Q9Y4C0 (NRX3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexin-3

Alternative name(s):
Neurexin III-alpha
Neurexin-3-alpha

Gene names

Name:	NRXN3
Synonyms:	C14orf60, KIAA0743

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1643 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Subunit structure	The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific. Ref.1 Ref.7
Sequence similarities	Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains.
Sequence caution	The sequence BAA34463.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative promoter usage Alternative splicing
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement PubMed 1621094. Source: ProtInc cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW neurotransmitter secretion Inferred from electronic annotation. Source: Compara synapse assembly Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement PubMed 1621094. Source: ProtInc
Molecular_function	calcium channel regulator activity Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Traceable author statement PubMed 1621094. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: A number of isoforms alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.

Isoform 1a (identifier: Q9Y4C0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3a (identifier: Q9Y4C0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-373: Missing.
     1334-1542: Missing.

Note: Produced by alternative splicing.

Isoform 4a (identifier: Q9Y4C0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     237-242: Missing.
     252-252: Q → QGRSK
     750-759: DCIRINCNSS → G
     1205-1205: T → TGNTDNERFQMVKQKIPFKYNRPVEEWLQEK
     1335-1373: TGGELVIPLL...PPTFRPLLTI → GRSARSSNAA...IIFISCVVHS
     1374-1643: Missing.

Note: Produced by alternative splicing.

Isoform 1b (identifier: Q9HDB5-1)

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2b (identifier: Q9HDB5-2)

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing.

Isoform 3b (identifier: Q9HDB5-3)

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing. No experimental confirmation available.

Isoform 4b (identifier: Q9HDB5-4)

The sequence of this isoform can be found in the external entry Q9HDB5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative splicing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	By similarity
	Chain	28 – 1643	1616	Neurexin-3		PRO_0000019499
Regions
	Topological domain	28 – 1568	1541	Extracellular Potential
	Transmembrane	1569 – 1589	21	Helical; Potential
	Topological domain	1590 – 1643	54	Cytoplasmic Potential
	Domain	28 – 202	175	Laminin G-like 1
	Domain	198 – 235	38	EGF-like 1
	Domain	258 – 440	183	Laminin G-like 2
	Domain	447 – 639	193	Laminin G-like 3
	Domain	643 – 680	38	EGF-like 2
	Domain	685 – 857	173	Laminin G-like 4
	Domain	871 – 1046	176	Laminin G-like 5
	Domain	1049 – 1086	38	EGF-like 3
	Domain	1090 – 1260	171	Laminin G-like 6
Sites
	Metal binding	304	1	Calcium By similarity
	Metal binding	321	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	374	1	Calcium; via carbonyl oxygen By similarity
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	757	1	N-linked (GlcNAc...) Potential
	Glycosylation	1189	1	N-linked (GlcNAc...) Potential
	Glycosylation	1257	1	N-linked (GlcNAc...) Potential
	Glycosylation	1301	1	N-linked (GlcNAc...) Potential
	Disulfide bond	202 ↔ 213		By similarity
	Disulfide bond	207 ↔ 222		By similarity
	Disulfide bond	224 ↔ 234		By similarity
	Disulfide bond	404 ↔ 440		By similarity
	Disulfide bond	610 ↔ 639		By similarity
	Disulfide bond	647 ↔ 658		By similarity
	Disulfide bond	652 ↔ 667		By similarity
	Disulfide bond	669 ↔ 679		By similarity
	Disulfide bond	1018 ↔ 1046		By similarity
	Disulfide bond	1053 ↔ 1064		By similarity
	Disulfide bond	1058 ↔ 1073		By similarity
	Disulfide bond	1075 ↔ 1085		By similarity
Natural variations
	Alternative sequence	1 – 373	373	Missing in isoform 3a.		VSP_036463
	Alternative sequence	237 – 242	6	Missing in isoform 4a.		VSP_041699
	Alternative sequence	252	1	Q → QGRSK in isoform 4a.		VSP_041700
	Alternative sequence	750 – 759	10	DCIRINCNSS → G in isoform 4a.		VSP_041701
	Alternative sequence	1205	1	T → TGNTDNERFQMVKQKIPFKY NRPVEEWLQEK in isoform 4a.		VSP_041702
	Alternative sequence	1334 – 1542	209	Missing in isoform 3a.		VSP_036464
	Alternative sequence	1335 – 1373	39	TGGEL…PLLTI → GRSARSSNAARSLRAALTWT WRLTYTFTPIIFISCVVHS in isoform 4a.		VSP_041703
	Alternative sequence	1374 – 1643	270	Missing in isoform 4a.		VSP_041704
Experimental info
	Sequence conflict	1043	1	E → K in BAA34463. Ref.3
	Sequence conflict	1043	1	E → K in AAI52458. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1a [UniParc]. Last modified March 3, 2009. Version 4. Checksum: E7360348E263C6EC	FASTA	1,643	180,599
	10 20 30 40 50 60 MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 70 80 90 100 110 120 TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 130 140 150 160 170 180 TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 190 200 210 220 230 240 YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 250 260 270 280 290 300 DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 310 320 330 340 350 360 KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 370 380 390 400 410 420 ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 430 440 450 460 470 480 RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 490 500 510 520 530 540 NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 550 560 570 580 590 600 EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 610 620 630 640 650 660 AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 670 680 690 700 710 720 GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 730 740 750 760 770 780 LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 790 800 810 820 830 840 VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 850 860 870 880 890 900 NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 910 920 930 940 950 960 TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 970 980 990 1000 1010 1020 RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 1030 1040 1050 1060 1070 1080 SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 1090 1100 1110 1120 1130 1140 SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 1150 1160 1170 1180 1190 1200 GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 1210 1220 1230 1240 1250 1260 EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV 1270 1280 1290 1300 1310 1320 RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC 1330 1340 1350 1360 1370 1380 SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS 1390 1400 1410 1420 1430 1440 LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL 1450 1460 1470 1480 1490 1500 STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK 1510 1520 1530 1540 1550 1560 MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV 1570 1580 1590 1600 1610 1620 IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM 1630 1640 KEKQQSSKSG HKKQKNKDRE YYV
	Isoform 3a [UniParc]. Checksum: 5BB0495CAE63A1AD	FASTA	1,061	117,317
	10 20 30 40 50 60 MLGSDDFFYV GGSPSTADLP GSPVSNNFMG CLKEVVYKNN DIRLELSRLA RIADTKMKIY 70 80 90 100 110 120 GEVVFKCENV ATLDPINFET PEAYISLPKW NTKRMGSISF DFRTTEPNGL ILFTHGKPQE 130 140 150 160 170 180 RKDARSQKNT KVDFFAVELL DGNLYLLLDM GSGTIKVKAT QKKANDGEWY HVDIQRDGRS 190 200 210 220 230 240 GTISVNSRRT PFTASGESEI LDLEGDMYLG GLPENRAGLI LPTELWTAML NYGYVGCIRD 250 260 270 280 290 300 LFIDGRSKNI RQLAEMQNAA GVKSSCSRMS AKQCDSYPCK NNAVCKDGWN RFICDCTGTG 310 320 330 340 350 360 YWGRTCEREA SILSYDGSMY MKIIMPMVMH TEAEDVSFRF MSQRAYGLLV ATTSRDSADT 370 380 390 400 410 420 LRLELDGGRV KLMVNLDCIR INCNSSKGPE TLYAGQKLND NEWHTVRVVR RGKSLKLTVD 430 440 450 460 470 480 DDVAEGTMVG DHTRLEFHNI ETGIMTEKRY ISVVPSSFIG HLQSLMFNGL LYIDLCKNGD 490 500 510 520 530 540 IDYCELKARF GLRNIIADPV TFKTKSSYLS LATLQAYTSM HLFFQFKTTS PDGFILFNSG 550 560 570 580 590 600 DGNDFIAVEL VKGYIHYVFD LGNGPNVIKG NSDRPLNDNQ WHNVVITRDN SNTHSLKVDT 610 620 630 640 650 660 KVVTQVINGA KNLDLKGDLY MAGLAQGMYS NLPKLVASRD GFQGCLASVD LNGRLPDLIN 670 680 690 700 710 720 DALHRSGQIE RGCEGPSTTC QEDSCANQGV CMQQWEGFTC DCSMTSYSGN QCNDPGATYI 730 740 750 760 770 780 FGKSGGLILY TWPANDRPST RSDRLAVGFS TTVKDGILVR IDSAPGLGDF LQLHIEQGKI 790 800 810 820 830 840 GVVFNIGTVD ISIKEERTPV NDGKYHVVRF TRNGGNATLQ VDNWPVNEHY PTGRQLTIFN 850 860 870 880 890 900 TQAQIAIGGK DKGRLFQGQL SGLYYDGLKV LNMAAENNPN IKINGSVRLV GEVPSILGTT 910 920 930 940 950 960 QTTSMPPEMS TTVMETTTTM ATTTTRKNRS TASIQPTSDD LVSSAECSSD DEDFVECEPS 970 980 990 1000 1010 1020 TANPTEPGIR RVPGASEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYQV 1030 1040 1050 1060 DETRNYISNS AQSNGTLMKE KQQSSKSGHK KQKNKDREYY V
	Isoform 4a [UniParc]. Checksum: 32D1B3F77340C23D	FASTA	1,392	153,885
	10 20 30 40 50 60 MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 70 80 90 100 110 120 TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 130 140 150 160 170 180 TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 190 200 210 220 230 240 YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEGLSH 250 260 270 280 290 300 LMMSEQGRSK AREENVATFR GSEYLCYDLS QNPIQSSSDE ITLSFKTWQR NGLILHTGKS 310 320 330 340 350 360 ADYVNLALKD GAVSLVINLG SGAFEAIVEP VNGKFNDNAW HDVKVTRNLR QVTISVDGIL 370 380 390 400 410 420 TTTGYTQEDY TMLGSDDFFY VGGSPSTADL PGSPVSNNFM GCLKEVVYKN NDIRLELSRL 430 440 450 460 470 480 ARIADTKMKI YGEVVFKCEN VATLDPINFE TPEAYISLPK WNTKRMGSIS FDFRTTEPNG 490 500 510 520 530 540 LILFTHGKPQ ERKDARSQKN TKVDFFAVEL LDGNLYLLLD MGSGTIKVKA TQKKANDGEW 550 560 570 580 590 600 YHVDIQRDGR SGTISVNSRR TPFTASGESE ILDLEGDMYL GGLPENRAGL ILPTELWTAM 610 620 630 640 650 660 LNYGYVGCIR DLFIDGRSKN IRQLAEMQNA AGVKSSCSRM SAKQCDSYPC KNNAVCKDGW 670 680 690 700 710 720 NRFICDCTGT GYWGRTCERE ASILSYDGSM YMKIIMPMVM HTEAEDVSFR FMSQRAYGLL 730 740 750 760 770 780 VATTSRDSAD TLRLELDGGR VKLMVNLGKG PETLYAGQKL NDNEWHTVRV VRRGKSLKLT 790 800 810 820 830 840 VDDDVAEGTM VGDHTRLEFH NIETGIMTEK RYISVVPSSF IGHLQSLMFN GLLYIDLCKN 850 860 870 880 890 900 GDIDYCELKA RFGLRNIIAD PVTFKTKSSY LSLATLQAYT SMHLFFQFKT TSPDGFILFN 910 920 930 940 950 960 SGDGNDFIAV ELVKGYIHYV FDLGNGPNVI KGNSDRPLND NQWHNVVITR DNSNTHSLKV 970 980 990 1000 1010 1020 DTKVVTQVIN GAKNLDLKGD LYMAGLAQGM YSNLPKLVAS RDGFQGCLAS VDLNGRLPDL 1030 1040 1050 1060 1070 1080 INDALHRSGQ IERGCEGPST TCQEDSCANQ GVCMQQWEGF TCDCSMTSYS GNQCNDPGAT 1090 1100 1110 1120 1130 1140 YIFGKSGGLI LYTWPANDRP STRSDRLAVG FSTTVKDGIL VRIDSAPGLG DFLQLHIEQG 1150 1160 1170 1180 1190 1200 KIGVVFNIGT VDISIKEERT PVNDGKYHVV RFTRNGGNAT LQVDNWPVNE HYPTGNTDNE 1210 1220 1230 1240 1250 1260 RFQMVKQKIP FKYNRPVEEW LQEKGRQLTI FNTQAQIAIG GKDKGRLFQG QLSGLYYDGL 1270 1280 1290 1300 1310 1320 KVLNMAAENN PNIKINGSVR LVGEVPSILG TTQTTSMPPE MSTTVMETTT TMATTTTRKN 1330 1340 1350 1360 1370 1380 RSTASIQPTS DDLVSSAECS SDDEDFVECE PSTGRSARSS NAARSLRAAL TWTWRLTYTF 1390 TPIIFISCVV HS
	Isoform 1b [UniParc]. See Q9HDB5.		–	–
	Isoform 2b [UniParc]. See Q9HDB5.		–	–
	Isoform 3b [UniParc]. See Q9HDB5.		–	–
	Isoform 4b [UniParc]. See Q9HDB5.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3)." Occhi G., Rampazzo A., Beffagna G., Antonio Danieli G. Biochem. Biophys. Res. Commun. 298:151-155(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4A), TISSUE SPECIFICITY. Tissue: Heart.
[2]	"Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity." Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps D.L., Qin S., Minx P., Wilson R.K., Hood L., Graveley B.R. Genomics 79:587-597(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[3]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3A). Tissue: Brain.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3A).
[7]	"The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions." Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M. Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ316284 mRNA. Translation: CAC87720.2. AF099810 Genomic DNA. Translation: AAC68909.1. AF123462 Genomic DNA. Translation: AAD13621.1. AB018286 mRNA. Translation: BAA34463.2. Different initiation. AC008056 Genomic DNA. Translation: AAF09143.1. AC012099 Genomic DNA. Translation: AAF15058.1. AC009396 Genomic DNA. Translation: AAF21147.1. AC008045 Genomic DNA. Translation: AAF28465.1. AC011440 Genomic DNA. Translation: AAF61277.1. AC026888 Genomic DNA. Translation: AAF87841.1. CH471061 Genomic DNA. Translation: EAW81316.1. BC152457 mRNA. Translation: AAI52458.1.
IPI	IPI00414249. IPI00854729. IPI01025492.
RefSeq	NP_004787.2. NM_004796.5.
UniGene	Hs.368307.
3D structure databases
HSSP	HSSP built from PDB template 1C4R based on UniProtKB Q63373.
ProteinModelPortal	Q9Y4C0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4C0. 1 interaction.
PTM databases
PhosphoSite	Q9Y4C0.
Polymorphism databases
DMDM	224471902.
Proteomic databases
PaxDb	Q9Y4C0.
PRIDE	Q9Y4C0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335750; ENSP00000338349; ENSG00000021645. ENST00000554719; ENSP00000451648; ENSG00000021645. ENST00000554738; ENSP00000450683; ENSG00000021645.
GeneID	9369.
KEGG	hsa:9369.
UCSC	uc001xun.3. human.
Organism-specific databases
CTD	9369.
GeneCards	GC14P078710.
HGNC	HGNC:8010. NRXN3.
HPA	HPA002727.
MIM	600567. gene.
neXtProt	NX_Q9Y4C0.
PharmGKB	PA31788.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302266.
HOVERGEN	HBG052670.
KO	K07377.
Gene expression databases
ArrayExpress	Q9Y4C0.
Bgee	Q9Y4C0.
CleanEx	HS_NRXN3.
Genevestigator	Q9Y4C0.
GermOnline	ENSG00000021645. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 6 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR001791. Laminin_G. IPR003585. Neurexin-like. IPR027149. NRXN3-alpha. [Graphical view]
PANTHER	PTHR10127:SF405. PTHR10127:SF405. 1 hit.
Pfam	PF02210. Laminin_G_2. 6 hits. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. SM00181. EGF. 3 hits. SM00282. LamG. 6 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 6 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. 3 hits. PS50025. LAM_G_DOMAIN. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NRXN3. human.
GenomeRNAi	9369.
NextBio	35088.
SOURCE	Search...

Entry information

Entry name

NRX3A_HUMAN

Accession

Primary (citable) accession number: Q9Y4C0
Secondary accession number(s): A6NGR4 , A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 132 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.