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Protein

Olfactory receptor 10H1

Gene

OR10H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H1
Alternative name(s):
Olfactory receptor OR19-27
Gene namesi
Name:OR10H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8172. OR10H1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31825CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 10H1PRO_0000150702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y4A9.
PRIDEiQ9Y4A9.

Expressioni

Gene expression databases

CleanExiHS_OR10H1.
GenevestigatoriQ9Y4A9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335596.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A9.
SMRiQ9Y4A9. Positions 27-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9Y4A9.
KOiK04257.
OMAiKLACGND.
OrthoDBiEOG78PV9F.
PhylomeDBiQ9Y4A9.
TreeFamiTF337675.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW
60 70 80 90 100
SERSLHTPMY LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ
110 120 130 140 150
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA
160 170 180 190 200
GGLVMGMVVT SAIFHLAFCG HKEIHHFACH VPPLLKLACG DDVLVVAKGV
210 220 230 240 250
GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV
260 270 280 290 300
VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV
310
AMKKTFFSKL YPEKNVMM
Length:318
Mass (Da):35,254
Last modified:October 31, 1999 - v1
Checksum:iD289E18D8A56FC57
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161G → R.
Corresponds to variant rs4808383 [ dbSNP | Ensembl ].
VAR_024127
Natural varianti65 – 651A → V.
Corresponds to variant rs4808382 [ dbSNP | Ensembl ].
VAR_054124
Natural varianti175 – 1751H → Q.
Corresponds to variant rs1859298 [ dbSNP | Ensembl ].
VAR_054125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004510 Genomic DNA. Translation: AAC08454.1.
BC130360 mRNA. Translation: AAI30361.1.
BC132969 mRNA. Translation: AAI32970.1.
AF399584 Genomic DNA. Translation: AAK95069.1.
BK004210 Genomic DNA. Translation: DAA04608.1.
CCDSiCCDS12335.1.
RefSeqiNP_039228.1. NM_013940.2.
UniGeneiHs.533925.

Genome annotation databases

EnsembliENST00000334920; ENSP00000335596; ENSG00000186723.
GeneIDi26539.
KEGGihsa:26539.
UCSCiuc002nbq.2. human.

Polymorphism databases

DMDMi14423829.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004510 Genomic DNA. Translation: AAC08454.1.
BC130360 mRNA. Translation: AAI30361.1.
BC132969 mRNA. Translation: AAI32970.1.
AF399584 Genomic DNA. Translation: AAK95069.1.
BK004210 Genomic DNA. Translation: DAA04608.1.
CCDSiCCDS12335.1.
RefSeqiNP_039228.1. NM_013940.2.
UniGeneiHs.533925.

3D structure databases

ProteinModelPortaliQ9Y4A9.
SMRiQ9Y4A9. Positions 27-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335596.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi14423829.

Proteomic databases

PaxDbiQ9Y4A9.
PRIDEiQ9Y4A9.

Protocols and materials databases

DNASUi26539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334920; ENSP00000335596; ENSG00000186723.
GeneIDi26539.
KEGGihsa:26539.
UCSCiuc002nbq.2. human.

Organism-specific databases

CTDi26539.
GeneCardsiGC19M015917.
H-InvDBHIX0174446.
HGNCiHGNC:8172. OR10H1.
neXtProtiNX_Q9Y4A9.
PharmGKBiPA31977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ9Y4A9.
KOiK04257.
OMAiKLACGND.
OrthoDBiEOG78PV9F.
PhylomeDBiQ9Y4A9.
TreeFamiTF337675.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10H1.
GenomeRNAii26539.
NextBioi48898.
PROiQ9Y4A9.

Gene expression databases

CleanExiHS_OR10H1.
GenevestigatoriQ9Y4A9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO10H1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A9
Secondary accession number(s): Q6IFQ2, Q96R59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 19, 2001
Last sequence update: October 31, 1999
Last modified: January 6, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.