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Protein

Probable RNA-binding protein 19

Gene

RBM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in embryo pre-implantation development.By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein 19
Alternative name(s):
RNA-binding motif protein 19
Gene namesi
Name:RBM19
Synonyms:KIAA0682
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29098. RBM19.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886784.

Polymorphism and mutation databases

BioMutaiRBM19.
DMDMi308153566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Probable RNA-binding protein 19PRO_0000081781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineCombined sources
Modified residuei176 – 1761PhosphoserineCombined sources
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei936 – 9361PhosphoserineCombined sources
Modified residuei949 – 9491PhosphoserineCombined sources
Modified residuei951 – 9511PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4C8.
MaxQBiQ9Y4C8.
PaxDbiQ9Y4C8.
PeptideAtlasiQ9Y4C8.
PRIDEiQ9Y4C8.

2D gel databases

SWISS-2DPAGEQ9Y4C8.

PTM databases

iPTMnetiQ9Y4C8.
PhosphoSiteiQ9Y4C8.

Expressioni

Tissue specificityi

Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000122965.
CleanExiHS_RBM19.
ExpressionAtlasiQ9Y4C8. baseline and differential.
GenevisibleiQ9Y4C8. HS.

Organism-specific databases

HPAiHPA038860.
HPA058732.

Interactioni

Protein-protein interaction databases

BioGridi115233. 39 interactions.
IntActiQ9Y4C8. 2 interactions.
MINTiMINT-1196129.
STRINGi9606.ENSP00000261741.

Structurei

Secondary structure

1
960
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi295 – 2995Combined sources
Helixi307 – 3148Combined sources
Beta strandi320 – 3267Combined sources
Beta strandi332 – 3398Combined sources
Helixi343 – 3519Combined sources
Beta strandi354 – 3574Combined sources
Beta strandi360 – 3689Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DGWNMR-A291-368[»]
ProteinModelPortaliQ9Y4C8.
SMRiQ9Y4C8. Positions 4-78, 291-492, 586-685, 732-918.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4C8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 36976RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini402 – 48079RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini587 – 65973RRM 4PROSITE-ProRule annotationAdd
BLAST
Domaini730 – 81182RRM 5PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 91281RRM 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 2328Poly-Glu
Compositional biasi391 – 3966Poly-Glu
Compositional biasi714 – 72512Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated
Contains 6 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0110. Eukaryota.
ENOG410XQZ5. LUCA.
GeneTreeiENSGT00840000129953.
HOGENOMiHOG000211156.
HOVERGENiHBG055637.
InParanoidiQ9Y4C8.
KOiK14787.
OMAiPNGMKED.
OrthoDBiEOG091G02IZ.
PhylomeDBiQ9Y4C8.
TreeFamiTF105725.

Family and domain databases

Gene3Di3.30.70.330. 6 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 6 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 6 hits.
PROSITEiPS50102. RRM. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK
60 70 80 90 100
SEEEAQKAQK HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK
110 120 130 140 150
QPPKDSTTPE IKKDEKKKKV AGQLEKLKED TEFQEFLSVH QRRAQAATWA
160 170 180 190 200
NDGLDAEPSK GKSKPASDYL NFDSDSGQES EEEGAGEDLE EEASLEPKAA
210 220 230 240 250
VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS EAEEEDSSAT
260 270 280 290 300
PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
310 320 330 340 350
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL
360 370 380 390 400
KCNREYMGGR YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE
410 420 430 440 450
SGRLFVRNLP YTSTEEDLEK LFSKYGPLSE LHYPIDSLTK KPKGFAFITF
460 470 480 490 500
MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI KKEASEDASA LGSSSYKKKK
510 520 530 540 550
EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF DHETKGSVAV
560 570 580 590 600
RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
610 620 630 640 650
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV
660 670 680 690 700
PLYLEWAPVG VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN
710 720 730 740 750
PTEEGADNSS AKMEEEEEEE EEEEESLPGC TLFIKNLNFD TTEEKLKEVF
760 770 780 790 800
SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE YRKPEQAQKA LKQLQGHVVD
810 820 830 840 850
GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP FQAHSREIRE
860 870 880 890 900
LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
910 920 930 940 950
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD
960
SDSEEQTLQL
Length:960
Mass (Da):107,332
Last modified:October 5, 2010 - v3
Checksum:i28B6F37B18D7B9B1
GO

Sequence cautioni

The sequence BAA31657 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411Q → R in BAA31657 (PubMed:9734811).Curated
Sequence conflicti259 – 2591K → R in BAA31657 (PubMed:9734811).Curated
Sequence conflicti259 – 2591K → R in AAH06137 (PubMed:15489334).Curated
Sequence conflicti259 – 2591K → R in AAH04289 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti602 – 6021Q → E.4 Publications
Corresponds to variant rs7299217 [ dbSNP | Ensembl ].
VAR_059822
Natural varianti609 – 6091H → R.2 Publications
Corresponds to variant rs2290789 [ dbSNP | Ensembl ].
VAR_023114
Natural varianti623 – 6231I → T.2 Publications
Corresponds to variant rs2290788 [ dbSNP | Ensembl ].
VAR_023115
Natural varianti665 – 6651T → A.2 Publications
Corresponds to variant rs2290787 [ dbSNP | Ensembl ].
VAR_023116
Natural varianti821 – 8211R → G.
Corresponds to variant rs16943379 [ dbSNP | Ensembl ].
VAR_057246
Natural varianti921 – 9211R → Q.1 Publication
Corresponds to variant rs2075387 [ dbSNP | Ensembl ].
VAR_023117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014582 mRNA. Translation: BAA31657.2. Different initiation.
AL117547 mRNA. Translation: CAB55987.1.
AK291444 mRNA. Translation: BAF84133.1.
AK314606 mRNA. Translation: BAG37176.1.
AC009731 Genomic DNA. No translation available.
AC073863 Genomic DNA. No translation available.
AC090669 Genomic DNA. No translation available.
BC004289 mRNA. Translation: AAH04289.1.
BC006137 mRNA. Translation: AAH06137.1.
CCDSiCCDS9172.1.
PIRiT17297.
RefSeqiNP_001140170.1. NM_001146698.1.
NP_001140171.1. NM_001146699.1.
NP_057280.2. NM_016196.3.
UniGeneiHs.7482.

Genome annotation databases

EnsembliENST00000261741; ENSP00000261741; ENSG00000122965.
ENST00000392561; ENSP00000376344; ENSG00000122965.
ENST00000545145; ENSP00000442053; ENSG00000122965.
GeneIDi9904.
KEGGihsa:9904.
UCSCiuc001tvm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014582 mRNA. Translation: BAA31657.2. Different initiation.
AL117547 mRNA. Translation: CAB55987.1.
AK291444 mRNA. Translation: BAF84133.1.
AK314606 mRNA. Translation: BAG37176.1.
AC009731 Genomic DNA. No translation available.
AC073863 Genomic DNA. No translation available.
AC090669 Genomic DNA. No translation available.
BC004289 mRNA. Translation: AAH04289.1.
BC006137 mRNA. Translation: AAH06137.1.
CCDSiCCDS9172.1.
PIRiT17297.
RefSeqiNP_001140170.1. NM_001146698.1.
NP_001140171.1. NM_001146699.1.
NP_057280.2. NM_016196.3.
UniGeneiHs.7482.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DGWNMR-A291-368[»]
ProteinModelPortaliQ9Y4C8.
SMRiQ9Y4C8. Positions 4-78, 291-492, 586-685, 732-918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115233. 39 interactions.
IntActiQ9Y4C8. 2 interactions.
MINTiMINT-1196129.
STRINGi9606.ENSP00000261741.

PTM databases

iPTMnetiQ9Y4C8.
PhosphoSiteiQ9Y4C8.

Polymorphism and mutation databases

BioMutaiRBM19.
DMDMi308153566.

2D gel databases

SWISS-2DPAGEQ9Y4C8.

Proteomic databases

EPDiQ9Y4C8.
MaxQBiQ9Y4C8.
PaxDbiQ9Y4C8.
PeptideAtlasiQ9Y4C8.
PRIDEiQ9Y4C8.

Protocols and materials databases

DNASUi9904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261741; ENSP00000261741; ENSG00000122965.
ENST00000392561; ENSP00000376344; ENSG00000122965.
ENST00000545145; ENSP00000442053; ENSG00000122965.
GeneIDi9904.
KEGGihsa:9904.
UCSCiuc001tvm.4. human.

Organism-specific databases

CTDi9904.
GeneCardsiRBM19.
HGNCiHGNC:29098. RBM19.
HPAiHPA038860.
HPA058732.
MIMi616444. gene.
neXtProtiNX_Q9Y4C8.
PharmGKBiPA134886784.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0110. Eukaryota.
ENOG410XQZ5. LUCA.
GeneTreeiENSGT00840000129953.
HOGENOMiHOG000211156.
HOVERGENiHBG055637.
InParanoidiQ9Y4C8.
KOiK14787.
OMAiPNGMKED.
OrthoDBiEOG091G02IZ.
PhylomeDBiQ9Y4C8.
TreeFamiTF105725.

Miscellaneous databases

ChiTaRSiRBM19. human.
EvolutionaryTraceiQ9Y4C8.
GeneWikiiRBM19.
GenomeRNAii9904.
PROiQ9Y4C8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122965.
CleanExiHS_RBM19.
ExpressionAtlasiQ9Y4C8. baseline and differential.
GenevisibleiQ9Y4C8. HS.

Family and domain databases

Gene3Di3.30.70.330. 6 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 5 hits.
[Graphical view]
SMARTiSM00360. RRM. 6 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 6 hits.
PROSITEiPS50102. RRM. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM19_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4C8
Secondary accession number(s): A8K5X9, Q9BPY6, Q9UFN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.