ID   NF2L3_HUMAN             Reviewed;         694 AA.
AC   Q9Y4A8; Q6NUS0; Q7Z498; Q86UJ4; Q86VR5; Q9UQA4;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 179.
DE   RecName: Full=Nuclear factor erythroid 2-related factor 3;
DE            Short=NF-E2-related factor 3;
DE            Short=NFE2-related factor 3;
DE   AltName: Full=Nuclear factor, erythroid derived 2, like 3;
GN   Name=NFE2L3; Synonyms=NRF3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH MAFG.
RA   Blank V., Andrews N.C.;
RT   "NRF3, a basic leucine zipper protein interacting with MAFG.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Stoesz S.P., Liu S., Pickett C.B.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, Lymph, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH
RP   MAFK, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   PubMed=10037736; DOI=10.1074/jbc.274.10.6443;
RA   Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K.,
RA   Hayashi N., Yamamoto M.;
RT   "Molecular cloning and functional characterization of a new Cap'n' collar
RT   family transcription factor Nrf3.";
RL   J. Biol. Chem. 274:6443-6452(1999).
CC   -!- FUNCTION: Activates erythroid-specific, globin gene expression.
CC   -!- SUBUNIT: Heterodimer with MAFG, MAFK and other small MAF proteins that
CC       binds to the MAF recognition elements (MARE).
CC       {ECO:0000269|PubMed:10037736, ECO:0000269|Ref.1}.
CC   -!- INTERACTION:
CC       Q9Y4A8; Q9ULX9: MAFF; NbExp=3; IntAct=EBI-10890629, EBI-721128;
CC       Q9Y4A8; O15525: MAFG; NbExp=5; IntAct=EBI-10890629, EBI-713514;
CC       Q9Y4A8; Q16621: NFE2; NbExp=4; IntAct=EBI-10890629, EBI-726369;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in human placenta and also in B-
CC       cell and monocyte cell lines. Low expression in heart, brain, lung,
CC       skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10037736}.
CC   -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP22344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAA76288.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF133059; AAG43275.1; -; mRNA.
DR   EMBL; AF134891; AAF61404.1; -; mRNA.
DR   EMBL; AF135116; AAF61415.1; -; Genomic_DNA.
DR   EMBL; AC004520; AAP22344.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC049219; AAH49219.1; -; mRNA.
DR   EMBL; BC056142; AAH56142.1; -; mRNA.
DR   EMBL; BC068455; AAH68455.1; -; mRNA.
DR   EMBL; AB010812; BAA76288.1; ALT_INIT; mRNA.
DR   CCDS; CCDS5396.1; -.
DR   RefSeq; NP_004280.5; NM_004289.6.
DR   AlphaFoldDB; Q9Y4A8; -.
DR   SMR; Q9Y4A8; -.
DR   BioGRID; 114967; 16.
DR   ComplexPortal; CPX-2471; bZIP transcription factor complex, BACH2-NFE2L3.
DR   ComplexPortal; CPX-6572; bZIP transcription factor complex, ATF4-NFE2L3.
DR   IntAct; Q9Y4A8; 13.
DR   STRING; 9606.ENSP00000056233; -.
DR   iPTMnet; Q9Y4A8; -.
DR   PhosphoSitePlus; Q9Y4A8; -.
DR   BioMuta; NFE2L3; -.
DR   DMDM; 56404677; -.
DR   EPD; Q9Y4A8; -.
DR   MassIVE; Q9Y4A8; -.
DR   PaxDb; 9606-ENSP00000056233; -.
DR   PeptideAtlas; Q9Y4A8; -.
DR   ProteomicsDB; 86144; -.
DR   Antibodypedia; 12307; 213 antibodies from 27 providers.
DR   DNASU; 9603; -.
DR   Ensembl; ENST00000056233.4; ENSP00000056233.3; ENSG00000050344.9.
DR   GeneID; 9603; -.
DR   KEGG; hsa:9603; -.
DR   MANE-Select; ENST00000056233.4; ENSP00000056233.3; NM_004289.7; NP_004280.5.
DR   UCSC; uc003sxq.4; human.
DR   AGR; HGNC:7783; -.
DR   CTD; 9603; -.
DR   DisGeNET; 9603; -.
DR   GeneCards; NFE2L3; -.
DR   HGNC; HGNC:7783; NFE2L3.
DR   HPA; ENSG00000050344; Tissue enhanced (placenta).
DR   MIM; 604135; gene.
DR   neXtProt; NX_Q9Y4A8; -.
DR   OpenTargets; ENSG00000050344; -.
DR   PharmGKB; PA31589; -.
DR   VEuPathDB; HostDB:ENSG00000050344; -.
DR   eggNOG; KOG3863; Eukaryota.
DR   GeneTree; ENSGT00950000182892; -.
DR   HOGENOM; CLU_024173_1_0_1; -.
DR   InParanoid; Q9Y4A8; -.
DR   OMA; SQAVSHD; -.
DR   OrthoDB; 382726at2759; -.
DR   PhylomeDB; Q9Y4A8; -.
DR   TreeFam; TF337360; -.
DR   PathwayCommons; Q9Y4A8; -.
DR   SignaLink; Q9Y4A8; -.
DR   SIGNOR; Q9Y4A8; -.
DR   BioGRID-ORCS; 9603; 99 hits in 1180 CRISPR screens.
DR   ChiTaRS; NFE2L3; human.
DR   GeneWiki; NFE2L3; -.
DR   GenomeRNAi; 9603; -.
DR   Pharos; Q9Y4A8; Tbio.
DR   PRO; PR:Q9Y4A8; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9Y4A8; Protein.
DR   Bgee; ENSG00000050344; Expressed in primordial germ cell in gonad and 133 other cell types or tissues.
DR   ExpressionAtlas; Q9Y4A8; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ComplexPortal.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0140467; P:integrated stress response signaling; NAS:ComplexPortal.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR   CDD; cd14720; bZIP_NFE2-like; 1.
DR   Gene3D; 1.10.880.10; Transcription factor, Skn-1-like, DNA-binding domain; 1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR004826; bZIP_Maf.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR047167; NFE2-like.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   PANTHER; PTHR24411; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR; 1.
DR   PANTHER; PTHR24411:SF8; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3; 1.
DR   Pfam; PF03131; bZIP_Maf; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR   SUPFAM; SSF57959; Leucine zipper domain; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
DR   Genevisible; Q9Y4A8; HS.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..694
FT                   /note="Nuclear factor erythroid 2-related factor 3"
FT                   /id="PRO_0000076452"
FT   DOMAIN          578..641
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          133..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..599
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          606..620
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   COMPBIAS        192..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         441
FT                   /note="V -> E (in dbSNP:rs2072129)"
FT                   /id="VAR_055562"
FT   CONFLICT        286
FT                   /note="P -> L (in Ref. 4; AAH68455)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   694 AA;  76154 MW;  DAD6D883FCCBA982 CRC64;
     MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG GPASSAYALS
     PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV PFVPRTSVDA WLVHSVAAGS
     ADEAHGLLGA AAASSTGGAG ASVDGGSQAV QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ
     VPDAGGCASE ENGVLREKHE AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE
     AEKTTESRNE RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH
     YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT NPEQTLPGTN
     LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE DNFDPIDVSQ LFDEPDSDSG
     LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ
     SDSDFHGDLT FQHVFHNHTY HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ
     RAKALHIPFS VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL
     DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR DDQGRPVNPN
     HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK
//