PTHR21669:SF4. 1 hit.
    Pfami PF15255. CAP-ZIP_m. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 984-1318.
      Tissue: Lung and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1014-1318.
      Tissue: Kidney.
    6. "A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis."
      Huang C.Y., Lu T.Y., Bair C.H., Chang Y.S., Jwo J.K., Chang W.
      J. Virol. 82:7988-7999(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "A FAM21-containing WASH complex regulates retromer-dependent sorting."
      Gomez T.S., Billadeau D.D.
      Dev. Cell 17:699-711(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WASH1.
    9. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."
      Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.
      Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE WASH COMPLEX.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFA21C_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4E1
    Secondary accession number(s): B4DZQ6
    , B9EK53, F5H0J6, F5H871, Q5SQU4, Q5SQU5, Q7L521, Q9UG79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3