SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y4A9

- O10H1_HUMAN

UniProt

Q9Y4A9 - O10H1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 10H1
Gene
OR10H1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10H1
    Alternative name(s):
    Olfactory receptor OR19-27
    Gene namesi
    Name:OR10H1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8172. OR10H1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini47 – 548Cytoplasmic Reviewed prediction
    Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini76 – 9924Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 13919Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini161 – 19737Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 23820Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini294 – 31825Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31977.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Olfactory receptor 10H1
    PRO_0000150702Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi97 ↔ 189 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y4A9.
    PRIDEiQ9Y4A9.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10H1.
    GenevestigatoriQ9Y4A9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335596.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4A9.
    SMRiQ9Y4A9. Positions 27-160.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79272.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ9Y4A9.
    KOiK04257.
    OMAiKLACGND.
    OrthoDBiEOG78PV9F.
    PhylomeDBiQ9Y4A9.
    TreeFamiTF337675.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y4A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW    50
    SERSLHTPMY LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ 100
    MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSPRG CACLVGCSWA 150
    GGLVMGMVVT SAIFHLAFCG HKEIHHFACH VPPLLKLACG DDVLVVAKGV 200
    GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV 250
    VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV 300
    AMKKTFFSKL YPEKNVMM 318
    Length:318
    Mass (Da):35,254
    Last modified:November 1, 1999 - v1
    Checksum:iD289E18D8A56FC57
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161G → R.
    Corresponds to variant rs4808383 [ dbSNP | Ensembl ].
    VAR_024127
    Natural varianti65 – 651A → V.
    Corresponds to variant rs4808382 [ dbSNP | Ensembl ].
    VAR_054124
    Natural varianti175 – 1751H → Q.
    Corresponds to variant rs1859298 [ dbSNP | Ensembl ].
    VAR_054125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004510 Genomic DNA. Translation: AAC08454.1.
    BC130360 mRNA. Translation: AAI30361.1.
    BC132969 mRNA. Translation: AAI32970.1.
    AF399584 Genomic DNA. Translation: AAK95069.1.
    BK004210 Genomic DNA. Translation: DAA04608.1.
    CCDSiCCDS12335.1.
    RefSeqiNP_039228.1. NM_013940.2.
    UniGeneiHs.533925.

    Genome annotation databases

    EnsembliENST00000334920; ENSP00000335596; ENSG00000186723.
    GeneIDi26539.
    KEGGihsa:26539.
    UCSCiuc002nbq.2. human.

    Polymorphism databases

    DMDMi14423829.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004510 Genomic DNA. Translation: AAC08454.1 .
    BC130360 mRNA. Translation: AAI30361.1 .
    BC132969 mRNA. Translation: AAI32970.1 .
    AF399584 Genomic DNA. Translation: AAK95069.1 .
    BK004210 Genomic DNA. Translation: DAA04608.1 .
    CCDSi CCDS12335.1.
    RefSeqi NP_039228.1. NM_013940.2.
    UniGenei Hs.533925.

    3D structure databases

    ProteinModelPortali Q9Y4A9.
    SMRi Q9Y4A9. Positions 27-160.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335596.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423829.

    Proteomic databases

    PaxDbi Q9Y4A9.
    PRIDEi Q9Y4A9.

    Protocols and materials databases

    DNASUi 26539.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334920 ; ENSP00000335596 ; ENSG00000186723 .
    GeneIDi 26539.
    KEGGi hsa:26539.
    UCSCi uc002nbq.2. human.

    Organism-specific databases

    CTDi 26539.
    GeneCardsi GC19M015917.
    H-InvDB HIX0174446.
    HGNCi HGNC:8172. OR10H1.
    neXtProti NX_Q9Y4A9.
    PharmGKBi PA31977.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79272.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q9Y4A9.
    KOi K04257.
    OMAi KLACGND.
    OrthoDBi EOG78PV9F.
    PhylomeDBi Q9Y4A9.
    TreeFami TF337675.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10H1.
    GenomeRNAii 26539.
    NextBioi 48898.
    PROi Q9Y4A9.

    Gene expression databases

    CleanExi HS_OR10H1.
    Genevestigatori Q9Y4A9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10H1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4A9
    Secondary accession number(s): Q6IFQ2, Q96R59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1999
    Last modified: September 3, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi