Q9Y4D1 (DAAM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disheveled-associated activator of morphogenesis 1

Gene names

Name:	DAAM1
Synonyms:	KIAA0666

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1078 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Ref.7 Ref.8
Subunit structure	Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. Ref.7 Ref.8
Subcellular location	Cytoplasm. Note: Perinuclear. Ref.7
Tissue specificity	Expressed in all tissues examined.
Domain	The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
Sequence similarities	Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Sequence caution	The sequence BAA31641.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04230.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	Actin-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular function	Rho GTPase binding Inferred from electronic annotation. Source: InterPro actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4D1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4D1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     656-665: Missing.

Isoform 3 (identifier: Q9Y4D1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     788-818: Missing.
     888-916: NMTELDKEISTLRSGLKAVETELEYQKSQ → KSWNIRSLSPHSPEISLCLLSASSSQ
     917-1078: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1078

1078

Disheveled-associated activator of morphogenesis 1

PRO_0000194907

Regions

Domain

45 – 420

376

GBD/FH3

Domain

528 – 599

72

FH1

Domain

600 – 1009

410

FH2

Domain

1027 – 1058

32

DAD

Region

693 – 702

10

Actin-binding

Coiled coil

437 – 526

90

Potential

Compositional bias

528 – 593

66

Pro-rich

Natural variations

Alternative sequence

656 – 665

10

Missing in isoform 2.

VSP_008000

Alternative sequence

788 – 818

31

Missing in isoform 3.

VSP_008001

Alternative sequence

888 – 916

29

NMTEL…YQKSQ → KSWNIRSLSPHSPEISLCLL SASSSQ in isoform 3.

VSP_008002

Alternative sequence

917 – 1078

162

Missing in isoform 3.

VSP_008003

Experimental info

Mutagenesis

698

1

I → A: Abolishes actin-binding. Ref.8

Sequence conflict

940

1

S → F in AAH24781. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1078

Helix Strand Turn

Details...

Beta strand

596 – 598

3

Helix

620 – 622

3

Beta strand

624 – 626

3

Helix

627 – 630

4

Helix

633 – 635

3

Helix

636 – 639

4

Helix

642 – 648

7

Beta strand

650 – 652

3

Helix

690 – 703

14

Helix

707 – 715

9

Helix

725 – 733

9

Helix

738 – 745

8

Turn

746 – 749

4

Helix

751 – 753

3

Helix

756 – 765

10

Helix

770 – 806

37

Helix

808 – 824

17

Beta strand

827 – 829

3

Helix

837 – 845

9

Helix

856 – 867

12

Helix

869 – 873

5

Helix

874 – 877

4

Turn

878 – 880

3

Helix

881 – 885

5

Helix

889 – 914

26

Helix

924 – 959

36

Helix

969 – 994

26

Helix

996 – 999

4

Helix

1001 – 1022

22

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: E82D9892390254B6	FASTA	1,078	123,473
	10 20 30 40 50 60 MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV EELDVMFSEL 70 80 90 100 110 120 VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT SWPEFYIDQL NSMAARKSLL 130 140 150 160 170 180 ALEKEEEEER SKTIESLKTA LRTKPMRFVT RFIDLDGLSC ILNFLKTMDY ETSESRIHTS 190 200 210 220 230 240 LIGCIKALMN NSQGRAHVLA HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV 250 260 270 280 290 300 LQAMLHYQKY ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 310 320 330 340 350 360 RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF ELVHIDTKSA 370 380 390 400 410 420 TQMFELTRKR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ YWLLLDRIIQ QIVIQNDKGQ 430 440 450 460 470 480 DPDSTPLENF NIKNVVRMLV NENEVKQWKE QAEKMRKEHN ELQQKLEKKE RECDAKTQEK 490 500 510 520 530 540 EEMMQTLNKM KEKLEKETTE HKQVKQQVAD LTAQLHELSR RAVCASIPGG PSPGAPGGPF 550 560 570 580 590 600 PSSVPGSLLP PPPPPPLPGG MLPPPPPPLP PGGPPPPPGP PPLGAIMPPP GAPMGLALKK 610 620 630 640 650 660 KSIPQPTNAL KSFNWSKLPE NKLEGTVWTE IDDTKVFKIL DLEDLERTFS AYQRQQDFFV 670 680 690 700 710 720 NSNSKQKEAD AIDDTLSSKL KVKELSVIDG RRAQNCNILL SRLKLSNDEI KRAILTMDEQ 730 740 750 760 770 780 EDLPKDMLEQ LLKFVPEKSD IDLLEEHKHE LDRMAKADRF LFEMSRINHY QQRLQSLYFK 790 800 810 820 830 840 KKFAERVAEV KPKVEAIRSG SEEVFRSGAL KQLLEVVLAF GNYMNKGQRG NAYGFKISSL 850 860 870 880 890 900 NKIADTKSSI DKNITLLHYL ITIVENKYPS VLNLNEELRD IPQAAKVNMT ELDKEISTLR 910 920 930 940 950 960 SGLKAVETEL EYQKSQPPQP GDKFVSVVSQ FITVASFSFS DVEDLLAEAK DLFTKAVKHF 970 980 990 1000 1010 1020 GEEAGKIQPD EFFGIFDQFL QAVSEAKQEN ENMRKKKEEE ERRARMEAQL KEQRERERKM 1030 1040 1050 1060 1070 RKAKENSEES GEFDDLVSAL RSGEVFDKDL SKLKRNRKRI TNQMTDSSRE RPITKLNF
	Isoform 2 [UniParc]. Checksum: C58B1A7445080313	FASTA	1,068	122,306
	10 20 30 40 50 60 MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV EELDVMFSEL 70 80 90 100 110 120 VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT SWPEFYIDQL NSMAARKSLL 130 140 150 160 170 180 ALEKEEEEER SKTIESLKTA LRTKPMRFVT RFIDLDGLSC ILNFLKTMDY ETSESRIHTS 190 200 210 220 230 240 LIGCIKALMN NSQGRAHVLA HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV 250 260 270 280 290 300 LQAMLHYQKY ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 310 320 330 340 350 360 RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF ELVHIDTKSA 370 380 390 400 410 420 TQMFELTRKR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ YWLLLDRIIQ QIVIQNDKGQ 430 440 450 460 470 480 DPDSTPLENF NIKNVVRMLV NENEVKQWKE QAEKMRKEHN ELQQKLEKKE RECDAKTQEK 490 500 510 520 530 540 EEMMQTLNKM KEKLEKETTE HKQVKQQVAD LTAQLHELSR RAVCASIPGG PSPGAPGGPF 550 560 570 580 590 600 PSSVPGSLLP PPPPPPLPGG MLPPPPPPLP PGGPPPPPGP PPLGAIMPPP GAPMGLALKK 610 620 630 640 650 660 KSIPQPTNAL KSFNWSKLPE NKLEGTVWTE IDDTKVFKIL DLEDLERTFS AYQRQQKEAD 670 680 690 700 710 720 AIDDTLSSKL KVKELSVIDG RRAQNCNILL SRLKLSNDEI KRAILTMDEQ EDLPKDMLEQ 730 740 750 760 770 780 LLKFVPEKSD IDLLEEHKHE LDRMAKADRF LFEMSRINHY QQRLQSLYFK KKFAERVAEV 790 800 810 820 830 840 KPKVEAIRSG SEEVFRSGAL KQLLEVVLAF GNYMNKGQRG NAYGFKISSL NKIADTKSSI 850 860 870 880 890 900 DKNITLLHYL ITIVENKYPS VLNLNEELRD IPQAAKVNMT ELDKEISTLR SGLKAVETEL 910 920 930 940 950 960 EYQKSQPPQP GDKFVSVVSQ FITVASFSFS DVEDLLAEAK DLFTKAVKHF GEEAGKIQPD 970 980 990 1000 1010 1020 EFFGIFDQFL QAVSEAKQEN ENMRKKKEEE ERRARMEAQL KEQRERERKM RKAKENSEES 1030 1040 1050 1060 GEFDDLVSAL RSGEVFDKDL SKLKRNRKRI TNQMTDSSRE RPITKLNF
	Isoform 3 [UniParc]. Checksum: 1BB2D1876B212852	FASTA	882	100,745
	10 20 30 40 50 60 MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV EELDVMFSEL 70 80 90 100 110 120 VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT SWPEFYIDQL NSMAARKSLL 130 140 150 160 170 180 ALEKEEEEER SKTIESLKTA LRTKPMRFVT RFIDLDGLSC ILNFLKTMDY ETSESRIHTS 190 200 210 220 230 240 LIGCIKALMN NSQGRAHVLA HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV 250 260 270 280 290 300 LQAMLHYQKY ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 310 320 330 340 350 360 RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF ELVHIDTKSA 370 380 390 400 410 420 TQMFELTRKR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ YWLLLDRIIQ QIVIQNDKGQ 430 440 450 460 470 480 DPDSTPLENF NIKNVVRMLV NENEVKQWKE QAEKMRKEHN ELQQKLEKKE RECDAKTQEK 490 500 510 520 530 540 EEMMQTLNKM KEKLEKETTE HKQVKQQVAD LTAQLHELSR RAVCASIPGG PSPGAPGGPF 550 560 570 580 590 600 PSSVPGSLLP PPPPPPLPGG MLPPPPPPLP PGGPPPPPGP PPLGAIMPPP GAPMGLALKK 610 620 630 640 650 660 KSIPQPTNAL KSFNWSKLPE NKLEGTVWTE IDDTKVFKIL DLEDLERTFS AYQRQQDFFV 670 680 690 700 710 720 NSNSKQKEAD AIDDTLSSKL KVKELSVIDG RRAQNCNILL SRLKLSNDEI KRAILTMDEQ 730 740 750 760 770 780 EDLPKDMLEQ LLKFVPEKSD IDLLEEHKHE LDRMAKADRF LFEMSRINHY QQRLQSLYFK 790 800 810 820 830 840 KKFAERVAFG NYMNKGQRGN AYGFKISSLN KIADTKSSID KNITLLHYLI TIVENKYPSV 850 860 870 880 LNLNEELRDI PQAAKVKSWN IRSLSPHSPE ISLCLLSASS SQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta and Uterus.
[4]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-497 (ISOFORM 1). Tissue: Fetal brain.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 706-1078 (ISOFORM 3). Tissue: Thymus.
[6]	"Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1." Habas R., Kato Y., He X. Cell 107:843-854(2001) [PubMed: 11779461] [Abstract] Cited for: CHARACTERIZATION.
[7]	"The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics." Aspenstroem P., Richnau N., Johansson A.-S. Exp. Cell Res. 312:2180-2194(2006) [PubMed: 16630611] [Abstract] Cited for: FUNCTION, INTERACTION WITH ABL1; BTK; CDC42; CIP4; ENDOPHILIN; FNBP1; FNBP1L; RHOA; SPECTRIN AND SRC, SUBCELLULAR LOCATION.
[8]	"Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly." Lu J., Meng W., Poy F., Maiti S., Goode B.L., Eck M.J. J. Mol. Biol. 369:1258-1269(2007) [PubMed: 17482208] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 596-1078, SUBUNIT, MUTAGENESIS OF ILE-698, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB014566 mRNA. Translation: BAA31641.1. Different initiation.
AL133502 Genomic DNA. No translation available.
BC024781 mRNA. Translation: AAH24781.1.
BC038428 mRNA. Translation: AAH38428.1.
BC064999 mRNA. Translation: AAH64999.1.
BX247986 mRNA. Translation: CAD62320.1.
AK093813 mRNA. Translation: BAC04230.1. Different initiation.

IPI

IPI00337800.
IPI00337801.
IPI00337802.

RefSeq

NP_055807.1. NM_014992.1.

UniGene

Hs.654934.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2J1D	X-ray	2.55	G	596-1078	[»]
2Z6E	X-ray	2.80	A/B/C/D	594-1012	[»]

ProteinModelPortal

Q9Y4D1.

SMR

Q9Y4D1. Positions 53-424, 594-1048.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29641N.

IntAct

Q9Y4D1. 4 interactions.

MINT

MINT-1180756.

STRING

Q9Y4D1.

PTM databases

PhosphoSite

Q9Y4D1.

Polymorphism databases

DMDM

34098767.

Proteomic databases

PRIDE

Q9Y4D1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000351081; ENSP00000247170; ENSG00000100592.
ENST00000395125; ENSP00000378557; ENSG00000100592.

GeneID

23002.

KEGG

hsa:23002.

UCSC

uc001xdz.1. human.
uc001xea.1. human.

Organism-specific databases

CTD

23002.

GeneCards

GC14P059655.

H-InvDB

HIX0011701.

HGNC

HGNC:18142. DAAM1.

HPA

HPA026605.

MIM

606626. gene.

neXtProt

NX_Q9Y4D1.

PharmGKB

PA27129.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG06028.

GeneTree

ENSGT00600000084372.

HOGENOM

HBG357301.

HOVERGEN

HBG101333.

InParanoid

Q9Y4D1.

OMA

PMGLALK.

OrthoDB

EOG4RBQHV.

PhylomeDB

Q9Y4D1.

Gene expression databases

ArrayExpress

Q9Y4D1.

Bgee

Q9Y4D1.

CleanEx

HS_DAAM1.

Genevestigator

Q9Y4D1.

GermOnline

ENSG00000100592. Homo sapiens.

Family and domain databases

InterPro

IPR003104. Actin-bd_FH2/DRF_autoreg.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014767. Diaphanous_autoregulatory.
IPR010472. Drf_FH3.
IPR010473. Drf_GTPase-bd.
IPR015425. FH2_actin-bd.
IPR014768. GTPase-bd/formin_homology_3.
[Graphical view]

Gene3D

G3DSA:1.25.10.10. ARM-like. 1 hit.

KO

K04512.

Pfam

PF06367. Drf_FH3. 1 hit.
PF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]

SMART

SM00498. FH2. 1 hit.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.
SSF101447. FH2_actin_bd. 1 hit.

PROSITE

PS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

43908.

SOURCE

Search...

Entry information

Entry name

DAAM1_HUMAN

Accession

Primary (citable) accession number: Q9Y4D1
Secondary accession number(s): Q86U34, Q8N1Z8, Q8TB39

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	August 15, 2003
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.