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Q9Y4D7

- PLXD1_HUMAN

UniProt

Q9Y4D7 - PLXD1_HUMAN

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Protein

Plexin-D1

Gene

PLXND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.By similarity1 Publication

GO - Molecular functioni

  1. protein domain specific binding Source: UniProt
  2. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. axon guidance Source: Reactome
  3. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  4. endothelial cell migration Source: UniProtKB
  5. outflow tract morphogenesis Source: Ensembl
  6. patterning of blood vessels Source: Ensembl
  7. positive regulation of protein binding Source: Ensembl
  8. regulation of angiogenesis Source: UniProtKB
  9. regulation of cell migration Source: UniProtKB
  10. semaphorin-plexin signaling pathway Source: UniProtKB
  11. synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

ReactomeiREACT_19200. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-D1
Gene namesi
Name:PLXND1
Synonyms:KIAA0620
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:9107. PLXND1.

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 12711225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1272 – 129221HelicalSequence AnalysisAdd
BLAST
Topological domaini1293 – 1925633CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. intracellular Source: InterPro
  3. lamellipodium Source: UniProt
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti3384. Truncus arteriosus.
PharmGKBiPA128394602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence AnalysisAdd
BLAST
Chaini47 – 19251879Plexin-D1PRO_0000024676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 114PROSITE-ProRule annotation
Disulfide bondi140 ↔ 148PROSITE-ProRule annotation
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi322 ↔ 445PROSITE-ProRule annotation
Disulfide bondi345 ↔ 389PROSITE-ProRule annotation
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)2 Publications
Disulfide bondi549 ↔ 566PROSITE-ProRule annotation
Disulfide bondi555 ↔ 600PROSITE-ProRule annotation
Disulfide bondi558 ↔ 575PROSITE-ProRule annotation
Disulfide bondi569 ↔ 581PROSITE-ProRule annotation
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi637 ↔ 661PROSITE-ProRule annotation
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi736 – 7361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi965 – 9651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1017 – 10171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1060 – 10601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1099 – 10991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1118 – 11181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1132 – 11321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1237 – 12371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1257 – 12571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y4D7.
PaxDbiQ9Y4D7.
PRIDEiQ9Y4D7.

PTM databases

PhosphoSiteiQ9Y4D7.

Expressioni

Tissue specificityi

Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiQ9Y4D7.
CleanExiHS_PLXND1.
ExpressionAtlasiQ9Y4D7. baseline and differential.
GenevestigatoriQ9Y4D7.

Organism-specific databases

HPAiCAB020819.

Interactioni

Subunit structurei

Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-310731,EBI-721550
SEMA3EO150412EBI-310731,EBI-7283693
Sema3eP702752EBI-310731,EBI-8876322From a different organism.
SEMA4AQ9H3S12EBI-310731,EBI-3924922

Protein-protein interaction databases

BioGridi116747. 2 interactions.
IntActiQ9Y4D7. 5 interactions.
MINTiMINT-4507885.
STRINGi9606.ENSP00000317128.

Structurei

Secondary structure

1
1925
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1555 – 15639Combined sources
Beta strandi1570 – 15756Combined sources
Helixi1580 – 159112Combined sources
Helixi1597 – 15993Combined sources
Helixi1603 – 16053Combined sources
Beta strandi1606 – 16116Combined sources
Beta strandi1613 – 16153Combined sources
Beta strandi1617 – 16193Combined sources
Beta strandi1622 – 16243Combined sources
Turni1639 – 16435Combined sources
Beta strandi1649 – 16546Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H6NX-ray2.00A1553-1678[»]
ProteinModelPortaliQ9Y4D7.
SMRiQ9Y4D7. Positions 54-595, 1310-1915.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4D7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 546500SemaPROSITE-ProRule annotationAdd
BLAST
Domaini891 – 97989IPT/TIG 1Add
BLAST
Domaini981 – 106686IPT/TIG 2Add
BLAST
Domaini1069 – 116092IPT/TIG 3Add
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 3 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG252136.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiQ9Y4D7.
KOiK06822.
OMAiKKSHRQS.
OrthoDBiEOG7Q8CM9.
PhylomeDBiQ9Y4D7.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 2 hits.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y4D7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ
60 70 80 90 100
RRFPSPTPTN NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD
110 120 130 140 150
SPLCHAPQLP QASCEHPRRL TDNYNKILQL DPGQGLVVVC GSIYQGFCQL
160 170 180 190 200
RRRGNISAVA VRFPPAAPPA EPVTVFPSML NVAANHPNAS TVGLVLPPAA
210 220 230 240 250
GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI RSLDTRGDLA
260 270 280 290 300
KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA
310 320 330 340 350
LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG
360 370 380 390 400
RGDLYSRLVS VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI
410 420 430 440 450
RAARTACFVE PAPDVVAVLD SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL
460 470 480 490 500
QHPLSILQPL KATPVFRAPG LTSVAVASVN NYTAVFLGTV NGRLLKINLN
510 520 530 540 550
ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ MARVKVAACN
560 570 580 590 600
VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC
610 620 630 640 650
PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP
660 670 680 690 700
GPAFGHQIAY CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY
710 720 730 740 750
DCSRTAQVYP HTACTSCLSA QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ
760 770 780 790 800
DCPRTLLSPL APVPTGGSQN ILVPLANTAF FQGAALECSF GLEEIFEAVW
810 820 830 840 850
VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE PMTVMVYNCA
860 870 880 890 900
MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS
910 920 930 940 950
GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV
960 970 980 990 1000
TGPAPGPLSG VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT
1010 1020 1030 1040 1050
IHGNDLHVGS ELQVLVNDTD PCTELMRTDT SIACTMPEGA LPAPVPVCVR
1060 1070 1080 1090 1100
FERRGCVHGN LTFWYMQNPV ITAISPRRSP VSGGRTITVA GERFHMVQNV
1110 1120 1130 1140 1150
SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF INGRAYADEV
1160 1170 1180 1190 1200
AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
1210 1220 1230 1240 1250
KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT
1260 1270 1280 1290 1300
IQVGNFNQTI ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA
1310 1320 1330 1340 1350
ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE
1360 1370 1380 1390 1400
YKHFVTRTFF PKCSSLYEER YVLPSQTLNS QGSSQAQETH PLLGEWKIPE
1410 1420 1430 1440 1450
SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI
1460 1470 1480 1490 1500
ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
1510 1520 1530 1540 1550
CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN
1560 1570 1580 1590 1600
IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW
1610 1620 1630 1640 1650
PRAEDVDLEW FASSTQSYIL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL
1660 1670 1680 1690 1700
AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT DELAEPKKSH RQSHRKKVLP
1710 1720 1730 1740 1750
EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK
1760 1770 1780 1790 1800
RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ
1810 1820 1830 1840 1850
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE
1860 1870 1880 1890 1900
QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR
1910 1920
TQLQHKFEQV VALMEDNIYE CYSEA
Length:1,925
Mass (Da):212,007
Last modified:May 18, 2010 - v3
Checksum:i28967933B2D17CE1
GO
Isoform 2 (identifier: Q9Y4D7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

Show »
Length:1,785
Mass (Da):195,558
Checksum:i4CA3AE813635414A
GO

Sequence cautioni

The sequence BAA31595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti531 – 5311G → V in BAA31595. (PubMed:9734811)Curated
Sequence conflicti531 – 5311G → V in AAM49063. (PubMed:12412018)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti617 – 6171P → S.
Corresponds to variant rs2285372 [ dbSNP | Ensembl ].
VAR_056723
Natural varianti870 – 8701M → V.
Corresponds to variant rs2255703 [ dbSNP | Ensembl ].
VAR_022144
Natural varianti894 – 8941H → R.2 Publications
Corresponds to variant rs2625962 [ dbSNP | Ensembl ].
VAR_059558
Natural varianti1412 – 14121L → V.
Corresponds to variant rs2625973 [ dbSNP | Ensembl ].
VAR_056724
Natural varianti1542 – 15421S → N.3 Publications
Corresponds to variant rs2713625 [ dbSNP | Ensembl ].
VAR_061539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1766 – 1925160SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2. 1 PublicationVSP_011516Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014520 mRNA. Translation: BAA31595.2. Different initiation.
AY116661 mRNA. Translation: AAM49063.1.
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1.
BC011848 mRNA. Translation: AAH11848.1.
BC150280 mRNA. Translation: AAI50281.1.
CCDSiCCDS33854.1. [Q9Y4D7-1]
RefSeqiNP_055918.2. NM_015103.2.
UniGeneiHs.301685.

Genome annotation databases

EnsembliENST00000324093; ENSP00000317128; ENSG00000004399. [Q9Y4D7-1]
GeneIDi23129.
KEGGihsa:23129.
UCSCiuc003emx.2. human. [Q9Y4D7-1]

Polymorphism databases

DMDMi296452982.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014520 mRNA. Translation: BAA31595.2 . Different initiation.
AY116661 mRNA. Translation: AAM49063.1 .
AC023162 Genomic DNA. No translation available.
AC080007 Genomic DNA. No translation available.
BC003526 mRNA. Translation: AAH03526.1 .
BC011848 mRNA. Translation: AAH11848.1 .
BC150280 mRNA. Translation: AAI50281.1 .
CCDSi CCDS33854.1. [Q9Y4D7-1 ]
RefSeqi NP_055918.2. NM_015103.2.
UniGenei Hs.301685.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3H6N X-ray 2.00 A 1553-1678 [» ]
ProteinModelPortali Q9Y4D7.
SMRi Q9Y4D7. Positions 54-595, 1310-1915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116747. 2 interactions.
IntActi Q9Y4D7. 5 interactions.
MINTi MINT-4507885.
STRINGi 9606.ENSP00000317128.

PTM databases

PhosphoSitei Q9Y4D7.

Polymorphism databases

DMDMi 296452982.

Proteomic databases

MaxQBi Q9Y4D7.
PaxDbi Q9Y4D7.
PRIDEi Q9Y4D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324093 ; ENSP00000317128 ; ENSG00000004399 . [Q9Y4D7-1 ]
GeneIDi 23129.
KEGGi hsa:23129.
UCSCi uc003emx.2. human. [Q9Y4D7-1 ]

Organism-specific databases

CTDi 23129.
GeneCardsi GC03M129274.
HGNCi HGNC:9107. PLXND1.
HPAi CAB020819.
MIMi 604282. gene.
neXtProti NX_Q9Y4D7.
Orphaneti 3384. Truncus arteriosus.
PharmGKBi PA128394602.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252136.
GeneTreei ENSGT00760000119048.
HOGENOMi HOG000231376.
HOVERGENi HBG053404.
InParanoidi Q9Y4D7.
KOi K06822.
OMAi KKSHRQS.
OrthoDBi EOG7Q8CM9.
PhylomeDBi Q9Y4D7.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_19200. Other semaphorin interactions.

Miscellaneous databases

ChiTaRSi PLXND1. human.
EvolutionaryTracei Q9Y4D7.
GeneWikii PLXND1.
GenomeRNAii 23129.
NextBioi 44371.
PROi Q9Y4D7.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4D7.
CleanExi HS_PLXND1.
ExpressionAtlasi Q9Y4D7. baseline and differential.
Genevestigatori Q9Y4D7.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 2 hits.
PF01833. TIG. 3 hits.
[Graphical view ]
SMARTi SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 3 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ARG-894 AND ASN-1542.
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis."
    van der Zwaag B., Hellemons A.J.C.G.M., Leenders W.P.J., Burbach J.P.H., Brunner H.G., Padberg G.W., Van Bokhoven H.
    Dev. Dyn. 225:336-343(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS VARIANT ARG-894 AND ASN-1542.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1386-1925 (ISOFORMS 1 AND 2), VARIANT ASN-1542.
    Tissue: Muscle and Uterus.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-500.
    Tissue: Liver.
  8. "Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras."
    Sakurai A., Gavard J., Annas-Linhares Y., Basile J.R., Amornphimoltham P., Palmby T.R., Yagi H., Zhang F., Randazzo P.A., Li X., Weigert R., Gutkind J.S.
    Mol. Cell. Biol. 30:3086-3098(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Crystal structure of the ubiquitin-like domain of plexin D1."
    Structural genomics consortium (SGC)
    Submitted (MAY-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1553-1678.

Entry informationi

Entry nameiPLXD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4D7
Secondary accession number(s): A7E2C6
, C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3