Reviewed, UniProtKB/Swiss-Prot Q5T1M5 (FKB15_HUMAN)

Names and origin

Protein names

Recommended name:
    FK506-binding protein 15

Gene names

Name:	FKBP15
Synonyms:	KIAA0674

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase By similarity.
Subcellular location	CytoplasmBy similarity. Cell projection › axonBy similarity. Note= Present in axons and neuronal growth cones By similarity.
Domain	The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T1M5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T1M5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     629-638: Missing.

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q5T1M5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     462-472: PYAGMQAYAYP → VTFYNRINYIL
     473-1219: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1219	1219	FK506-binding protein 15		PRO_0000299556
Regions
	Domain	197 – 290	94	PPIase FKBP-type
	Region	72 – 169	98	Important for function in growth cone organization By similarity
	Coiled coil	522 – 789	268	Potential
	Coiled coil	818 – 878	61	Potential
	Coiled coil	925 – 951	27	Potential
	Compositional bias	1208 – 1216	9	Poly-Asp
Amino acid modifications
	Modified residue	311	1	Phosphoserine
	Modified residue	956	1	Phosphoserine
	Modified residue	1097	1	Phosphoserine By similarity
	Modified residue	1099	1	Phosphothreonine By similarity
	Modified residue	1114	1	Phosphoserine
	Modified residue	1161	1	Phosphoserine
	Modified residue	1162	1	Phosphoserine
	Modified residue	1164	1	Phosphoserine
	Modified residue	1195	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	462 – 472	11	PYAGMQAYAYP → VTFYNRINYIL in isoform 3.		VSP_027756
	Alternative sequence	473 – 1219	747	Missing in isoform 3.		VSP_027757
	Alternative sequence	629 – 638	10	Missing in isoform 2.		VSP_027758
	Natural variant	106	1	A → T: dbSNP rs1133618.		VAR_034851
	Natural variant	413	1	H → Q: dbSNP rs10435864.		VAR_034852
	Natural variant	434	1	L → F: dbSNP rs10465129.		VAR_034853

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: 86563D82B540B51D	FASTA	1,219	133,630
	10 20 30 40 50 60 MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA 70 80 90 100 110 120 TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP 130 140 150 160 170 180 VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA 190 200 210 220 230 240 VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG 250 260 270 280 290 300 WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH 310 320 330 340 350 360 SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV 370 380 390 400 410 420 KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP 430 440 450 460 470 480 QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ 490 500 510 520 530 540 LQPVRPLYPA PLSQPPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL 550 560 570 580 590 600 QKHSAGNSML IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE 610 620 630 640 650 660 RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA QVSHLQLKMT 670 680 690 700 710 720 AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET SEQAQSKFKS EKQNRKQLEL 730 740 750 760 770 780 KVTSLEEELT DLRVEKESLE KNLSERKKKS AQERSQAEEE IDEIRKSYQE ELDKLRQLLK 790 800 810 820 830 840 KTRVSTDQAA AEQLSLVQAE LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ 850 860 870 880 890 900 LQEKCLALQA QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR 910 920 930 940 950 960 EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE RPRRPSQEQS 970 980 990 1000 1010 1020 ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT TSQDGHRRKG DSEAEALSEI 1030 1040 1050 1060 1070 1080 KDGSLPPELS CIPSHRVLGP PTSIPPEPLG PVSMDSECEE SLAASPMAAK PDNPSGKVCV 1090 1100 1110 1120 1130 1140 REVAPDGPLQ ESSTRLSLTS DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS 1150 1160 1170 1180 1190 1200 TEAGSTVAGA ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP 1210 PPTPLFGDDD DDDDIDWLG
	Isoform 2 [UniParc]. Checksum: AD3F9C4AA1FD65A6		1,209	132,467
	10 20 30 40 50 60 MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA 70 80 90 100 110 120 TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP 130 140 150 160 170 180 VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA 190 200 210 220 230 240 VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG 250 260 270 280 290 300 WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH 310 320 330 340 350 360 SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV 370 380 390 400 410 420 KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP 430 440 450 460 470 480 QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ 490 500 510 520 530 540 LQPVRPLYPA PLSQPPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL 550 560 570 580 590 600 QKHSAGNSML IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE 610 620 630 640 650 660 RNQRYVEQSN LMMEKRNNSL QTATENTQAK VTEELAAATA QVSHLQLKMT AHQKKETELQ 670 680 690 700 710 720 MQLTESLKET DLLRGQLTKV QAKLSELQET SEQAQSKFKS EKQNRKQLEL KVTSLEEELT 730 740 750 760 770 780 DLRVEKESLE KNLSERKKKS AQERSQAEEE IDEIRKSYQE ELDKLRQLLK KTRVSTDQAA 790 800 810 820 830 840 AEQLSLVQAE LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ LQEKCLALQA 850 860 870 880 890 900 QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR EFELEESYNG 910 920 930 940 950 960 RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE RPRRPSQEQS ASASSGQPQA 970 980 990 1000 1010 1020 PLNRERPESP MVPSEQVVEE AVPLPPQALT TSQDGHRRKG DSEAEALSEI KDGSLPPELS 1030 1040 1050 1060 1070 1080 CIPSHRVLGP PTSIPPEPLG PVSMDSECEE SLAASPMAAK PDNPSGKVCV REVAPDGPLQ 1090 1100 1110 1120 1130 1140 ESSTRLSLTS DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS TEAGSTVAGA 1150 1160 1170 1180 1190 1200 ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP PPTPLFGDDD DDDDIDWLG
	Isoform 3 [UniParc]. Checksum: 2112364B487D6E69		472	50,330
	10 20 30 40 50 60 MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA 70 80 90 100 110 120 TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP 130 140 150 160 170 180 VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA 190 200 210 220 230 240 VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG 250 260 270 280 290 300 WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH 310 320 330 340 350 360 SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV 370 380 390 400 410 420 KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP 430 440 450 460 470 QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QVTFYNRINY IL

References

[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-413. Tissue: Brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 548-1219 (ISOFORM 2), VARIANT GLN-413. Tissue: Eye and Prostate.
[4]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1114 AND SER-1164, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-956, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161; SER-1162 AND SER-1164, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161; SER-1162 AND SER-1164, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB014574 mRNA. Translation: BAA31649.1. Different initiation. AL449305 Genomic DNA. Translation: CAI10963.1. Different initiation. AL449305, AL449105 Genomic DNA. Translation: CAI10964.1. Different initiation. AL449105, AL449305 Genomic DNA. Translation: CAI95402.1. BC009609 mRNA. Translation: AAH09609.1. Different initiation. BC077732 mRNA. Translation: AAH77732.1.
PIR	T00363.
RefSeq	NP_056073.1.
UniGene	Hs.522351
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5T1M5.
Genome annotation databases
Ensembl	ENSG00000119321. Homo sapiens. [Contig view]
GeneID	23307.
KEGG	hsa:23307.
Organism-specific databases
HGNC	HGNC:23397. FKBP15.
HPA	HPA007979.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q5T1M5.
HOVERGEN	Q5T1M5.
Gene expression databases
CleanEx	HS_FKBP15.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	45162.

Entry information

Entry name

FKB15_HUMAN

Accession

Primary (citable) accession number: Q5T1M5
Secondary accession number(s): Q05DK8 , Q5T1M2, Q6DD85, Q9Y4D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	November 4, 2008
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)