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Protein

Probable RNA-binding protein 19

Gene

RBM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in embryo pre-implantation development.By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein 19
Alternative name(s):
RNA-binding motif protein 19
Gene namesi
Name:RBM19
Synonyms:KIAA0682
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29098. RBM19.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9904.
OpenTargetsiENSG00000122965.
PharmGKBiPA134886784.

Polymorphism and mutation databases

BioMutaiRBM19.
DMDMi308153566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817811 – 960Probable RNA-binding protein 19Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei936PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y4C8.
MaxQBiQ9Y4C8.
PaxDbiQ9Y4C8.
PeptideAtlasiQ9Y4C8.
PRIDEiQ9Y4C8.

2D gel databases

SWISS-2DPAGEiQ9Y4C8.

PTM databases

iPTMnetiQ9Y4C8.
PhosphoSitePlusiQ9Y4C8.

Expressioni

Tissue specificityi

Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000122965.
CleanExiHS_RBM19.
ExpressionAtlasiQ9Y4C8. baseline and differential.
GenevisibleiQ9Y4C8. HS.

Organism-specific databases

HPAiHPA038860.
HPA058732.

Interactioni

Protein-protein interaction databases

BioGridi115233. 116 interactors.
IntActiQ9Y4C8. 2 interactors.
MINTiMINT-1196129.
STRINGi9606.ENSP00000261741.

Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi295 – 299Combined sources5
Helixi307 – 314Combined sources8
Beta strandi320 – 326Combined sources7
Beta strandi332 – 339Combined sources8
Helixi343 – 351Combined sources9
Beta strandi354 – 357Combined sources4
Beta strandi360 – 368Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGWNMR-A291-368[»]
ProteinModelPortaliQ9Y4C8.
SMRiQ9Y4C8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4C8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 369RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini402 – 480RRM 3PROSITE-ProRule annotationAdd BLAST79
Domaini587 – 659RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini730 – 811RRM 5PROSITE-ProRule annotationAdd BLAST82
Domaini832 – 912RRM 6PROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 232Poly-Glu8
Compositional biasi391 – 396Poly-Glu6
Compositional biasi714 – 725Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0110. Eukaryota.
ENOG410XQZ5. LUCA.
GeneTreeiENSGT00840000129953.
HOGENOMiHOG000211156.
HOVERGENiHBG055637.
InParanoidiQ9Y4C8.
KOiK14787.
OMAiCKSFGDP.
OrthoDBiEOG091G02IZ.
PhylomeDBiQ9Y4C8.
TreeFamiTF105725.

Family and domain databases

CDDicd12564. RRM1_RBM19. 1 hit.
cd12502. RRM2_RMB19. 1 hit.
cd12567. RRM3_RBM19. 1 hit.
cd12569. RRM4_RBM19. 1 hit.
cd12318. RRM5_RBM19_like. 1 hit.
cd12571. RRM6_RBM19. 1 hit.
InterProiView protein in InterPro
IPR034419. RBM19_RRM3.
IPR034420. RBM19_RRM4.
IPR034423. RBM19_RRM5.
IPR034421. RBM19_RRM6.
IPR034418. RMB19_RRM1.
IPR034417. RMB19_RRM2.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PfamiView protein in Pfam
PF00076. RRM_1. 5 hits.
SMARTiView protein in SMART
SM00360. RRM. 6 hits.
SM00361. RRM_1. 2 hits.
SUPFAMiSSF54928. SSF54928. 6 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 6 hits.

Sequencei

Sequence statusi: Complete.

Q9Y4C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK
60 70 80 90 100
SEEEAQKAQK HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK
110 120 130 140 150
QPPKDSTTPE IKKDEKKKKV AGQLEKLKED TEFQEFLSVH QRRAQAATWA
160 170 180 190 200
NDGLDAEPSK GKSKPASDYL NFDSDSGQES EEEGAGEDLE EEASLEPKAA
210 220 230 240 250
VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS EAEEEDSSAT
260 270 280 290 300
PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
310 320 330 340 350
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL
360 370 380 390 400
KCNREYMGGR YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE
410 420 430 440 450
SGRLFVRNLP YTSTEEDLEK LFSKYGPLSE LHYPIDSLTK KPKGFAFITF
460 470 480 490 500
MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI KKEASEDASA LGSSSYKKKK
510 520 530 540 550
EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF DHETKGSVAV
560 570 580 590 600
RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
610 620 630 640 650
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV
660 670 680 690 700
PLYLEWAPVG VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN
710 720 730 740 750
PTEEGADNSS AKMEEEEEEE EEEEESLPGC TLFIKNLNFD TTEEKLKEVF
760 770 780 790 800
SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE YRKPEQAQKA LKQLQGHVVD
810 820 830 840 850
GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP FQAHSREIRE
860 870 880 890 900
LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
910 920 930 940 950
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD
960
SDSEEQTLQL
Length:960
Mass (Da):107,332
Last modified:October 5, 2010 - v3
Checksum:i28B6F37B18D7B9B1
GO

Sequence cautioni

The sequence BAA31657 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141Q → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in AAH06137 (PubMed:15489334).Curated1
Sequence conflicti259K → R in AAH04289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059822602Q → E4 PublicationsCorresponds to variant dbSNP:rs7299217Ensembl.1
Natural variantiVAR_023114609H → R2 PublicationsCorresponds to variant dbSNP:rs2290789Ensembl.1
Natural variantiVAR_023115623I → T2 PublicationsCorresponds to variant dbSNP:rs2290788Ensembl.1
Natural variantiVAR_023116665T → A2 PublicationsCorresponds to variant dbSNP:rs2290787Ensembl.1
Natural variantiVAR_057246821R → G. Corresponds to variant dbSNP:rs16943379Ensembl.1
Natural variantiVAR_023117921R → Q1 PublicationCorresponds to variant dbSNP:rs2075387Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014582 mRNA. Translation: BAA31657.2. Different initiation.
AL117547 mRNA. Translation: CAB55987.1.
AK291444 mRNA. Translation: BAF84133.1.
AK314606 mRNA. Translation: BAG37176.1.
AC009731 Genomic DNA. No translation available.
AC073863 Genomic DNA. No translation available.
AC090669 Genomic DNA. No translation available.
BC004289 mRNA. Translation: AAH04289.1.
BC006137 mRNA. Translation: AAH06137.1.
CCDSiCCDS9172.1.
PIRiT17297.
RefSeqiNP_001140170.1. NM_001146698.1.
NP_001140171.1. NM_001146699.1.
NP_057280.2. NM_016196.3.
UniGeneiHs.7482.

Genome annotation databases

EnsembliENST00000261741; ENSP00000261741; ENSG00000122965.
ENST00000392561; ENSP00000376344; ENSG00000122965.
ENST00000545145; ENSP00000442053; ENSG00000122965.
GeneIDi9904.
KEGGihsa:9904.
UCSCiuc001tvm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM19_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4C8
Secondary accession number(s): A8K5X9, Q9BPY6, Q9UFN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: August 30, 2017
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families