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Q9Y4D7

- PLXD1_HUMAN

UniProt

Q9Y4D7 - PLXD1_HUMAN

Protein

Plexin-D1

Gene

PLXND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature By similarity. Mediates anti-angiogenic signaling in response to SEMA3E.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein domain specific binding Source: UniProt
    3. semaphorin receptor activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. axon guidance Source: Reactome
    3. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
    4. endothelial cell migration Source: UniProtKB
    5. patterning of blood vessels Source: Ensembl
    6. positive regulation of protein binding Source: Ensembl
    7. regulation of angiogenesis Source: UniProtKB
    8. regulation of cell migration Source: UniProtKB
    9. semaphorin-plexin signaling pathway Source: UniProtKB
    10. synapse assembly Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Angiogenesis

    Enzyme and pathway databases

    ReactomeiREACT_19200. Other semaphorin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin-D1
    Gene namesi
    Name:PLXND1
    Synonyms:KIAA0620
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:9107. PLXND1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. intracellular Source: InterPro
    3. lamellipodium Source: UniProt
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti3384. Truncus arteriosus.
    PharmGKBiPA128394602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4646Sequence AnalysisAdd
    BLAST
    Chaini47 – 19251879Plexin-D1PRO_0000024676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 114PROSITE-ProRule annotation
    Disulfide bondi140 ↔ 148PROSITE-ProRule annotation
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 445PROSITE-ProRule annotation
    Disulfide bondi345 ↔ 389PROSITE-ProRule annotation
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)2 Publications
    Disulfide bondi549 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi555 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi558 ↔ 575PROSITE-ProRule annotation
    Disulfide bondi569 ↔ 581PROSITE-ProRule annotation
    Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi637 ↔ 661PROSITE-ProRule annotation
    Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi736 – 7361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi965 – 9651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1017 – 10171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1060 – 10601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1099 – 10991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1118 – 11181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1132 – 11321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1237 – 12371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1257 – 12571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y4D7.
    PaxDbiQ9Y4D7.
    PRIDEiQ9Y4D7.

    PTM databases

    PhosphoSiteiQ9Y4D7.

    Expressioni

    Tissue specificityi

    Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y4D7.
    BgeeiQ9Y4D7.
    CleanExiHS_PLXND1.
    GenevestigatoriQ9Y4D7.

    Organism-specific databases

    HPAiCAB020819.

    Interactioni

    Subunit structurei

    Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NR4A1P227362EBI-310731,EBI-721550
    SEMA3EO150412EBI-310731,EBI-7283693
    Sema3eP702752EBI-310731,EBI-8876322From a different organism.
    SEMA4AQ9H3S12EBI-310731,EBI-3924922

    Protein-protein interaction databases

    BioGridi116747. 2 interactions.
    IntActiQ9Y4D7. 5 interactions.
    MINTiMINT-4507885.
    STRINGi9606.ENSP00000317128.

    Structurei

    Secondary structure

    1
    1925
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1555 – 15639
    Beta strandi1570 – 15756
    Helixi1580 – 159112
    Helixi1597 – 15993
    Helixi1603 – 16053
    Beta strandi1606 – 16116
    Beta strandi1613 – 16153
    Beta strandi1617 – 16193
    Beta strandi1622 – 16243
    Turni1639 – 16435
    Beta strandi1649 – 16546

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3H6NX-ray2.00A1553-1678[»]
    ProteinModelPortaliQ9Y4D7.
    SMRiQ9Y4D7. Positions 54-595, 1310-1915.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y4D7.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini47 – 12711225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1293 – 1925633CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1272 – 129221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 546500SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini891 – 97989IPT/TIG 1Add
    BLAST
    Domaini981 – 106686IPT/TIG 2Add
    BLAST
    Domaini1069 – 116092IPT/TIG 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the plexin family.Curated
    Contains 3 IPT/TIG domains.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG252136.
    HOGENOMiHOG000231376.
    HOVERGENiHBG053404.
    InParanoidiQ9Y4D7.
    KOiK06822.
    OMAiKKSHRQS.
    OrthoDBiEOG7Q8CM9.
    PhylomeDBiQ9Y4D7.
    TreeFamiTF312962.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 2 hits.
    PF01403. Sema. 2 hits.
    PF01833. TIG. 3 hits.
    [Graphical view]
    SMARTiSM00429. IPT. 3 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 3 hits.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y4D7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ     50
    RRFPSPTPTN NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD 100
    SPLCHAPQLP QASCEHPRRL TDNYNKILQL DPGQGLVVVC GSIYQGFCQL 150
    RRRGNISAVA VRFPPAAPPA EPVTVFPSML NVAANHPNAS TVGLVLPPAA 200
    GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI RSLDTRGDLA 250
    KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 300
    LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG 350
    RGDLYSRLVS VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI 400
    RAARTACFVE PAPDVVAVLD SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL 450
    QHPLSILQPL KATPVFRAPG LTSVAVASVN NYTAVFLGTV NGRLLKINLN 500
    ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ MARVKVAACN 550
    VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC 600
    PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP 650
    GPAFGHQIAY CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY 700
    DCSRTAQVYP HTACTSCLSA QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ 750
    DCPRTLLSPL APVPTGGSQN ILVPLANTAF FQGAALECSF GLEEIFEAVW 800
    VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE PMTVMVYNCA 850
    MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS 900
    GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV 950
    TGPAPGPLSG VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT 1000
    IHGNDLHVGS ELQVLVNDTD PCTELMRTDT SIACTMPEGA LPAPVPVCVR 1050
    FERRGCVHGN LTFWYMQNPV ITAISPRRSP VSGGRTITVA GERFHMVQNV 1100
    SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF INGRAYADEV 1150
    AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200
    KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT 1250
    IQVGNFNQTI ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA 1300
    ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE 1350
    YKHFVTRTFF PKCSSLYEER YVLPSQTLNS QGSSQAQETH PLLGEWKIPE 1400
    SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI 1450
    ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500
    CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN 1550
    IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW 1600
    PRAEDVDLEW FASSTQSYIL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL 1650
    AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT DELAEPKKSH RQSHRKKVLP 1700
    EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK 1750
    RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ 1800
    AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE 1850
    QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR 1900
    TQLQHKFEQV VALMEDNIYE CYSEA 1925
    Length:1,925
    Mass (Da):212,007
    Last modified:May 18, 2010 - v3
    Checksum:i28967933B2D17CE1
    GO
    Isoform 2 (identifier: Q9Y4D7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

    Show »
    Length:1,785
    Mass (Da):195,558
    Checksum:i4CA3AE813635414A
    GO

    Sequence cautioni

    The sequence BAA31595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti531 – 5311G → V in BAA31595. (PubMed:9734811)Curated
    Sequence conflicti531 – 5311G → V in AAM49063. (PubMed:12412018)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171P → S.
    Corresponds to variant rs2285372 [ dbSNP | Ensembl ].
    VAR_056723
    Natural varianti870 – 8701M → V.
    Corresponds to variant rs2255703 [ dbSNP | Ensembl ].
    VAR_022144
    Natural varianti894 – 8941H → R.2 Publications
    Corresponds to variant rs2625962 [ dbSNP | Ensembl ].
    VAR_059558
    Natural varianti1412 – 14121L → V.
    Corresponds to variant rs2625973 [ dbSNP | Ensembl ].
    VAR_056724
    Natural varianti1542 – 15421S → N.3 Publications
    Corresponds to variant rs2713625 [ dbSNP | Ensembl ].
    VAR_061539

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1766 – 1925160SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2. 1 PublicationVSP_011516Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014520 mRNA. Translation: BAA31595.2. Different initiation.
    AY116661 mRNA. Translation: AAM49063.1.
    AC023162 Genomic DNA. No translation available.
    AC080007 Genomic DNA. No translation available.
    BC003526 mRNA. Translation: AAH03526.1.
    BC011848 mRNA. Translation: AAH11848.1.
    BC150280 mRNA. Translation: AAI50281.1.
    CCDSiCCDS33854.1. [Q9Y4D7-1]
    RefSeqiNP_055918.2. NM_015103.2.
    UniGeneiHs.301685.

    Genome annotation databases

    EnsembliENST00000324093; ENSP00000317128; ENSG00000004399. [Q9Y4D7-1]
    GeneIDi23129.
    KEGGihsa:23129.
    UCSCiuc003emx.2. human. [Q9Y4D7-1]

    Polymorphism databases

    DMDMi296452982.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014520 mRNA. Translation: BAA31595.2 . Different initiation.
    AY116661 mRNA. Translation: AAM49063.1 .
    AC023162 Genomic DNA. No translation available.
    AC080007 Genomic DNA. No translation available.
    BC003526 mRNA. Translation: AAH03526.1 .
    BC011848 mRNA. Translation: AAH11848.1 .
    BC150280 mRNA. Translation: AAI50281.1 .
    CCDSi CCDS33854.1. [Q9Y4D7-1 ]
    RefSeqi NP_055918.2. NM_015103.2.
    UniGenei Hs.301685.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3H6N X-ray 2.00 A 1553-1678 [» ]
    ProteinModelPortali Q9Y4D7.
    SMRi Q9Y4D7. Positions 54-595, 1310-1915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116747. 2 interactions.
    IntActi Q9Y4D7. 5 interactions.
    MINTi MINT-4507885.
    STRINGi 9606.ENSP00000317128.

    PTM databases

    PhosphoSitei Q9Y4D7.

    Polymorphism databases

    DMDMi 296452982.

    Proteomic databases

    MaxQBi Q9Y4D7.
    PaxDbi Q9Y4D7.
    PRIDEi Q9Y4D7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324093 ; ENSP00000317128 ; ENSG00000004399 . [Q9Y4D7-1 ]
    GeneIDi 23129.
    KEGGi hsa:23129.
    UCSCi uc003emx.2. human. [Q9Y4D7-1 ]

    Organism-specific databases

    CTDi 23129.
    GeneCardsi GC03M129274.
    HGNCi HGNC:9107. PLXND1.
    HPAi CAB020819.
    MIMi 604282. gene.
    neXtProti NX_Q9Y4D7.
    Orphaneti 3384. Truncus arteriosus.
    PharmGKBi PA128394602.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252136.
    HOGENOMi HOG000231376.
    HOVERGENi HBG053404.
    InParanoidi Q9Y4D7.
    KOi K06822.
    OMAi KKSHRQS.
    OrthoDBi EOG7Q8CM9.
    PhylomeDBi Q9Y4D7.
    TreeFami TF312962.

    Enzyme and pathway databases

    Reactomei REACT_19200. Other semaphorin interactions.

    Miscellaneous databases

    ChiTaRSi PLXND1. human.
    EvolutionaryTracei Q9Y4D7.
    GeneWikii PLXND1.
    GenomeRNAii 23129.
    NextBioi 44371.
    PROi Q9Y4D7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y4D7.
    Bgeei Q9Y4D7.
    CleanExi HS_PLXND1.
    Genevestigatori Q9Y4D7.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 2 hits.
    PF01403. Sema. 2 hits.
    PF01833. TIG. 3 hits.
    [Graphical view ]
    SMARTi SM00429. IPT. 3 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 3 hits.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-894 AND ASN-1542.
      Tissue: Brain.
    2. Ohara O., Suyama M., Nagase T., Ishikawa K.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis."
      van der Zwaag B., Hellemons A.J.C.G.M., Leenders W.P.J., Burbach J.P.H., Brunner H.G., Padberg G.W., Van Bokhoven H.
      Dev. Dyn. 225:336-343(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANT ARG-894 AND ASN-1542.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1386-1925 (ISOFORMS 1 AND 2), VARIANT ASN-1542.
      Tissue: Muscle and Uterus.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
      Tissue: Plasma.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
      Tissue: Liver.
    8. "Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras."
      Sakurai A., Gavard J., Annas-Linhares Y., Basile J.R., Amornphimoltham P., Palmby T.R., Yagi H., Zhang F., Randazzo P.A., Li X., Weigert R., Gutkind J.S.
      Mol. Cell. Biol. 30:3086-3098(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Crystal structure of the ubiquitin-like domain of plexin D1."
      Structural genomics consortium (SGC)
      Submitted (MAY-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1553-1678.

    Entry informationi

    Entry nameiPLXD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4D7
    Secondary accession number(s): A7E2C6
    , C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3