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Q9Y4D7

- PLXD1_HUMAN

UniProt

Q9Y4D7 - PLXD1_HUMAN

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Protein

Plexin-D1

Gene
PLXND1, KIAA0620
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature By similarity. Mediates anti-angiogenic signaling in response to SEMA3E.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein domain specific binding Source: UniProt
  3. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. axon guidance Source: Reactome
  3. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  4. endothelial cell migration Source: UniProtKB
  5. patterning of blood vessels Source: Ensembl
  6. positive regulation of protein binding Source: Ensembl
  7. regulation of angiogenesis Source: UniProtKB
  8. regulation of cell migration Source: UniProtKB
  9. semaphorin-plexin signaling pathway Source: UniProtKB
  10. synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiREACT_19200. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-D1
Gene namesi
Name:PLXND1
Synonyms:KIAA0620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:9107. PLXND1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 12711225Extracellular Reviewed predictionAdd
BLAST
Transmembranei1272 – 129221Helical; Reviewed predictionAdd
BLAST
Topological domaini1293 – 1925633Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. intracellular Source: InterPro
  3. lamellipodium Source: UniProt
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti3384. Truncus arteriosus.
PharmGKBiPA128394602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646 Reviewed predictionAdd
BLAST
Chaini47 – 19251879Plexin-D1PRO_0000024676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 114 By similarity
Disulfide bondi140 ↔ 148 By similarity
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi224 – 2241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 445 By similarity
Disulfide bondi345 ↔ 389 By similarity
Glycosylationi481 – 4811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...)2 Publications
Disulfide bondi549 ↔ 566 By similarity
Disulfide bondi555 ↔ 600 By similarity
Disulfide bondi558 ↔ 575 By similarity
Disulfide bondi569 ↔ 581 By similarity
Glycosylationi583 – 5831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi637 ↔ 661 By similarity
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi736 – 7361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi802 – 8021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi965 – 9651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1017 – 10171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1060 – 10601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1099 – 10991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1118 – 11181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1132 – 11321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1237 – 12371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1257 – 12571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y4D7.
PaxDbiQ9Y4D7.
PRIDEiQ9Y4D7.

PTM databases

PhosphoSiteiQ9Y4D7.

Expressioni

Tissue specificityi

Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.1 Publication

Gene expression databases

ArrayExpressiQ9Y4D7.
BgeeiQ9Y4D7.
CleanExiHS_PLXND1.
GenevestigatoriQ9Y4D7.

Organism-specific databases

HPAiCAB020819.

Interactioni

Subunit structurei

Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-310731,EBI-721550
SEMA3EO150412EBI-310731,EBI-7283693
Sema3eP702752EBI-310731,EBI-8876322From a different organism.
SEMA4AQ9H3S12EBI-310731,EBI-3924922

Protein-protein interaction databases

BioGridi116747. 2 interactions.
IntActiQ9Y4D7. 5 interactions.
MINTiMINT-4507885.
STRINGi9606.ENSP00000317128.

Structurei

Secondary structure

1
1925
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1555 – 15639
Beta strandi1570 – 15756
Helixi1580 – 159112
Helixi1597 – 15993
Helixi1603 – 16053
Beta strandi1606 – 16116
Beta strandi1613 – 16153
Beta strandi1617 – 16193
Beta strandi1622 – 16243
Turni1639 – 16435
Beta strandi1649 – 16546

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H6NX-ray2.00A1553-1678[»]
ProteinModelPortaliQ9Y4D7.
SMRiQ9Y4D7. Positions 54-595, 1310-1915.

Miscellaneous databases

EvolutionaryTraceiQ9Y4D7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 546500SemaAdd
BLAST
Domaini891 – 97989IPT/TIG 1Add
BLAST
Domaini981 – 106686IPT/TIG 2Add
BLAST
Domaini1069 – 116092IPT/TIG 3Add
BLAST

Sequence similaritiesi

Belongs to the plexin family.
Contains 3 IPT/TIG domains.
Contains 1 Sema domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG252136.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ9Y4D7.
KOiK06822.
OMAiKKSHRQS.
OrthoDBiEOG7Q8CM9.
PhylomeDBiQ9Y4D7.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 2 hits.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4D7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ     50
RRFPSPTPTN NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD 100
SPLCHAPQLP QASCEHPRRL TDNYNKILQL DPGQGLVVVC GSIYQGFCQL 150
RRRGNISAVA VRFPPAAPPA EPVTVFPSML NVAANHPNAS TVGLVLPPAA 200
GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI RSLDTRGDLA 250
KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 300
LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG 350
RGDLYSRLVS VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI 400
RAARTACFVE PAPDVVAVLD SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL 450
QHPLSILQPL KATPVFRAPG LTSVAVASVN NYTAVFLGTV NGRLLKINLN 500
ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ MARVKVAACN 550
VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC 600
PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP 650
GPAFGHQIAY CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY 700
DCSRTAQVYP HTACTSCLSA QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ 750
DCPRTLLSPL APVPTGGSQN ILVPLANTAF FQGAALECSF GLEEIFEAVW 800
VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE PMTVMVYNCA 850
MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS 900
GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV 950
TGPAPGPLSG VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT 1000
IHGNDLHVGS ELQVLVNDTD PCTELMRTDT SIACTMPEGA LPAPVPVCVR 1050
FERRGCVHGN LTFWYMQNPV ITAISPRRSP VSGGRTITVA GERFHMVQNV 1100
SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF INGRAYADEV 1150
AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200
KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT 1250
IQVGNFNQTI ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA 1300
ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE 1350
YKHFVTRTFF PKCSSLYEER YVLPSQTLNS QGSSQAQETH PLLGEWKIPE 1400
SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI 1450
ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500
CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN 1550
IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW 1600
PRAEDVDLEW FASSTQSYIL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL 1650
AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT DELAEPKKSH RQSHRKKVLP 1700
EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK 1750
RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ 1800
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE 1850
QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR 1900
TQLQHKFEQV VALMEDNIYE CYSEA 1925
Length:1,925
Mass (Da):212,007
Last modified:May 18, 2010 - v3
Checksum:i28967933B2D17CE1
GO
Isoform 2 (identifier: Q9Y4D7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

Show »
Length:1,785
Mass (Da):195,558
Checksum:i4CA3AE813635414A
GO

Sequence cautioni

The sequence BAA31595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti617 – 6171P → S.
Corresponds to variant rs2285372 [ dbSNP | Ensembl ].
VAR_056723
Natural varianti870 – 8701M → V.
Corresponds to variant rs2255703 [ dbSNP | Ensembl ].
VAR_022144
Natural varianti894 – 8941H → R.2 Publications
Corresponds to variant rs2625962 [ dbSNP | Ensembl ].
VAR_059558
Natural varianti1412 – 14121L → V.
Corresponds to variant rs2625973 [ dbSNP | Ensembl ].
VAR_056724
Natural varianti1542 – 15421S → N.3 Publications
Corresponds to variant rs2713625 [ dbSNP | Ensembl ].
VAR_061539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1766 – 1925160SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2. VSP_011516Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti531 – 5311G → V in BAA31595. 1 Publication
Sequence conflicti531 – 5311G → V in AAM49063. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014520 mRNA. Translation: BAA31595.2. Different initiation.
AY116661 mRNA. Translation: AAM49063.1.
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1.
BC011848 mRNA. Translation: AAH11848.1.
BC150280 mRNA. Translation: AAI50281.1.
CCDSiCCDS33854.1. [Q9Y4D7-1]
RefSeqiNP_055918.2. NM_015103.2.
UniGeneiHs.301685.

Genome annotation databases

EnsembliENST00000324093; ENSP00000317128; ENSG00000004399. [Q9Y4D7-1]
ENST00000393239; ENSP00000376931; ENSG00000004399. [Q9Y4D7-2]
GeneIDi23129.
KEGGihsa:23129.
UCSCiuc003emx.2. human. [Q9Y4D7-1]

Polymorphism databases

DMDMi296452982.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014520 mRNA. Translation: BAA31595.2 . Different initiation.
AY116661 mRNA. Translation: AAM49063.1 .
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1 .
BC011848 mRNA. Translation: AAH11848.1 .
BC150280 mRNA. Translation: AAI50281.1 .
CCDSi CCDS33854.1. [Q9Y4D7-1 ]
RefSeqi NP_055918.2. NM_015103.2.
UniGenei Hs.301685.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3H6N X-ray 2.00 A 1553-1678 [» ]
ProteinModelPortali Q9Y4D7.
SMRi Q9Y4D7. Positions 54-595, 1310-1915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116747. 2 interactions.
IntActi Q9Y4D7. 5 interactions.
MINTi MINT-4507885.
STRINGi 9606.ENSP00000317128.

PTM databases

PhosphoSitei Q9Y4D7.

Polymorphism databases

DMDMi 296452982.

Proteomic databases

MaxQBi Q9Y4D7.
PaxDbi Q9Y4D7.
PRIDEi Q9Y4D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324093 ; ENSP00000317128 ; ENSG00000004399 . [Q9Y4D7-1 ]
ENST00000393239 ; ENSP00000376931 ; ENSG00000004399 . [Q9Y4D7-2 ]
GeneIDi 23129.
KEGGi hsa:23129.
UCSCi uc003emx.2. human. [Q9Y4D7-1 ]

Organism-specific databases

CTDi 23129.
GeneCardsi GC03M129274.
HGNCi HGNC:9107. PLXND1.
HPAi CAB020819.
MIMi 604282. gene.
neXtProti NX_Q9Y4D7.
Orphaneti 3384. Truncus arteriosus.
PharmGKBi PA128394602.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252136.
HOGENOMi HOG000231376.
HOVERGENi HBG053404.
InParanoidi Q9Y4D7.
KOi K06822.
OMAi KKSHRQS.
OrthoDBi EOG7Q8CM9.
PhylomeDBi Q9Y4D7.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_19200. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSi PLXND1. human.
EvolutionaryTracei Q9Y4D7.
GeneWikii PLXND1.
GenomeRNAii 23129.
NextBioi 44371.
PROi Q9Y4D7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y4D7.
Bgeei Q9Y4D7.
CleanExi HS_PLXND1.
Genevestigatori Q9Y4D7.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 2 hits.
PF01833. TIG. 3 hits.
[Graphical view ]
SMARTi SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-894 AND ASN-1542.
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis."
    van der Zwaag B., Hellemons A.J.C.G.M., Leenders W.P.J., Burbach J.P.H., Brunner H.G., Padberg G.W., Van Bokhoven H.
    Dev. Dyn. 225:336-343(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANT ARG-894 AND ASN-1542.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1386-1925 (ISOFORMS 1 AND 2), VARIANT ASN-1542.
    Tissue: Muscle and Uterus.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
    Tissue: Liver.
  8. "Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras."
    Sakurai A., Gavard J., Annas-Linhares Y., Basile J.R., Amornphimoltham P., Palmby T.R., Yagi H., Zhang F., Randazzo P.A., Li X., Weigert R., Gutkind J.S.
    Mol. Cell. Biol. 30:3086-3098(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Crystal structure of the ubiquitin-like domain of plexin D1."
    Structural genomics consortium (SGC)
    Submitted (MAY-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1553-1678.

Entry informationi

Entry nameiPLXD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4D7
Secondary accession number(s): A7E2C6
, C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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