Q9Y4B5 (SOGA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SOGA2

Alternative name(s):
Coiled-coil domain-containing protein 165

Gene names

Name:	SOGA2
Synonyms:	CCDC165, KIAA0802

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1905 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Isoform 4 is phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Belongs to the SOGA family.
Sequence caution	The sequence BAA34522.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y4B5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y4B5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9Y4B5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     989-989: E → ELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHK

Isoform 4 (identifier: Q9Y4B5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1004: Missing.
     1187-1187: Q → QNCCGYPRINIEEETLGFTRLPAGSTVKTLKSLGLQRLE
     1273-1300: Missing.
     1894-1905: NQTVLLTAPWGL → ELPCSALAPS...LHGLSQYNSL

Note: Contains a phosphoserine at position 941. Contains a phosphoserine at position 975.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1905	1905	Protein SOGA2		PRO_0000280113
Regions
	Coiled coil	330 – 404	75	Potential
	Coiled coil	432 – 483	52	Potential
	Coiled coil	513 – 718	206	Potential
	Coiled coil	1143 – 1201	59	Potential
	Coiled coil	1238 – 1278	41	Potential
	Compositional bias	42 – 319	278	Pro-rich
	Compositional bias	54 – 198	145	Ala-rich
Amino acid modifications
	Modified residue	77	1	Phosphoserine Ref.12
	Modified residue	263	1	Phosphoserine Ref.12
	Modified residue	549	1	Phosphoserine Ref.9 Ref.10 Ref.11
	Modified residue	618	1	Phosphoserine Ref.9
	Modified residue	621	1	Phosphothreonine Ref.9
	Modified residue	685	1	Phosphoserine Ref.12
	Modified residue	749	1	Phosphoserine By similarity
	Modified residue	776	1	Phosphoserine Ref.9 Ref.12
	Modified residue	901	1	Phosphoserine Ref.9
	Modified residue	923	1	Phosphoserine Ref.9
	Modified residue	1385	1	Phosphoserine Ref.9
	Modified residue	1388	1	Phosphoserine Ref.9
	Modified residue	1399	1	Phosphoserine Ref.12
	Modified residue	1417	1	Phosphothreonine Ref.7 Ref.9
	Modified residue	1421	1	Phosphoserine Ref.7 Ref.9
	Modified residue	1427	1	Phosphotyrosine Ref.9
	Modified residue	1561	1	Phosphoserine Ref.9
	Modified residue	1578	1	Phosphoserine Ref.9
	Modified residue	1583	1	Phosphoserine Ref.9
	Modified residue	1592	1	Phosphoserine Ref.9
	Modified residue	1661	1	Phosphoserine Ref.9
	Modified residue	1667	1	Phosphothreonine Ref.9
	Modified residue	1675	1	Phosphothreonine Ref.7 Ref.9
	Modified residue	1679	1	Phosphoserine Ref.7
	Modified residue	1683	1	Phosphoserine Ref.9
	Modified residue	1812	1	Phosphoserine Ref.9
	Modified residue	1814	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 1004	1004	Missing in isoform 4.		VSP_023549
	Alternative sequence	1 – 360	360	Missing in isoform 2 and isoform 3.		VSP_023550
	Alternative sequence	989	1	E → ELRGPPVLPEQSVSIEELQG QLVQAARLHQEETETFTNKI HK in isoform 3.		VSP_023551
	Alternative sequence	1187	1	Q → QNCCGYPRINIEEETLGFTR LPAGSTVKTLKSLGLQRLE in isoform 4.		VSP_023552
	Alternative sequence	1273 – 1300	28	Missing in isoform 4.		VSP_023553
	Alternative sequence	1894 – 1905	12	NQTVL…APWGL → ELPCSALAPSLEPCFSRPER PANRRPPSRWAPHSPTASQP QSPGDPTSLEEHGGEEPPEE QPHRDASLHGLSQYNSL in isoform 4.		VSP_023554
	Natural variant	602	1	M → T. Corresponds to variant rs35739383 [ dbSNP | Ensembl ].		VAR_055942
	Natural variant	861	1	Q → R. Ref.1 Corresponds to variant rs1965665 [ dbSNP | Ensembl ].		VAR_031073
	Natural variant	898	1	D → G. Ref.3 Ref.9 Corresponds to variant rs3744979 [ dbSNP | Ensembl ].		VAR_031074
	Natural variant	1097	1	G → S. Ref.1 Corresponds to variant rs12386117 [ dbSNP | Ensembl ].		VAR_031075
	Natural variant	1211	1	K → Q. Corresponds to variant rs11874468 [ dbSNP | Ensembl ].		VAR_031076

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 18, 2012. Version 5. Checksum: BD7455BB2B822CE0	FASTA	1,905	209,526
	10 20 30 40 50 60 METLNGPAGG GAPDAKLQPP GQHHRHHHLH PVAERRRLHR APSPARPFLK DLHARPAAPG 70 80 90 100 110 120 PAVPSSGRAP APAAPRSPNL AGKAPPSPGS LAAPGRLSRR SGGVPGAKDK PPPGAGARAA 130 140 150 160 170 180 GGAKAALGSR RAARVAPAEP LSRAGKPPGA EPPSAAAKGR KAKRGSRAPP ARTVGPPTPA 190 200 210 220 230 240 ARIPAVTLAV TSVAGSPARC SRISHTDSSS DLSDCPSEPL SDEQRLLPAA SSDAESGTGS 250 260 270 280 290 300 SDREPPRGAP TPSPAARGAP PGSPEPPALL AAPLAAGACP GGRSIPSGVS GGFAGPGVAE 310 320 330 340 350 360 DVRGRSPPER PVPGTPKEPS LGEQSRLVPA AEEEELLREM EELRSENDYL KDELDELRAE 370 380 390 400 410 420 MEEMRDSYLE EDVYQLQELR RELDRANKNC RILQYRLRKA EQKSLKVAET GQVDGELIRS 430 440 450 460 470 480 LEQDLKVAKD VSVRLHHELK TVEEKRAKAE DENETLRQQM IEVEISKQAL QNELERLKES 490 500 510 520 530 540 SLKRRSTREM YKEKKTFNQD DSADLRCQLQ FAKEEAFLMR KKMAKLGREK DELEQELQKY 550 560 570 580 590 600 KSLYGDVDSP LPTGEAGGPP STREAELKLR LKLVEEEANI LGRKIVELEV ENRGLKAEME 610 620 630 640 650 660 DMRGQQEREG PGRDHAPSIP TSPFGDSLES STELRRHLQF VEEEAELLRR SISEIEDHNR 670 680 690 700 710 720 QLTHELSKFK FEPPREPGWL GEGASPGAGG GAPLQEELKS ARLQISELSG KVLKLQHENH 730 740 750 760 770 780 ALLSNIQRCD LAAHLGLRAP SPRDSDAESD AGKKESDGEE SRLPQPKREG PVGGESDSEE 790 800 810 820 830 840 MFEKTSGFGS GKPSEASEPC PTELLKARED SEYLVTLKHE AQRLERTVER LITDTDSFLH 850 860 870 880 890 900 DAGLRGGAPL PGPGLQGEEE QGEGDQQEPQ LLGTINAKMK AFKKELQAFL EQVNRIGDGL 910 920 930 940 950 960 SPLPHLTESS SFLSTVTSVS RDSPIGNLGK ELGPDLQSRL KEQLEWQLGP ARGDERESLR 970 980 990 1000 1010 1020 LRAARELHRR ADGDTGSHGL GGQTCFSLEM EEEHLYALRW KELEMHSLAL QNTLHERTWS 1030 1040 1050 1060 1070 1080 DEKNLMQQEL RSLKQNIFLF YVKLRWLLKH WRQGKQMEEE GEEFTEGEHP ETLSRLGELG 1090 1100 1110 1120 1130 1140 VQGGHQADGP DHDSDRGCGF PVGEHSPHSR VQIGDHSLRL QTADRGQPHK QVVENQQLFS 1150 1160 1170 1180 1190 1200 AFKALLEDFR AELREDERAR LRLQQQYASD KAAWDVEWAV LKCRLEQLEE KTENKLGELG 1210 1220 1230 1240 1250 1260 SSAESKGALK KEREVHQKLL ADSHSLVMDL RWQIHHSEKN WNREKVELLD RLDRDRQEWE 1270 1280 1290 1300 1310 1320 RQKKEFLWRI EQLQKENSPR RGGSFLCDQK DGNVRPFPHQ GSLRMPRPVA MWPCADADSI 1330 1340 1350 1360 1370 1380 PFEDRPLSKL KESDRCSASE NLYLDALSLD DEPEEPPAHR PEREFRNRLP EEEENHKGNL 1390 1400 1410 1420 1430 1440 QRAVSVSSMS EFQRLMDISP FLPEKGLPST SSKEDVTPPL SPDDLKYIEE FNKSWDYTPN 1450 1460 1470 1480 1490 1500 RGHNGGGPDL WADRTEVGRA GHEDSTEPFP DSSWYLTTSV TMTTDTMTSP EHCQKQPLRS 1510 1520 1530 1540 1550 1560 HVLTEQSGLR VLHSPPAVRR VDSITAAGGE GPFPTSRARG SPGDTKGGPP EPMLSRWPCT 1570 1580 1590 1600 1610 1620 SPRHSRDYVE GARRPLDSPL CTSLGFASPL HSLEMSKNLS DDMKEVAFSV RNAICSGPGE 1630 1640 1650 1660 1670 1680 LQVKDMACQT NGSRTMGTQT VQTISVGLQT EALRGSGVTS SPHKCLTPKA GGGATPVSSP 1690 1700 1710 1720 1730 1740 SRSLRSRQVA PAIEKVQAKF ERTCCSPKYG SPKLQRKPLP KADQPNNRTS PGMAQKGYSE 1750 1760 1770 1780 1790 1800 SAWARSTTTR ESPVHTTIND GLSSLFNIID HSPVVQDPFQ KGLRAGSRSR SAEPRPELGP 1810 1820 1830 1840 1850 1860 GQETGTNSRG RSPSPIGVGS EMCREEGGEG TPVKQDLSAP PGYTLTENVA RILNKKLLEH 1870 1880 1890 1900 ALKEERRQAA HGPPGLHSDS HSLGDTAEPG PMENQTVLLT APWGL
	Isoform 2 [UniParc]. Checksum: DF457AEFCFAFB40A	FASTA	1,545	173,310
	10 20 30 40 50 60 MEEMRDSYLE EDVYQLQELR RELDRANKNC RILQYRLRKA EQKSLKVAET GQVDGELIRS 70 80 90 100 110 120 LEQDLKVAKD VSVRLHHELK TVEEKRAKAE DENETLRQQM IEVEISKQAL QNELERLKES 130 140 150 160 170 180 SLKRRSTREM YKEKKTFNQD DSADLRCQLQ FAKEEAFLMR KKMAKLGREK DELEQELQKY 190 200 210 220 230 240 KSLYGDVDSP LPTGEAGGPP STREAELKLR LKLVEEEANI LGRKIVELEV ENRGLKAEME 250 260 270 280 290 300 DMRGQQEREG PGRDHAPSIP TSPFGDSLES STELRRHLQF VEEEAELLRR SISEIEDHNR 310 320 330 340 350 360 QLTHELSKFK FEPPREPGWL GEGASPGAGG GAPLQEELKS ARLQISELSG KVLKLQHENH 370 380 390 400 410 420 ALLSNIQRCD LAAHLGLRAP SPRDSDAESD AGKKESDGEE SRLPQPKREG PVGGESDSEE 430 440 450 460 470 480 MFEKTSGFGS GKPSEASEPC PTELLKARED SEYLVTLKHE AQRLERTVER LITDTDSFLH 490 500 510 520 530 540 DAGLRGGAPL PGPGLQGEEE QGEGDQQEPQ LLGTINAKMK AFKKELQAFL EQVNRIGDGL 550 560 570 580 590 600 SPLPHLTESS SFLSTVTSVS RDSPIGNLGK ELGPDLQSRL KEQLEWQLGP ARGDERESLR 610 620 630 640 650 660 LRAARELHRR ADGDTGSHGL GGQTCFSLEM EEEHLYALRW KELEMHSLAL QNTLHERTWS 670 680 690 700 710 720 DEKNLMQQEL RSLKQNIFLF YVKLRWLLKH WRQGKQMEEE GEEFTEGEHP ETLSRLGELG 730 740 750 760 770 780 VQGGHQADGP DHDSDRGCGF PVGEHSPHSR VQIGDHSLRL QTADRGQPHK QVVENQQLFS 790 800 810 820 830 840 AFKALLEDFR AELREDERAR LRLQQQYASD KAAWDVEWAV LKCRLEQLEE KTENKLGELG 850 860 870 880 890 900 SSAESKGALK KEREVHQKLL ADSHSLVMDL RWQIHHSEKN WNREKVELLD RLDRDRQEWE 910 920 930 940 950 960 RQKKEFLWRI EQLQKENSPR RGGSFLCDQK DGNVRPFPHQ GSLRMPRPVA MWPCADADSI 970 980 990 1000 1010 1020 PFEDRPLSKL KESDRCSASE NLYLDALSLD DEPEEPPAHR PEREFRNRLP EEEENHKGNL 1030 1040 1050 1060 1070 1080 QRAVSVSSMS EFQRLMDISP FLPEKGLPST SSKEDVTPPL SPDDLKYIEE FNKSWDYTPN 1090 1100 1110 1120 1130 1140 RGHNGGGPDL WADRTEVGRA GHEDSTEPFP DSSWYLTTSV TMTTDTMTSP EHCQKQPLRS 1150 1160 1170 1180 1190 1200 HVLTEQSGLR VLHSPPAVRR VDSITAAGGE GPFPTSRARG SPGDTKGGPP EPMLSRWPCT 1210 1220 1230 1240 1250 1260 SPRHSRDYVE GARRPLDSPL CTSLGFASPL HSLEMSKNLS DDMKEVAFSV RNAICSGPGE 1270 1280 1290 1300 1310 1320 LQVKDMACQT NGSRTMGTQT VQTISVGLQT EALRGSGVTS SPHKCLTPKA GGGATPVSSP 1330 1340 1350 1360 1370 1380 SRSLRSRQVA PAIEKVQAKF ERTCCSPKYG SPKLQRKPLP KADQPNNRTS PGMAQKGYSE 1390 1400 1410 1420 1430 1440 SAWARSTTTR ESPVHTTIND GLSSLFNIID HSPVVQDPFQ KGLRAGSRSR SAEPRPELGP 1450 1460 1470 1480 1490 1500 GQETGTNSRG RSPSPIGVGS EMCREEGGEG TPVKQDLSAP PGYTLTENVA RILNKKLLEH 1510 1520 1530 1540 ALKEERRQAA HGPPGLHSDS HSLGDTAEPG PMENQTVLLT APWGL
	Isoform 3 [UniParc]. Checksum: 1D44ACAC4C4977A3	FASTA	1,586	177,945
	10 20 30 40 50 60 MEEMRDSYLE EDVYQLQELR RELDRANKNC RILQYRLRKA EQKSLKVAET GQVDGELIRS 70 80 90 100 110 120 LEQDLKVAKD VSVRLHHELK TVEEKRAKAE DENETLRQQM IEVEISKQAL QNELERLKES 130 140 150 160 170 180 SLKRRSTREM YKEKKTFNQD DSADLRCQLQ FAKEEAFLMR KKMAKLGREK DELEQELQKY 190 200 210 220 230 240 KSLYGDVDSP LPTGEAGGPP STREAELKLR LKLVEEEANI LGRKIVELEV ENRGLKAEME 250 260 270 280 290 300 DMRGQQEREG PGRDHAPSIP TSPFGDSLES STELRRHLQF VEEEAELLRR SISEIEDHNR 310 320 330 340 350 360 QLTHELSKFK FEPPREPGWL GEGASPGAGG GAPLQEELKS ARLQISELSG KVLKLQHENH 370 380 390 400 410 420 ALLSNIQRCD LAAHLGLRAP SPRDSDAESD AGKKESDGEE SRLPQPKREG PVGGESDSEE 430 440 450 460 470 480 MFEKTSGFGS GKPSEASEPC PTELLKARED SEYLVTLKHE AQRLERTVER LITDTDSFLH 490 500 510 520 530 540 DAGLRGGAPL PGPGLQGEEE QGEGDQQEPQ LLGTINAKMK AFKKELQAFL EQVNRIGDGL 550 560 570 580 590 600 SPLPHLTESS SFLSTVTSVS RDSPIGNLGK ELGPDLQSRL KEQLEWQLGP ARGDERESLR 610 620 630 640 650 660 LRAARELHRR ADGDTGSHGL GGQTCFSLEL RGPPVLPEQS VSIEELQGQL VQAARLHQEE 670 680 690 700 710 720 TETFTNKIHK MEEEHLYALR WKELEMHSLA LQNTLHERTW SDEKNLMQQE LRSLKQNIFL 730 740 750 760 770 780 FYVKLRWLLK HWRQGKQMEE EGEEFTEGEH PETLSRLGEL GVQGGHQADG PDHDSDRGCG 790 800 810 820 830 840 FPVGEHSPHS RVQIGDHSLR LQTADRGQPH KQVVENQQLF SAFKALLEDF RAELREDERA 850 860 870 880 890 900 RLRLQQQYAS DKAAWDVEWA VLKCRLEQLE EKTENKLGEL GSSAESKGAL KKEREVHQKL 910 920 930 940 950 960 LADSHSLVMD LRWQIHHSEK NWNREKVELL DRLDRDRQEW ERQKKEFLWR IEQLQKENSP 970 980 990 1000 1010 1020 RRGGSFLCDQ KDGNVRPFPH QGSLRMPRPV AMWPCADADS IPFEDRPLSK LKESDRCSAS 1030 1040 1050 1060 1070 1080 ENLYLDALSL DDEPEEPPAH RPEREFRNRL PEEEENHKGN LQRAVSVSSM SEFQRLMDIS 1090 1100 1110 1120 1130 1140 PFLPEKGLPS TSSKEDVTPP LSPDDLKYIE EFNKSWDYTP NRGHNGGGPD LWADRTEVGR 1150 1160 1170 1180 1190 1200 AGHEDSTEPF PDSSWYLTTS VTMTTDTMTS PEHCQKQPLR SHVLTEQSGL RVLHSPPAVR 1210 1220 1230 1240 1250 1260 RVDSITAAGG EGPFPTSRAR GSPGDTKGGP PEPMLSRWPC TSPRHSRDYV EGARRPLDSP 1270 1280 1290 1300 1310 1320 LCTSLGFASP LHSLEMSKNL SDDMKEVAFS VRNAICSGPG ELQVKDMACQ TNGSRTMGTQ 1330 1340 1350 1360 1370 1380 TVQTISVGLQ TEALRGSGVT SSPHKCLTPK AGGGATPVSS PSRSLRSRQV APAIEKVQAK 1390 1400 1410 1420 1430 1440 FERTCCSPKY GSPKLQRKPL PKADQPNNRT SPGMAQKGYS ESAWARSTTT RESPVHTTIN 1450 1460 1470 1480 1490 1500 DGLSSLFNII DHSPVVQDPF QKGLRAGSRS RSAEPRPELG PGQETGTNSR GRSPSPIGVG 1510 1520 1530 1540 1550 1560 SEMCREEGGE GTPVKQDLSA PPGYTLTENV ARILNKKLLE HALKEERRQA AHGPPGLHSD 1570 1580 SHSLGDTAEP GPMENQTVLL TAPWGL
	Isoform 4 [UniParc]. Checksum: F49E33A334D49052	FASTA	976	108,707
	10 20 30 40 50 60 MHSLALQNTL HERTWSDEKN LMQQELRSLK QNIFLFYVKL RWLLKHWRQG KQMEEEGEEF 70 80 90 100 110 120 TEGEHPETLS RLGELGVQGG HQADGPDHDS DRGCGFPVGE HSPHSRVQIG DHSLRLQTAD 130 140 150 160 170 180 RGQPHKQVVE NQQLFSAFKA LLEDFRAELR EDERARLRLQ QQYASDKAAW DVEWAVLKCR 190 200 210 220 230 240 LEQNCCGYPR INIEEETLGF TRLPAGSTVK TLKSLGLQRL ELEEKTENKL GELGSSAESK 250 260 270 280 290 300 GALKKEREVH QKLLADSHSL VMDLRWQIHH SEKNWNREKV ELLDRLDRDR QEWERQKKEF 310 320 330 340 350 360 LWRIEQGSLR MPRPVAMWPC ADADSIPFED RPLSKLKESD RCSASENLYL DALSLDDEPE 370 380 390 400 410 420 EPPAHRPERE FRNRLPEEEE NHKGNLQRAV SVSSMSEFQR LMDISPFLPE KGLPSTSSKE 430 440 450 460 470 480 DVTPPLSPDD LKYIEEFNKS WDYTPNRGHN GGGPDLWADR TEVGRAGHED STEPFPDSSW 490 500 510 520 530 540 YLTTSVTMTT DTMTSPEHCQ KQPLRSHVLT EQSGLRVLHS PPAVRRVDSI TAAGGEGPFP 550 560 570 580 590 600 TSRARGSPGD TKGGPPEPML SRWPCTSPRH SRDYVEGARR PLDSPLCTSL GFASPLHSLE 610 620 630 640 650 660 MSKNLSDDMK EVAFSVRNAI CSGPGELQVK DMACQTNGSR TMGTQTVQTI SVGLQTEALR 670 680 690 700 710 720 GSGVTSSPHK CLTPKAGGGA TPVSSPSRSL RSRQVAPAIE KVQAKFERTC CSPKYGSPKL 730 740 750 760 770 780 QRKPLPKADQ PNNRTSPGMA QKGYSESAWA RSTTTRESPV HTTINDGLSS LFNIIDHSPV 790 800 810 820 830 840 VQDPFQKGLR AGSRSRSAEP RPELGPGQET GTNSRGRSPS PIGVGSEMCR EEGGEGTPVK 850 860 870 880 890 900 QDLSAPPGYT LTENVARILN KKLLEHALKE ERRQAAHGPP GLHSDSHSLG DTAEPGPMEE 910 920 930 940 950 960 LPCSALAPSL EPCFSRPERP ANRRPPSRWA PHSPTASQPQ SPGDPTSLEE HGGEEPPEEQ 970 PHRDASLHGL SQYNSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-861 AND SER-1097. Tissue: Brain.
[2]	Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-898. Tissue: Cerebellum.
[4]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Testis.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1417; SER-1421; THR-1675 AND SER-1679, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549; SER-618; THR-621; SER-776; SER-901; SER-923; SER-1385; SER-1388; THR-1417; SER-1421; TYR-1427; SER-1561; SER-1578; SER-1583; SER-1592; SER-1661; THR-1667; THR-1675; SER-1683; SER-1812 AND SER-1814, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-941 AND SER-975 (ISOFORM 4), VARIANT [LARGE SCALE ANALYSIS] GLY-898, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549, MASS SPECTROMETRY.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-263; SER-685; SER-776 AND SER-1399, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-975 (ISOFORM 4), MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018345 mRNA. Translation: BAA34522.2. Different initiation. AK131528 mRNA. Translation: BAD18666.1. AP000864 Genomic DNA. No translation available. AP001531 Genomic DNA. No translation available. BC040542 mRNA. Translation: AAH40542.2.
IPI	IPI00375286. IPI00477620. IPI00792611. IPI00829780.
RefSeq	NP_056025.2. NM_015210.3.
UniGene	Hs.731797.
3D structure databases
ProteinModelPortal	Q9Y4B5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4B5. 6 interactions.
STRING	9606.ENSP00000352927.
PTM databases
PhosphoSite	Q9Y4B5.
Polymorphism databases
DMDM	134048492.
Proteomic databases
PaxDb	Q9Y4B5.
PRIDE	Q9Y4B5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306285; ENSP00000303670; ENSG00000168502. ENST00000306329; ENSP00000305027; ENSG00000168502. ENST00000359865; ENSP00000352927; ENSG00000168502. ENST00000400050; ENSP00000382924; ENSG00000168502. ENST00000517570; ENSP00000429556; ENSG00000168502. ENST00000518815; ENSP00000463465; ENSG00000168502.
GeneID	23255.
KEGG	hsa:23255.
UCSC	uc002knq.2. human. uc002knr.2. human. uc002kns.2. human.
Organism-specific databases
CTD	23255.
GeneCards	GC18P008708.
HGNC	HGNC:29121. SOGA2.
HPA	HPA046245.
neXtProt	NX_Q9Y4B5.
PharmGKB	PA128394616.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80576.
HOVERGEN	HBG080205.
Gene expression databases
Bgee	Q9Y4B5.
CleanEx	HS_KIAA0802.
Genevestigator	Q9Y4B5.
Family and domain databases
InterPro	IPR021507. DUF3166. [Graphical view]
Pfam	PF11365. DUF3166. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23255.
NextBio	44978.

Entry information

Entry name

SOGA2_HUMAN

Accession

Primary (citable) accession number: Q9Y4B5
Secondary accession number(s): E9PAY7, Q6ZMQ9, Q8IWA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	April 18, 2012
Last modified:	April 3, 2013
This is version 82 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.