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Q9Y4C0

- NRX3A_HUMAN

UniProt

Q9Y4C0 - NRX3A_HUMAN

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Protein

Neurexin-3

Gene

NRXN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi304 – 3041CalciumBy similarity
Metal bindingi321 – 3211Calcium; via carbonyl oxygenBy similarity
Metal bindingi374 – 3741Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. calcium channel regulator activity Source: Ensembl
  2. cell adhesion molecule binding Source: BHF-UCL
  3. metal ion binding Source: UniProtKB-KW
  4. neuroligin family protein binding Source: BHF-UCL
  5. receptor activity Source: ProtInc

GO - Biological processi

  1. adult behavior Source: BHF-UCL
  2. axon guidance Source: ProtInc
  3. learning Source: BHF-UCL
  4. neuron cell-cell adhesion Source: BHF-UCL
  5. neurotransmitter secretion Source: Ensembl
  6. positive regulation of synapse assembly Source: InterPro
  7. positive regulation of synapse maturation Source: InterPro
  8. social behavior Source: BHF-UCL
  9. synapse assembly Source: Ensembl
  10. vocalization behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-3
Alternative name(s):
Neurexin III-alpha
Neurexin-3-alpha
Gene namesi
Name:NRXN3
Synonyms:C14orf60, KIAA0743
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:8010. NRXN3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 16431616Neurexin-3PRO_0000019499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi202 ↔ 213By similarity
Disulfide bondi207 ↔ 222By similarity
Disulfide bondi224 ↔ 234By similarity
Disulfide bondi404 ↔ 440By similarity
Disulfide bondi610 ↔ 639By similarity
Disulfide bondi647 ↔ 658By similarity
Disulfide bondi652 ↔ 667By similarity
Disulfide bondi669 ↔ 679By similarity
Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1018 ↔ 1046By similarity
Disulfide bondi1053 ↔ 1064By similarity
Disulfide bondi1058 ↔ 1073By similarity
Disulfide bondi1075 ↔ 1085By similarity
Glycosylationi1189 – 11891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1257 – 12571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1301 – 13011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y4C0.
PaxDbiQ9Y4C0.
PRIDEiQ9Y4C0.

PTM databases

PhosphoSiteiQ9Y4C0.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific.2 Publications

Gene expression databases

BgeeiQ9Y4C0.
CleanExiHS_NRXN3.
ExpressionAtlasiQ9Y4C0. baseline and differential.
GenevestigatoriQ9Y4C0.

Organism-specific databases

HPAiHPA002727.

Interactioni

Subunit structurei

The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK (By similarity).By similarity

Protein-protein interaction databases

BioGridi114770. 7 interactions.
IntActiQ9Y4C0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4C0.
SMRiQ9Y4C0. Positions 38-1266.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 15681541ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1590 – 164354CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1569 – 158921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 202175Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 23538EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 440183Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini447 – 639193Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini643 – 68038EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini685 – 857173Laminin G-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini871 – 1046176Laminin G-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1049 – 108638EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1090 – 1260171Laminin G-like 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 6 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302266.
GeneTreeiENSGT00760000118991.
HOVERGENiHBG052670.
InParanoidiQ9Y4C0.
KOiK07377.
OMAiRDIKCGD.
OrthoDBiEOG7XWPMM.
PhylomeDBiQ9Y4C0.
TreeFamiTF321302.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027158. NRXN3.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF405. PTHR10127:SF405. 1 hit.
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 6 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative promoter usage and alternative splicing. Align

Note: A number of isoforms alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.1 Publication

Isoform 1a (identifier: Q9Y4C0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD
60 70 80 90 100
LSFQFKTNVS TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS
110 120 130 140 150
NKQVNDSSWH FLMVSRDRLR TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG
160 170 180 190 200
GVPTDIRPSA LTLDGVQAMP GFKGLILDLK YGNSEPRLLG SRGVQMDAEG
210 220 230 240 250
PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ DPGLSHLMMS
260 270 280 290 300
EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG
310 320 330 340 350
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN
360 370 380 390 400
LRQVTISVDG ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN
410 420 430 440 450
FMGCLKEVVY KNNDIRLELS RLARIADTKM KIYGEVVFKC ENVATLDPIN
460 470 480 490 500
FETPEAYISL PKWNTKRMGS ISFDFRTTEP NGLILFTHGK PQERKDARSQ
510 520 530 540 550
KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG EWYHVDIQRD
560 570 580 590 600
GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT
610 620 630 640 650
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY
660 670 680 690 700
PCKNNAVCKD GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM
710 720 730 740 750
VMHTEAEDVS FRFMSQRAYG LLVATTSRDS ADTLRLELDG GRVKLMVNLD
760 770 780 790 800
CIRINCNSSK GPETLYAGQK LNDNEWHTVR VVRRGKSLKL TVDDDVAEGT
810 820 830 840 850
MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF NGLLYIDLCK
860 870 880 890 900
NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK
910 920 930 940 950
TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN
960 970 980 990 1000
DNQWHNVVIT RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG
1010 1020 1030 1040 1050
MYSNLPKLVA SRDGFQGCLA SVDLNGRLPD LINDALHRSG QIERGCEGPS
1060 1070 1080 1090 1100
TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY SGNQCNDPGA TYIFGKSGGL
1110 1120 1130 1140 1150
ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL GDFLQLHIEQ
1160 1170 1180 1190 1200
GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN
1210 1220 1230 1240 1250
EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN
1260 1270 1280 1290 1300
NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK
1310 1320 1330 1340 1350
NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTTGGELV IPLLVEDPLA
1360 1370 1380 1390 1400
TPPIATRAPS ITLPPTFRPL LTIIETTKDS LSMTSEAGLP CLSDQGSDGC
1410 1420 1430 1440 1450
DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL STSIFEGGYK
1460 1470 1480 1490 1500
AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK
1510 1520 1530 1540 1550
MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG
1560 1570 1580 1590 1600
IRRVPGASEV IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY
1610 1620 1630 1640
QVDETRNYIS NSAQSNGTLM KEKQQSSKSG HKKQKNKDRE YYV
Length:1,643
Mass (Da):180,599
Last modified:March 3, 2009 - v4
Checksum:iE7360348E263C6EC
GO
Isoform 3a (identifier: Q9Y4C0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-373: Missing.
     1334-1542: Missing.

Note: Produced by alternative splicing.

Show »
Length:1,061
Mass (Da):117,317
Checksum:i5BB0495CAE63A1AD
GO
Isoform 4a (identifier: Q9Y4C0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-242: Missing.
     252-252: Q → QGRSK
     750-759: DCIRINCNSS → G
     1205-1205: T → TGNTDNERFQMVKQKIPFKYNRPVEEWLQEK
     1335-1373: TGGELVIPLL...PPTFRPLLTI → GRSARSSNAA...IIFISCVVHS
     1374-1643: Missing.

Note: Produced by alternative splicing.

Show »
Length:1,392
Mass (Da):153,885
Checksum:i32D1B3F77340C23D
GO
Isoform 1b (identifier: Q9HDB5-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:637
Mass (Da):69,305
GO
Isoform 2b (identifier: Q9HDB5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing.

Length:432
Mass (Da):47,270
GO
Isoform 3b (identifier: Q9HDB5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing. No experimental confirmation available.

Length:396
Mass (Da):43,766
GO
Isoform 4b (identifier: Q9HDB5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing.

Length:459
Mass (Da):50,705
GO

Sequence cautioni

The sequence BAA34463.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1043 – 10431E → K in BAA34463. (PubMed:9872452)Curated
Sequence conflicti1043 – 10431E → K in AAI52458. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 373373Missing in isoform 3a. 2 PublicationsVSP_036463Add
BLAST
Alternative sequencei237 – 2426Missing in isoform 4a. 1 PublicationVSP_041699
Alternative sequencei252 – 2521Q → QGRSK in isoform 4a. 1 PublicationVSP_041700
Alternative sequencei750 – 75910DCIRINCNSS → G in isoform 4a. 1 PublicationVSP_041701
Alternative sequencei1205 – 12051T → TGNTDNERFQMVKQKIPFKY NRPVEEWLQEK in isoform 4a. 1 PublicationVSP_041702
Alternative sequencei1334 – 1542209Missing in isoform 3a. 2 PublicationsVSP_036464Add
BLAST
Alternative sequencei1335 – 137339TGGEL…PLLTI → GRSARSSNAARSLRAALTWT WRLTYTFTPIIFISCVVHS in isoform 4a. 1 PublicationVSP_041703Add
BLAST
Alternative sequencei1374 – 1643270Missing in isoform 4a. 1 PublicationVSP_041704Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316284 mRNA. Translation: CAC87720.2.
AF099810 Genomic DNA. Translation: AAC68909.1.
AF123462 Genomic DNA. Translation: AAD13621.1.
AB018286 mRNA. Translation: BAA34463.2. Different initiation.
AC008056 Genomic DNA. Translation: AAF09143.1.
AC012099 Genomic DNA. Translation: AAF15058.1.
AC009396 Genomic DNA. Translation: AAF21147.1.
AC008045 Genomic DNA. Translation: AAF28465.1.
AC011440 Genomic DNA. Translation: AAF61277.1.
AC026888 Genomic DNA. Translation: AAF87841.1.
CH471061 Genomic DNA. Translation: EAW81316.1.
BC152457 mRNA. Translation: AAI52458.1.
CCDSiCCDS9870.1. [Q9Y4C0-3]
RefSeqiNP_004787.2. NM_004796.5. [Q9Y4C0-3]
UniGeneiHs.368307.

Genome annotation databases

EnsembliENST00000554719; ENSP00000451648; ENSG00000021645. [Q9Y4C0-3]
ENST00000554738; ENSP00000450683; ENSG00000021645. [Q9Y4C0-4]
GeneIDi9369.
KEGGihsa:9369.
UCSCiuc001xun.4. human. [Q9Y4C0-3]
uc010asv.1. human. [Q9Y4C0-4]

Polymorphism databases

DMDMi224471902.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316284 mRNA. Translation: CAC87720.2 .
AF099810 Genomic DNA. Translation: AAC68909.1 .
AF123462 Genomic DNA. Translation: AAD13621.1 .
AB018286 mRNA. Translation: BAA34463.2 . Different initiation.
AC008056 Genomic DNA. Translation: AAF09143.1 .
AC012099 Genomic DNA. Translation: AAF15058.1 .
AC009396 Genomic DNA. Translation: AAF21147.1 .
AC008045 Genomic DNA. Translation: AAF28465.1 .
AC011440 Genomic DNA. Translation: AAF61277.1 .
AC026888 Genomic DNA. Translation: AAF87841.1 .
CH471061 Genomic DNA. Translation: EAW81316.1 .
BC152457 mRNA. Translation: AAI52458.1 .
CCDSi CCDS9870.1. [Q9Y4C0-3 ]
RefSeqi NP_004787.2. NM_004796.5. [Q9Y4C0-3 ]
UniGenei Hs.368307.

3D structure databases

ProteinModelPortali Q9Y4C0.
SMRi Q9Y4C0. Positions 38-1266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114770. 7 interactions.
IntActi Q9Y4C0. 1 interaction.

PTM databases

PhosphoSitei Q9Y4C0.

Polymorphism databases

DMDMi 224471902.

Proteomic databases

MaxQBi Q9Y4C0.
PaxDbi Q9Y4C0.
PRIDEi Q9Y4C0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000554719 ; ENSP00000451648 ; ENSG00000021645 . [Q9Y4C0-3 ]
ENST00000554738 ; ENSP00000450683 ; ENSG00000021645 . [Q9Y4C0-4 ]
GeneIDi 9369.
KEGGi hsa:9369.
UCSCi uc001xun.4. human. [Q9Y4C0-3 ]
uc010asv.1. human. [Q9Y4C0-4 ]

Organism-specific databases

CTDi 9369.
GeneCardsi GC14P078710.
HGNCi HGNC:8010. NRXN3.
HPAi HPA002727.
MIMi 600567. gene.
neXtProti NX_Q9Y4C0.
PharmGKBi PA31788.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302266.
GeneTreei ENSGT00760000118991.
HOVERGENi HBG052670.
InParanoidi Q9Y4C0.
KOi K07377.
OMAi RDIKCGD.
OrthoDBi EOG7XWPMM.
PhylomeDBi Q9Y4C0.
TreeFami TF321302.

Miscellaneous databases

ChiTaRSi NRXN3. human.
GenomeRNAii 9369.
NextBioi 35088.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4C0.
CleanExi HS_NRXN3.
ExpressionAtlasi Q9Y4C0. baseline and differential.
Genevestigatori Q9Y4C0.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027158. NRXN3.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
PANTHERi PTHR10127:SF405. PTHR10127:SF405. 1 hit.
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 6 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3)."
    Occhi G., Rampazzo A., Beffagna G., Antonio Danieli G.
    Biochem. Biophys. Res. Commun. 298:151-155(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4A), TISSUE SPECIFICITY.
    Tissue: Heart.
  2. "Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity."
    Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps D.L., Qin S., Minx P., Wilson R.K., Hood L., Graveley B.R.
    Genomics 79:587-597(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3A).
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3A).
  7. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
    Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
    Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNRX3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4C0
Secondary accession number(s): A6NGR4
, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 147 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3