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Protein

Plexin-D1

Gene

PLXND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.By similarity1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004399-MONOMER.
ReactomeiR-HSA-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-D1
Gene namesi
Name:PLXND1
Synonyms:KIAA0620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9107. PLXND1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini47 – 1271ExtracellularSequence analysisAdd BLAST1225
Transmembranei1272 – 1292HelicalSequence analysisAdd BLAST21
Topological domaini1293 – 1925CytoplasmicSequence analysisAdd BLAST633

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23129.
MalaCardsiPLXND1.
OpenTargetsiENSG00000004399.
Orphaneti3384. Truncus arteriosus.
PharmGKBiPA128394602.

Polymorphism and mutation databases

BioMutaiPLXND1.
DMDMi296452982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_000002467647 – 1925Plexin-D1Add BLAST1879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 114PROSITE-ProRule annotation
Disulfide bondi140 ↔ 148PROSITE-ProRule annotation
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi322 ↔ 445PROSITE-ProRule annotation
Disulfide bondi345 ↔ 389PROSITE-ProRule annotation
Glycosylationi481N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)2 Publications1
Disulfide bondi549 ↔ 566PROSITE-ProRule annotation
Disulfide bondi555 ↔ 600PROSITE-ProRule annotation
Disulfide bondi558 ↔ 575PROSITE-ProRule annotation
Disulfide bondi569 ↔ 581PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi637 ↔ 661PROSITE-ProRule annotation
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1
Glycosylationi736N-linked (GlcNAc...)Sequence analysis1
Glycosylationi802N-linked (GlcNAc...)Sequence analysis1
Glycosylationi965N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1017N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1060N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1099N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1132N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1237N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1257N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y4D7.
PaxDbiQ9Y4D7.
PeptideAtlasiQ9Y4D7.
PRIDEiQ9Y4D7.

PTM databases

iPTMnetiQ9Y4D7.
PhosphoSitePlusiQ9Y4D7.

Expressioni

Tissue specificityi

Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000004399.
CleanExiHS_PLXND1.
ExpressionAtlasiQ9Y4D7. baseline and differential.
GenevisibleiQ9Y4D7. HS.

Organism-specific databases

HPAiCAB020819.

Interactioni

Subunit structurei

Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-310731,EBI-721550
SEMA3EO150412EBI-310731,EBI-7283693
Sema3eP702752EBI-310731,EBI-8876322From a different organism.
SEMA4AQ9H3S12EBI-310731,EBI-3924922

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116747. 1 interactor.
IntActiQ9Y4D7. 5 interactors.
MINTiMINT-4507885.
STRINGi9606.ENSP00000317128.

Structurei

Secondary structure

11925
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1555 – 1563Combined sources9
Beta strandi1570 – 1575Combined sources6
Helixi1580 – 1591Combined sources12
Helixi1597 – 1599Combined sources3
Helixi1603 – 1605Combined sources3
Beta strandi1606 – 1611Combined sources6
Beta strandi1613 – 1615Combined sources3
Beta strandi1617 – 1619Combined sources3
Beta strandi1622 – 1624Combined sources3
Turni1639 – 1643Combined sources5
Beta strandi1649 – 1654Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H6NX-ray2.00A1553-1678[»]
ProteinModelPortaliQ9Y4D7.
SMRiQ9Y4D7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4D7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 546SemaPROSITE-ProRule annotationAdd BLAST500
Domaini891 – 979IPT/TIG 1Add BLAST89
Domaini981 – 1066IPT/TIG 2Add BLAST86
Domaini1069 – 1160IPT/TIG 3Add BLAST92

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 3 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410ZUMY. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ9Y4D7.
KOiK06822.
OMAiAGERFHM.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9Y4D7.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 2 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ
60 70 80 90 100
RRFPSPTPTN NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD
110 120 130 140 150
SPLCHAPQLP QASCEHPRRL TDNYNKILQL DPGQGLVVVC GSIYQGFCQL
160 170 180 190 200
RRRGNISAVA VRFPPAAPPA EPVTVFPSML NVAANHPNAS TVGLVLPPAA
210 220 230 240 250
GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI RSLDTRGDLA
260 270 280 290 300
KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA
310 320 330 340 350
LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG
360 370 380 390 400
RGDLYSRLVS VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI
410 420 430 440 450
RAARTACFVE PAPDVVAVLD SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL
460 470 480 490 500
QHPLSILQPL KATPVFRAPG LTSVAVASVN NYTAVFLGTV NGRLLKINLN
510 520 530 540 550
ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ MARVKVAACN
560 570 580 590 600
VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC
610 620 630 640 650
PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP
660 670 680 690 700
GPAFGHQIAY CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY
710 720 730 740 750
DCSRTAQVYP HTACTSCLSA QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ
760 770 780 790 800
DCPRTLLSPL APVPTGGSQN ILVPLANTAF FQGAALECSF GLEEIFEAVW
810 820 830 840 850
VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE PMTVMVYNCA
860 870 880 890 900
MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS
910 920 930 940 950
GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV
960 970 980 990 1000
TGPAPGPLSG VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT
1010 1020 1030 1040 1050
IHGNDLHVGS ELQVLVNDTD PCTELMRTDT SIACTMPEGA LPAPVPVCVR
1060 1070 1080 1090 1100
FERRGCVHGN LTFWYMQNPV ITAISPRRSP VSGGRTITVA GERFHMVQNV
1110 1120 1130 1140 1150
SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF INGRAYADEV
1160 1170 1180 1190 1200
AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
1210 1220 1230 1240 1250
KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT
1260 1270 1280 1290 1300
IQVGNFNQTI ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA
1310 1320 1330 1340 1350
ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE
1360 1370 1380 1390 1400
YKHFVTRTFF PKCSSLYEER YVLPSQTLNS QGSSQAQETH PLLGEWKIPE
1410 1420 1430 1440 1450
SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI
1460 1470 1480 1490 1500
ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
1510 1520 1530 1540 1550
CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN
1560 1570 1580 1590 1600
IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW
1610 1620 1630 1640 1650
PRAEDVDLEW FASSTQSYIL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL
1660 1670 1680 1690 1700
AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT DELAEPKKSH RQSHRKKVLP
1710 1720 1730 1740 1750
EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK
1760 1770 1780 1790 1800
RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ
1810 1820 1830 1840 1850
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE
1860 1870 1880 1890 1900
QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR
1910 1920
TQLQHKFEQV VALMEDNIYE CYSEA
Length:1,925
Mass (Da):212,007
Last modified:May 18, 2010 - v3
Checksum:i28967933B2D17CE1
GO
Isoform 2 (identifier: Q9Y4D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

Show »
Length:1,785
Mass (Da):195,558
Checksum:i4CA3AE813635414A
GO

Sequence cautioni

The sequence BAA31595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531G → V in BAA31595 (PubMed:9734811).Curated1
Sequence conflicti531G → V in AAM49063 (PubMed:12412018).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056723617P → S.Corresponds to variant rs2285372dbSNPEnsembl.1
Natural variantiVAR_022144870M → V.Corresponds to variant rs2255703dbSNPEnsembl.1
Natural variantiVAR_059558894H → R.2 PublicationsCorresponds to variant rs2625962dbSNPEnsembl.1
Natural variantiVAR_0567241412L → V.Corresponds to variant rs2625973dbSNPEnsembl.1
Natural variantiVAR_0615391542S → N.3 PublicationsCorresponds to variant rs2713625dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0115161766 – 1925SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014520 mRNA. Translation: BAA31595.2. Different initiation.
AY116661 mRNA. Translation: AAM49063.1.
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1.
BC011848 mRNA. Translation: AAH11848.1.
BC150280 mRNA. Translation: AAI50281.1.
CCDSiCCDS33854.1. [Q9Y4D7-1]
RefSeqiNP_055918.2. NM_015103.2.
UniGeneiHs.301685.

Genome annotation databases

EnsembliENST00000324093; ENSP00000317128; ENSG00000004399. [Q9Y4D7-1]
GeneIDi23129.
KEGGihsa:23129.
UCSCiuc003emx.3. human. [Q9Y4D7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014520 mRNA. Translation: BAA31595.2. Different initiation.
AY116661 mRNA. Translation: AAM49063.1.
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1.
BC011848 mRNA. Translation: AAH11848.1.
BC150280 mRNA. Translation: AAI50281.1.
CCDSiCCDS33854.1. [Q9Y4D7-1]
RefSeqiNP_055918.2. NM_015103.2.
UniGeneiHs.301685.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H6NX-ray2.00A1553-1678[»]
ProteinModelPortaliQ9Y4D7.
SMRiQ9Y4D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116747. 1 interactor.
IntActiQ9Y4D7. 5 interactors.
MINTiMINT-4507885.
STRINGi9606.ENSP00000317128.

PTM databases

iPTMnetiQ9Y4D7.
PhosphoSitePlusiQ9Y4D7.

Polymorphism and mutation databases

BioMutaiPLXND1.
DMDMi296452982.

Proteomic databases

EPDiQ9Y4D7.
PaxDbiQ9Y4D7.
PeptideAtlasiQ9Y4D7.
PRIDEiQ9Y4D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324093; ENSP00000317128; ENSG00000004399. [Q9Y4D7-1]
GeneIDi23129.
KEGGihsa:23129.
UCSCiuc003emx.3. human. [Q9Y4D7-1]

Organism-specific databases

CTDi23129.
DisGeNETi23129.
GeneCardsiPLXND1.
HGNCiHGNC:9107. PLXND1.
HPAiCAB020819.
MalaCardsiPLXND1.
MIMi604282. gene.
neXtProtiNX_Q9Y4D7.
OpenTargetsiENSG00000004399.
Orphaneti3384. Truncus arteriosus.
PharmGKBiPA128394602.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410ZUMY. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ9Y4D7.
KOiK06822.
OMAiAGERFHM.
OrthoDBiEOG091G00EK.
PhylomeDBiQ9Y4D7.
TreeFamiTF312962.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004399-MONOMER.
ReactomeiR-HSA-416700. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSiPLXND1. human.
EvolutionaryTraceiQ9Y4D7.
GeneWikiiPLXND1.
GenomeRNAii23129.
PROiQ9Y4D7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004399.
CleanExiHS_PLXND1.
ExpressionAtlasiQ9Y4D7. baseline and differential.
GenevisibleiQ9Y4D7. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 2 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4D7
Secondary accession number(s): A7E2C6
, C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.