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Protein

Probable RNA-binding protein 19

Gene

RBM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in embryo pre-implantation development.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein 19
Alternative name(s):
RNA-binding motif protein 19
Gene namesi
Name:RBM19
Synonyms:KIAA0682
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000122965.10
HGNCiHGNC:29098 RBM19
MIMi616444 gene
neXtProtiNX_Q9Y4C8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9904
OpenTargetsiENSG00000122965
PharmGKBiPA134886784

Polymorphism and mutation databases

BioMutaiRBM19
DMDMi308153566

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817811 – 960Probable RNA-binding protein 19Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei936PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y4C8
MaxQBiQ9Y4C8
PaxDbiQ9Y4C8
PeptideAtlasiQ9Y4C8
PRIDEiQ9Y4C8

2D gel databases

SWISS-2DPAGEiQ9Y4C8

PTM databases

iPTMnetiQ9Y4C8
PhosphoSitePlusiQ9Y4C8

Expressioni

Tissue specificityi

Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000122965
CleanExiHS_RBM19
ExpressionAtlasiQ9Y4C8 baseline and differential
GenevisibleiQ9Y4C8 HS

Organism-specific databases

HPAiHPA038860
HPA058732

Interactioni

Protein-protein interaction databases

BioGridi115233, 118 interactors
IntActiQ9Y4C8, 4 interactors
MINTiQ9Y4C8
STRINGi9606.ENSP00000261741

Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi295 – 299Combined sources5
Helixi307 – 314Combined sources8
Beta strandi320 – 326Combined sources7
Beta strandi332 – 339Combined sources8
Helixi343 – 351Combined sources9
Beta strandi354 – 357Combined sources4
Beta strandi360 – 368Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGWNMR-A291-368[»]
ProteinModelPortaliQ9Y4C8
SMRiQ9Y4C8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4C8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 369RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini402 – 480RRM 3PROSITE-ProRule annotationAdd BLAST79
Domaini587 – 659RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini730 – 811RRM 5PROSITE-ProRule annotationAdd BLAST82
Domaini832 – 912RRM 6PROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 232Poly-Glu8
Compositional biasi391 – 396Poly-Glu6
Compositional biasi714 – 725Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0110 Eukaryota
ENOG410XQZ5 LUCA
GeneTreeiENSGT00840000129953
HOGENOMiHOG000211156
HOVERGENiHBG055637
InParanoidiQ9Y4C8
KOiK14787
OMAiCKSFGDP
OrthoDBiEOG091G02IZ
PhylomeDBiQ9Y4C8
TreeFamiTF105725

Family and domain databases

CDDicd12564 RRM1_RBM19, 1 hit
cd12502 RRM2_RMB19, 1 hit
cd12567 RRM3_RBM19, 1 hit
cd12569 RRM4_RBM19, 1 hit
cd12318 RRM5_RBM19_like, 1 hit
cd12571 RRM6_RBM19, 1 hit
Gene3Di3.30.70.330, 6 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034419 RBM19_RRM3
IPR034420 RBM19_RRM4
IPR034423 RBM19_RRM5
IPR034421 RBM19_RRM6
IPR034418 RMB19_RRM1
IPR034417 RMB19_RRM2
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 5 hits
SMARTiView protein in SMART
SM00360 RRM, 6 hits
SM00361 RRM_1, 2 hits
SUPFAMiSSF54928 SSF54928, 6 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 6 hits

Sequencei

Sequence statusi: Complete.

Q9Y4C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK
60 70 80 90 100
SEEEAQKAQK HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK
110 120 130 140 150
QPPKDSTTPE IKKDEKKKKV AGQLEKLKED TEFQEFLSVH QRRAQAATWA
160 170 180 190 200
NDGLDAEPSK GKSKPASDYL NFDSDSGQES EEEGAGEDLE EEASLEPKAA
210 220 230 240 250
VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS EAEEEDSSAT
260 270 280 290 300
PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
310 320 330 340 350
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL
360 370 380 390 400
KCNREYMGGR YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE
410 420 430 440 450
SGRLFVRNLP YTSTEEDLEK LFSKYGPLSE LHYPIDSLTK KPKGFAFITF
460 470 480 490 500
MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI KKEASEDASA LGSSSYKKKK
510 520 530 540 550
EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF DHETKGSVAV
560 570 580 590 600
RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
610 620 630 640 650
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV
660 670 680 690 700
PLYLEWAPVG VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN
710 720 730 740 750
PTEEGADNSS AKMEEEEEEE EEEEESLPGC TLFIKNLNFD TTEEKLKEVF
760 770 780 790 800
SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE YRKPEQAQKA LKQLQGHVVD
810 820 830 840 850
GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP FQAHSREIRE
860 870 880 890 900
LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
910 920 930 940 950
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD
960
SDSEEQTLQL
Length:960
Mass (Da):107,332
Last modified:October 5, 2010 - v3
Checksum:i28B6F37B18D7B9B1
GO

Sequence cautioni

The sequence BAA31657 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141Q → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in AAH06137 (PubMed:15489334).Curated1
Sequence conflicti259K → R in AAH04289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059822602Q → E4 PublicationsCorresponds to variant dbSNP:rs7299217Ensembl.1
Natural variantiVAR_023114609H → R2 PublicationsCorresponds to variant dbSNP:rs2290789Ensembl.1
Natural variantiVAR_023115623I → T2 PublicationsCorresponds to variant dbSNP:rs2290788Ensembl.1
Natural variantiVAR_023116665T → A2 PublicationsCorresponds to variant dbSNP:rs2290787Ensembl.1
Natural variantiVAR_057246821R → G. Corresponds to variant dbSNP:rs16943379Ensembl.1
Natural variantiVAR_023117921R → Q1 PublicationCorresponds to variant dbSNP:rs2075387Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014582 mRNA Translation: BAA31657.2 Different initiation.
AL117547 mRNA Translation: CAB55987.1
AK291444 mRNA Translation: BAF84133.1
AK314606 mRNA Translation: BAG37176.1
AC009731 Genomic DNA No translation available.
AC073863 Genomic DNA No translation available.
AC090669 Genomic DNA No translation available.
BC004289 mRNA Translation: AAH04289.1
BC006137 mRNA Translation: AAH06137.1
CCDSiCCDS9172.1
PIRiT17297
RefSeqiNP_001140170.1, NM_001146698.1
NP_001140171.1, NM_001146699.1
NP_057280.2, NM_016196.3
UniGeneiHs.7482

Genome annotation databases

EnsembliENST00000261741; ENSP00000261741; ENSG00000122965
ENST00000392561; ENSP00000376344; ENSG00000122965
ENST00000545145; ENSP00000442053; ENSG00000122965
GeneIDi9904
KEGGihsa:9904
UCSCiuc001tvm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM19_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4C8
Secondary accession number(s): A8K5X9, Q9BPY6, Q9UFN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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