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Protein

TRPM8 channel-associated factor 1

Gene

TCAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.1 Publication

GO - Molecular functioni

  • ion channel binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell migration Source: UniProtKB
  • positive regulation of anion channel activity Source: UniProtKB
  • positive regulation of protein targeting to membrane Source: UniProtKB
  • transport Source: UniProtKB-KW

Keywordsi

Biological processTransport

Protein family/group databases

MEROPSiM98.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
TRPM8 channel-associated factor 11 Publication
Alternative name(s):
TRP channel-associated factor 11 Publication
Gene namesi
Name:TCAF11 PublicationImported
Synonyms:FAM115A, KIAA0738
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22201. TCAF1.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9747.
OpenTargetsiENSG00000198420.
PharmGKBiPA162385749.

Polymorphism and mutation databases

BioMutaiFAM115A.
DMDMi182628294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201821 – 921TRPM8 channel-associated factor 1Add BLAST921

Proteomic databases

EPDiQ9Y4C2.
PaxDbiQ9Y4C2.
PeptideAtlasiQ9Y4C2.
PRIDEiQ9Y4C2.

PTM databases

iPTMnetiQ9Y4C2.
PhosphoSitePlusiQ9Y4C2.

Expressioni

Tissue specificityi

Isoform 2 is expressed in the prostate and strongly expressed in cancerous prostate samples.1 Publication

Gene expression databases

BgeeiENSG00000198420.
CleanExiHS_FAM115A.
ExpressionAtlasiQ9Y4C2. baseline and differential.
GenevisibleiQ9Y4C2. HS.

Organism-specific databases

HPAiHPA011732.
HPA061989.

Interactioni

Subunit structurei

Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115095. 25 interactors.
IntActiQ9Y4C2. 34 interactors.
MINTiMINT-2867437.
STRINGi9606.ENSP00000419235.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini542 – 841Peptidase M60PROSITE-ProRule annotationAdd BLAST300

Domaini

The C-terminal region is necessary for the channel activity stimulation.1 Publication

Sequence similaritiesi

Belongs to the TCAF family.Curated

Phylogenomic databases

eggNOGiENOG410IKE5. Eukaryota.
ENOG410YE3A. LUCA.
GeneTreeiENSGT00390000017365.
HOGENOMiHOG000069981.
HOVERGENiHBG057241.
InParanoidiQ9Y4C2.
OMAiFQVIMGR.
OrthoDBiEOG090B02PT.
PhylomeDBiQ9Y4C2.
TreeFamiTF331520.

Family and domain databases

InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR031161. Peptidase_M60_dom.
PfamiView protein in Pfam
PF13402. Peptidase_M60. 1 hit.
SMARTiView protein in SMART
SM01276. M60-like. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
PROSITEiView protein in PROSITE
PS51723. PEPTIDASE_M60. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4C2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPSAAFEA LMNGVTSWDV PEDAVPCELL LIGEASFPVM VNDMGQVLIA
60 70 80 90 100
ASSYGRGRLV VVSHEDYLVE AQLTPFLLNA VGWLCSSPGA PIGVHPSLAP
110 120 130 140 150
LAKILEGSGV DAKVEPEVKD SLGVYCIDAY NETMTEKLVK FMKCGGGLLI
160 170 180 190 200
GGQAWDWANQ GEDERVLFTF PGNLVTSVAG IYFTDNKGDT SFFKVSKKMP
210 220 230 240 250
KIPVLVSCED DLSDDREELL HGISELDISN SDCFPSQLLV HGALAFPLGL
260 270 280 290 300
DSYHGCVIAA ARYGRGRVVV TGHKVLFTVG KLGPFLLNAV RWLDGGRRGK
310 320 330 340 350
VVVQTELRTL SGLLAVGGID TSIEPNLTSD ASVYCFEPVS EVGVKELQEF
360 370 380 390 400
VAEGGGLFVG AQAWWWAFKN PGVSPLARFP GNLLLNPFGI SITSQSLNPG
410 420 430 440 450
PFRTPKAGIR TYHFRSTLAE FQVIMGRKRG NVEKGWLAKL GPDGAAFLQI
460 470 480 490 500
PAEEIPAYMS VHRLLRKLLS RYRLPVATRE NPVINDCCRG AMLSLATGLA
510 520 530 540 550
HSGSDLSLLV PEIEDMYSSP YLRPSESPIT VEVNCTNPGT RYCWMSTGLY
560 570 580 590 600
IPGRQIIEVS LPEAAASADL KIQIGCHTDD LTRASKLFRG PLVINRCCLD
610 620 630 640 650
KPTKSITCLW GGLLYIIVPQ NSKLGSVPVT VKGAVHAPYY KLGETTLEEW
660 670 680 690 700
KRRIQENPGP WGELATDNII LTVPTANLRT LENPEPLLRL WDEVMQAVAR
710 720 730 740 750
LGAEPFPLRL PQRIVADVQI SVGWMHAGYP IMCHLESVQE LINEKLIRTK
760 770 780 790 800
GLWGPVHELG RNQQRQEWEF PPHTTEATCN LWCVYVHETV LGIPRSRANI
810 820 830 840 850
ALWPPVREKR VRIYLSKGPN VKNWNAWTAL ETYLQLQEAF GWEPFIRLFT
860 870 880 890 900
EYRNQTNLPT ENVDKMNLWV KMFSHQVQKN LAPFFEAWAW PIQKEVATSL
910 920
AYLPEWKENI MKLYLLTQMP H
Length:921
Mass (Da):102,126
Last modified:February 26, 2008 - v3
Checksum:iBE654261858729B4
GO
Isoform 2 (identifier: Q9Y4C2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-921: Missing.

Show »
Length:919
Mass (Da):101,892
Checksum:i7261858729B485A9
GO

Sequence cautioni

The sequence BAA34458 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301V → I in BAA34458 (PubMed:9872452).Curated1
Sequence conflicti301V → I in BAF84294 (PubMed:14702039).Curated1
Sequence conflicti301V → I in AAH00609 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031631920 – 921Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018281 mRNA. Translation: BAA34458.2. Different initiation.
AK291605 mRNA. Translation: BAF84294.1.
AC099548 Genomic DNA. Translation: AAQ96852.1.
AC099548 Genomic DNA. Translation: AAQ96853.1.
BC000609 mRNA. Translation: AAH00609.1.
CCDSiCCDS56514.1. [Q9Y4C2-2]
CCDS5886.1. [Q9Y4C2-1]
RefSeqiNP_001193867.1. NM_001206938.1.
NP_001193870.1. NM_001206941.1.
NP_055534.1. NM_014719.2.
XP_005250131.1. XM_005250074.3. [Q9Y4C2-1]
XP_005250132.1. XM_005250075.2. [Q9Y4C2-1]
XP_005250133.1. XM_005250076.3. [Q9Y4C2-1]
XP_005250134.1. XM_005250077.2. [Q9Y4C2-1]
XP_006716254.1. XM_006716191.2. [Q9Y4C2-1]
XP_006716255.1. XM_006716192.3. [Q9Y4C2-2]
XP_016868322.1. XM_017012833.1. [Q9Y4C2-2]
XP_016868323.1. XM_017012834.1. [Q9Y4C2-2]
XP_016868324.1. XM_017012835.1. [Q9Y4C2-2]
XP_016868325.1. XM_017012836.1. [Q9Y4C2-2]
UniGeneiHs.735149.
Hs.744048.

Genome annotation databases

EnsembliENST00000355951; ENSP00000348220; ENSG00000198420. [Q9Y4C2-2]
ENST00000479870; ENSP00000419235; ENSG00000198420. [Q9Y4C2-1]
GeneIDi9747.
KEGGihsa:9747.
UCSCiuc003wdo.3. human. [Q9Y4C2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018281 mRNA. Translation: BAA34458.2. Different initiation.
AK291605 mRNA. Translation: BAF84294.1.
AC099548 Genomic DNA. Translation: AAQ96852.1.
AC099548 Genomic DNA. Translation: AAQ96853.1.
BC000609 mRNA. Translation: AAH00609.1.
CCDSiCCDS56514.1. [Q9Y4C2-2]
CCDS5886.1. [Q9Y4C2-1]
RefSeqiNP_001193867.1. NM_001206938.1.
NP_001193870.1. NM_001206941.1.
NP_055534.1. NM_014719.2.
XP_005250131.1. XM_005250074.3. [Q9Y4C2-1]
XP_005250132.1. XM_005250075.2. [Q9Y4C2-1]
XP_005250133.1. XM_005250076.3. [Q9Y4C2-1]
XP_005250134.1. XM_005250077.2. [Q9Y4C2-1]
XP_006716254.1. XM_006716191.2. [Q9Y4C2-1]
XP_006716255.1. XM_006716192.3. [Q9Y4C2-2]
XP_016868322.1. XM_017012833.1. [Q9Y4C2-2]
XP_016868323.1. XM_017012834.1. [Q9Y4C2-2]
XP_016868324.1. XM_017012835.1. [Q9Y4C2-2]
XP_016868325.1. XM_017012836.1. [Q9Y4C2-2]
UniGeneiHs.735149.
Hs.744048.

3D structure databases

ProteinModelPortaliQ9Y4C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115095. 25 interactors.
IntActiQ9Y4C2. 34 interactors.
MINTiMINT-2867437.
STRINGi9606.ENSP00000419235.

Protein family/group databases

MEROPSiM98.A01.

PTM databases

iPTMnetiQ9Y4C2.
PhosphoSitePlusiQ9Y4C2.

Polymorphism and mutation databases

BioMutaiFAM115A.
DMDMi182628294.

Proteomic databases

EPDiQ9Y4C2.
PaxDbiQ9Y4C2.
PeptideAtlasiQ9Y4C2.
PRIDEiQ9Y4C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355951; ENSP00000348220; ENSG00000198420. [Q9Y4C2-2]
ENST00000479870; ENSP00000419235; ENSG00000198420. [Q9Y4C2-1]
GeneIDi9747.
KEGGihsa:9747.
UCSCiuc003wdo.3. human. [Q9Y4C2-1]

Organism-specific databases

CTDi9747.
DisGeNETi9747.
GeneCardsiTCAF1.
H-InvDBHIX0007175.
HIX0187378.
HGNCiHGNC:22201. TCAF1.
HPAiHPA011732.
HPA061989.
MIMi616251. gene.
neXtProtiNX_Q9Y4C2.
OpenTargetsiENSG00000198420.
PharmGKBiPA162385749.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKE5. Eukaryota.
ENOG410YE3A. LUCA.
GeneTreeiENSGT00390000017365.
HOGENOMiHOG000069981.
HOVERGENiHBG057241.
InParanoidiQ9Y4C2.
OMAiFQVIMGR.
OrthoDBiEOG090B02PT.
PhylomeDBiQ9Y4C2.
TreeFamiTF331520.

Miscellaneous databases

ChiTaRSiFAM115A. human.
GenomeRNAii9747.
PROiQ9Y4C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198420.
CleanExiHS_FAM115A.
ExpressionAtlasiQ9Y4C2. baseline and differential.
GenevisibleiQ9Y4C2. HS.

Family and domain databases

InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR031161. Peptidase_M60_dom.
PfamiView protein in Pfam
PF13402. Peptidase_M60. 1 hit.
SMARTiView protein in SMART
SM01276. M60-like. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
PROSITEiView protein in PROSITE
PS51723. PEPTIDASE_M60. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCAF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4C2
Secondary accession number(s): A8K6E0
, Q75KM8, Q75KM9, Q7L665, Q9BW63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 15, 2017
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.