Q9Y4D7 (PLXD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin-D1

Gene names

Name:	PLXND1
Synonyms:	KIAA0620

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1925 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature By similarity. Mediates anti-angiogenic signaling in response to SEMA3E. Ref.8
Subunit structure	Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E By similarity.
Subcellular location	Cell membrane; Single-pass membrane protein By similarity.
Tissue specificity	Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes. Ref.3
Sequence similarities	Belongs to the plexin family. Contains 3 IPT/TIG domains. Contains 1 Sema domain.
Sequence caution	The sequence BAA31595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Angiogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB axon guidance Traceable author statement. Source: Reactome dichotomous subdivision of terminal units involved in salivary gland branching Inferred from electronic annotation. Source: Compara endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB patterning of blood vessels Inferred from electronic annotation. Source: Compara regulation of angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB synapse assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	semaphorin receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4D7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4D7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 46

46

Potential

Chain

47 – 1925

1879

Plexin-D1

PRO_0000024676

Regions

Topological domain

47 – 1271

1225

Extracellular Potential

Transmembrane

1272 – 1292

21

Helical; Potential

Topological domain

1293 – 1925

633

Cytoplasmic Potential

Domain

47 – 546

500

Sema

Domain

891 – 979

89

IPT/TIG 1

Domain

981 – 1066

86

IPT/TIG 2

Domain

1069 – 1160

92

IPT/TIG 3

Amino acid modifications

Glycosylation

86

1

N-linked (GlcNAc...) Potential

Glycosylation

155

1

N-linked (GlcNAc...) Potential

Glycosylation

188

1

N-linked (GlcNAc...) Potential

Glycosylation

224

1

N-linked (GlcNAc...) Potential

Glycosylation

481

1

N-linked (GlcNAc...) Potential

Glycosylation

500

1

N-linked (GlcNAc...) Ref.6 Ref.7

Glycosylation

583

1

N-linked (GlcNAc...) Potential

Glycosylation

696

1

N-linked (GlcNAc...) Potential

Glycosylation

736

1

N-linked (GlcNAc...) Potential

Glycosylation

802

1

N-linked (GlcNAc...) Potential

Glycosylation

965

1

N-linked (GlcNAc...) Potential

Glycosylation

1017

1

N-linked (GlcNAc...) Potential

Glycosylation

1060

1

N-linked (GlcNAc...) Potential

Glycosylation

1099

1

N-linked (GlcNAc...) Potential

Glycosylation

1118

1

N-linked (GlcNAc...) Potential

Glycosylation

1132

1

N-linked (GlcNAc...) Potential

Glycosylation

1237

1

N-linked (GlcNAc...) Potential

Glycosylation

1257

1

N-linked (GlcNAc...) Potential

Disulfide bond

104 ↔ 114

By similarity

Disulfide bond

140 ↔ 148

By similarity

Disulfide bond

322 ↔ 445

By similarity

Disulfide bond

345 ↔ 389

By similarity

Disulfide bond

549 ↔ 566

By similarity

Disulfide bond

555 ↔ 600

By similarity

Disulfide bond

558 ↔ 575

By similarity

Disulfide bond

569 ↔ 581

By similarity

Disulfide bond

637 ↔ 661

By similarity

Natural variations

Alternative sequence

1766 – 1925

160

SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2.

VSP_011516

Natural variant

617

1

P → S.
Corresponds to variant rs2285372 [ dbSNP | Ensembl ].

VAR_056723

Natural variant

870

1

M → V.
Corresponds to variant rs2255703 [ dbSNP | Ensembl ].

VAR_022144

Natural variant

894

1

H → R. Ref.1 Ref.3
Corresponds to variant rs2625962 [ dbSNP | Ensembl ].

VAR_059558

Natural variant

1412

1

L → V.
Corresponds to variant rs2625973 [ dbSNP | Ensembl ].

VAR_056724

Natural variant

1542

1

S → N. Ref.1 Ref.3 Ref.5
Corresponds to variant rs2713625 [ dbSNP | Ensembl ].

VAR_061539

Experimental info

Sequence conflict

531

1

G → V in BAA31595. Ref.1

Sequence conflict

531

1

G → V in AAM49063. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1925

Helix Strand Turn

Details...

Beta strand

1555 – 1563

9

Beta strand

1570 – 1575

6

Helix

1580 – 1591

12

Helix

1597 – 1599

3

Helix

1603 – 1605

3

Beta strand

1606 – 1611

6

Beta strand

1613 – 1615

3

Beta strand

1617 – 1619

3

Beta strand

1622 – 1624

3

Turn

1639 – 1643

5

Beta strand

1649 – 1654

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 28967933B2D17CE1	FASTA	1,925	212,007
	10 20 30 40 50 60 MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ RRFPSPTPTN 70 80 90 100 110 120 NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD SPLCHAPQLP QASCEHPRRL 130 140 150 160 170 180 TDNYNKILQL DPGQGLVVVC GSIYQGFCQL RRRGNISAVA VRFPPAAPPA EPVTVFPSML 190 200 210 220 230 240 NVAANHPNAS TVGLVLPPAA GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI 250 260 270 280 290 300 RSLDTRGDLA KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 310 320 330 340 350 360 LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG RGDLYSRLVS 370 380 390 400 410 420 VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI RAARTACFVE PAPDVVAVLD 430 440 450 460 470 480 SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL QHPLSILQPL KATPVFRAPG LTSVAVASVN 490 500 510 520 530 540 NYTAVFLGTV NGRLLKINLN ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ 550 560 570 580 590 600 MARVKVAACN VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC 610 620 630 640 650 660 PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP GPAFGHQIAY 670 680 690 700 710 720 CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY DCSRTAQVYP HTACTSCLSA 730 740 750 760 770 780 QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ DCPRTLLSPL APVPTGGSQN ILVPLANTAF 790 800 810 820 830 840 FQGAALECSF GLEEIFEAVW VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE 850 860 870 880 890 900 PMTVMVYNCA MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS 910 920 930 940 950 960 GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV TGPAPGPLSG 970 980 990 1000 1010 1020 VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT IHGNDLHVGS ELQVLVNDTD 1030 1040 1050 1060 1070 1080 PCTELMRTDT SIACTMPEGA LPAPVPVCVR FERRGCVHGN LTFWYMQNPV ITAISPRRSP 1090 1100 1110 1120 1130 1140 VSGGRTITVA GERFHMVQNV SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF 1150 1160 1170 1180 1190 1200 INGRAYADEV AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1210 1220 1230 1240 1250 1260 KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT IQVGNFNQTI 1270 1280 1290 1300 1310 1320 ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1330 1340 1350 1360 1370 1380 EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSQTLNS 1390 1400 1410 1420 1430 1440 QGSSQAQETH PLLGEWKIPE SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1450 1460 1470 1480 1490 1500 RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1510 1520 1530 1540 1550 1560 CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN IEAKPRNLNV 1570 1580 1590 1600 1610 1620 SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYIL 1630 1640 1650 1660 1670 1680 RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT 1690 1700 1710 1720 1730 1740 DELAEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1750 1760 1770 1780 1790 1800 FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ 1810 1820 1830 1840 1850 1860 AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE QEMNAHLAEE 1870 1880 1890 1900 1910 1920 SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMEDNIYE CYSEA
	Isoform 2 [UniParc]. Checksum: 4CA3AE813635414A	FASTA	1,785	195,558
	10 20 30 40 50 60 MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ RRFPSPTPTN 70 80 90 100 110 120 NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD SPLCHAPQLP QASCEHPRRL 130 140 150 160 170 180 TDNYNKILQL DPGQGLVVVC GSIYQGFCQL RRRGNISAVA VRFPPAAPPA EPVTVFPSML 190 200 210 220 230 240 NVAANHPNAS TVGLVLPPAA GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI 250 260 270 280 290 300 RSLDTRGDLA KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 310 320 330 340 350 360 LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG RGDLYSRLVS 370 380 390 400 410 420 VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI RAARTACFVE PAPDVVAVLD 430 440 450 460 470 480 SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL QHPLSILQPL KATPVFRAPG LTSVAVASVN 490 500 510 520 530 540 NYTAVFLGTV NGRLLKINLN ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ 550 560 570 580 590 600 MARVKVAACN VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC 610 620 630 640 650 660 PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP GPAFGHQIAY 670 680 690 700 710 720 CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY DCSRTAQVYP HTACTSCLSA 730 740 750 760 770 780 QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ DCPRTLLSPL APVPTGGSQN ILVPLANTAF 790 800 810 820 830 840 FQGAALECSF GLEEIFEAVW VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE 850 860 870 880 890 900 PMTVMVYNCA MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS 910 920 930 940 950 960 GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV TGPAPGPLSG 970 980 990 1000 1010 1020 VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT IHGNDLHVGS ELQVLVNDTD 1030 1040 1050 1060 1070 1080 PCTELMRTDT SIACTMPEGA LPAPVPVCVR FERRGCVHGN LTFWYMQNPV ITAISPRRSP 1090 1100 1110 1120 1130 1140 VSGGRTITVA GERFHMVQNV SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF 1150 1160 1170 1180 1190 1200 INGRAYADEV AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1210 1220 1230 1240 1250 1260 KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT IQVGNFNQTI 1270 1280 1290 1300 1310 1320 ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1330 1340 1350 1360 1370 1380 EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSQTLNS 1390 1400 1410 1420 1430 1440 QGSSQAQETH PLLGEWKIPE SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1450 1460 1470 1480 1490 1500 RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1510 1520 1530 1540 1550 1560 CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN IEAKPRNLNV 1570 1580 1590 1600 1610 1620 SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYIL 1630 1640 1650 1660 1670 1680 RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT 1690 1700 1710 1720 1730 1740 DELAEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1750 1760 1770 1780 FDFLEEQAEK RGISDPDTLH IWKTNRWRPS SPVLGEHPEE PPVCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-894 AND ASN-1542. Tissue: Brain.
[2]	Ohara O., Suyama M., Nagase T., Ishikawa K. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis." van der Zwaag B., Hellemons A.J.C.G.M., Leenders W.P.J., Burbach J.P.H., Brunner H.G., Padberg G.W., Van Bokhoven H. Dev. Dyn. 225:336-343(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANT ARG-894 AND ASN-1542.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1386-1925 (ISOFORMS 1 AND 2), VARIANT ASN-1542. Tissue: Muscle and Uterus.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras." Sakurai A., Gavard J., Annas-Linhares Y., Basile J.R., Amornphimoltham P., Palmby T.R., Yagi H., Zhang F., Randazzo P.A., Li X., Weigert R., Gutkind J.S. Mol. Cell. Biol. 30:3086-3098(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Crystal structure of the ubiquitin-like domain of plexin D1." Structural genomics consortium (SGC) Submitted (MAY-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1553-1678.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB014520 mRNA. Translation: BAA31595.2. Different initiation.
AY116661 mRNA. Translation: AAM49063.1.
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1.
BC011848 mRNA. Translation: AAH11848.1.
BC150280 mRNA. Translation: AAI50281.1.

IPI

IPI00412492.
IPI00472139.

RefSeq

NP_055918.2. NM_015103.2.

UniGene

Hs.301685.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3H6N	X-ray	2.00	A	1553-1678	[»]

ProteinModelPortal

Q9Y4D7.

SMR

Q9Y4D7. Positions 54-595, 891-1076, 1305-1915.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y4D7. 1 interaction.

MINT

MINT-4507885.

STRING

9606.ENSP00000317128.

PTM databases

PhosphoSite

Q9Y4D7.

Polymorphism databases

DMDM

296452982.

Proteomic databases

PaxDb

Q9Y4D7.

PRIDE

Q9Y4D7.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000324093; ENSP00000317128; ENSG00000004399.
ENST00000393239; ENSP00000376931; ENSG00000004399.

GeneID

23129.

KEGG

hsa:23129.

UCSC

uc003emx.2. human.

Organism-specific databases

CTD

23129.

GeneCards

GC03M129274.

HGNC

HGNC:9107. PLXND1.

HPA

CAB020819.

MIM

604282. gene.

neXtProt

NX_Q9Y4D7.

PharmGKB

PA128394602.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG252136.

HOGENOM

HOG000231376.

HOVERGEN

HBG053404.

InParanoid

Q9Y4D7.

KO

K06822.

OMA

KKSHRQS.

OrthoDB

EOG49CQ6S.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q9Y4D7.

Bgee

Q9Y4D7.

CleanEx

HS_PLXND1.

Genevestigator

Q9Y4D7.

GermOnline

ENSG00000004399. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.
2.60.40.10. 4 hits.

InterPro

IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]

Pfam

PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 2 hits.
PF01833. TIG. 3 hits.
[Graphical view]

SMART

SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]

SUPFAM

SSF81296. Ig_E-set. 3 hits.
SSF103575. Plexin-like_fold. 1 hit.
SSF48350. Rho_GAP. 1 hit.
SSF101912. Sema. 1 hit.

PROSITE

PS51004. SEMA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PLXND1. human.

EvolutionaryTrace

Q9Y4D7.

GenomeRNAi

23129.

NextBio

44371.

SOURCE

Search...

Entry information

Entry name

PLXD1_HUMAN

Accession

Primary (citable) accession number: Q9Y4D7
Secondary accession number(s): A7E2C6 , C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.